ATE216988T1 - Verfahren und zwischenprodukte zur herstellung von amlodipin-benzolsulfonat - Google Patents
Verfahren und zwischenprodukte zur herstellung von amlodipin-benzolsulfonatInfo
- Publication number
- ATE216988T1 ATE216988T1 AT98115155T AT98115155T ATE216988T1 AT E216988 T1 ATE216988 T1 AT E216988T1 AT 98115155 T AT98115155 T AT 98115155T AT 98115155 T AT98115155 T AT 98115155T AT E216988 T1 ATE216988 T1 AT E216988T1
- Authority
- AT
- Austria
- Prior art keywords
- ämethylü
- chem
- formula
- preparing
- intermediate products
- Prior art date
Links
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 abstract 1
- 229940092714 benzenesulfonic acid Drugs 0.000 abstract 1
- 150000008107 benzenesulfonic acids Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9701379A HU221810B1 (hu) | 1997-08-12 | 1997-08-12 | Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE216988T1 true ATE216988T1 (de) | 2002-05-15 |
Family
ID=89995490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98115155T ATE216988T1 (de) | 1997-08-12 | 1998-08-12 | Verfahren und zwischenprodukte zur herstellung von amlodipin-benzolsulfonat |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6046337A (de) |
| EP (1) | EP0902016B1 (de) |
| AT (1) | ATE216988T1 (de) |
| CZ (1) | CZ291430B6 (de) |
| DE (1) | DE69805143T2 (de) |
| ES (1) | ES2175573T3 (de) |
| HR (1) | HRP980440B1 (de) |
| HU (1) | HU221810B1 (de) |
| PL (2) | PL191995B1 (de) |
| RU (1) | RU2163597C2 (de) |
| SI (1) | SI0902016T1 (de) |
| SK (1) | SK283422B6 (de) |
| UA (1) | UA57722C2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA72768C2 (en) * | 1999-07-05 | 2005-04-15 | Richter Gedeon Vegyeszet | A method for obtaining amilodipine benzenesulphonate |
| US7266501B2 (en) * | 2000-03-02 | 2007-09-04 | Akiba Electronics Institute Llc | Method and apparatus for accommodating primary content audio and secondary content remaining audio capability in the digital audio production process |
| EP1309556B1 (de) | 2000-12-29 | 2004-11-24 | Pfizer Limited | Amlodipinfumarat |
| EP1309557B9 (de) | 2000-12-29 | 2006-11-15 | Pfizer Limited | Amlodipin-hemimaleat |
| GB2371862B (en) * | 2000-12-29 | 2004-07-14 | Bioorg Bv | Reference standards for determining the purity or stability of amlodipine maleate and processes therefor |
| MXPA03005882A (es) * | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
| BR0116557A (pt) * | 2000-12-29 | 2003-10-28 | Pfizer Ltd | Processo, processo para fabricação de um sal de maleato de amlodipina substancialmente livre de aspartato de amlodipina, processo para purificação, maleato de amlodipina, composição farmacêutica para tratar ou prevenir angina ou hipertenção, método para tratar hipertenção, angina ou ataque cardìaco, benzeno sulfonato de amlodipina, hidrocloreto de amlodipina e uso de maleato de amlodipina substancialmente livre de aspartato de amlodipina |
| US6653481B2 (en) * | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
| US7335380B2 (en) | 2000-12-29 | 2008-02-26 | Synthon Ip Inc. | Amlodipine free base |
| WO2002053541A1 (en) * | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amide derivative of amlodipine |
| AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
| GB2372036B (en) | 2000-12-29 | 2004-05-19 | Bioorg Bv | Aspartate derivative of amlodipine |
| KR100374767B1 (ko) * | 2001-03-13 | 2003-03-03 | 한미약품공업 주식회사 | 개선된 암로디핀의 제조 방법 |
| EP1435954B1 (de) * | 2001-07-06 | 2010-01-13 | LEK Pharmaceuticals D.D. | Verfahren zur herstellung hochreines amlodipinbenzolsulfonat |
| US6680334B2 (en) | 2001-08-28 | 2004-01-20 | Pfizer Inc | Crystalline material |
| US6828339B2 (en) * | 2001-11-21 | 2004-12-07 | Synthon Bv | Amlodipine salt forms and processes for preparing them |
| US6699892B2 (en) | 2002-06-04 | 2004-03-02 | Yung Shin Pharmaceutical Industrial Co., Ltd. | Pharmaceutically acceptable salt of amlodipine and method of preparing the same |
| US6784297B2 (en) | 2002-09-04 | 2004-08-31 | Kopran Limited | Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate |
| US6608206B1 (en) * | 2002-10-30 | 2003-08-19 | Council Of Scientific & Industrial Research | Process for making S(-) Amlodipine salts |
| WO2005089353A2 (en) * | 2004-03-16 | 2005-09-29 | Sepracor Inc. | (s)-amlodipine malate |
| KR100807336B1 (ko) | 2006-10-23 | 2008-02-28 | 명문제약주식회사 | 암로디핀의 제조를 위한 신규한 중간체 화합물, 이의 제조방법 및 이를 이용한 암로디핀의 제조 방법 |
| HU230877B1 (hu) * | 2008-09-30 | 2018-11-29 | EGIS Gyógyszergyár NyR | Stabil kombinációs gyógyszerkészítmény |
| CN102070516A (zh) * | 2011-02-22 | 2011-05-25 | 广东东阳光药业有限公司 | 一种制备氨氯地平的方法 |
| RU2755349C1 (ru) * | 2021-02-16 | 2021-09-15 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| GB8608335D0 (en) * | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
| US5001119A (en) * | 1987-11-25 | 1991-03-19 | Schwartz Arthur G | 16-substituted androstanes and 16-substituted androstenes |
| US5352684A (en) * | 1990-04-10 | 1994-10-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyridines as medicaments |
| US5389654A (en) * | 1992-11-26 | 1995-02-14 | Lek, Tovarna, Farmacevtskih In Kemicnih . . . | 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate |
| SI9200344B (sl) * | 1992-11-26 | 1998-06-30 | Lek, | Postopek za pripravo amlodipin benzensulfonata |
-
1997
- 1997-08-12 HU HU9701379A patent/HU221810B1/hu not_active IP Right Cessation
-
1998
- 1998-07-30 CZ CZ19982396A patent/CZ291430B6/cs not_active IP Right Cessation
- 1998-08-03 SK SK1045-98A patent/SK283422B6/sk unknown
- 1998-08-10 UA UA98084353A patent/UA57722C2/uk unknown
- 1998-08-11 HR HR980440A patent/HRP980440B1/xx not_active IP Right Cessation
- 1998-08-11 RU RU98115586/04A patent/RU2163597C2/ru not_active IP Right Cessation
- 1998-08-11 PL PL327952A patent/PL191995B1/pl not_active IP Right Cessation
- 1998-08-11 PL PL375449A patent/PL192097B1/pl not_active IP Right Cessation
- 1998-08-12 SI SI9830190T patent/SI0902016T1/xx unknown
- 1998-08-12 DE DE69805143T patent/DE69805143T2/de not_active Expired - Fee Related
- 1998-08-12 EP EP98115155A patent/EP0902016B1/de not_active Expired - Lifetime
- 1998-08-12 ES ES98115155T patent/ES2175573T3/es not_active Expired - Lifetime
- 1998-08-12 AT AT98115155T patent/ATE216988T1/de not_active IP Right Cessation
- 1998-08-12 US US09/133,108 patent/US6046337A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2175573T3 (es) | 2002-11-16 |
| DE69805143T2 (de) | 2002-11-28 |
| SK104598A3 (en) | 1999-03-12 |
| UA57722C2 (uk) | 2003-07-15 |
| HRP980440B1 (en) | 2003-06-30 |
| SK283422B6 (sk) | 2003-07-01 |
| CZ291430B6 (cs) | 2003-03-12 |
| EP0902016A3 (de) | 2000-01-05 |
| US6046337A (en) | 2000-04-04 |
| PL327952A1 (en) | 1999-02-15 |
| HUP9701379A3 (en) | 2000-06-28 |
| EP0902016B1 (de) | 2002-05-02 |
| HU9701379D0 (en) | 1997-10-28 |
| CZ239698A3 (cs) | 1999-02-17 |
| HUP9701379A2 (hu) | 2000-05-28 |
| PL191995B1 (pl) | 2006-08-31 |
| RU2163597C2 (ru) | 2001-02-27 |
| HRP980440A2 (en) | 1999-06-30 |
| PL192097B1 (pl) | 2006-08-31 |
| DE69805143D1 (de) | 2002-06-06 |
| SI0902016T1 (en) | 2002-08-31 |
| EP0902016A1 (de) | 1999-03-17 |
| HU221810B1 (hu) | 2003-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0902016 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |