GR3024416T3 - Process for the synthesis of semisynthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-0-sulfate acid. - Google Patents

Process for the synthesis of semisynthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-0-sulfate acid.

Info

Publication number
GR3024416T3
GR3024416T3 GR970402059T GR970402059T GR3024416T3 GR 3024416 T3 GR3024416 T3 GR 3024416T3 GR 970402059 T GR970402059 T GR 970402059T GR 970402059 T GR970402059 T GR 970402059T GR 3024416 T3 GR3024416 T3 GR 3024416T3
Authority
GR
Greece
Prior art keywords
heparin
iduronic
alpha
synthesis
heparan structure
Prior art date
Application number
GR970402059T
Other languages
English (en)
Inventor
Fabrizio Ungarelli
Silvano Piani
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of GR3024416T3 publication Critical patent/GR3024416T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR970402059T 1993-03-29 1997-08-13 Process for the synthesis of semisynthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-0-sulfate acid. GR3024416T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93BO000125A IT1264101B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2

Publications (1)

Publication Number Publication Date
GR3024416T3 true GR3024416T3 (en) 1997-11-28

Family

ID=11338858

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970402059T GR3024416T3 (en) 1993-03-29 1997-08-13 Process for the synthesis of semisynthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-0-sulfate acid.

Country Status (18)

Country Link
US (1) US5405949A (el)
EP (1) EP0618234B1 (el)
JP (1) JP2731721B2 (el)
KR (1) KR100194122B1 (el)
AT (1) ATE154039T1 (el)
AU (1) AU664939B2 (el)
CA (1) CA2114862C (el)
DE (1) DE69403537T2 (el)
DK (1) DK0618234T3 (el)
ES (1) ES2102087T3 (el)
FI (1) FI105101B (el)
GR (1) GR3024416T3 (el)
IL (1) IL108689A (el)
IT (1) IT1264101B1 (el)
NO (1) NO305994B1 (el)
NZ (1) NZ250815A (el)
TW (1) TW266215B (el)
ZA (1) ZA94970B (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
EP1353556A4 (en) 2001-01-23 2009-09-09 Massachusetts Inst Technology SYNTHESIS OF HEPARIN AND OTHER GLYCOSAMINOGLYCANS IN SOLID PHASE AND SOLUTION PHASE
PT2343077E (pt) 2001-09-12 2013-08-29 Sigma Tau Res Switzerland Sa Derivados de glicosaminoglicanos totalmente n-dessulfatados como inibidores da heparanase, capazes de atividade antiangiogénica e desprovidos de efeito anticoagulante
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
US10913763B2 (en) 2016-03-09 2021-02-09 Glytech, Inc. Method for producing sugar having sulfate group and/or phosphate group
CN114901702B (zh) * 2019-12-27 2024-01-09 深圳市海普瑞药业集团股份有限公司 一种糖胺聚糖衍生物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5011919A (en) * 1989-01-30 1991-04-30 Ajorca S.A. Modified heparins and obtention process
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
BE1006134A6 (fr) * 1992-08-25 1994-05-24 Syntex Sa Procede de preparation de derives 2-desoxy-2-amino hexuronyles d'heparine, derives tels qu'ainsi obtenus et leur utilisation.

Also Published As

Publication number Publication date
NO941128D0 (no) 1994-03-28
ZA94970B (en) 1994-08-24
NZ250815A (en) 1996-02-27
FI941431A (fi) 1994-09-30
FI941431A0 (fi) 1994-03-28
DE69403537D1 (de) 1997-07-10
AU664939B2 (en) 1995-12-07
IT1264101B1 (it) 1996-09-10
ITBO930125A0 (it) 1993-03-29
NO305994B1 (no) 1999-08-30
CA2114862C (en) 1999-05-25
EP0618234A1 (en) 1994-10-05
DK0618234T3 (da) 1997-08-25
NO941128L (no) 1994-09-30
KR940021582A (ko) 1994-10-19
ATE154039T1 (de) 1997-06-15
DE69403537T2 (de) 1997-09-18
JPH06298805A (ja) 1994-10-25
TW266215B (el) 1995-12-21
AU5508594A (en) 1994-10-06
EP0618234B1 (en) 1997-06-04
IL108689A0 (en) 1994-05-30
ITBO930125A1 (it) 1994-09-29
CA2114862A1 (en) 1994-09-30
IL108689A (en) 1998-03-10
FI105101B (fi) 2000-06-15
US5405949A (en) 1995-04-11
JP2731721B2 (ja) 1998-03-25
ES2102087T3 (es) 1997-07-16
KR100194122B1 (ko) 1999-06-15

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