DK170403B1 - Terapeutisk aktive indolizinderivater og fremgangsmåder til fremstilling deraf samt midler indeholdende derivaterne - Google Patents

Terapeutisk aktive indolizinderivater og fremgangsmåder til fremstilling deraf samt midler indeholdende derivaterne Download PDF

Info

Publication number
DK170403B1
DK170403B1 DK074087A DK74087A DK170403B1 DK 170403 B1 DK170403 B1 DK 170403B1 DK 074087 A DK074087 A DK 074087A DK 74087 A DK74087 A DK 74087A DK 170403 B1 DK170403 B1 DK 170403B1
Authority
DK
Denmark
Prior art keywords
group
indolizine
methyl
benzenesulfonyl
ethyl
Prior art date
Application number
DK074087A
Other languages
Danish (da)
English (en)
Other versions
DK74087D0 (da
DK74087A (da
Inventor
Jean Gubin
Pierre Chatelain
Marcel Descamps
Dino Nisato
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of DK74087D0 publication Critical patent/DK74087D0/da
Publication of DK74087A publication Critical patent/DK74087A/da
Application granted granted Critical
Publication of DK170403B1 publication Critical patent/DK170403B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK074087A 1986-02-14 1987-02-13 Terapeutisk aktive indolizinderivater og fremgangsmåder til fremstilling deraf samt midler indeholdende derivaterne DK170403B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8602045 1986-02-14
FR8602045A FR2594438B1 (fr) 1986-02-14 1986-02-14 Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant

Publications (3)

Publication Number Publication Date
DK74087D0 DK74087D0 (da) 1987-02-13
DK74087A DK74087A (da) 1987-08-15
DK170403B1 true DK170403B1 (da) 1995-08-21

Family

ID=9332147

Family Applications (1)

Application Number Title Priority Date Filing Date
DK074087A DK170403B1 (da) 1986-02-14 1987-02-13 Terapeutisk aktive indolizinderivater og fremgangsmåder til fremstilling deraf samt midler indeholdende derivaterne

Country Status (33)

Country Link
US (5) US4957925A (ja)
EP (1) EP0235111B1 (ja)
JP (1) JP2547004B2 (ja)
KR (1) KR870007931A (ja)
AR (1) AR245127A1 (ja)
AT (1) ATE62485T1 (ja)
AU (1) AU587525B2 (ja)
BE (1) BE1006666A4 (ja)
CA (1) CA1310965C (ja)
CZ (1) CZ97787A3 (ja)
DD (1) DD264436A5 (ja)
DE (1) DE3769174D1 (ja)
DK (1) DK170403B1 (ja)
ES (1) ES2040276T3 (ja)
FI (1) FI84353C (ja)
FR (1) FR2594438B1 (ja)
GR (1) GR3001883T3 (ja)
HU (1) HU196401B (ja)
IE (1) IE59656B1 (ja)
IL (1) IL81358A (ja)
MA (1) MA20878A1 (ja)
MY (1) MY101541A (ja)
NO (1) NO165344C (ja)
NZ (1) NZ219274A (ja)
OA (1) OA08481A (ja)
PH (1) PH24830A (ja)
PL (2) PL152609B1 (ja)
PT (1) PT84277B (ja)
SK (1) SK279557B6 (ja)
SU (2) SU1486064A3 (ja)
TN (1) TNSN87021A1 (ja)
YU (2) YU21287A (ja)
ZA (1) ZA87471B (ja)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215988A (en) * 1986-02-14 1993-06-01 Sanofi Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same
FR2594438B1 (fr) * 1986-02-14 1990-01-26 Labaz Sanofi Nv Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
US5182291A (en) * 1986-02-14 1993-01-26 Sanofi Pyrozala-pyridyl aminoabkoxyphenol compounds
IL87181A (en) * 1987-08-07 1993-08-18 Sanofi Sa Aminoalkoxyphenyl derivatives, their preparation and pharmaceutical and veterinary compositions containing them
FR2633622B1 (fr) * 1988-07-04 1991-05-17 Sanofi Sa Derives de sulfonyl indolizine, leur procede de preparation et leur utilisation comme intermediaires de synthese
CA2008985A1 (en) * 1989-02-06 1990-08-06 Jean Gubin Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same
FR2642755B1 (ja) * 1989-02-07 1993-11-05 Sanofi
FR2642756B1 (fr) * 1989-02-07 1994-03-04 Sanofi Derives cycloaminoalkoxyphenyle, leur procede de preparation ainsi que les compositions pharmaceutiques ou veterinaires en contenant
JPH07103105B2 (ja) * 1989-05-12 1995-11-08 杏林製薬株式会社 インドール誘導体及びその製造方法
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
US5118707A (en) * 1990-10-31 1992-06-02 The Procter & Gamble Company Compositions for regulating skin wrinkles comprising a benzofuran derivative
US5435991A (en) * 1991-08-09 1995-07-25 Nycomed Innovation Ab Use of persistent heterocyclic free-radicals in magnetic resonance imaging
FR2692574B1 (fr) * 1992-06-23 1995-06-23 Sanofi Elf Derives hydroxy-4 benzenethio, leur preparation ainsi que leur utilisation pour la preparation de derives aminoalkoxybenzenesulfonyles.
FR2692578B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Derives d'indolizines, procede de preparation et utilisation pour la preparation de composes aminoalkoxybenzenesulfonyl-indolizines a activite pharmaceutique.
US5922773A (en) * 1992-12-04 1999-07-13 The Children's Medical Center Corp. Glaucoma treatment
FR2725133B1 (fr) * 1994-09-30 1996-12-20 Sanofi Sa Composition pharmaceutique de fantofarone pour administration orale
US6514971B1 (en) 1996-03-15 2003-02-04 Zeneca Limited Cinnoline derivatives and use as medicine
US6482854B1 (en) 1999-03-25 2002-11-19 Massachusetts Eye And Ear Infirmary Glaucoma treatment
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
US6699866B2 (en) * 2001-04-17 2004-03-02 Sepracor Inc. Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
PL214231B1 (pl) * 2001-04-27 2013-07-31 Eisai R & D Man Co Pochodne pirazolo [1,5-a] pirydyny, kompozycje je zawierajace oraz zastosowanie
FR2838123B1 (fr) * 2002-04-04 2005-06-10 Sanofi Synthelabo Nouveaux derives d'indolozine-1,2,3 substituee, inhibiteurs selectifs du b-fgf
EP1554260A1 (en) * 2002-10-22 2005-07-20 Glaxo Group Limited Aryloxyalkylamine derivatives as h3 receptor ligands
US7470803B2 (en) * 2003-01-31 2008-12-30 Nippon Soda Co., Ltd. Compounds for forming photoconvertible organic thin film and organic thin film formed body
ES2388138T3 (es) 2003-08-27 2012-10-09 Ophthotech Corporation Terapia de combinación para tratamiento de trastornos neovasculares oculares
US20060141049A1 (en) * 2003-11-12 2006-06-29 Allergan, Inc. Triamcinolone compositions for intravitreal administration to treat ocular conditions
US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
US20070224278A1 (en) * 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
ES2318453T3 (es) 2004-01-20 2009-05-01 Allergan, Inc. Composiciones para terapia localizada del ojo, que comprenden, de preferencia,triamcinolona acetonida y acido hialuronico.
WO2005110374A1 (en) * 2004-04-30 2005-11-24 Allergan, Inc. Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component
US8147865B2 (en) 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8673341B2 (en) * 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US8591885B2 (en) * 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US20050244466A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Photodynamic therapy in conjunction with intraocular implants
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20050244462A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Devices and methods for treating a mammalian eye
US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US20050244465A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Drug delivery systems and methods for treatment of an eye
US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US20050244461A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US7799336B2 (en) * 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US20070059336A1 (en) * 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
US20050244478A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Anti-excititoxic sustained release intraocular implants and related methods
US8455656B2 (en) 2004-04-30 2013-06-04 Allergan, Inc. Kinase inhibitors
US20050244471A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Estradiol derivative and estratopone containing sustained release intraocular implants and related methods
US7993634B2 (en) * 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8512738B2 (en) 2004-04-30 2013-08-20 Allergan, Inc. Biodegradable intravitreal tyrosine kinase implants
JP2008505978A (ja) * 2004-07-12 2008-02-28 アラーガン、インコーポレイテッド 眼病用組成物および眼病治療法
WO2006043965A1 (en) * 2004-10-14 2006-04-27 Allergan, Inc. Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods
WO2006073938A2 (en) * 2004-12-30 2006-07-13 East Carolina University Method for the synthesis of 3-substituted indolizine and benzoindolizine compounds
CA2644240A1 (en) * 2006-03-01 2007-09-13 Roskamp Research, Llc Compounds for inhibiting beta-amyloid production
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
EP2120557A4 (en) * 2006-12-08 2010-02-10 Roskamp Res Llc POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION
US7911053B2 (en) * 2007-04-19 2011-03-22 Marvell World Trade Ltd. Semiconductor packaging with internal wiring bus
BRPI0911659B8 (pt) * 2008-04-15 2021-05-25 Eisai R&D Man Co Ltd composto 3-fenilpirazolo[5,1-b]tiazol e composição farmacêutica compreendendo o mesmo
JPWO2011043387A1 (ja) * 2009-10-08 2013-03-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロオキサゾール化合物
AR078521A1 (es) * 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
WO2011057129A2 (en) 2009-11-09 2011-05-12 Allergan, Inc. Compositions and methods for stimulating hair growth
AU2014216112B2 (en) 2013-02-15 2019-02-21 Allergan, Inc. Sustained drug delivery implant
CN108084186B (zh) * 2016-11-16 2021-06-25 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
WO2023078252A1 (en) 2021-11-02 2023-05-11 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1720033A1 (de) * 1966-03-02 1971-05-19 Yoshitomi Pharmaceutical Neue Indolderivate und Verfahren zu ihrer Herstellung
US3485835A (en) * 1968-04-10 1969-12-23 Haessle Ab 2-benzoyl-3-tertiaryamino alkoxy benzofuran derivatives
IL32186A (en) * 1968-05-24 1974-10-22 Fisons Ltd 5-benzofuranyl compounds,their preparation,and physiologically active compositions containing them
US3860609A (en) * 1969-05-27 1975-01-14 Novo Terapeutisk Labor As 3-aminoalkyloxyindoles
US3859305A (en) * 1970-03-10 1975-01-07 Degussa Indole aminoketones
SE379196B (ja) * 1971-06-24 1975-09-29 Sandoz Ag
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4013012A (en) * 1974-11-18 1977-03-22 Altus Corporation Electronic safe arming and fuzing system
FI61030C (fi) * 1976-02-19 1982-05-10 Sanofi Sa Foerfarande foer framstaellning av terapeutiskt verkande 2-substituerade-1- eller 3-benzoyl-indolizinderivat
US4117128A (en) * 1976-08-03 1978-09-26 Smithkline Corporation Sulfonyl benzofurans and benzothiophenes having coronary vasodilator activity
FR2376145A1 (fr) * 1977-01-03 1978-07-28 Thea Therapeutiques Applic Sa Nouveaux derives de chromones a activite medicamenteuse et leur preparation
GB1560006A (en) * 1977-08-18 1980-01-30 Laroche Navarron Sa Benzoyl furan derivatives process for their preparation and therapeutic applications thereof
US4128552A (en) * 1977-09-26 1978-12-05 Warner-Lambert Company 1-[4,4-Bis(4-fluorophenyl)butyl]-4-phenylthio-1,2,3,6-tetrahydropyridines and related sulfoxides and sulfones
JPS59204191A (ja) * 1983-03-26 1984-11-19 Kyorin Pharmaceut Co Ltd ピラゾロピリジン誘導体、その製法及びそれを含有する治療剤
US4654360A (en) * 1984-06-01 1987-03-31 Syntex (U.S.A.) Inc. 1,2,3-trisubstituted indoles for treatment of inflammation
DE3426419A1 (de) * 1984-07-18 1986-01-23 Boehringer Mannheim Gmbh, 6800 Mannheim Neue oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte
US4675405A (en) * 1984-09-21 1987-06-23 American Home Products Corporation Quinoline compounds as antiallergic and antithrombotic agents
FR2584723B1 (fr) * 1985-07-09 1988-02-12 Adir Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
DE3531658A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
FR2594438B1 (fr) * 1986-02-14 1990-01-26 Labaz Sanofi Nv Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
IL87181A (en) * 1987-08-07 1993-08-18 Sanofi Sa Aminoalkoxyphenyl derivatives, their preparation and pharmaceutical and veterinary compositions containing them

Also Published As

Publication number Publication date
FI84353C (fi) 1991-11-25
DK74087D0 (da) 1987-02-13
NO165344B (no) 1990-10-22
JP2547004B2 (ja) 1996-10-23
MY101541A (en) 1991-12-17
PL264078A1 (en) 1988-07-21
CZ281209B6 (cs) 1996-07-17
FI870629A0 (fi) 1987-02-13
KR870007931A (ko) 1987-09-23
NZ219274A (en) 1989-04-26
NO870579L (no) 1987-08-17
BE1006666A4 (fr) 1994-11-16
SU1528321A3 (ru) 1989-12-07
AR245127A1 (es) 1993-12-30
SK97787A3 (en) 1998-12-02
CZ97787A3 (en) 1996-07-17
JPS62192380A (ja) 1987-08-22
ATE62485T1 (de) 1991-04-15
PL153650B1 (en) 1991-05-31
NO870579D0 (no) 1987-02-13
US4994474A (en) 1991-02-19
SU1486064A3 (ru) 1989-06-07
AU6884687A (en) 1987-08-20
IL81358A0 (en) 1987-08-31
FI870629A (fi) 1987-08-15
PT84277A (en) 1987-03-01
IE870345L (en) 1987-08-14
ES2040276T3 (es) 1993-10-16
FI84353B (fi) 1991-08-15
AU587525B2 (en) 1989-08-17
US5039700A (en) 1991-08-13
YU21287A (en) 1988-08-31
DD264436A5 (de) 1989-02-01
PL152609B1 (en) 1991-01-31
IL81358A (en) 1991-03-10
EP0235111B1 (fr) 1991-04-10
DE3769174D1 (de) 1991-05-16
GR3001883T3 (en) 1992-11-23
PT84277B (pt) 1989-09-14
US4957925A (en) 1990-09-18
IE59656B1 (en) 1994-03-09
SK279557B6 (sk) 1998-12-02
CA1310965C (en) 1992-12-01
US5147878A (en) 1992-09-15
HU196401B (en) 1988-11-28
MA20878A1 (fr) 1987-10-01
HUT43604A (en) 1987-11-30
TNSN87021A1 (fr) 1990-01-01
ZA87471B (en) 1988-09-28
FR2594438B1 (fr) 1990-01-26
PH24830A (en) 1990-10-30
OA08481A (fr) 1988-07-29
DK74087A (da) 1987-08-15
US5017579A (en) 1991-05-21
FR2594438A1 (fr) 1987-08-21
NO165344C (no) 1991-01-30
EP0235111A1 (fr) 1987-09-02
YU46588A (en) 1989-08-31

Similar Documents

Publication Publication Date Title
DK170403B1 (da) Terapeutisk aktive indolizinderivater og fremgangsmåder til fremstilling deraf samt midler indeholdende derivaterne
RU2095357C1 (ru) Производные бензофурана, бензотиофена, индола или индолизина, способы их получения, композиция, обладающая антиаритмическим действием
JPS63146882A (ja) イミダゾ[4,5―b]ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
EP0113782A1 (en) Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
BG62089B1 (bg) Инхибитори на hiv реверсивна транскриптаза
TW200812970A (en) Inhibitors of AKT (protein kinase B)
AU620040B2 (en) Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same
US5444056A (en) Aminoalkoxyphenyl derivatives, process for their preparation and compositions containing them
US3989709A (en) Fused ring benzimidazole derivatives
US5635511A (en) Treatment of heart rhythm disorders by administration of 3-phenylsulfonyl-3,7-diazabicyclo[3.3.1]nonane compounds.
DK158000B (da) Analogifremgangsmaade til fremstilling af 3-(substitueret benzoyl)-indolizinderivater
KR950007179B1 (ko) 인돌리진 유도체, 그 약제학적 조성물, 그 용도 및 그 제조방법
JPH02250862A (ja) アミノアルコキシフェニル誘導体、その製法およびそれを含有する組成物
DK157683B (da) Analogifremgangsmaade til fremstilling af et benzoquinolizinderivat eller et farmaceutisk acceptabelt syreadditionssalt deraf
JPH02282368A (ja) カルシウム拮抗剤
JP2588193B2 (ja) ベンゾジオキソ−ル誘導体
NO147384B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-hydroksy-1,2-benzisotiazol-derivater
NO118916B (ja)

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired