DK173590B1 - Fremgangsmåde til fremstilling af et antiviralt polypeptid og at et dobbeltstrenget DNA, der omfatter en sekvens, der koder - Google Patents

Fremgangsmåde til fremstilling af et antiviralt polypeptid og at et dobbeltstrenget DNA, der omfatter en sekvens, der koder Download PDF

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Publication number
DK173590B1
DK173590B1 DK198104946A DK494681A DK173590B1 DK 173590 B1 DK173590 B1 DK 173590B1 DK 198104946 A DK198104946 A DK 198104946A DK 494681 A DK494681 A DK 494681A DK 173590 B1 DK173590 B1 DK 173590B1
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DK
Denmark
Prior art keywords
leif
amino acids
polypeptide
amino acid
fragment
Prior art date
Application number
DK198104946A
Other languages
Danish (da)
English (en)
Other versions
DK494681A (da
Inventor
David Norman Van Goeddel
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/237,388 external-priority patent/US4414150A/en
Priority claimed from US06/305,657 external-priority patent/US4456748A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK494681A publication Critical patent/DK494681A/da
Application granted granted Critical
Publication of DK173590B1 publication Critical patent/DK173590B1/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK198104946A 1980-11-10 1981-11-09 Fremgangsmåde til fremstilling af et antiviralt polypeptid og at et dobbeltstrenget DNA, der omfatter en sekvens, der koder DK173590B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US20557980A 1980-11-10 1980-11-10
US20557980 1980-11-10
US23738881 1981-02-23
US06/237,388 US4414150A (en) 1980-11-10 1981-02-23 Hybrid human leukocyte interferons
US30565781 1981-09-25
US06/305,657 US4456748A (en) 1981-02-23 1981-09-25 Hybrid human leukocyte interferons

Publications (2)

Publication Number Publication Date
DK494681A DK494681A (da) 1982-05-11
DK173590B1 true DK173590B1 (da) 2001-04-02

Family

ID=27394813

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198104946A DK173590B1 (da) 1980-11-10 1981-11-09 Fremgangsmåde til fremstilling af et antiviralt polypeptid og at et dobbeltstrenget DNA, der omfatter en sekvens, der koder

Country Status (34)

Country Link
EP (1) EP0051873B1 (xx)
JP (1) JP2642291B2 (xx)
KR (1) KR920007439B1 (xx)
AT (1) ATE46718T1 (xx)
AU (1) AU555293B2 (xx)
BR (1) BR8107293A (xx)
CA (2) CA1212915A (xx)
CH (2) CH660743A5 (xx)
DE (2) DE3144469A1 (xx)
DK (1) DK173590B1 (xx)
DO (1) DOP1981004064A (xx)
DZ (1) DZ350A1 (xx)
ES (2) ES506955A0 (xx)
FI (1) FI79550C (xx)
FR (1) FR2493867B1 (xx)
GB (1) GB2090258B (xx)
GR (1) GR81947B (xx)
HK (1) HK51685A (xx)
IE (1) IE51850B1 (xx)
IL (1) IL64243A (xx)
IT (1) IT1169276B (xx)
KE (1) KE3536A (xx)
LU (1) LU83745A1 (xx)
MC (1) MC1424A1 (xx)
MY (2) MY8700710A (xx)
NL (1) NL189092C (xx)
NO (1) NO165201C (xx)
NZ (1) NZ198906A (xx)
PH (1) PH18565A (xx)
PL (1) PL233748A1 (xx)
PT (1) PT73955B (xx)
SE (1) SE460539B (xx)
YU (1) YU46597B (xx)
ZW (1) ZW26981A1 (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH657141A5 (de) * 1980-07-01 1986-08-15 Hoffmann La Roche Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen.
EP0072541A3 (en) * 1981-08-14 1984-04-18 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Human leukocyte interferons, process for their microbial production, intermediates therefor and compositions containing them
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
GB2108510B (en) * 1981-10-03 1984-12-12 Ciba Geigy Ag Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof
IT1167610B (it) * 1982-01-19 1987-05-13 Cetus Corp Interfreron ibrido multiclasse, composizione farmaceutica che lo contiene e procedimento di produzione
DE3220116A1 (de) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung
CA1252046A (en) * 1982-11-04 1989-04-04 Martin J. Cline Methods for oncogenic detection
DE3490055T1 (de) * 1983-02-24 1985-05-02 Institut bioorganičeskoj chimii imeni M.M. Šemjakina Akademii nauk SSSR, Moskau/Moskva Menschliches Leukozyteninterferon N und Verfahren zu dessen Herstellung in Bakterienzellen
GB8315980D0 (en) * 1983-06-10 1983-07-13 Biogen Nv Producing hybrid dna sequences
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons
US4892743A (en) * 1983-12-21 1990-01-09 Schering Corporation Novel hybrid interferon species
EP0146903A3 (en) * 1983-12-19 1987-07-22 Schering Corporation Production of a vector encoding a novel hybrid interferon species
DE3409966A1 (de) * 1984-03-19 1985-09-26 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-gammainterferon und mittel zur durchfuehrung dieses verfahrens
JPS6156199A (ja) * 1984-08-27 1986-03-20 Shionogi & Co Ltd 新規ヒトインタ−フエロンα類
EP0173935A1 (en) * 1984-08-31 1986-03-12 University Patents, Inc. Hybrid lymphoblastoid-leukocyte human interferons
DE3434345A1 (de) * 1984-09-19 1986-03-27 Hoechst Ag, 6230 Frankfurt Verwendung von (alpha)-interferonen zur bekaempfung von durchfaellen
EP0194006B1 (en) * 1985-02-01 1992-04-29 Imperial Chemical Industries Plc Analogous interferon polypeptides, process for their preparation and pharmaceutical compositions containing them
DE3685996T2 (de) * 1985-06-11 1993-01-14 Ciba Geigy Ag Hybrid-interferone.
WO1987002037A1 (en) * 1985-09-26 1987-04-09 Genetics Institute, Inc. Pulmonary surfactant proteins
US4806347A (en) * 1985-12-11 1989-02-21 Schering Corporation Interferon combinations
EP0490233A1 (de) * 1986-03-10 1992-06-17 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Monoclonale Antikörper gegen BgIII-Hybridinterferone, deren Verwendung und Verfahren zu ihrer Herstellung
DE3607835A1 (de) * 1986-03-10 1987-09-24 Boehringer Ingelheim Int Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung
US4851220A (en) * 1986-11-26 1989-07-25 Schering Corporation Stable oleaginous gel
US4853218A (en) * 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
EP0331635A3 (en) * 1988-02-29 1990-02-28 The Board of Regents of the University of Texas System Preparations for treating bladder cancer
US5372808A (en) † 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
GB2273931A (en) * 1992-09-28 1994-07-06 Unilever Plc Mutant polypeptides
EP0830368A1 (en) 1995-06-07 1998-03-25 Genta Incorporated Novel carbamate-based cationic lipids
TW442492B (en) * 1995-07-26 2001-06-23 Novartis Ag Process for the enrichment of interferon
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
US7314613B2 (en) 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
AU2005245918A1 (en) 2004-05-19 2005-12-01 F. Hoffmann-La Roche Ag Interferon-alpha polypeptides and conjugates
BRPI0609809A2 (pt) 2005-05-18 2011-10-11 Maxygen Inc polipeptìdeo isolado ou recombinante, conjugado, composição, polinucleotìdeo isolado ou recombinante, célula hospedeira, vetor, métodos para preparar o polipeptìdeo, para preparar um conjugado, para inibir replicação de um vìrus em células infectadas com o vìrus para reduzir o numero de cópias de um vìrus em células infectadas com o vìrus, para reduzir o nìvel de rna de hcv no soro de um paciente infectado com hcv, para reduzir o nìvel de dna de hbv em soro de um paciente infectado com hbv e para reduzir o nìvel de rna de hiv em soro de um paciente infectado com hiv, e, uso do polipeptìdeo ou do conjugado

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO164037C (no) * 1980-01-08 1990-08-22 Biogen Inc Fremgangsmaate ved fremstilling av et polypeptid av interferon alfa (ifnalfa)-type.

Also Published As

Publication number Publication date
NL8105078A (nl) 1982-06-01
AU7730481A (en) 1982-05-20
JPH07308191A (ja) 1995-11-28
DK494681A (da) 1982-05-11
MC1424A1 (fr) 1982-10-18
EP0051873A2 (en) 1982-05-19
IL64243A0 (en) 1982-02-28
NO813785L (no) 1982-05-11
IT1169276B (it) 1987-05-27
PH18565A (en) 1985-08-09
SE8106641L (sv) 1982-06-24
AU555293B2 (en) 1986-09-18
KE3536A (en) 1985-06-07
PL233748A1 (en) 1983-07-18
CA1212915A (en) 1986-10-21
NL189092C (nl) 1993-01-04
ES512354A0 (es) 1983-03-01
KR830007825A (ko) 1983-11-07
ES8302778A1 (es) 1983-02-01
CH663032A5 (de) 1987-11-13
DOP1981004064A (es) 1988-03-16
EP0051873B1 (en) 1989-09-27
NZ198906A (en) 1985-12-13
LU83745A1 (de) 1983-09-01
FR2493867A1 (fr) 1982-05-14
FR2493867B1 (fr) 1986-06-27
GR81947B (xx) 1984-12-12
GB2090258A (en) 1982-07-07
MY8700710A (en) 1987-12-31
HK51685A (en) 1985-07-12
PT73955B (en) 1983-11-23
NO165201B (no) 1990-10-01
FI79550B (fi) 1989-09-29
FI79550C (fi) 1990-01-10
YU46597B (sh) 1994-01-20
IE51850B1 (en) 1987-04-15
IE812622L (en) 1982-05-10
IL64243A (en) 1985-11-29
CH660743A5 (de) 1987-06-15
CA1277616C (en) 1990-12-11
PT73955A (en) 1981-12-01
DE3177106D1 (en) 1989-11-02
DZ350A1 (fr) 2004-09-13
JP2642291B2 (ja) 1997-08-20
NL189092B (nl) 1992-08-03
YU265681A (en) 1984-08-31
DE3144469A1 (de) 1982-09-02
ZW26981A1 (en) 1982-06-02
ATE46718T1 (de) 1989-10-15
NO165201C (no) 1991-01-16
SE460539B (sv) 1989-10-23
GB2090258B (en) 1984-05-02
KR920007439B1 (ko) 1992-09-01
MY8800066A (en) 1988-12-31
IT8124967A0 (it) 1981-11-10
FI813539L (fi) 1982-05-11
ES8304200A1 (es) 1983-03-01
BR8107293A (pt) 1982-08-03
EP0051873A3 (en) 1982-09-22
ES506955A0 (es) 1983-02-01

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