JPS6445359A - Production of penem-3-carboxylic acid derivative - Google Patents
Production of penem-3-carboxylic acid derivativeInfo
- Publication number
- JPS6445359A JPS6445359A JP63191071A JP19107188A JPS6445359A JP S6445359 A JPS6445359 A JP S6445359A JP 63191071 A JP63191071 A JP 63191071A JP 19107188 A JP19107188 A JP 19107188A JP S6445359 A JPS6445359 A JP S6445359A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- alkyl
- treating
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To obtain the titled compound which is an important synthetic intermediate for a compound having excellent antibacterial action, by treating an azitidinone derivative with a base, successively reacting with carbon disulfide and a halogenoketone and subjecting the reaction product to halogenation and cyclization. CONSTITUTION:The objective compound is produced by treating a compound of formula I [R<5> is H, alkyl or R<8>B (R<8> is alkoxy, acyloxy, alkylthio, etc.; B is alkylene); R<6> is carboxyl-protecting group; R<7> is alkyl] with a base, reacting with carbon disulfide, reacting the reaction product with a compound of formula II (X is halogen; Ra<2> is H, alkyl, aralkyl or aryl; A is alkylene), treating the resultant compound of formula III with a halogenation agent to obtain a compound of formula IV (Y is halogen), cyclizing the compound in the presence of a base and, as necessary, removing protecting group from the groups R<5> and R<6>.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63191071A JPS6445359A (en) | 1988-07-29 | 1988-07-29 | Production of penem-3-carboxylic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63191071A JPS6445359A (en) | 1988-07-29 | 1988-07-29 | Production of penem-3-carboxylic acid derivative |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3322234A Division JPH0631256B2 (en) | 1991-12-06 | 1991-12-06 | Process for producing penem-3-carboxylic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6445359A true JPS6445359A (en) | 1989-02-17 |
JPH0552835B2 JPH0552835B2 (en) | 1993-08-06 |
Family
ID=16268387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63191071A Granted JPS6445359A (en) | 1988-07-29 | 1988-07-29 | Production of penem-3-carboxylic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6445359A (en) |
-
1988
- 1988-07-29 JP JP63191071A patent/JPS6445359A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPH0552835B2 (en) | 1993-08-06 |
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