DE69403537D1 - Verfahren zur Synthese von halbsynthetischen Glykosaminoglykanen mit Heparin- oder Heparanstruktur, die in 2-Position modifiziertes Alpha-L-Iduronsäure-2-O-Sulfat enthalten - Google Patents

Verfahren zur Synthese von halbsynthetischen Glykosaminoglykanen mit Heparin- oder Heparanstruktur, die in 2-Position modifiziertes Alpha-L-Iduronsäure-2-O-Sulfat enthalten

Info

Publication number
DE69403537D1
DE69403537D1 DE69403537T DE69403537T DE69403537D1 DE 69403537 D1 DE69403537 D1 DE 69403537D1 DE 69403537 T DE69403537 T DE 69403537T DE 69403537 T DE69403537 T DE 69403537T DE 69403537 D1 DE69403537 D1 DE 69403537D1
Authority
DE
Germany
Prior art keywords
heparin
sulfate
synthesis
semi
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69403537T
Other languages
English (en)
Other versions
DE69403537T2 (de
Inventor
Fabrizio Ungarelli
Silvano Piani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Wasserman SpA
Original Assignee
Alfa Wasserman SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wasserman SpA filed Critical Alfa Wasserman SpA
Application granted granted Critical
Publication of DE69403537D1 publication Critical patent/DE69403537D1/de
Publication of DE69403537T2 publication Critical patent/DE69403537T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69403537T 1993-03-29 1994-03-18 Verfahren zur Synthese von halbsynthetischen Glykosaminoglykanen mit Heparin- oder Heparanstruktur, die in 2-Position modifiziertes Alpha-L-Iduronsäure-2-O-Sulfat enthalten Expired - Fee Related DE69403537T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93BO000125A IT1264101B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2

Publications (2)

Publication Number Publication Date
DE69403537D1 true DE69403537D1 (de) 1997-07-10
DE69403537T2 DE69403537T2 (de) 1997-09-18

Family

ID=11338858

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69403537T Expired - Fee Related DE69403537T2 (de) 1993-03-29 1994-03-18 Verfahren zur Synthese von halbsynthetischen Glykosaminoglykanen mit Heparin- oder Heparanstruktur, die in 2-Position modifiziertes Alpha-L-Iduronsäure-2-O-Sulfat enthalten

Country Status (18)

Country Link
US (1) US5405949A (de)
EP (1) EP0618234B1 (de)
JP (1) JP2731721B2 (de)
KR (1) KR100194122B1 (de)
AT (1) ATE154039T1 (de)
AU (1) AU664939B2 (de)
CA (1) CA2114862C (de)
DE (1) DE69403537T2 (de)
DK (1) DK0618234T3 (de)
ES (1) ES2102087T3 (de)
FI (1) FI105101B (de)
GR (1) GR3024416T3 (de)
IL (1) IL108689A (de)
IT (1) IT1264101B1 (de)
NO (1) NO305994B1 (de)
NZ (1) NZ250815A (de)
TW (1) TW266215B (de)
ZA (1) ZA94970B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
EP1353556A4 (de) 2001-01-23 2009-09-09 Massachusetts Inst Technology Fest- und flüssigphasen-synthese von heparin und anderen glykosaminoglykanen
ES2431362T3 (es) 2001-09-12 2013-11-26 Sigma-Tau Research Switzerland S.A. Derivados de glicosaminoglicanos totalmente N-desulfatados como agentes inhibidores de la heparanasa, dotados con actividad antiangiogénica y desprovistos de efecto anticoagulante
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
CA3015193A1 (en) 2016-03-09 2017-09-14 Glytech, Inc. Method of producing saccharide having sulfate group and/or phosphate group
WO2021128253A1 (zh) * 2019-12-27 2021-07-01 深圳市海普瑞药业集团股份有限公司 一种糖胺聚糖衍生物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5011919A (en) * 1989-01-30 1991-04-30 Ajorca S.A. Modified heparins and obtention process
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
BE1006134A6 (fr) * 1992-08-25 1994-05-24 Syntex Sa Procede de preparation de derives 2-desoxy-2-amino hexuronyles d'heparine, derives tels qu'ainsi obtenus et leur utilisation.

Also Published As

Publication number Publication date
US5405949A (en) 1995-04-11
IT1264101B1 (it) 1996-09-10
ITBO930125A0 (it) 1993-03-29
ZA94970B (en) 1994-08-24
NO941128L (no) 1994-09-30
AU664939B2 (en) 1995-12-07
EP0618234A1 (de) 1994-10-05
KR100194122B1 (ko) 1999-06-15
IL108689A (en) 1998-03-10
EP0618234B1 (de) 1997-06-04
FI941431A0 (fi) 1994-03-28
DK0618234T3 (da) 1997-08-25
DE69403537T2 (de) 1997-09-18
ES2102087T3 (es) 1997-07-16
NZ250815A (en) 1996-02-27
JPH06298805A (ja) 1994-10-25
GR3024416T3 (en) 1997-11-28
ITBO930125A1 (it) 1994-09-29
KR940021582A (ko) 1994-10-19
FI941431A (fi) 1994-09-30
IL108689A0 (en) 1994-05-30
NO941128D0 (no) 1994-03-28
TW266215B (de) 1995-12-21
ATE154039T1 (de) 1997-06-15
CA2114862C (en) 1999-05-25
AU5508594A (en) 1994-10-06
NO305994B1 (no) 1999-08-30
JP2731721B2 (ja) 1998-03-25
FI105101B (fi) 2000-06-15
CA2114862A1 (en) 1994-09-30

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Legal Events

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8339 Ceased/non-payment of the annual fee