DE69805143D1 - Verfahren und Zwischenprodukte zur Herstellung von Amlodipin-Benzolsulfonat - Google Patents

Verfahren und Zwischenprodukte zur Herstellung von Amlodipin-Benzolsulfonat

Info

Publication number
DE69805143D1
DE69805143D1 DE69805143T DE69805143T DE69805143D1 DE 69805143 D1 DE69805143 D1 DE 69805143D1 DE 69805143 T DE69805143 T DE 69805143T DE 69805143 T DE69805143 T DE 69805143T DE 69805143 D1 DE69805143 D1 DE 69805143D1
Authority
DE
Germany
Prior art keywords
ämethylü
intermediates
chem
formula
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69805143T
Other languages
English (en)
Other versions
DE69805143T2 (de
Inventor
Dr Bozsing
Lax Kovanyi
Dr Simig
Gyoergy Krasznai
Dr Blasko
Dr Toempe
Dr Nagy
Gyoergyi Donath Vereczkey
Gabor Nemet
Norbert Nemeth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of DE69805143D1 publication Critical patent/DE69805143D1/de
Application granted granted Critical
Publication of DE69805143T2 publication Critical patent/DE69805143T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69805143T 1997-08-12 1998-08-12 Verfahren und Zwischenprodukte zur Herstellung von Amlodipin-Benzolsulfonat Expired - Fee Related DE69805143T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9701379A HU221810B1 (hu) 1997-08-12 1997-08-12 Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei

Publications (2)

Publication Number Publication Date
DE69805143D1 true DE69805143D1 (de) 2002-06-06
DE69805143T2 DE69805143T2 (de) 2002-11-28

Family

ID=89995490

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69805143T Expired - Fee Related DE69805143T2 (de) 1997-08-12 1998-08-12 Verfahren und Zwischenprodukte zur Herstellung von Amlodipin-Benzolsulfonat

Country Status (13)

Country Link
US (1) US6046337A (de)
EP (1) EP0902016B1 (de)
AT (1) ATE216988T1 (de)
CZ (1) CZ291430B6 (de)
DE (1) DE69805143T2 (de)
ES (1) ES2175573T3 (de)
HR (1) HRP980440B1 (de)
HU (1) HU221810B1 (de)
PL (2) PL192097B1 (de)
RU (1) RU2163597C2 (de)
SI (1) SI0902016T1 (de)
SK (1) SK283422B6 (de)
UA (1) UA57722C2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72768C2 (en) * 1999-07-05 2005-04-15 Richter Gedeon Vegyeszet A method for obtaining amilodipine benzenesulphonate
US7266501B2 (en) * 2000-03-02 2007-09-04 Akiba Electronics Institute Llc Method and apparatus for accommodating primary content audio and secondary content remaining audio capability in the digital audio production process
MXPA03005882A (es) * 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
US7335380B2 (en) * 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
ATE315026T1 (de) 2000-12-29 2006-02-15 Pfizer Ltd Amlodipin-hemimaleat
CN1272319C (zh) * 2000-12-29 2006-08-30 辉瑞有限公司 制备氨氯地平马来酸盐的工艺、所制得的氨氯地平马来酸盐、其药物组合物和用途
WO2002054062A2 (en) 2000-12-29 2002-07-11 Pfizer Limited Reference standards and processes for determining the purity or stability of amlodipine maleate
EP1309554A1 (de) 2000-12-29 2003-05-14 Synthon Licensing, Ltd. Amid-derivat von amlodipin
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
EP1309556B1 (de) 2000-12-29 2004-11-24 Pfizer Limited Amlodipinfumarat
BR0116553A (pt) 2000-12-29 2004-02-03 Pfizer Ltd Composto, composição farmacêutica para tratamento de angina ou hipertensão, processo, processo para tratamento ou prevenção de angina ou hipertensão, composição de ingredientes farmaceuticamente ativos, composição farmacêutica para tratamento ou prevenção de angina ou hipertensão e processo para tratar ou prevenir angina ou hipertensão
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
KR100374767B1 (ko) * 2001-03-13 2003-03-03 한미약품공업 주식회사 개선된 암로디핀의 제조 방법
WO2003004025A1 (en) * 2001-07-06 2003-01-16 Lek Pharmaceutical And Chemical Company D.D. High purity amlodipine benzenesulfonate and a process for its preparation
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
US6828339B2 (en) * 2001-11-21 2004-12-07 Synthon Bv Amlodipine salt forms and processes for preparing them
US6699892B2 (en) 2002-06-04 2004-03-02 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salt of amlodipine and method of preparing the same
US6784297B2 (en) 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
US6608206B1 (en) * 2002-10-30 2003-08-19 Council Of Scientific & Industrial Research Process for making S(-) Amlodipine salts
US20060030602A1 (en) * 2004-03-16 2006-02-09 Sepracor Inc. (S)-amlodipine malate
KR100807336B1 (ko) 2006-10-23 2008-02-28 명문제약주식회사 암로디핀의 제조를 위한 신규한 중간체 화합물, 이의 제조방법 및 이를 이용한 암로디핀의 제조 방법
HU230877B1 (hu) * 2008-09-30 2018-11-29 EGIS Gyógyszergyár NyR Stabil kombinációs gyógyszerkészítmény
CN102070516A (zh) * 2011-02-22 2011-05-25 广东东阳光药业有限公司 一种制备氨氯地平的方法
RU2755349C1 (ru) * 2021-02-16 2021-09-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
US5001119A (en) * 1987-11-25 1991-03-19 Schwartz Arthur G 16-substituted androstanes and 16-substituted androstenes
CA2080127A1 (en) * 1990-04-10 1991-10-11 Peter Zimmermann Pyridines as medicaments
SI9200344B (sl) * 1992-11-26 1998-06-30 Lek, Postopek za pripravo amlodipin benzensulfonata
US5389654A (en) * 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate

Also Published As

Publication number Publication date
HRP980440A2 (en) 1999-06-30
RU2163597C2 (ru) 2001-02-27
US6046337A (en) 2000-04-04
ES2175573T3 (es) 2002-11-16
EP0902016A1 (de) 1999-03-17
DE69805143T2 (de) 2002-11-28
EP0902016B1 (de) 2002-05-02
CZ239698A3 (cs) 1999-02-17
UA57722C2 (uk) 2003-07-15
HUP9701379A2 (hu) 2000-05-28
PL191995B1 (pl) 2006-08-31
SK283422B6 (sk) 2003-07-01
PL192097B1 (pl) 2006-08-31
HU221810B1 (hu) 2003-01-28
HU9701379D0 (en) 1997-10-28
HUP9701379A3 (en) 2000-06-28
EP0902016A3 (de) 2000-01-05
CZ291430B6 (cs) 2003-03-12
SI0902016T1 (en) 2002-08-31
HRP980440B1 (en) 2003-06-30
PL327952A1 (en) 1999-02-15
ATE216988T1 (de) 2002-05-15
SK104598A3 (en) 1999-03-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee