ATE148713T1 - Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitor - Google Patents

Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitor

Info

Publication number
ATE148713T1
ATE148713T1 AT91913108T AT91913108T ATE148713T1 AT E148713 T1 ATE148713 T1 AT E148713T1 AT 91913108 T AT91913108 T AT 91913108T AT 91913108 T AT91913108 T AT 91913108T AT E148713 T1 ATE148713 T1 AT E148713T1
Authority
AT
Austria
Prior art keywords
glycosaminoglycan
lipid
derivative
phospholipide
mixed
Prior art date
Application number
AT91913108T
Other languages
English (en)
Inventor
Katsukiyo - Zohshiki Sakurai
Nobuo Tokudanishi -Cho Sugiura
Koji Uedayama -Chome T Kimata
Sakaru - The Ci Mansion Suzuki
Original Assignee
Seikagaku Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2193816A external-priority patent/JP2986518B2/ja
Priority claimed from JP2193818A external-priority patent/JP2986519B2/ja
Priority claimed from JP2193817A external-priority patent/JP2997018B2/ja
Application filed by Seikagaku Kogyo Co Ltd filed Critical Seikagaku Kogyo Co Ltd
Application granted granted Critical
Publication of ATE148713T1 publication Critical patent/ATE148713T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
AT91913108T 1990-07-24 1991-07-24 Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitor ATE148713T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2193816A JP2986518B2 (ja) 1990-07-24 1990-07-24 癌転移抑制剤
JP2193818A JP2986519B2 (ja) 1990-07-24 1990-07-24 燐脂質結合グリコサミノグリカン
JP2193817A JP2997018B2 (ja) 1990-07-24 1990-07-24 燐脂質又は脂質結合グリコサミノグリカン

Publications (1)

Publication Number Publication Date
ATE148713T1 true ATE148713T1 (de) 1997-02-15

Family

ID=27326820

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91913108T ATE148713T1 (de) 1990-07-24 1991-07-24 Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitor

Country Status (10)

Country Link
US (1) US5464942A (de)
EP (1) EP0493622B1 (de)
KR (1) KR0181295B1 (de)
AT (1) ATE148713T1 (de)
AU (1) AU647814B2 (de)
CA (1) CA2067211C (de)
DE (1) DE69124590T2 (de)
FI (1) FI103279B (de)
NO (1) NO305368B1 (de)
WO (1) WO1992001720A1 (de)

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IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
CA2118586A1 (en) * 1992-07-13 1994-01-20 Bernard Malfroy-Camine Transvascular and intracellular delivery of lipidized proteins
JP3714683B2 (ja) * 1992-07-30 2005-11-09 生化学工業株式会社 抗リウマチ剤
JP2787279B2 (ja) * 1994-05-17 1998-08-13 雪印乳業株式会社 糖リン脂質及びその調製法
US6228998B1 (en) * 1994-07-22 2001-05-08 Seikagaku Kogyo Kabushiki Kaisha Amino spacered glycosaminoglycan derivatives and their use in copolymerization with acrylamide
FR2725622A1 (fr) * 1994-10-14 1996-04-19 Fabre Pierre Dermo Cosmetique Ceramide greffee anti-elastase
CA2175282A1 (en) * 1996-04-29 1997-10-30 Rudolf Edgar Falk Use of forms of hyaluronic acid (ha) for the treatment of cancer
AU2602200A (en) * 1999-01-08 2000-07-24 Board Of Trustees Of The University Of Arkansas, The Synthetic, highly charged molecules and uses thereof
JP3032824B1 (ja) * 1999-01-28 2000-04-17 東京医科歯科大学長 骨誘導促進剤
WO2001012675A1 (fr) * 1999-08-10 2001-02-22 Seikagaku Corporation Derives de glycosaminoglycane et leur utilisation
US8916539B2 (en) * 2000-01-10 2014-12-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of disease
US7393938B2 (en) * 2000-01-10 2008-07-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US8076312B2 (en) * 2000-01-10 2011-12-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Use of lipid conjugates in the treatment of disease
US7141552B2 (en) * 2000-01-10 2006-11-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US7811999B2 (en) * 2000-01-10 2010-10-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Use of lipid conjugates in the treatment of diseases
US20090325876A1 (en) * 2004-09-29 2009-12-31 Saul Yedgar Use of lipid conjugates in the treatment of diseases associated with vasculature
US7893226B2 (en) * 2004-09-29 2011-02-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Use of lipid conjugates in the treatment of diseases
US20060189569A1 (en) * 2000-01-10 2006-08-24 Saul Yedgar Use of lipid conjugates in the treatment of infection
US7772196B2 (en) * 2000-01-10 2010-08-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US8501701B2 (en) * 2000-01-10 2013-08-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Use of lipid conjugates in the treatment of disease
US7608598B2 (en) * 2000-01-10 2009-10-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of conjunctivitis
US8304395B2 (en) * 2000-01-10 2012-11-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Lipid conjugates in the treatment of disease
US9040078B2 (en) * 2000-01-10 2015-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases of the nervous system
US7101859B2 (en) * 2000-01-10 2006-09-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
US8883761B2 (en) * 2001-01-10 2014-11-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases associated with vasculature
US7280612B2 (en) * 2003-07-25 2007-10-09 Zarbana Digital Fund Llc Digital branch calibrator for an RF transmitter
EP1681306B1 (de) * 2003-10-29 2013-02-20 Teijin Limited Hyaluronsäureverbindung, hydrogel davon und material zur behandlung von gelenken
CN104546891A (zh) * 2005-08-03 2015-04-29 塞尔索斯治疗公司 脂质结合物在囊性纤维化病中的用途及其应用
JP4744973B2 (ja) * 2005-08-05 2011-08-10 株式会社トプコン 眼底カメラ
US8475694B2 (en) 2005-10-25 2013-07-02 Zephyros, Inc. Shaped expandable material
US8906882B2 (en) 2005-11-17 2014-12-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lipid conjugates in the treatment of allergic rhinitis
US8859524B2 (en) 2005-11-17 2014-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lipid conjugates in the treatment of chronic rhinosinusitis
US20080183282A1 (en) * 2006-03-09 2008-07-31 Saul Yedgar Use of lipid conjugates for the coating of stents and catheters
CA2705785A1 (en) * 2006-11-14 2008-05-22 Saul Yedgar Use of lipid conjugates in the treatment of diseases or disorders of the eye
AU2007320737B2 (en) * 2006-11-14 2014-04-03 Celsus Therapeutics Plc Contact lens compositions
AU2010247814B2 (en) * 2009-05-11 2015-08-13 Celsus Therapeutics Plc Lipid-polymer conjugates, their preparation and uses thereof
GB0916205D0 (en) 2009-09-15 2009-10-28 Zephyros Inc Improvements in or relating to cavity filling
WO2011113892A2 (en) * 2010-03-17 2011-09-22 Ktb Tumorforschungsgesellschaft Mbh Combined use of phospholipid and sulfate groups-carrying polysaccharides for inhibiting metastatic spread
CA2703532C (en) * 2010-05-10 2018-05-01 Eva Turley Topically administered, skin-penetrating glycosaminoglycan formulations suitable for use in cosmetic and pharmaceutical applications
JP2022530253A (ja) * 2019-04-29 2022-06-28 ボシュ・アンド・ロム・インコーポレイテッド 糖リン脂質ポリマーネットワーク及びその使用

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FR2374910A1 (fr) * 1976-10-23 1978-07-21 Choay Sa Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations
FR2492259A1 (fr) * 1980-10-21 1982-04-23 Idinvex Sa Formulation d'heparine
US4362737A (en) * 1981-04-13 1982-12-07 Schaefer Rolf Transdermal carrier materials
US4604376A (en) * 1982-04-21 1986-08-05 Research Corporation Enteric compounds and complexes
US4654327A (en) * 1982-04-21 1987-03-31 Research Corp. Quaternary ammonium complexes of heparin
CA1226816A (en) * 1982-12-20 1987-09-15 Moses J. Folkman Inhibition of angiogenesis
JPS6117A (ja) * 1984-06-11 1986-01-06 Seikagaku Kogyo Co Ltd ムコ多糖系癌転移抑制剤
US5122450A (en) * 1985-10-24 1992-06-16 Research Corporation Limited Biochemical reagent
IL79255A0 (en) * 1986-06-26 1986-09-30 Hadassah Med Org Composition for metastasis prevention
IT1203515B (it) * 1987-02-26 1989-02-15 Indena Spa Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono
WO1989008499A1 (en) * 1988-03-17 1989-09-21 Nippon Fine Chemical Co., Ltd. Liposome
JPH0219393A (ja) * 1988-07-08 1990-01-23 Higeta Shoyu Kk Ｎ‐アセチルガラクトサミノオリゴ糖及びその製造方法
JPH0258501A (ja) * 1988-08-25 1990-02-27 Mitsubishi Gas Chem Co Inc リポ多糖およびその用途
JPH03220201A (ja) * 1988-11-18 1991-09-27 Eisai Co Ltd プロスタグランジン類と多糖類の結合体

Also Published As

Publication number Publication date
KR0181295B1 (ko) 1999-04-01
FI103279B1 (fi) 1999-05-31
EP0493622A4 (en) 1993-10-27
NO921083D0 (no) 1992-03-19
NO305368B1 (no) 1999-05-18
US5464942A (en) 1995-11-07
FI920717A0 (fi) 1992-02-19
DE69124590D1 (de) 1997-03-20
EP0493622A1 (de) 1992-07-08
NO921083L (no) 1992-05-21
EP0493622B1 (de) 1997-02-05
KR920702377A (ko) 1992-09-03
FI103279B (fi) 1999-05-31
DE69124590T2 (de) 1997-06-12
CA2067211A1 (en) 1992-01-25
AU8226691A (en) 1992-02-18
AU647814B2 (en) 1994-03-31
CA2067211C (en) 2004-06-15
WO1992001720A1 (en) 1992-02-06

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee