HUP9701379A2 - Eljárás dihidro-piridin-származék előállítására - Google Patents

Eljárás dihidro-piridin-származék előállítására

Info

Publication number
HUP9701379A2
HUP9701379A2 HU9701379A HUP9701379A HUP9701379A2 HU P9701379 A2 HUP9701379 A2 HU P9701379A2 HU 9701379 A HU9701379 A HU 9701379A HU P9701379 A HUP9701379 A HU P9701379A HU P9701379 A2 HUP9701379 A2 HU P9701379A2
Authority
HU
Hungary
Prior art keywords
formula
pyridine derivatives
besylate
producing dihydro
dihydro
Prior art date
Application number
HU9701379A
Other languages
English (en)
Inventor
Dániel Bózsing
dr. Lax Györgyi Koványiné
Gyula Simig
György Krasznai
Gábor Blaskó
Kálmán Nagy
Péter Tömpe
Donáth Györgyi Vereczkeyné
Gábor Németh
Norbert Németh
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU9701379A priority Critical patent/HU221810B1/hu
Publication of HU9701379D0 publication Critical patent/HU9701379D0/hu
Priority to CZ19982396A priority patent/CZ291430B6/cs
Priority to SK1045-98A priority patent/SK283422B6/sk
Priority to UA98084353A priority patent/UA57722C2/uk
Priority to RU98115586/04A priority patent/RU2163597C2/ru
Priority to PL327952A priority patent/PL191995B1/pl
Priority to PL375449A priority patent/PL192097B1/pl
Priority to HR980440A priority patent/HRP980440B1/xx
Priority to AT98115155T priority patent/ATE216988T1/de
Priority to EP98115155A priority patent/EP0902016B1/en
Priority to US09/133,108 priority patent/US6046337A/en
Priority to SI9830190T priority patent/SI0902016T1/xx
Priority to DE69805143T priority patent/DE69805143T2/de
Priority to ES98115155T priority patent/ES2175573T3/es
Publication of HUP9701379A2 publication Critical patent/HUP9701379A2/hu
Publication of HUP9701379A3 publication Critical patent/HUP9701379A3/hu
Publication of HU221810B1 publication Critical patent/HU221810B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

A találmány tárgya új eljárás az (I) képletű amlőpidin-bezilátelőállítására, őly módőn, hőgy a (IX) képletű vegyületet (X) képletűhexametilén-tetraminnal hőzzák reakcióba, majd a kapőtt (XI) képletűvegyületet benzőlszűlfőnsavval reagáltatják. Az (I) képletű amlőpidin-bezilát vérnyőmáscsökkentő, valamint antianginás hatással rendelkezőismert gyógyászati hatóanyag. ŕ
HU9701379A 1997-08-12 1997-08-12 Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei HU221810B1 (hu)

Priority Applications (14)

Application Number Priority Date Filing Date Title
HU9701379A HU221810B1 (hu) 1997-08-12 1997-08-12 Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
CZ19982396A CZ291430B6 (cs) 1997-08-12 1998-07-30 Způsob výroby dihydropyridinových derivátů
SK1045-98A SK283422B6 (sk) 1997-08-12 1998-08-03 Spôsob prípravy 3-etyl-5-metyl-2-(2-aminoetoxymetyl)-4-(2- chlórfenyl)-6-metyl-1,4-dihydro-3,5-pyridíndikarboxylátovej soli benzénsulfónovej kyseliny a medziprodukty na jej prípravu
UA98084353A UA57722C2 (uk) 1997-08-12 1998-08-10 Спосіб одержання солі 3-етил-5-метил-2-(2-аміноетоксиметил)-4-(2-хлорфеніл)-6-метил-1,4-дигідро-3,5-піридиндикарбоксилату і бензолсульфокислоти (безилату амлодипіну)
HR980440A HRP980440B1 (en) 1997-08-12 1998-08-11 Process for the preparation of a dihydropyridine derivative
PL375449A PL192097B1 (pl) 1997-08-12 1998-08-11 4-(2-chloroetoksy)-acetylooctan etylu, 4-(2-jodoetoksy)-acetylooctan etylu, 4-(2-chloroetoksy)-2-(2-chlorobenzylideno)-acetylooctan etylu i 4-(2-jodoetoksy)-2-(2-chlorobenzylideno)-acetylooctan etylu
PL327952A PL191995B1 (pl) 1997-08-12 1998-08-11 Sposób otrzymywania soli kwasu benzenosulfonowego 3-etylo-5-metylo-2-(2-aminoetoksymetylo)-4-(2-chlorofenylo)-6-metylo-1,4-dihydropirydyno-3,5-dikarboksylanu oraz związki przejściowe
RU98115586/04A RU2163597C2 (ru) 1997-08-12 1998-08-11 Способ получения соли 3-этил-5-метил-2-(2-аминоэтоксиметил)-4-(2-хлорфенил)-6-метил-1,4-дигидро-3,5-пиридиндикарбоксилата и бензолсульфокислоты (безилата амлодипина)
AT98115155T ATE216988T1 (de) 1997-08-12 1998-08-12 Verfahren und zwischenprodukte zur herstellung von amlodipin-benzolsulfonat
EP98115155A EP0902016B1 (en) 1997-08-12 1998-08-12 A process and intermediate compounds for the preparation of amlodipine benzene sulphonate
US09/133,108 US6046337A (en) 1997-08-12 1998-08-12 Process for the preparation of a dihydropyridine derivative
SI9830190T SI0902016T1 (en) 1997-08-12 1998-08-12 A process and intermediate compounds for the preparation of amlodipine benzene sulphonate
DE69805143T DE69805143T2 (de) 1997-08-12 1998-08-12 Verfahren und Zwischenprodukte zur Herstellung von Amlodipin-Benzolsulfonat
ES98115155T ES2175573T3 (es) 1997-08-12 1998-08-12 Procedimiento y compuestos intermedios para la preparacion de bencensulfonato de amlodipina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9701379A HU221810B1 (hu) 1997-08-12 1997-08-12 Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei

Publications (4)

Publication Number Publication Date
HU9701379D0 HU9701379D0 (en) 1997-10-28
HUP9701379A2 true HUP9701379A2 (hu) 2000-05-28
HUP9701379A3 HUP9701379A3 (en) 2000-06-28
HU221810B1 HU221810B1 (hu) 2003-01-28

Family

ID=89995490

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9701379A HU221810B1 (hu) 1997-08-12 1997-08-12 Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei

Country Status (13)

Country Link
US (1) US6046337A (hu)
EP (1) EP0902016B1 (hu)
AT (1) ATE216988T1 (hu)
CZ (1) CZ291430B6 (hu)
DE (1) DE69805143T2 (hu)
ES (1) ES2175573T3 (hu)
HR (1) HRP980440B1 (hu)
HU (1) HU221810B1 (hu)
PL (2) PL192097B1 (hu)
RU (1) RU2163597C2 (hu)
SI (1) SI0902016T1 (hu)
SK (1) SK283422B6 (hu)
UA (1) UA57722C2 (hu)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72768C2 (en) * 1999-07-05 2005-04-15 Richter Gedeon Vegyeszet A method for obtaining amilodipine benzenesulphonate
US7266501B2 (en) * 2000-03-02 2007-09-04 Akiba Electronics Institute Llc Method and apparatus for accommodating primary content audio and secondary content remaining audio capability in the digital audio production process
CA2433181C (en) 2000-12-29 2005-11-22 Pfizer Limited Amlodipine hemifumarate
US6653481B2 (en) * 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
WO2002053539A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Amlodipine hemimaleate
WO2002054062A2 (en) 2000-12-29 2002-07-11 Pfizer Limited Reference standards and processes for determining the purity or stability of amlodipine maleate
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
CA2433193C (en) 2000-12-29 2006-01-31 Pfizer Limited Amide derivative of amlodipine
US7335380B2 (en) * 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
MXPA03005886A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado de aspartato de amlodipina como antagonista del canal de calcio.
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
RS53403A (en) 2000-12-29 2006-10-27 Pfizer Limited Process for making amlodipine maleate
KR100374767B1 (ko) * 2001-03-13 2003-03-03 한미약품공업 주식회사 개선된 암로디핀의 제조 방법
DE60235101D1 (de) 2001-07-06 2010-03-04 Lek Pharmaceuticals Verfahren zur herstellung hochreines amlodipinbenzolsulfonat
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
US6828339B2 (en) * 2001-11-21 2004-12-07 Synthon Bv Amlodipine salt forms and processes for preparing them
US6699892B2 (en) 2002-06-04 2004-03-02 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salt of amlodipine and method of preparing the same
US6784297B2 (en) 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
US6608206B1 (en) * 2002-10-30 2003-08-19 Council Of Scientific & Industrial Research Process for making S(-) Amlodipine salts
WO2005089353A2 (en) * 2004-03-16 2005-09-29 Sepracor Inc. (s)-amlodipine malate
KR100807336B1 (ko) 2006-10-23 2008-02-28 명문제약주식회사 암로디핀의 제조를 위한 신규한 중간체 화합물, 이의 제조방법 및 이를 이용한 암로디핀의 제조 방법
HU230877B1 (hu) * 2008-09-30 2018-11-29 EGIS Gyógyszergyár NyR Stabil kombinációs gyógyszerkészítmény
CN102070516A (zh) * 2011-02-22 2011-05-25 广东东阳光药业有限公司 一种制备氨氯地平的方法
RU2755349C1 (ru) * 2021-02-16 2021-09-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
US5001119A (en) * 1987-11-25 1991-03-19 Schwartz Arthur G 16-substituted androstanes and 16-substituted androstenes
WO1991015484A1 (de) * 1990-04-10 1991-10-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyridine als arzneimittel
US5389654A (en) * 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
SI9200344B (sl) * 1992-11-26 1998-06-30 Lek, Postopek za pripravo amlodipin benzensulfonata

Also Published As

Publication number Publication date
HRP980440A2 (en) 1999-06-30
CZ291430B6 (cs) 2003-03-12
DE69805143T2 (de) 2002-11-28
EP0902016A3 (en) 2000-01-05
EP0902016B1 (en) 2002-05-02
ES2175573T3 (es) 2002-11-16
SK283422B6 (sk) 2003-07-01
DE69805143D1 (de) 2002-06-06
PL327952A1 (en) 1999-02-15
HU221810B1 (hu) 2003-01-28
HRP980440B1 (en) 2003-06-30
HU9701379D0 (en) 1997-10-28
UA57722C2 (uk) 2003-07-15
RU2163597C2 (ru) 2001-02-27
SK104598A3 (en) 1999-03-12
PL192097B1 (pl) 2006-08-31
PL191995B1 (pl) 2006-08-31
ATE216988T1 (de) 2002-05-15
EP0902016A1 (en) 1999-03-17
HUP9701379A3 (en) 2000-06-28
US6046337A (en) 2000-04-04
CZ239698A3 (cs) 1999-02-17
SI0902016T1 (en) 2002-08-31

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20021105

HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYRT., HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU

MM4A Lapse of definitive patent protection due to non-payment of fees