ATE154039T1 - Verfahren zur synthese von halbsynthetischen glykosaminoglykanen mit heparin- oder heparanstruktur, die in 2-position modifiziertes alpha-l-iduronsäure-2-o-sulfat enthalten - Google Patents

Verfahren zur synthese von halbsynthetischen glykosaminoglykanen mit heparin- oder heparanstruktur, die in 2-position modifiziertes alpha-l-iduronsäure-2-o-sulfat enthalten

Info

Publication number
ATE154039T1
ATE154039T1 AT94104306T AT94104306T ATE154039T1 AT E154039 T1 ATE154039 T1 AT E154039T1 AT 94104306 T AT94104306 T AT 94104306T AT 94104306 T AT94104306 T AT 94104306T AT E154039 T1 ATE154039 T1 AT E154039T1
Authority
AT
Austria
Prior art keywords
heparin
sulfate
synthesis
semi
heparatic
Prior art date
Application number
AT94104306T
Other languages
English (en)
Inventor
Fabrizio Ungarelli
Silvano Piani
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Application granted granted Critical
Publication of ATE154039T1 publication Critical patent/ATE154039T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT94104306T 1993-03-29 1994-03-18 Verfahren zur synthese von halbsynthetischen glykosaminoglykanen mit heparin- oder heparanstruktur, die in 2-position modifiziertes alpha-l-iduronsäure-2-o-sulfat enthalten ATE154039T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93BO000125A IT1264101B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2

Publications (1)

Publication Number Publication Date
ATE154039T1 true ATE154039T1 (de) 1997-06-15

Family

ID=11338858

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94104306T ATE154039T1 (de) 1993-03-29 1994-03-18 Verfahren zur synthese von halbsynthetischen glykosaminoglykanen mit heparin- oder heparanstruktur, die in 2-position modifiziertes alpha-l-iduronsäure-2-o-sulfat enthalten

Country Status (18)

Country Link
US (1) US5405949A (de)
EP (1) EP0618234B1 (de)
JP (1) JP2731721B2 (de)
KR (1) KR100194122B1 (de)
AT (1) ATE154039T1 (de)
AU (1) AU664939B2 (de)
CA (1) CA2114862C (de)
DE (1) DE69403537T2 (de)
DK (1) DK0618234T3 (de)
ES (1) ES2102087T3 (de)
FI (1) FI105101B (de)
GR (1) GR3024416T3 (de)
IL (1) IL108689A (de)
IT (1) IT1264101B1 (de)
NO (1) NO305994B1 (de)
NZ (1) NZ250815A (de)
TW (1) TW266215B (de)
ZA (1) ZA94970B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
AU2002243630A1 (en) 2001-01-23 2002-08-06 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
MXPA04002217A (es) 2001-09-12 2004-07-08 Sigma Tau Ind Farmaceuti Derivados de glucosaminoglucanas parcialmente desulfatados como inhibidores de heparanasa, dotados con actividad antiangiogenica y libres de efectos anticoagulantes.
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
JP7401882B2 (ja) * 2016-03-09 2023-12-20 株式会社糖鎖工学研究所 硫酸基を有する糖の製造方法
WO2021128253A1 (zh) * 2019-12-27 2021-07-01 深圳市海普瑞药业集团股份有限公司 一种糖胺聚糖衍生物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5011919A (en) * 1989-01-30 1991-04-30 Ajorca S.A. Modified heparins and obtention process
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
BE1006134A6 (fr) * 1992-08-25 1994-05-24 Syntex Sa Procede de preparation de derives 2-desoxy-2-amino hexuronyles d'heparine, derives tels qu'ainsi obtenus et leur utilisation.

Also Published As

Publication number Publication date
FI941431A (fi) 1994-09-30
ITBO930125A1 (it) 1994-09-29
AU664939B2 (en) 1995-12-07
EP0618234A1 (de) 1994-10-05
US5405949A (en) 1995-04-11
CA2114862C (en) 1999-05-25
EP0618234B1 (de) 1997-06-04
IL108689A (en) 1998-03-10
ZA94970B (en) 1994-08-24
JPH06298805A (ja) 1994-10-25
DK0618234T3 (da) 1997-08-25
DE69403537T2 (de) 1997-09-18
NO305994B1 (no) 1999-08-30
NZ250815A (en) 1996-02-27
GR3024416T3 (en) 1997-11-28
TW266215B (de) 1995-12-21
KR100194122B1 (ko) 1999-06-15
FI105101B (fi) 2000-06-15
NO941128D0 (no) 1994-03-28
NO941128L (no) 1994-09-30
IT1264101B1 (it) 1996-09-10
ITBO930125A0 (it) 1993-03-29
DE69403537D1 (de) 1997-07-10
FI941431A0 (fi) 1994-03-28
JP2731721B2 (ja) 1998-03-25
ES2102087T3 (es) 1997-07-16
KR940021582A (ko) 1994-10-19
CA2114862A1 (en) 1994-09-30
AU5508594A (en) 1994-10-06
IL108689A0 (en) 1994-05-30

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee