IT1260137B - Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato - Google Patents

Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato

Info

Publication number
IT1260137B
IT1260137B ITBO920141A ITBO920141A IT1260137B IT 1260137 B IT1260137 B IT 1260137B IT BO920141 A ITBO920141 A IT BO920141A IT BO920141 A ITBO920141 A IT BO920141A IT 1260137 B IT1260137 B IT 1260137B
Authority
IT
Italy
Prior art keywords
iduronic
alpha
synthetic
semi
eparinic
Prior art date
Application number
ITBO920141A
Other languages
English (en)
Inventor
Silvano Piani
Egidio Marchi
Gianfranco Tamagnone
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of ITBO920141A0 publication Critical patent/ITBO920141A0/it
Priority to ITBO920141A priority Critical patent/IT1260137B/it
Priority to EP93103848A priority patent/EP0565863B1/en
Priority to AT93103848T priority patent/ATE154616T1/de
Priority to DK93103848.3T priority patent/DK0565863T3/da
Priority to DE69311619T priority patent/DE69311619T2/de
Priority to ES93103848T priority patent/ES2103992T3/es
Priority to ZA931798A priority patent/ZA931798B/xx
Priority to NZ247196A priority patent/NZ247196A/en
Priority to IL10511293A priority patent/IL105112A/xx
Priority to TW082102014A priority patent/TW239148B/zh
Priority to NO931184A priority patent/NO305992B1/no
Priority to CA002093147A priority patent/CA2093147C/en
Priority to US08/046,248 priority patent/US5430133A/en
Priority to AU36895/93A priority patent/AU658498B2/en
Priority to FI931741A priority patent/FI106556B/fi
Priority to JP5089976A priority patent/JP2702376B2/ja
Priority to KR1019930006473A priority patent/KR0171624B1/ko
Publication of ITBO920141A1 publication Critical patent/ITBO920141A1/it
Application granted granted Critical
Publication of IT1260137B publication Critical patent/IT1260137B/it
Priority to GR970402062T priority patent/GR3024419T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ITBO920141A 1992-04-17 1992-04-17 Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato IT1260137B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
ITBO920141A IT1260137B (it) 1992-04-17 1992-04-17 Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
EP93103848A EP0565863B1 (en) 1992-04-17 1993-03-10 Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-L-iduronic-2-0-sulfate acid modified in position 2
AT93103848T ATE154616T1 (de) 1992-04-17 1993-03-10 Halbsynthetische glykosaminoglykane mit heparin- oder heparinstruktur, die jedoch in 2-position modifziertes alpha-l-iduronsäure-2-0-sulfat enthalten
DK93103848.3T DK0565863T3 (da) 1992-04-17 1993-03-10 Semisyntetiske clycosaminoglycaner med heparin- eller heparanstruktur af i 2-stillingen modificeret alfa-L-iduron-2-O-sulfatsyre
DE69311619T DE69311619T2 (de) 1992-04-17 1993-03-10 Halbsynthetische Glykosaminoglykane mit Heparin- oder Heparinstruktur, die jedoch in 2-Position modifziertes Alpha-L-Iduronsäure-2-0-Sulfat enthalten
ES93103848T ES2103992T3 (es) 1992-04-17 1993-03-10 Glicosaminoglicanos semisinteticos con estructura de heparina o heparano de acido alfa-l-iduronico-2-o-sulfato modificado en posicion 2.
ZA931798A ZA931798B (en) 1992-04-17 1993-03-12 Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-L-iduranic-2-0-sulfate acid modified in position 2
NZ247196A NZ247196A (en) 1992-04-17 1993-03-18 Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-l-iduronic-2-0 sulphate acid modified in position 2
IL10511293A IL105112A (en) 1992-04-17 1993-03-19 Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-l-iduronic-2-o-sulfate acid modified in position 2 and their preparation
TW082102014A TW239148B (it) 1992-04-17 1993-03-19
NO931184A NO305992B1 (no) 1992-04-17 1993-03-30 Halvsyntetiske glykosaminglykosaner med heparin- eller heparanstruktur og fremgangsmåte til fremstilling derav
CA002093147A CA2093147C (en) 1992-04-17 1993-04-01 Semi-synthetic glycosaminoglycans with heparin or heparan structure of –-l-iduronic-2-sulfate acid modified in position 2
US08/046,248 US5430133A (en) 1992-04-17 1993-04-13 Semi-synthetic glycosaminoglycans with heparin or heparan structure of α-L-iduronic-2-O-sulfate acid modified in position 2
AU36895/93A AU658498B2 (en) 1992-04-17 1993-04-13 Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-L-iduronic-2-sulfate acid modified in position 2
FI931741A FI106556B (fi) 1992-04-17 1993-04-16 Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi
JP5089976A JP2702376B2 (ja) 1992-04-17 1993-04-16 α−Ｌ−イズロン酸−２−Ｏ−硫酸が修飾されたヘパリンまたはヘパラン構造を有する半合成グリコサミノグリカン
KR1019930006473A KR0171624B1 (ko) 1992-04-17 1993-04-17 2-위치가 수정된 알파-엘-이두로닉-2-o-황산의 헤파린 또는 헤파란 구조를 갖는 반-합성 글리코스아미노글리칸
GR970402062T GR3024419T3 (en) 1992-04-17 1997-08-13 Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-L-iduronic-2-0-sulfate acid modified in position 2

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO920141A IT1260137B (it) 1992-04-17 1992-04-17 Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato

Publications (3)

Publication Number Publication Date
ITBO920141A0 ITBO920141A0 (it) 1992-04-17
ITBO920141A1 ITBO920141A1 (it) 1993-10-17
IT1260137B true IT1260137B (it) 1996-03-28

Family

ID=11338176

Family Applications (1)

Application Number Title Priority Date Filing Date
ITBO920141A IT1260137B (it) 1992-04-17 1992-04-17 Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato

Country Status (18)

Country Link
US (1) US5430133A (it)
EP (1) EP0565863B1 (it)
JP (1) JP2702376B2 (it)
KR (1) KR0171624B1 (it)
AT (1) ATE154616T1 (it)
AU (1) AU658498B2 (it)
CA (1) CA2093147C (it)
DE (1) DE69311619T2 (it)
DK (1) DK0565863T3 (it)
ES (1) ES2103992T3 (it)
FI (1) FI106556B (it)
GR (1) GR3024419T3 (it)
IL (1) IL105112A (it)
IT (1) IT1260137B (it)
NO (1) NO305992B1 (it)
NZ (1) NZ247196A (it)
TW (1) TW239148B (it)
ZA (1) ZA931798B (it)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
US5583121A (en) * 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US6127347A (en) * 1994-01-12 2000-10-03 Univ Michigan Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
MXPA02000142A (es) * 1999-06-30 2003-07-21 Hamilton Civic Hospitals Res Composiciones de heparina que inhiben los factores de coagulacion asociados con el coagulo.
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
JP2004507562A (ja) * 2000-09-08 2004-03-11 ハミルトン　シビック　ホスピタルズ　リサーチ　ディベロップメント　インコーポレイテッド 抗血栓性組成物
EP2402753A1 (en) * 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
WO2009014715A2 (en) * 2007-07-23 2009-01-29 The University Of North Carolina At Chapel Hill Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues
EP2526122B1 (en) * 2010-01-19 2020-06-10 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN103209997B (zh) * 2010-09-14 2016-03-16 国立大学法人宫崎大学 高纯度肝素及其制备方法
US11203772B2 (en) 2010-12-23 2021-12-21 The University Of North Carolina At Chapel Hill Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
DE102011077393A1 (de) * 2011-06-10 2012-12-13 Johannes Reinmüller Antiinfektives Mittel
CN105452479B (zh) 2013-06-17 2021-05-18 北卡罗来纳大学查珀尔希尔分校 可逆肝素分子
JP7330893B2 (ja) 2017-03-10 2023-08-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 短時間作用型ヘパリンベースの抗凝集剤化合物及び方法
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
WO2019090203A1 (en) 2017-11-03 2019-05-09 The University Of North Carolina At Chapel Hill Sulfated oligosaccharides having anti-inflammatory activity
JP7538724B2 (ja) 2018-06-20 2024-08-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 細胞保護の方法と組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
DE3821271A1 (de) * 1988-06-23 1989-12-28 Solco Basel Ag Derivatisiertes heparin, verfahren zu dessen herstellung und arzneimittel, welches dieses enthaelt
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
ATE148713T1 (de) * 1990-07-24 1997-02-15 Seikagaku Kogyo Co Ltd Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitor
US5200523A (en) * 1990-10-10 1993-04-06 Monsanto Company Synthesis of nojirimycin derivatives
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3

Also Published As

Publication number Publication date
EP0565863B1 (en) 1997-06-18
ITBO920141A0 (it) 1992-04-17
DE69311619T2 (de) 1997-12-11
US5430133A (en) 1995-07-04
EP0565863A2 (en) 1993-10-20
ZA931798B (en) 1993-11-22
NO931184L (no) 1993-10-18
EP0565863A3 (en) 1993-11-10
IL105112A (en) 1997-01-10
KR930021650A (ko) 1993-11-22
TW239148B (it) 1995-01-21
GR3024419T3 (en) 1997-11-28
KR0171624B1 (ko) 1999-02-01
CA2093147A1 (en) 1993-10-18
CA2093147C (en) 1999-01-26
AU3689593A (en) 1993-10-21
ITBO920141A1 (it) 1993-10-17
AU658498B2 (en) 1995-04-13
NO931184D0 (no) 1993-03-30
JP2702376B2 (ja) 1998-01-21
NO305992B1 (no) 1999-08-30
ATE154616T1 (de) 1997-07-15
IL105112A0 (en) 1993-07-08
DK0565863T3 (da) 1997-12-15
FI106556B (fi) 2001-02-28
NZ247196A (en) 1995-02-24
DE69311619D1 (de) 1997-07-24
JPH0616703A (ja) 1994-01-25
ES2103992T3 (es) 1997-10-01
FI931741A0 (fi) 1993-04-16
FI931741A (fi) 1993-10-18

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Effective date: 19970423