NO305368B1 - AnalogifremgangsmÕte for fremstilling av et terapeutisk aktivt fosfolipidbundet glykosaminglykan - Google Patents
AnalogifremgangsmÕte for fremstilling av et terapeutisk aktivt fosfolipidbundet glykosaminglykan Download PDFInfo
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- NO305368B1 NO305368B1 NO921083A NO921083A NO305368B1 NO 305368 B1 NO305368 B1 NO 305368B1 NO 921083 A NO921083 A NO 921083A NO 921083 A NO921083 A NO 921083A NO 305368 B1 NO305368 B1 NO 305368B1
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- Norway
- Prior art keywords
- group
- gag
- phospholipid
- formula
- reducing terminal
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- -1 Glycosamine Glycan Chemical class 0.000 title claims description 109
- 238000000034 method Methods 0.000 title claims description 69
- 238000002360 preparation method Methods 0.000 title claims description 44
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- 150000002632 lipids Chemical class 0.000 claims abstract description 68
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 53
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 46
- 229920002683 Glycosaminoglycan Polymers 0.000 claims abstract description 9
- 230000007717 exclusion Effects 0.000 claims description 59
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- 238000006243 chemical reaction Methods 0.000 claims description 41
- 150000003839 salts Chemical class 0.000 claims description 40
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 39
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 39
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 39
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims description 35
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims description 35
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- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims description 34
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- KSVMTHKYDGMXFJ-UHFFFAOYSA-N n,n'-bis(trimethylsilyl)methanediimine Chemical compound C[Si](C)(C)N=C=N[Si](C)(C)C KSVMTHKYDGMXFJ-UHFFFAOYSA-N 0.000 description 1
- UHAAFJWANJYDIS-UHFFFAOYSA-N n,n'-diethylmethanediimine Chemical compound CCN=C=NCC UHAAFJWANJYDIS-UHFFFAOYSA-N 0.000 description 1
- CMESPBFFDMPSIY-UHFFFAOYSA-N n,n'-diphenylmethanediimine Chemical compound C1=CC=CC=C1N=C=NC1=CC=CC=C1 CMESPBFFDMPSIY-UHFFFAOYSA-N 0.000 description 1
- QXHKSZBIXVHRNF-UHFFFAOYSA-N n-methyl-n'-propylmethanediimine Chemical compound CCCN=C=NC QXHKSZBIXVHRNF-UHFFFAOYSA-N 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2193818A JP2986519B2 (ja) | 1990-07-24 | 1990-07-24 | 燐脂質結合グリコサミノグリカン |
| JP2193817A JP2997018B2 (ja) | 1990-07-24 | 1990-07-24 | 燐脂質又は脂質結合グリコサミノグリカン |
| JP2193816A JP2986518B2 (ja) | 1990-07-24 | 1990-07-24 | 癌転移抑制剤 |
| PCT/JP1991/000995 WO1992001720A1 (en) | 1990-07-24 | 1991-07-24 | Phospholipid- or lipid-combining glycosaminoglycan, production thereof, and cancer metastasis inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO921083D0 NO921083D0 (no) | 1992-03-19 |
| NO921083L NO921083L (no) | 1992-05-21 |
| NO305368B1 true NO305368B1 (no) | 1999-05-18 |
Family
ID=27326820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO921083A NO305368B1 (no) | 1990-07-24 | 1992-03-19 | AnalogifremgangsmÕte for fremstilling av et terapeutisk aktivt fosfolipidbundet glykosaminglykan |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5464942A (de) |
| EP (1) | EP0493622B1 (de) |
| KR (1) | KR0181295B1 (de) |
| AT (1) | ATE148713T1 (de) |
| AU (1) | AU647814B2 (de) |
| CA (1) | CA2067211C (de) |
| DE (1) | DE69124590T2 (de) |
| FI (1) | FI103279B1 (de) |
| NO (1) | NO305368B1 (de) |
| WO (1) | WO1992001720A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3199405B2 (ja) * | 1991-08-30 | 2001-08-20 | 生化学工業株式会社 | 肝細胞球状集塊化剤及び球状集塊化肝細胞の製造方法 |
| IT1260137B (it) * | 1992-04-17 | 1996-03-28 | Alfa Wassermann Spa | Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato |
| EP0607408A4 (en) * | 1992-07-13 | 1997-12-10 | Eukarion Inc | Transvascular and intracellular delivery of lipidized proteins. |
| JP3714683B2 (ja) * | 1992-07-30 | 2005-11-09 | 生化学工業株式会社 | 抗リウマチ剤 |
| JP2787279B2 (ja) * | 1994-05-17 | 1998-08-13 | 雪印乳業株式会社 | 糖リン脂質及びその調製法 |
| US6228998B1 (en) | 1994-07-22 | 2001-05-08 | Seikagaku Kogyo Kabushiki Kaisha | Amino spacered glycosaminoglycan derivatives and their use in copolymerization with acrylamide |
| FR2725622A1 (fr) * | 1994-10-14 | 1996-04-19 | Fabre Pierre Dermo Cosmetique | Ceramide greffee anti-elastase |
| CA2175282A1 (en) * | 1996-04-29 | 1997-10-30 | Rudolf Edgar Falk | Use of forms of hyaluronic acid (ha) for the treatment of cancer |
| WO2000040253A1 (en) * | 1999-01-08 | 2000-07-13 | The Board Of Trustees Of The University Of Arkansas | Synthetic, highly charged molecules and uses thereof |
| JP3032824B1 (ja) * | 1999-01-28 | 2000-04-17 | 東京医科歯科大学長 | 骨誘導促進剤 |
| JP4754137B2 (ja) * | 1999-08-10 | 2011-08-24 | 生化学工業株式会社 | グリコサミノグリカン誘導体およびその使用 |
| US7893226B2 (en) | 2004-09-29 | 2011-02-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Use of lipid conjugates in the treatment of diseases |
| US7141552B2 (en) * | 2000-01-10 | 2006-11-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| US7608598B2 (en) | 2000-01-10 | 2009-10-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of conjunctivitis |
| US7811999B2 (en) * | 2000-01-10 | 2010-10-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Use of lipid conjugates in the treatment of diseases |
| US9040078B2 (en) * | 2000-01-10 | 2015-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases of the nervous system |
| US20090325876A1 (en) * | 2004-09-29 | 2009-12-31 | Saul Yedgar | Use of lipid conjugates in the treatment of diseases associated with vasculature |
| US7772196B2 (en) * | 2000-01-10 | 2010-08-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| US20060189569A1 (en) * | 2000-01-10 | 2006-08-24 | Saul Yedgar | Use of lipid conjugates in the treatment of infection |
| US8304395B2 (en) * | 2000-01-10 | 2012-11-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Lipid conjugates in the treatment of disease |
| US7393938B2 (en) * | 2000-01-10 | 2008-07-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| US7101859B2 (en) * | 2000-01-10 | 2006-09-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| US8916539B2 (en) * | 2000-01-10 | 2014-12-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of disease |
| US8076312B2 (en) * | 2000-01-10 | 2011-12-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Use of lipid conjugates in the treatment of disease |
| US8501701B2 (en) * | 2000-01-10 | 2013-08-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Use of lipid conjugates in the treatment of disease |
| US7259152B2 (en) | 2000-06-07 | 2007-08-21 | Alfa Wasserman, Inc. | Methods and compositions using sulodexide for the treatment of diabetic nephropathy |
| US8883761B2 (en) * | 2001-01-10 | 2014-11-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases associated with vasculature |
| US7280612B2 (en) * | 2003-07-25 | 2007-10-09 | Zarbana Digital Fund Llc | Digital branch calibrator for an RF transmitter |
| US8137685B2 (en) * | 2003-10-29 | 2012-03-20 | Teijin Limited | Hyaluronic acid compound, hydrogel thereof and joint treating material |
| CN104546891A (zh) * | 2005-08-03 | 2015-04-29 | 塞尔索斯治疗公司 | 脂质结合物在囊性纤维化病中的用途及其应用 |
| JP4744973B2 (ja) * | 2005-08-05 | 2011-08-10 | 株式会社トプコン | 眼底カメラ |
| US8475694B2 (en) | 2005-10-25 | 2013-07-02 | Zephyros, Inc. | Shaped expandable material |
| US8906882B2 (en) | 2005-11-17 | 2014-12-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Lipid conjugates in the treatment of allergic rhinitis |
| US8859524B2 (en) | 2005-11-17 | 2014-10-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Lipid conjugates in the treatment of chronic rhinosinusitis |
| US20080183282A1 (en) * | 2006-03-09 | 2008-07-31 | Saul Yedgar | Use of lipid conjugates for the coating of stents and catheters |
| CA2705785A1 (en) * | 2006-11-14 | 2008-05-22 | Saul Yedgar | Use of lipid conjugates in the treatment of diseases or disorders of the eye |
| AU2007320737B2 (en) * | 2006-11-14 | 2014-04-03 | Celsus Therapeutics Plc | Contact lens compositions |
| JP2012526819A (ja) * | 2009-05-11 | 2012-11-01 | イッサム リサーチ ディベロプメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム リミテッド | 脂質−ポリマー複合体、その調製、及びその使用 |
| GB0916205D0 (en) | 2009-09-15 | 2009-10-28 | Zephyros Inc | Improvements in or relating to cavity filling |
| US20130012473A1 (en) * | 2010-03-17 | 2013-01-10 | Ktb Tumorforschungsgesellschaft Mbh | Combined use of phospholipid and sulfate groups-carrying polysaccharides for inhibiting metastatic spread |
| CA2703532C (en) * | 2010-05-10 | 2018-05-01 | Eva Turley | Topically administered, skin-penetrating glycosaminoglycan formulations suitable for use in cosmetic and pharmaceutical applications |
| US11673974B2 (en) * | 2019-04-29 | 2023-06-13 | Bausch & Lomb Incorporated | Glycophospholipid polymeric network and use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2374910A1 (fr) * | 1976-10-23 | 1978-07-21 | Choay Sa | Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations |
| FR2492259A1 (fr) * | 1980-10-21 | 1982-04-23 | Idinvex Sa | Formulation d'heparine |
| US4362737A (en) * | 1981-04-13 | 1982-12-07 | Schaefer Rolf | Transdermal carrier materials |
| US4654327A (en) * | 1982-04-21 | 1987-03-31 | Research Corp. | Quaternary ammonium complexes of heparin |
| US4604376A (en) * | 1982-04-21 | 1986-08-05 | Research Corporation | Enteric compounds and complexes |
| EP0114589B1 (de) * | 1982-12-20 | 1987-09-23 | The President And Fellows Of Harvard College | Hemmung der Gefässneubildung |
| JPS6117A (ja) * | 1984-06-11 | 1986-01-06 | Seikagaku Kogyo Co Ltd | ムコ多糖系癌転移抑制剤 |
| EP0282482B1 (de) * | 1985-10-24 | 1992-01-22 | Medical Research Council | Biochemisches reagenzmittel |
| IL79255A0 (en) * | 1986-06-26 | 1986-09-30 | Hadassah Med Org | Composition for metastasis prevention |
| IT1203515B (it) * | 1987-02-26 | 1989-02-15 | Indena Spa | Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono |
| US5169636A (en) * | 1988-03-17 | 1992-12-08 | Nippon Fine Chemical Co., Ltd. | Liposomes |
| JPH0219393A (ja) * | 1988-07-08 | 1990-01-23 | Higeta Shoyu Kk | Ｎ‐アセチルガラクトサミノオリゴ糖及びその製造方法 |
| JPH0258501A (ja) * | 1988-08-25 | 1990-02-27 | Mitsubishi Gas Chem Co Inc | リポ多糖およびその用途 |
| JPH03220201A (ja) * | 1988-11-18 | 1991-09-27 | Eisai Co Ltd | プロスタグランジン類と多糖類の結合体 |
-
1991
- 1991-07-24 WO PCT/JP1991/000995 patent/WO1992001720A1/ja active IP Right Grant
- 1991-07-24 AU AU82266/91A patent/AU647814B2/en not_active Ceased
- 1991-07-24 AT AT91913108T patent/ATE148713T1/de not_active IP Right Cessation
- 1991-07-24 US US07/847,065 patent/US5464942A/en not_active Expired - Lifetime
- 1991-07-24 EP EP91913108A patent/EP0493622B1/de not_active Expired - Lifetime
- 1991-07-24 DE DE69124590T patent/DE69124590T2/de not_active Expired - Fee Related
- 1991-07-24 KR KR1019920700665A patent/KR0181295B1/ko not_active IP Right Cessation
- 1991-07-24 CA CA002067211A patent/CA2067211C/en not_active Expired - Fee Related
-
1992
- 1992-02-19 FI FI920717A patent/FI103279B1/fi active
- 1992-03-19 NO NO921083A patent/NO305368B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR0181295B1 (ko) | 1999-04-01 |
| FI920717A0 (fi) | 1992-02-19 |
| FI103279B (fi) | 1999-05-31 |
| CA2067211C (en) | 2004-06-15 |
| AU647814B2 (en) | 1994-03-31 |
| NO921083L (no) | 1992-05-21 |
| NO921083D0 (no) | 1992-03-19 |
| US5464942A (en) | 1995-11-07 |
| AU8226691A (en) | 1992-02-18 |
| EP0493622B1 (de) | 1997-02-05 |
| EP0493622A1 (de) | 1992-07-08 |
| DE69124590D1 (de) | 1997-03-20 |
| ATE148713T1 (de) | 1997-02-15 |
| CA2067211A1 (en) | 1992-01-25 |
| DE69124590T2 (de) | 1997-06-12 |
| KR920702377A (ko) | 1992-09-03 |
| FI103279B1 (fi) | 1999-05-31 |
| EP0493622A4 (en) | 1993-10-27 |
| WO1992001720A1 (en) | 1992-02-06 |
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