DE69124590T2 - Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitor - Google Patents
Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitorInfo
- Publication number
- DE69124590T2 DE69124590T2 DE69124590T DE69124590T DE69124590T2 DE 69124590 T2 DE69124590 T2 DE 69124590T2 DE 69124590 T DE69124590 T DE 69124590T DE 69124590 T DE69124590 T DE 69124590T DE 69124590 T2 DE69124590 T2 DE 69124590T2
- Authority
- DE
- Germany
- Prior art keywords
- glycosaminoglycan
- phospholipid
- lipid
- derivative
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2193816A JP2986518B2 (ja) | 1990-07-24 | 1990-07-24 | 癌転移抑制剤 |
JP2193817A JP2997018B2 (ja) | 1990-07-24 | 1990-07-24 | 燐脂質又は脂質結合グリコサミノグリカン |
JP2193818A JP2986519B2 (ja) | 1990-07-24 | 1990-07-24 | 燐脂質結合グリコサミノグリカン |
PCT/JP1991/000995 WO1992001720A1 (en) | 1990-07-24 | 1991-07-24 | Phospholipid- or lipid-combining glycosaminoglycan, production thereof, and cancer metastasis inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69124590D1 DE69124590D1 (de) | 1997-03-20 |
DE69124590T2 true DE69124590T2 (de) | 1997-06-12 |
Family
ID=27326820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69124590T Expired - Fee Related DE69124590T2 (de) | 1990-07-24 | 1991-07-24 | Glykosaminoglykan gemischt mit phospholipid oder lipid, seine herstellung und krebszellenmetastaseninhibitor |
Country Status (10)
Country | Link |
---|---|
US (1) | US5464942A (de) |
EP (1) | EP0493622B1 (de) |
KR (1) | KR0181295B1 (de) |
AT (1) | ATE148713T1 (de) |
AU (1) | AU647814B2 (de) |
CA (1) | CA2067211C (de) |
DE (1) | DE69124590T2 (de) |
FI (1) | FI103279B1 (de) |
NO (1) | NO305368B1 (de) |
WO (1) | WO1992001720A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3199405B2 (ja) * | 1991-08-30 | 2001-08-20 | 生化学工業株式会社 | 肝細胞球状集塊化剤及び球状集塊化肝細胞の製造方法 |
IT1260137B (it) * | 1992-04-17 | 1996-03-28 | Alfa Wassermann Spa | Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato |
RU2157239C2 (ru) * | 1992-07-13 | 2000-10-10 | Юкэрион, Инк. | Способ модификации, способ обеспечения связывания белка с антителом, фармацевтические композиции, способ диагностики |
JP3714683B2 (ja) * | 1992-07-30 | 2005-11-09 | 生化学工業株式会社 | 抗リウマチ剤 |
JP2787279B2 (ja) * | 1994-05-17 | 1998-08-13 | 雪印乳業株式会社 | 糖リン脂質及びその調製法 |
US6228998B1 (en) | 1994-07-22 | 2001-05-08 | Seikagaku Kogyo Kabushiki Kaisha | Amino spacered glycosaminoglycan derivatives and their use in copolymerization with acrylamide |
FR2725622A1 (fr) * | 1994-10-14 | 1996-04-19 | Fabre Pierre Dermo Cosmetique | Ceramide greffee anti-elastase |
CA2175282A1 (en) * | 1996-04-29 | 1997-10-30 | Rudolf Edgar Falk | Use of forms of hyaluronic acid (ha) for the treatment of cancer |
AU2602200A (en) * | 1999-01-08 | 2000-07-24 | Board Of Trustees Of The University Of Arkansas, The | Synthetic, highly charged molecules and uses thereof |
JP3032824B1 (ja) * | 1999-01-28 | 2000-04-17 | 東京医科歯科大学長 | 骨誘導促進剤 |
AU6472900A (en) * | 1999-08-10 | 2001-03-13 | Seikagaku Corporation | Glycosaminoglycan derivatives and utilization thereof |
US7101859B2 (en) * | 2000-01-10 | 2006-09-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
US7772196B2 (en) * | 2000-01-10 | 2010-08-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
US7393938B2 (en) * | 2000-01-10 | 2008-07-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
US9040078B2 (en) * | 2000-01-10 | 2015-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases of the nervous system |
US7141552B2 (en) * | 2000-01-10 | 2006-11-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
US8501701B2 (en) * | 2000-01-10 | 2013-08-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Use of lipid conjugates in the treatment of disease |
US20090325876A1 (en) * | 2004-09-29 | 2009-12-31 | Saul Yedgar | Use of lipid conjugates in the treatment of diseases associated with vasculature |
US8076312B2 (en) * | 2000-01-10 | 2011-12-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Use of lipid conjugates in the treatment of disease |
US8304395B2 (en) * | 2000-01-10 | 2012-11-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Lipid conjugates in the treatment of disease |
US20060189571A1 (en) * | 2000-01-10 | 2006-08-24 | Saul Yedgar | Use of lipid conjugates in the treatment of infection |
US7893226B2 (en) | 2004-09-29 | 2011-02-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Use of lipid conjugates in the treatment of diseases |
US8916539B2 (en) * | 2000-01-10 | 2014-12-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of disease |
US7811999B2 (en) * | 2000-01-10 | 2010-10-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Use of lipid conjugates in the treatment of diseases |
US7608598B2 (en) | 2000-01-10 | 2009-10-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of conjunctivitis |
US7259152B2 (en) | 2000-06-07 | 2007-08-21 | Alfa Wasserman, Inc. | Methods and compositions using sulodexide for the treatment of diabetic nephropathy |
US8883761B2 (en) * | 2001-01-10 | 2014-11-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases associated with vasculature |
US20070185052A1 (en) * | 2005-08-03 | 2007-08-09 | Saul Yedgar | Use of lipid conjugates in cystic fibrosis and applications thereof |
US7280612B2 (en) * | 2003-07-25 | 2007-10-09 | Zarbana Digital Fund Llc | Digital branch calibrator for an RF transmitter |
US8137685B2 (en) * | 2003-10-29 | 2012-03-20 | Teijin Limited | Hyaluronic acid compound, hydrogel thereof and joint treating material |
JP4744973B2 (ja) * | 2005-08-05 | 2011-08-10 | 株式会社トプコン | 眼底カメラ |
US8475694B2 (en) | 2005-10-25 | 2013-07-02 | Zephyros, Inc. | Shaped expandable material |
US8859524B2 (en) | 2005-11-17 | 2014-10-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Lipid conjugates in the treatment of chronic rhinosinusitis |
US8906882B2 (en) | 2005-11-17 | 2014-12-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Lipid conjugates in the treatment of allergic rhinitis |
US20080183282A1 (en) * | 2006-03-09 | 2008-07-31 | Saul Yedgar | Use of lipid conjugates for the coating of stents and catheters |
AU2007320737B2 (en) * | 2006-11-14 | 2014-04-03 | Celsus Therapeutics Plc | Contact lens compositions |
CA2705785A1 (en) * | 2006-11-14 | 2008-05-22 | Saul Yedgar | Use of lipid conjugates in the treatment of diseases or disorders of the eye |
EP2429532A4 (de) * | 2009-05-11 | 2015-05-27 | Yissum Res Dev Co | Lipid-polymer-konjugate, ihre herstellung und verwendung |
GB0916205D0 (en) | 2009-09-15 | 2009-10-28 | Zephyros Inc | Improvements in or relating to cavity filling |
EP2547342A2 (de) * | 2010-03-17 | 2013-01-23 | KTB Tumorforschungsgesellschaft mbH | Kombinierte verwendung von phospholipiden und sulfatgruppentragenden polysacchariden zur hemmung von metastasierung |
