IT1260136B - Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3 - Google Patents

Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3

Info

Publication number
IT1260136B
IT1260136B ITBO920140A ITBO920140A IT1260136B IT 1260136 B IT1260136 B IT 1260136B IT BO920140 A ITBO920140 A IT BO920140A IT BO920140 A ITBO920140 A IT BO920140A IT 1260136 B IT1260136 B IT 1260136B
Authority
IT
Italy
Prior art keywords
synthetic
semi
galacturonic acid
glycosaminoglicans
alpha
Prior art date
Application number
ITBO920140A
Other languages
English (en)
Inventor
Silvano Piani
Egidio Marchi
Gianfranco Tamagnone
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of ITBO920140A0 publication Critical patent/ITBO920140A0/it
Priority to ITBO920140A priority Critical patent/IT1260136B/it
Priority to DK93103847.5T priority patent/DK0565862T3/da
Priority to AT93103847T priority patent/ATE154615T1/de
Priority to ES93103847T priority patent/ES2103991T3/es
Priority to DE69311618T priority patent/DE69311618T2/de
Priority to EP93103847A priority patent/EP0565862B1/en
Priority to ZA931799A priority patent/ZA931799B/xx
Priority to NZ247197A priority patent/NZ247197A/en
Priority to IL105111A priority patent/IL105111A/xx
Priority to TW082102015A priority patent/TW229213B/zh
Priority to NO931181A priority patent/NO306305B1/no
Priority to CA002093148A priority patent/CA2093148C/en
Priority to AU36896/93A priority patent/AU658499B2/en
Priority to US08/046,247 priority patent/US5430132A/en
Priority to FI931740A priority patent/FI106555B/fi
Priority to JP5089977A priority patent/JP2702377B2/ja
Priority to KR1019930006474A priority patent/KR0171623B1/ko
Publication of ITBO920140A1 publication Critical patent/ITBO920140A1/it
Application granted granted Critical
Publication of IT1260136B publication Critical patent/IT1260136B/it
Priority to GR970402225T priority patent/GR3024582T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
ITBO920140A 1992-04-17 1992-04-17 Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3 IT1260136B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
ITBO920140A IT1260136B (it) 1992-04-17 1992-04-17 Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
DK93103847.5T DK0565862T3 (da) 1992-04-17 1993-03-10 Semisyntetiske glucosaminoglycaner, der i 3-stillingen indeholder med nukleofile radikaler substitueret alfa-L-galacturonsyre
AT93103847T ATE154615T1 (de) 1992-04-17 1993-03-10 Halbsynthetische glykosaminoglykane, die in 3- position mit nukleophilen radikalen substituierte alpha-l-galakturonsäure enthalten
ES93103847T ES2103991T3 (es) 1992-04-17 1993-03-10 Glicosaminoglicanos semisinteticos que contienen acido alfa-l-galacturonico sustituido con radicales nucleofilos en posicion 3.
DE69311618T DE69311618T2 (de) 1992-04-17 1993-03-10 Halbsynthetische Glykosaminoglykane, die in 3-Position mit nukleophilen Radikalen substituierte alpha-L-Galakturonsäure enthalten
EP93103847A EP0565862B1 (en) 1992-04-17 1993-03-10 Semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3
ZA931799A ZA931799B (en) 1992-04-17 1993-03-12 Semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3
NZ247197A NZ247197A (en) 1992-04-17 1993-03-18 Semi-synthetic glycosaminoglycans with alpha-l-galacturonic acid substituted with nucleophilic radicals in position 3
IL105111A IL105111A (en) 1992-04-17 1993-03-19 SEMI-SYNTHETIC GLYCOSAMINOGLYCANS CONTAINING a-L- GALACTURONIC ACID SUBSTITUTED WITH NUCLEOPHILIC RADICALS IN POSITION 3 AND THEIR PREPARATION
TW082102015A TW229213B (it) 1992-04-17 1993-03-19
NO931181A NO306305B1 (no) 1992-04-17 1993-03-30 Halvsyntetiske glykosaminoglykaner som inneholder <alfa>-L-galakturonsyre med et nukleofilt radikal i 3-stillingen, samt fremgangsmÕte til fremstilling av samme
CA002093148A CA2093148C (en) 1992-04-17 1993-04-01 Semi-synthetic glycosaminoglycans containing .alpha.-l-galacturonic acid substituted with nucleophilic radicals in position 3
AU36896/93A AU658499B2 (en) 1992-04-17 1993-04-13 Semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3
US08/046,247 US5430132A (en) 1992-04-17 1993-04-13 Semi-synthetic glycosaminoglycans containing α-L-galacturonic acid substituted with nucleophilic groups in position 3
FI931740A FI106555B (fi) 1992-04-17 1993-04-16 Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi
JP5089977A JP2702377B2 (ja) 1992-04-17 1993-04-16 ３位を求核基で置換されたα−Ｌ−ガラクツロン酸を含有する半合成グリコサミノグリカン類
KR1019930006474A KR0171623B1 (ko) 1992-04-17 1993-04-17 3-위치가 친핵성 래디칼로 치환된 알파-엘-갈락투론산을 함유하는 반-합성 글리코스아미노글리칸
GR970402225T GR3024582T3 (en) 1992-04-17 1997-08-29 Semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO920140A IT1260136B (it) 1992-04-17 1992-04-17 Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3

Publications (3)

Publication Number Publication Date
ITBO920140A0 ITBO920140A0 (it) 1992-04-17
ITBO920140A1 ITBO920140A1 (it) 1993-10-17
IT1260136B true IT1260136B (it) 1996-03-28

Family

ID=11338174

Family Applications (1)

Application Number Title Priority Date Filing Date
ITBO920140A IT1260136B (it) 1992-04-17 1992-04-17 Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3

Country Status (18)

Country Link
US (1) US5430132A (it)
EP (1) EP0565862B1 (it)
JP (1) JP2702377B2 (it)
KR (1) KR0171623B1 (it)
AT (1) ATE154615T1 (it)
AU (1) AU658499B2 (it)
CA (1) CA2093148C (it)
DE (1) DE69311618T2 (it)
DK (1) DK0565862T3 (it)
ES (1) ES2103991T3 (it)
FI (1) FI106555B (it)
GR (1) GR3024582T3 (it)
IL (1) IL105111A (it)
IT (1) IT1260136B (it)
NO (1) NO306305B1 (it)
NZ (1) NZ247197A (it)
TW (1) TW229213B (it)
ZA (1) ZA931799B (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
US6127347A (en) * 1994-01-12 2000-10-03 Univ Michigan Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US5583121A (en) * 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
NO984143L (no) 1998-09-09 2000-03-10 Norsk Hydro As Ny prosess for å fremstille overflatemodifiserende stoffer
CA2377734A1 (en) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc. Heparin compositions that inhibit clot associated coagulation factors
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
HUP0300939A2 (hu) * 2000-09-08 2003-09-29 Hamilton Civic Hospitals Research Development, Inc. Antitrombotikus készítmények
EP2402753A1 (en) * 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US8435795B2 (en) * 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
EP3144325B1 (en) 2010-09-14 2020-11-04 University Of Miyazaki High purity heparin and production method therefor
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
US10913763B2 (en) 2016-03-09 2021-02-09 Glytech, Inc. Method for producing sugar having sulfate group and/or phosphate group

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
DE3821271A1 (de) * 1988-06-23 1989-12-28 Solco Basel Ag Derivatisiertes heparin, verfahren zu dessen herstellung und arzneimittel, welches dieses enthaelt
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5200523A (en) * 1990-10-10 1993-04-06 Monsanto Company Synthesis of nojirimycin derivatives

Also Published As

Publication number Publication date
EP0565862A3 (en) 1993-11-10
ATE154615T1 (de) 1997-07-15
ITBO920140A0 (it) 1992-04-17
AU658499B2 (en) 1995-04-13
JP2702377B2 (ja) 1998-01-21
DK0565862T3 (da) 1997-12-15
EP0565862B1 (en) 1997-06-18
AU3689693A (en) 1993-10-21
US5430132A (en) 1995-07-04
FI931740A0 (fi) 1993-04-16
TW229213B (it) 1994-09-01
ES2103991T3 (es) 1997-10-01
DE69311618D1 (de) 1997-07-24
ZA931799B (en) 1993-12-27
CA2093148C (en) 1999-01-26
NZ247197A (en) 1995-02-24
NO306305B1 (no) 1999-10-18
KR930021651A (ko) 1993-11-22
NO931181L (no) 1993-10-18
FI106555B (fi) 2001-02-28
GR3024582T3 (en) 1997-12-31
KR0171623B1 (ko) 1999-02-01
JPH0616704A (ja) 1994-01-25
EP0565862A2 (en) 1993-10-20
FI931740A (fi) 1993-10-18
ITBO920140A1 (it) 1993-10-17
IL105111A (en) 1997-03-18
NO931181D0 (no) 1993-03-30
DE69311618T2 (de) 1997-12-11
CA2093148A1 (en) 1993-10-18

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970423