TR200000196T2 - Avermektin bileşiklerinin üretimi. - Google Patents

Avermektin bileşiklerinin üretimi.

Info

Publication number
TR200000196T2
TR200000196T2 TR2000/00196T TR200000196T TR200000196T2 TR 200000196 T2 TR200000196 T2 TR 200000196T2 TR 2000/00196 T TR2000/00196 T TR 2000/00196T TR 200000196 T TR200000196 T TR 200000196T TR 200000196 T2 TR200000196 T2 TR 200000196T2
Authority
TR
Turkey
Prior art keywords
compound
reacting
formula
production
agent
Prior art date
Application number
TR2000/00196T
Other languages
English (en)
Inventor
Honda Masanori
Kadoi Hiroshi
Morita Hiromasa
Nagakura Isao
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of TR200000196T2 publication Critical patent/TR200000196T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Bu bulus, formül (I)'in bir bilesiginin hazirlanmasi için bir islem olup, asagidaki asamalari kapsar: (a) bir avermektin B2 türevinin, yükseltgen bir ajanla, bir 5-okso bilesigi meydana getirmek üzere reaksiyona sokulmasi; (b) 5-okso bilesiginin, bir 5-imino bilesigini meydene getirmek üzere, R1'in H veya bir hidroksiimino- koruyucu grup oldugu, formül R1-O- NH2'nin bir bilesigiyle reaksiyona sokulmasi; (c) 5-imino bilesiginin, bir 4", 23- bistiyonokarbonil ester meydana getirmek üzere, bir tiyonokarbonize edici ajanla reaksiyona sokulmasi; (d) 4", 23-bistiyonokarbonil ester'in, bir 4", 23-dideoksi bilesigini meydana getirmek üzere, bir deoksijenleme ajani ile reaksiyona sokulmasi; ve' (e) 4", 23-dideoksi bilesiginin, formül (I)'in bir bilesigini meydana getirmek üzere, bir asitle reaksiyona sokulmasi. Formül (I).
TR2000/00196T 1997-07-23 1998-06-25 Avermektin bileşiklerinin üretimi. TR200000196T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9700916 1997-07-23

Publications (1)

Publication Number Publication Date
TR200000196T2 true TR200000196T2 (tr) 2000-07-21

Family

ID=11004591

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00196T TR200000196T2 (tr) 1997-07-23 1998-06-25 Avermektin bileşiklerinin üretimi.

Country Status (22)

Country Link
EP (1) EP1001962B8 (tr)
JP (1) JP3267634B2 (tr)
KR (1) KR100339191B1 (tr)
CN (1) CN1184227C (tr)
AR (1) AR016522A1 (tr)
AT (1) ATE227733T1 (tr)
AU (1) AU725506B2 (tr)
CA (1) CA2294928C (tr)
CZ (1) CZ296326B6 (tr)
DE (1) DE69809433T2 (tr)
DK (1) DK1001962T3 (tr)
ES (1) ES2182317T3 (tr)
HK (1) HK1027110A1 (tr)
HU (1) HUP0004631A3 (tr)
ID (1) ID24327A (tr)
IL (1) IL133558A0 (tr)
PL (1) PL188159B1 (tr)
PT (1) PT1001962E (tr)
RU (1) RU2211221C2 (tr)
TR (1) TR200000196T2 (tr)
WO (1) WO1999005156A1 (tr)
YU (1) YU71699A (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009126310A2 (en) 2008-04-10 2009-10-15 Massachusetts Institute Of Technology Methods for identification and use of agents targeting cancer stem cells
WO2014074805A1 (en) 2012-11-08 2014-05-15 Whitehead Institute For Biomedical Research Selective targeting of cancer stem cells
US10398672B2 (en) 2014-04-29 2019-09-03 Whitehead Institute For Biomedical Research Methods and compositions for targeting cancer stem cells
CN104430397B (zh) * 2014-11-06 2016-08-24 山东永泰化工有限公司 一种用于防治红蜘蛛的水分散粒剂
CN107118247B (zh) * 2017-06-14 2019-07-26 博瑞生物医药（苏州）股份有限公司 塞拉菌素的制备方法
CN107021990B (zh) * 2017-06-14 2019-07-12 博瑞生物医药（苏州）股份有限公司 高纯度塞拉菌素的制备方法
CN107188915B (zh) * 2017-07-19 2019-08-02 苏州正永生物医药有限公司 一种塞拉菌素中间体的制备方法
CN107723325B (zh) * 2017-11-28 2021-03-30 山东齐发药业有限公司 基于pH控制的多拉菌素发酵生产方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9402916D0 (en) * 1994-02-16 1994-04-06 Pfizer Ltd Antiparasitic agents
EP0676236A1 (en) * 1994-04-05 1995-10-11 Pfizer Inc. Process for removal of allyl group or allyloxycarbonyl group

Also Published As

Publication number Publication date
HK1027110A1 (en) 2001-01-05
JP3267634B2 (ja) 2002-03-18
AR016522A1 (es) 2001-07-25
CZ296326B6 (cs) 2006-02-15
PL188159B1 (pl) 2004-12-31
DE69809433T2 (de) 2003-05-08
CN1184227C (zh) 2005-01-12
AU7671498A (en) 1999-02-16
HUP0004631A3 (en) 2002-11-28
CZ200097A3 (cs) 2000-05-17
ATE227733T1 (de) 2002-11-15
EP1001962B1 (en) 2002-11-13
RU2211221C2 (ru) 2003-08-27
IL133558A0 (en) 2001-04-30
JP2000513385A (ja) 2000-10-10
WO1999005156A1 (en) 1999-02-04
PL338354A1 (en) 2000-10-23
KR100339191B1 (ko) 2002-06-01
HUP0004631A2 (hu) 2001-05-28
CA2294928C (en) 2003-01-14
EP1001962B8 (en) 2003-03-05
PT1001962E (pt) 2003-01-31
CA2294928A1 (en) 1999-02-04
EP1001962A1 (en) 2000-05-24
DE69809433D1 (de) 2002-12-19
AU725506B2 (en) 2000-10-12
ID24327A (id) 2000-07-13
CN1265113A (zh) 2000-08-30
DK1001962T3 (da) 2002-12-16
KR20010014066A (ko) 2001-02-26
YU71699A (sh) 2002-06-19
ES2182317T3 (es) 2003-03-01

Similar Documents

Publication Publication Date Title
AU603525B2 (en) Tetrazole intermediates to antihypertensive compounds
TR200800474T2 (tr) Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
TR200401644T4 (tr) İkame edilmiş sülfonilaminometilbenzoik asit (türevleri) ve imalat yöntemleri
TR199902326T2 (tr) Anti-hiperkolesterinemikler olarak ikameli piridinler ve bifeniller.
TR200000837A2 (tr) Anti-kanser bileşimleri hazırlamak için işlem ve ara maddeler.
TR200103273T2 (tr) Hemisentetik yöntem ve yeni bileşimler.
HUP9701379A2 (hu) Eljárás dihidro-piridin-származék előállítására
TR200000196T2 (tr) Avermektin bileşiklerinin üretimi.
WO2001026629A3 (en) Neutral-cationic lipid for nucleic acid and drug delivery
TR199800624T1 (tr) Yeni 5-0- deosaminil 6-0-metil eritronolid a türevleri, bunlarin kullanimi.
ATE280767T1 (de) Antidiabetische thiazolidindione und ihre herstellung
TR199902213T2 (tr) Pirazol türevleri hazirlanmasi için bir proses.
HUP9701660A2 (hu) 10,13,15-trioxa-triciklo[9.2.1.1. 9.6]pentadekanon-származékok, eljárás ezek előállítására, és az e vegyületeket tartalmazó gyógyászati készítmények
TR199900592T2 (tr) Kromanol türevlerinin hazirlandigi islem ve ara baglar
TR200002670T2 (tr) Mukabil tio-türevlerinin perboratlarla oksidazyonu ile sülfinil türevlerinin üretimi
TR199902019T2 (tr) Ikame edilmis tiazolidion' un hazirlanmasi için proses.
TR200000271T2 (tr) Boyalar.
FI884345A (fi) Sackaridderivat.
TR200002959A2 (tr) Pirazolo [4,3-D] pirimidin -7-onlar-3-piridilsülfonun bileşikleri ve bunların ara-bağlarının preparasyon işlemi
MY105684A (en) Skin detergent composition
DE69917668D1 (de) Substanz gm-95, verfahren zu ihrer herstellung und ihre verwendung
CA2308315A1 (en) N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agents
FI954786A0 (fi) Menetelmä aminometaanifosfonihapon valmistamiseksi
BR0012599A (pt) Método para preparação de debromohimenialdisina e análogos desta
MX9804752A (es) Conjugados covalentes de lipidos-acidos fosfonocarboxilicos, la produccion de los mismos asi como su uso como agentes farmaceuticos antivirales .