CA2703532C (en) * | 2010-05-10 | 2018-05-01 | Eva Turley | Topically administered, skin-penetrating glycosaminoglycan formulations suitable for use in cosmetic and pharmaceutical applications |
MX2021012576A (es) * | 2019-04-29 | 2021-11-12 | Bausch & Lomb | Red polimerica de glicofosfolipidos y uso de la misma. |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2374910A1 (fr) * | 1976-10-23 | 1978-07-21 | Choay Sa | Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations |
FR2492259A1 (fr) * | 1980-10-21 | 1982-04-23 | Idinvex Sa | Formulation d'heparine |
US4362737A (en) * | 1981-04-13 | 1982-12-07 | Schaefer Rolf | Transdermal carrier materials |
US4654327A (en) * | 1982-04-21 | 1987-03-31 | Research Corp. | Quaternary ammonium complexes of heparin |
US4604376A (en) * | 1982-04-21 | 1986-08-05 | Research Corporation | Enteric compounds and complexes |
DK168876B1 (da) * | 1982-12-20 | 1994-07-04 | Harvard College | Middel, der kan administreres oralt eller subcutant, til inhibering af angiogenese hos pattedyr samt fremgangsmåde til fremstilling af et sådant middel |
JPS6117A (ja) * | 1984-06-11 | 1986-01-06 | Seikagaku Kogyo Co Ltd | ムコ多糖系癌転移抑制剤 |
US5122450A (en) * | 1985-10-24 | 1992-06-16 | Research Corporation Limited | Biochemical reagent |
IL79255A0 (en) * | 1986-06-26 | 1986-09-30 | Hadassah Med Org | Composition for metastasis prevention |
IT1203515B (it) * | 1987-02-26 | 1989-02-15 | Indena Spa | Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono |
WO1989008499A1 (en) * | 1988-03-17 | 1989-09-21 | Nippon Fine Chemical Co., Ltd. | Liposome |
JPH0219393A (ja) * | 1988-07-08 | 1990-01-23 | Higeta Shoyu Kk | N‐アセチルガラクトサミノオリゴ糖及びその製造方法 |
JPH0258501A (ja) * | 1988-08-25 | 1990-02-27 | Mitsubishi Gas Chem Co Inc | リポ多糖およびその用途 |
JPH03220201A (ja) * | 1988-11-18 | 1991-09-27 | Eisai Co Ltd | プロスタグランジン類と多糖類の結合体 |
-
1991
- 1991-07-24 AU AU82266/91A patent/AU647814B2/en not_active Ceased
- 1991-07-24 AT AT91913108T patent/ATE148713T1/de not_active IP Right Cessation
- 1991-07-24 CA CA002067211A patent/CA2067211C/en not_active Expired - Fee Related
- 1991-07-24 KR KR1019920700665A patent/KR0181295B1/ko not_active IP Right Cessation
- 1991-07-24 US US07/847,065 patent/US5464942A/en not_active Expired - Lifetime
- 1991-07-24 WO PCT/JP1991/000995 patent/WO1992001720A1/ja active IP Right Grant
- 1991-07-24 DE DE69124590T patent/DE69124590T2/de not_active Expired - Fee Related
- 1991-07-24 EP EP91913108A patent/EP0493622B1/de not_active Expired - Lifetime
-
1992
- 1992-02-19 FI FI920717A patent/FI103279B1/fi active
- 1992-03-19 NO NO921083A patent/NO305368B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1992001720A1 (en) | 1992-02-06 |
NO921083L (no) | 1992-05-21 |
EP0493622A1 (de) | 1992-07-08 |
DE69124590D1 (de) | 1997-03-20 |
AU8226691A (en) | 1992-02-18 |
CA2067211A1 (en) | 1992-01-25 |
NO305368B1 (no) | 1999-05-18 |
FI920717A0 (fi) | 1992-02-19 |
EP0493622A4 (en) | 1993-10-27 |
NO921083D0 (no) | 1992-03-19 |
ATE148713T1 (de) | 1997-02-15 |
CA2067211C (en) | 2004-06-15 |
US5464942A (en) | 1995-11-07 |
KR0181295B1 (ko) | 1999-04-01 |
EP0493622B1 (de) | 1997-02-05 |
FI103279B (fi) | 1999-05-31 |
FI103279B1 (fi) | 1999-05-31 |
AU647814B2 (en) | 1994-03-31 |
KR920702377A (ko) | 1992-09-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |