OA08481A - Dérivés d'indolizine, leur procédé de préparation ainsi que les compositions les contenant. - Google Patents

Dérivés d'indolizine, leur procédé de préparation ainsi que les compositions les contenant.

Info

Publication number
OA08481A
OA08481A OA59070A OA59070A OA08481A OA 08481 A OA08481 A OA 08481A OA 59070 A OA59070 A OA 59070A OA 59070 A OA59070 A OA 59070A OA 08481 A OA08481 A OA 08481A
Authority
OA
OAPI
Prior art keywords
preparation process
compositions containing
indolizine derivatives
indolizine
derivatives
Prior art date
Application number
OA59070A
Other languages
English (en)
French (fr)
Inventor
Jean Gubain
Pierre Chatelain
Marcel Deschamps
Dino Nisato
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of OA08481A publication Critical patent/OA08481A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
OA59070A 1986-02-14 1987-02-13 Dérivés d'indolizine, leur procédé de préparation ainsi que les compositions les contenant. OA08481A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8602045A FR2594438B1 (fr) 1986-02-14 1986-02-14 Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant

Publications (1)

Publication Number Publication Date
OA08481A true OA08481A (fr) 1988-07-29

Family

ID=9332147

Family Applications (1)

Application Number Title Priority Date Filing Date
OA59070A OA08481A (fr) 1986-02-14 1987-02-13 Dérivés d'indolizine, leur procédé de préparation ainsi que les compositions les contenant.

Country Status (33)

Country Link
US (5) US4957925A (xx)
EP (1) EP0235111B1 (xx)
JP (1) JP2547004B2 (xx)
KR (1) KR870007931A (xx)
AR (1) AR245127A1 (xx)
AT (1) ATE62485T1 (xx)
AU (1) AU587525B2 (xx)
BE (1) BE1006666A4 (xx)
CA (1) CA1310965C (xx)
CZ (1) CZ97787A3 (xx)
DD (1) DD264436A5 (xx)
DE (1) DE3769174D1 (xx)
DK (1) DK170403B1 (xx)
ES (1) ES2040276T3 (xx)
FI (1) FI84353C (xx)
FR (1) FR2594438B1 (xx)
GR (1) GR3001883T3 (xx)
HU (1) HU196401B (xx)
IE (1) IE59656B1 (xx)
IL (1) IL81358A (xx)
MA (1) MA20878A1 (xx)
MY (1) MY101541A (xx)
NO (1) NO165344C (xx)
NZ (1) NZ219274A (xx)
OA (1) OA08481A (xx)
PH (1) PH24830A (xx)
PL (2) PL152609B1 (xx)
PT (1) PT84277B (xx)
SK (1) SK279557B6 (xx)
SU (2) SU1486064A3 (xx)
TN (1) TNSN87021A1 (xx)
YU (2) YU21287A (xx)
ZA (1) ZA87471B (xx)

Families Citing this family (65)

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US5215988A (en) * 1986-02-14 1993-06-01 Sanofi Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same
FR2594438B1 (fr) * 1986-02-14 1990-01-26 Labaz Sanofi Nv Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
US5182291A (en) * 1986-02-14 1993-01-26 Sanofi Pyrozala-pyridyl aminoabkoxyphenol compounds
IL87181A (en) * 1987-08-07 1993-08-18 Sanofi Sa Aminoalkoxyphenyl derivatives, their preparation and pharmaceutical and veterinary compositions containing them
FR2633622B1 (fr) * 1988-07-04 1991-05-17 Sanofi Sa Derives de sulfonyl indolizine, leur procede de preparation et leur utilisation comme intermediaires de synthese
CA2008985A1 (en) * 1989-02-06 1990-08-06 Jean Gubin Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same
FR2642755B1 (xx) * 1989-02-07 1993-11-05 Sanofi
FR2642756B1 (fr) * 1989-02-07 1994-03-04 Sanofi Derives cycloaminoalkoxyphenyle, leur procede de preparation ainsi que les compositions pharmaceutiques ou veterinaires en contenant
JPH07103105B2 (ja) * 1989-05-12 1995-11-08 杏林製薬株式会社 インドール誘導体及びその製造方法
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
US5118707A (en) * 1990-10-31 1992-06-02 The Procter & Gamble Company Compositions for regulating skin wrinkles comprising a benzofuran derivative
US5435991A (en) * 1991-08-09 1995-07-25 Nycomed Innovation Ab Use of persistent heterocyclic free-radicals in magnetic resonance imaging
FR2692574B1 (fr) * 1992-06-23 1995-06-23 Sanofi Elf Derives hydroxy-4 benzenethio, leur preparation ainsi que leur utilisation pour la preparation de derives aminoalkoxybenzenesulfonyles.
FR2692578B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Derives d'indolizines, procede de preparation et utilisation pour la preparation de composes aminoalkoxybenzenesulfonyl-indolizines a activite pharmaceutique.
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US6514971B1 (en) 1996-03-15 2003-02-04 Zeneca Limited Cinnoline derivatives and use as medicine
US6482854B1 (en) 1999-03-25 2002-11-19 Massachusetts Eye And Ear Infirmary Glaucoma treatment
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US6699866B2 (en) * 2001-04-17 2004-03-02 Sepracor Inc. Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
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FR2838123B1 (fr) * 2002-04-04 2005-06-10 Sanofi Synthelabo Nouveaux derives d'indolozine-1,2,3 substituee, inhibiteurs selectifs du b-fgf
EP1554260A1 (en) * 2002-10-22 2005-07-20 Glaxo Group Limited Aryloxyalkylamine derivatives as h3 receptor ligands
US7470803B2 (en) * 2003-01-31 2008-12-30 Nippon Soda Co., Ltd. Compounds for forming photoconvertible organic thin film and organic thin film formed body
ES2388138T3 (es) 2003-08-27 2012-10-09 Ophthotech Corporation Terapia de combinación para tratamiento de trastornos neovasculares oculares
US20060141049A1 (en) * 2003-11-12 2006-06-29 Allergan, Inc. Triamcinolone compositions for intravitreal administration to treat ocular conditions
US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
US20070224278A1 (en) * 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
ES2318453T3 (es) 2004-01-20 2009-05-01 Allergan, Inc. Composiciones para terapia localizada del ojo, que comprenden, de preferencia,triamcinolona acetonida y acido hialuronico.
WO2005110374A1 (en) * 2004-04-30 2005-11-24 Allergan, Inc. Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component
US8147865B2 (en) 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8673341B2 (en) * 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US8591885B2 (en) * 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US20050244466A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Photodynamic therapy in conjunction with intraocular implants
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20050244462A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Devices and methods for treating a mammalian eye
US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US20050244465A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Drug delivery systems and methods for treatment of an eye
US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US20050244461A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US7799336B2 (en) * 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US20070059336A1 (en) * 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
US20050244478A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Anti-excititoxic sustained release intraocular implants and related methods
US8455656B2 (en) 2004-04-30 2013-06-04 Allergan, Inc. Kinase inhibitors
US20050244471A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Estradiol derivative and estratopone containing sustained release intraocular implants and related methods
US7993634B2 (en) * 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8512738B2 (en) 2004-04-30 2013-08-20 Allergan, Inc. Biodegradable intravitreal tyrosine kinase implants
JP2008505978A (ja) * 2004-07-12 2008-02-28 アラーガン、インコーポレイテッド 眼病用組成物および眼病治療法
WO2006043965A1 (en) * 2004-10-14 2006-04-27 Allergan, Inc. Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods
WO2006073938A2 (en) * 2004-12-30 2006-07-13 East Carolina University Method for the synthesis of 3-substituted indolizine and benzoindolizine compounds
CA2644240A1 (en) * 2006-03-01 2007-09-13 Roskamp Research, Llc Compounds for inhibiting beta-amyloid production
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
EP2120557A4 (en) * 2006-12-08 2010-02-10 Roskamp Res Llc POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION
US7911053B2 (en) * 2007-04-19 2011-03-22 Marvell World Trade Ltd. Semiconductor packaging with internal wiring bus
BRPI0911659B8 (pt) * 2008-04-15 2021-05-25 Eisai R&D Man Co Ltd composto 3-fenilpirazolo[5,1-b]tiazol e composição farmacêutica compreendendo o mesmo
JPWO2011043387A1 (ja) * 2009-10-08 2013-03-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロオキサゾール化合物
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AU2014216112B2 (en) 2013-02-15 2019-02-21 Allergan, Inc. Sustained drug delivery implant
CN108084186B (zh) * 2016-11-16 2021-06-25 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
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Family Cites Families (22)

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DE1720033A1 (de) * 1966-03-02 1971-05-19 Yoshitomi Pharmaceutical Neue Indolderivate und Verfahren zu ihrer Herstellung
US3485835A (en) * 1968-04-10 1969-12-23 Haessle Ab 2-benzoyl-3-tertiaryamino alkoxy benzofuran derivatives
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US3859305A (en) * 1970-03-10 1975-01-07 Degussa Indole aminoketones
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FR2376145A1 (fr) * 1977-01-03 1978-07-28 Thea Therapeutiques Applic Sa Nouveaux derives de chromones a activite medicamenteuse et leur preparation
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US4128552A (en) * 1977-09-26 1978-12-05 Warner-Lambert Company 1-[4,4-Bis(4-fluorophenyl)butyl]-4-phenylthio-1,2,3,6-tetrahydropyridines and related sulfoxides and sulfones
JPS59204191A (ja) * 1983-03-26 1984-11-19 Kyorin Pharmaceut Co Ltd ピラゾロピリジン誘導体、その製法及びそれを含有する治療剤
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DE3426419A1 (de) * 1984-07-18 1986-01-23 Boehringer Mannheim Gmbh, 6800 Mannheim Neue oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte
US4675405A (en) * 1984-09-21 1987-06-23 American Home Products Corporation Quinoline compounds as antiallergic and antithrombotic agents
FR2584723B1 (fr) * 1985-07-09 1988-02-12 Adir Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
DE3531658A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
FR2594438B1 (fr) * 1986-02-14 1990-01-26 Labaz Sanofi Nv Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
IL87181A (en) * 1987-08-07 1993-08-18 Sanofi Sa Aminoalkoxyphenyl derivatives, their preparation and pharmaceutical and veterinary compositions containing them

Also Published As

Publication number Publication date
FI84353C (fi) 1991-11-25
DK74087D0 (da) 1987-02-13
NO165344B (no) 1990-10-22
JP2547004B2 (ja) 1996-10-23
MY101541A (en) 1991-12-17
PL264078A1 (en) 1988-07-21
CZ281209B6 (cs) 1996-07-17
FI870629A0 (fi) 1987-02-13
KR870007931A (ko) 1987-09-23
NZ219274A (en) 1989-04-26
NO870579L (no) 1987-08-17
BE1006666A4 (fr) 1994-11-16
SU1528321A3 (ru) 1989-12-07
AR245127A1 (es) 1993-12-30
SK97787A3 (en) 1998-12-02
CZ97787A3 (en) 1996-07-17
JPS62192380A (ja) 1987-08-22
ATE62485T1 (de) 1991-04-15
PL153650B1 (en) 1991-05-31
NO870579D0 (no) 1987-02-13
DK170403B1 (da) 1995-08-21
US4994474A (en) 1991-02-19
SU1486064A3 (ru) 1989-06-07
AU6884687A (en) 1987-08-20
IL81358A0 (en) 1987-08-31
FI870629A (fi) 1987-08-15
PT84277A (en) 1987-03-01
IE870345L (en) 1987-08-14
ES2040276T3 (es) 1993-10-16
FI84353B (fi) 1991-08-15
AU587525B2 (en) 1989-08-17
US5039700A (en) 1991-08-13
YU21287A (en) 1988-08-31
DD264436A5 (de) 1989-02-01
PL152609B1 (en) 1991-01-31
IL81358A (en) 1991-03-10
EP0235111B1 (fr) 1991-04-10
DE3769174D1 (de) 1991-05-16
GR3001883T3 (en) 1992-11-23
PT84277B (pt) 1989-09-14
US4957925A (en) 1990-09-18
IE59656B1 (en) 1994-03-09
SK279557B6 (sk) 1998-12-02
CA1310965C (en) 1992-12-01
US5147878A (en) 1992-09-15
HU196401B (en) 1988-11-28
MA20878A1 (fr) 1987-10-01
HUT43604A (en) 1987-11-30
TNSN87021A1 (fr) 1990-01-01
ZA87471B (en) 1988-09-28
FR2594438B1 (fr) 1990-01-26
PH24830A (en) 1990-10-30
DK74087A (da) 1987-08-15
US5017579A (en) 1991-05-21
FR2594438A1 (fr) 1987-08-21
NO165344C (no) 1991-01-30
EP0235111A1 (fr) 1987-09-02
YU46588A (en) 1989-08-31

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