DK166324C - Oprenset, rekombineret interleukin-2-sammensaetning og fremgangsmaade til udvinding af samme fra en transformeret mikroorganisme - Google Patents

Oprenset, rekombineret interleukin-2-sammensaetning og fremgangsmaade til udvinding af samme fra en transformeret mikroorganisme

Info

Publication number
DK166324C
DK166324C DK135985A DK135985A DK166324C DK 166324 C DK166324 C DK 166324C DK 135985 A DK135985 A DK 135985A DK 135985 A DK135985 A DK 135985A DK 166324 C DK166324 C DK 166324C
Authority
DK
Denmark
Prior art keywords
extraction
purified
procedure
composition
same
Prior art date
Application number
DK135985A
Other languages
Danish (da)
English (en)
Other versions
DK166324B (da
DK135985A (da
DK135985D0 (da
Inventor
Kirston Edward Koths
Michael Kunitani
James William Thomson
Kenneth Wilson
Wolfgang Helmut Hanisch
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24378044&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK166324(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of DK135985D0 publication Critical patent/DK135985D0/da
Publication of DK135985A publication Critical patent/DK135985A/da
Publication of DK166324B publication Critical patent/DK166324B/da
Application granted granted Critical
Publication of DK166324C publication Critical patent/DK166324C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/55IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK135985A 1984-03-28 1985-03-26 Oprenset, rekombineret interleukin-2-sammensaetning og fremgangsmaade til udvinding af samme fra en transformeret mikroorganisme DK166324C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/594,223 US4569790A (en) 1984-03-28 1984-03-28 Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
US59422384 1984-03-28

Publications (4)

Publication Number Publication Date
DK135985D0 DK135985D0 (da) 1985-03-26
DK135985A DK135985A (da) 1985-09-29
DK166324B DK166324B (da) 1993-04-05
DK166324C true DK166324C (da) 1993-08-23

Family

ID=24378044

Family Applications (1)

Application Number Title Priority Date Filing Date
DK135985A DK166324C (da) 1984-03-28 1985-03-26 Oprenset, rekombineret interleukin-2-sammensaetning og fremgangsmaade til udvinding af samme fra en transformeret mikroorganisme

Country Status (20)

Country Link
US (3) US4569790A (fr)
EP (2) EP0470586B1 (fr)
JP (2) JP2599903B2 (fr)
KR (1) KR850007083A (fr)
AT (1) ATE81674T1 (fr)
AU (1) AU592751B2 (fr)
CA (1) CA1341083C (fr)
DE (2) DE3588189T2 (fr)
DK (1) DK166324C (fr)
ES (1) ES8609362A1 (fr)
FI (1) FI94960C (fr)
GR (1) GR850741B (fr)
IE (1) IE59100B1 (fr)
IL (1) IL74733A (fr)
IN (1) IN162903B (fr)
NO (1) NO851235L (fr)
NZ (1) NZ211569A (fr)
PH (1) PH21012A (fr)
PT (1) PT80172B (fr)
ZA (1) ZA852347B (fr)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925919A (en) * 1984-04-25 1990-05-15 Roland Mertelsmann Purified interleukin 2
US4992271A (en) * 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
US4853332A (en) * 1982-10-19 1989-08-01 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
JPS60115528A (ja) * 1983-11-28 1985-06-22 Takeda Chem Ind Ltd ヒトインタ―ロイキン―2蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物
ZA849910B (en) * 1983-12-23 1985-09-25 Hoffmann La Roche Purification of recombinant interleukin-2
US4656132A (en) * 1984-03-28 1987-04-07 Cetus Corporation Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
EP0158487B1 (fr) * 1984-04-09 1991-08-28 Takeda Chemical Industries, Ltd. Composition stable d'interleukine-2
US4908434A (en) * 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Process for preparing purified interleukin-2
US4908433A (en) * 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Uses of interleukin-2
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
DE3500681A1 (de) * 1985-01-11 1986-07-17 Hoechst Ag, 6230 Frankfurt Verfahren zur isolierung und reinigung von lymphokinen
JPH0646957B2 (ja) * 1985-03-11 1994-06-22 武田薬品工業株式会社 インタ−ロイキン−2の製造方法
US5523215A (en) * 1985-03-28 1996-06-04 Chiron Corporation Enhanced purification and expression of insoluble recombinant proteins
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
US5248769A (en) * 1985-06-26 1993-09-28 Cetus Oncology Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
US4788144A (en) * 1985-06-28 1988-11-29 International Minerals & Chemical Corp. Fermentation process for the high level production of swine growth
US4762784A (en) * 1985-07-15 1988-08-09 International Minerals & Chemical Corp. Fermemtation process for the high level production of bovine growth hormone
US4690915A (en) * 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
CA1297003C (fr) * 1985-09-20 1992-03-10 Jack H. Nunberg Composition et methode pour traiter les animaux
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
US4933433A (en) * 1986-01-31 1990-06-12 E. I. Du Pont De Nemours And Company Recombinant interleukin-2 composition and process for making it
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
US4931544A (en) * 1986-09-04 1990-06-05 Cetus Corporation Succinylated interleukin-2 for pharmaceutical compositions
US4683293A (en) * 1986-10-20 1987-07-28 Phillips Petroleum Company Purification of pichia produced lipophilic proteins
US4894330A (en) * 1986-12-23 1990-01-16 Cetus Corporation Purification of recombinant beta-interferon incorporating RP-HPLC
US5108911A (en) * 1987-03-13 1992-04-28 Immunex Corporation Process for preparing bovine interleukin-Iβ
US4879374A (en) * 1987-03-13 1989-11-07 Immunex Corporation Bovine interleukin-1β DNA sequence
CA1339757C (fr) * 1987-04-16 1998-03-17 Robert F. Halenbeck Methode de production bacteriologique de csf-1 humain recombinant biologiquement actif pur
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
JPS6463395A (en) 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
US5162507A (en) * 1987-05-11 1992-11-10 Cetus Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
ATE156491T1 (de) * 1987-05-11 1997-08-15 Chiron Corp Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen
US4801691A (en) * 1987-05-15 1989-01-31 International Minerals & Chemical Corp. Method for removing sodium dodecyl sulfate from sodium dodecyl sulfate solubilized protein solutions
WO1989001046A1 (fr) * 1987-07-29 1989-02-09 Schering Biotech Corporation Purification d'interleukine-4 humaines exprimee dans escherichia coli
JP2669859B2 (ja) * 1987-08-04 1997-10-29 協和醗酵工業株式会社 タンパク質の再活性化法
EP0337243A1 (fr) * 1988-04-14 1989-10-18 F. Hoffmann-La Roche Ag Procédé pour purifier de l'interleukine-2 recombinante
FR2635527B1 (fr) * 1988-07-28 1992-06-12 Roussel Uclaf Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament
US4923967A (en) * 1988-09-26 1990-05-08 Eli Lilly And Company Purification and refolding of recombinant proteins
US5830452A (en) * 1990-11-20 1998-11-03 Chiron Corporation Method for enhancing the anti-tumor therapeutic index of interleukin-2
DE69031596T2 (de) * 1990-11-23 1998-02-26 Roussel Uclaf Verfahren zur herstellung eines proteins gehörend zu der klasse der cytokine, das mindestens eine intramolekulare disulfidbrücke enthält, durch oxidation bei einem ph-wert kleiner als 5.0 des entsprechenden rekombinanten reduzierten proteins
US5939524A (en) * 1991-12-09 1999-08-17 The Scripps Research Institute Platelet GPIII P1A1 and P1A2 epitopes, their preparation and use
AU648214B2 (en) * 1991-12-31 1994-04-14 Lucky Limited Recombinant gene coding for human alpha interferon and expression vector thereof, etc.
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US20030171292A1 (en) * 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
WO1994009138A1 (fr) * 1992-10-20 1994-04-28 Cetus Oncology Corporation Antagonistes du recepteur d'interleukine 6
CN1051092C (zh) * 1993-05-21 2000-04-05 沈阳军区后勤部军事医学研究所 一种重组大肠杆菌培养液中分离和纯化重组人白细胞介素2的方法
US5632983A (en) 1994-11-17 1997-05-27 University Of South Florida Method for treating secondary immunodeficiency
US5912327A (en) * 1996-09-30 1999-06-15 Human Genome Sciences, Inc. Method of purifying chemokines from inclusion bodies
US6632425B1 (en) 1997-03-20 2003-10-14 Human Genome Sciences, Inc. Chemokine compositions
EP1935431A3 (fr) 2000-05-15 2008-08-13 Health Research, Inc. Traitements anti-cancéreux utilisant une combinaison d'anticorps contre le HER2 et l'interleukine-2
JP4303969B2 (ja) 2001-03-29 2009-07-29 シェーリング コーポレイション Ccr5アンタゴニストとして有用なアリールオキシム−ピペラジン
EA200400548A1 (ru) * 2001-10-15 2005-06-30 Чирон Корпорейшн Лечение тяжёлой пневмонии путём введения ингибитора пути тканевого фактора (tfpi)
AU2002304965A1 (en) 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
CN100469769C (zh) 2003-03-24 2009-03-18 弗·哈夫曼-拉罗切有限公司 作为逆转录酶抑制剂的苄基-哒嗪酮
EP1664086B1 (fr) * 2003-09-09 2009-10-28 Novartis Vaccines and Diagnostics, Inc. Separation chromatographique de polypeptides therapeutiques
CN1910293B (zh) 2003-10-23 2011-04-13 伊洛默格生物科学公司 检测与抗病毒感染性有关的基因oas1中的突变的方法
ATE447412T1 (de) 2003-11-04 2009-11-15 Novartis Vaccines & Diagnostic Antagonist-anti-cd40-monoklonale antikörper und anwendungsverfahren
EP1729791A2 (fr) * 2004-03-17 2006-12-13 Chiron Corporation Traitement de la pneumonie extra-hospitalière grave par administration de l'inhibiteur de parcours de facteur tissu (tfpi)
CU23297A1 (es) * 2004-11-16 2008-07-24 Ct De Inmunologa A Molecular Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer
DE102005005542A1 (de) * 2005-02-07 2006-08-10 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Herstellung von Aldesleukin für die pharmazeutische Verwendung
CN101291905A (zh) 2005-10-19 2008-10-22 弗·哈夫曼-拉罗切有限公司 苯乙酰胺nnrt抑制剂
RU2304586C1 (ru) * 2006-03-27 2007-08-20 Михаил Николаевич Смирнов Препарат интерлейкина-2 и способ его получения
RU2451676C2 (ru) 2006-08-16 2012-05-27 Ф.Хоффманн-Ля Рош Аг Ненуклеозидные ингибиторы обратной транскриптазы
MX2009005881A (es) 2006-12-13 2009-06-12 Hoffmann La Roche Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida.
JP5167350B2 (ja) 2007-05-30 2013-03-21 エフ.ホフマン−ラ ロシュ アーゲー 非ヌクレオシド系逆転写酵素阻害剤
WO2009080534A1 (fr) 2007-12-21 2009-07-02 F. Hoffmann-La Roche Ag Composés hétérocycliques antiviraux
MX2011001343A (es) * 2008-08-04 2011-05-25 Kai Bioenergy Cultivacion continua, recoleccion y estraccion de aciete de cultivos fotosinteticos.
WO2012065086A1 (fr) 2010-11-12 2012-05-18 Nektar Therapeutics Conjugués d'une fraction il-2 et d'un polymère
CA2860170C (fr) 2010-12-22 2022-06-14 The Board Of Trustees Of The Leland Stanford Junior University Super-agonistes et antagonistes de l'interleukine-2
CN104507953B (zh) * 2012-05-31 2018-05-18 新加坡科技研究局 通过用正电性有机添加剂处理来降低蛋白质制剂中蛋白质-污染物复合物和聚集物水平的方法
CN105722860A (zh) 2013-09-24 2016-06-29 梅迪塞纳医疗股份有限公司 白介素-2融合蛋白及其应用
WO2015164815A1 (fr) 2014-04-24 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Superagonistes, agonistes et antagonistes partiels de l'interleukine-2
WO2016057651A1 (fr) 2014-10-09 2016-04-14 Dana-Farber Cancer Institute, Inc. Schéma posologique d'il-2 variables multiples pour le traitement de troubles immunitaires
WO2017062832A1 (fr) 2015-10-08 2017-04-13 Nektar Therapeutics Combinaison d'un agoniste sélectif de l'il-2rbeta et d'un agoniste de l'il-15 à action prolongée
CN111201035A (zh) 2017-06-19 2020-05-26 梅迪塞纳医疗股份有限公司 Il-2超激动剂、激动剂及其融合体的用途和方法
JP7325341B2 (ja) 2017-07-11 2023-08-14 シンソークス,インク. 非天然ヌクレオチドの組み込み及びその方法
KR20240141853A (ko) 2017-08-03 2024-09-27 신톡스, 인크. 자가면역 질환의 치료를 위한 사이토카인 접합체
KR102777151B1 (ko) 2017-11-21 2025-03-05 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 인터루킨-2의 부분 효능제
BR112020021564A2 (pt) 2018-05-21 2021-03-02 Nektar Therapeutics estimulador de treg seletivo rur20kd-il-2 e composições relacionadas
WO2019241534A1 (fr) * 2018-06-13 2019-12-19 Akron Biotechnology, LLC. Procédé pour préparer une aldesleukine thérapeutiquement active hautement stable dans des compositions pharmaceutiques liquides
EP3923974A4 (fr) 2019-02-06 2023-02-08 Synthorx, Inc. Conjugués d'il-2 et méthodes d'utilisation de ceux-ci
EP3986917A1 (fr) 2019-06-20 2022-04-27 CSPC Megalith Biopharmaceutical Co., Ltd. Protéines d'il-2 modifiées, conjugués peg et utilisations associées
WO2021146436A2 (fr) 2020-01-14 2021-07-22 Synthekine, Inc. Méthodes et compositions de mutéines d'il2 biaisées
CN111793124A (zh) * 2020-06-24 2020-10-20 宁波博睿瀚达生物科技有限公司 一种去除重组白介素-2内毒素的方法
CN111676261A (zh) * 2020-06-24 2020-09-18 宁波博睿瀚达生物科技有限公司 一种高纯度重组白介素-2的制备工艺
EP4447995A1 (fr) 2021-12-14 2024-10-23 Nektar Therapeutics Schémas posologiques pour stimulateur treg sélectif, rur20kd-il-2, et compositions associées

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3897309A (en) * 1974-02-15 1975-07-29 Merck & Co Inc Process for removing pyrogenic material from aqueous solutions
JPS6030291B2 (ja) * 1978-03-20 1985-07-16 森永乳業株式会社 人顆粒球の分化増殖を促進するhgi糖蛋白質、hgi糖蛋白質の製造法及びhgi糖蛋白質を含有する白血球減少症治療剤
IN150740B (fr) * 1978-11-24 1982-12-04 Hoffmann La Roche
JPS55148098A (en) * 1979-05-10 1980-11-18 Toray Ind Inc Concentration and purification of interferon
CH648331A5 (de) * 1979-07-31 1985-03-15 Hoffmann La Roche Homogenes fibroblasten-interferon und dessen herstellung.
US4390623A (en) * 1980-10-02 1983-06-28 Hooper Trading Company Serum-free and mitogen-free T-cell growth factor and process for making same
US4315852A (en) * 1980-11-26 1982-02-16 Schering Corporation Extraction of interferon from bacteria
US4464355A (en) * 1981-03-26 1984-08-07 Hooper Trading Co. Serum-free and mitogen-free T-cell growth factor and process for making same
US4448879A (en) * 1981-03-26 1984-05-15 Hooper Trading Company High yield process for in vitro production of serum-free and mitogen-free interleukin-2
US4401756A (en) * 1981-04-14 1983-08-30 Immunex Corporation Process for preparing human interleukin 2
JPS58116498A (ja) * 1981-12-28 1983-07-11 Takeda Chem Ind Ltd Il‐2をコードする新規伝令rnaの製造法
US4450103A (en) * 1982-03-01 1984-05-22 Cetus Corporation Process for recovering human IFN-β from a transformed microorganism
DE3377363D1 (en) * 1982-03-31 1988-08-18 Ajinomoto Kk Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells
CA1341562C (fr) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene codant pour un polypeptide ayant une activite interleukine 2, adn recombinant portant ledit gene, lignees cellulaires possedant ledit adn recombinant et procede pour la preparation d'interleukine 2 en utilisant lesdites cellules
US4925919A (en) * 1984-04-25 1990-05-15 Roland Mertelsmann Purified interleukin 2
US4778879A (en) * 1982-04-20 1988-10-18 Sloan-Kettering Institute For Cancer Research Highly purified human interleukin 2 and method
ATE37564T1 (de) * 1982-04-20 1988-10-15 Sloan Kettering Inst Cancer Reinigung von interleukin-2.
JPS58198293A (ja) * 1982-05-12 1983-11-18 Shionogi & Co Ltd インタ−ロイキン等免疫調節因子の製造方法
US4490289A (en) * 1982-09-16 1984-12-25 Hoffmann-La Roche Inc. Homogeneous human interleukin 2
US4462940A (en) * 1982-09-23 1984-07-31 Cetus Corporation Process for the recovery of human β-interferon-like polypeptides
US4992271A (en) * 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
DE3242851A1 (de) * 1982-11-19 1984-05-24 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verfahren zur reinigung von menschlichen lymphokinen
EP0111344A2 (fr) * 1982-12-13 1984-06-20 Sloan-Kettering Institute For Cancer Research Anticorps monoclonaux anti-interleukine-2
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides
ZA842025B (en) * 1983-03-21 1984-11-28 Hoffmann La Roche Interleuken-2
GB8308483D0 (en) * 1983-03-28 1983-05-05 Health Lab Service Board Secretion of gene products
US4582799A (en) * 1983-04-15 1986-04-15 Damon Biotech, Inc. Process for recovering nonsecreted substances produced by cells
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
NZ208309A (en) * 1983-06-01 1988-04-29 Hoffmann La Roche Recombinant leukocyte, fibroblast, or immune interferons (rifn-#a#, b or #g#) with one cys residue replaced
WO1985000606A1 (fr) * 1983-07-19 1985-02-14 Takeda Chemical Industries, Ltd. Il-2 humaine et son procede de preparation
US4464295A (en) * 1983-08-17 1984-08-07 The United States Of America As Represented By The Secretary Of Agriculture Simple and rapid method for extraction of proteins from bacteria
US4476049A (en) * 1983-09-20 1984-10-09 Hoffmann-La Roche Inc. Method for the extraction of immune interferon
GB8327880D0 (en) * 1983-10-18 1983-11-16 Ajinomoto Kk Saccharomyces cerevisiae
US4675383A (en) * 1983-11-15 1987-06-23 The Salk Institute For Biological Studies Purification of T-cell growth factor
JPS60115528A (ja) * 1983-11-28 1985-06-22 Takeda Chem Ind Ltd ヒトインタ―ロイキン―2蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物
ZA849910B (en) * 1983-12-23 1985-09-25 Hoffmann La Roche Purification of recombinant interleukin-2
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
JPS61500790A (ja) * 1984-03-28 1986-04-24 シタス コ−ポレイシヨン 微生物的に製造されたインターロイキン―2を含有する組成物
EP0158198A1 (fr) * 1984-03-29 1985-10-16 Takeda Chemical Industries, Ltd. ADN et son utilisation
EP0158487B1 (fr) * 1984-04-09 1991-08-28 Takeda Chemical Industries, Ltd. Composition stable d'interleukine-2
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
US4782139A (en) * 1985-10-28 1988-11-01 Eli Lilly And Company Selective chemical removal of a protein amino-terminal residue
US4787658A (en) * 1986-07-29 1988-11-29 Harris Jr John Unibody bumper system
US5156968A (en) * 1988-06-24 1992-10-20 Genentech, Inc. Purified yeast ubiquitin hydrolase

Also Published As

Publication number Publication date
ZA852347B (en) 1986-11-26
IN162903B (fr) 1988-07-23
KR850007083A (ko) 1985-10-30
DK166324B (da) 1993-04-05
PT80172A (en) 1985-04-01
JP2648587B2 (ja) 1997-09-03
IE850799L (en) 1985-09-28
DK135985A (da) 1985-09-29
US4569790A (en) 1986-02-11
FI94960B (fi) 1995-08-15
PT80172B (pt) 1987-06-17
IL74733A0 (en) 1985-06-30
GR850741B (fr) 1985-06-26
DE3588189D1 (de) 1998-08-20
PH21012A (en) 1987-06-23
US5614185A (en) 1997-03-25
ES541608A0 (es) 1986-09-01
EP0156373B1 (fr) 1992-10-21
FI851231L (fi) 1985-09-29
AU592751B2 (en) 1990-01-25
ES8609362A1 (es) 1986-09-01
FI851231A0 (fi) 1985-03-27
ATE81674T1 (de) 1992-11-15
NZ211569A (en) 1988-05-30
DK135985D0 (da) 1985-03-26
CA1341083C (fr) 2000-08-15
JPS611393A (ja) 1986-01-07
IL74733A (en) 1990-11-05
IE59100B1 (en) 1994-01-12
EP0470586A1 (fr) 1992-02-12
JP2599903B2 (ja) 1997-04-16
DE3588189T2 (de) 1998-11-19
DE3586762D1 (de) 1992-11-26
DE3586762T2 (de) 1993-02-25
EP0470586B1 (fr) 1998-07-15
JPH08332089A (ja) 1996-12-17
HK1004474A1 (en) 1998-11-27
EP0156373A3 (en) 1987-09-02
NO851235L (no) 1985-09-30
US5419899A (en) 1995-05-30
EP0156373A2 (fr) 1985-10-02
FI94960C (fi) 1995-11-27
AU4046785A (en) 1985-10-03

Similar Documents

Publication Publication Date Title
DK166324C (da) Oprenset, rekombineret interleukin-2-sammensaetning og fremgangsmaade til udvinding af samme fra en transformeret mikroorganisme
DK426386D0 (da) Fremgangsmaade til rensning og aktivering af proteiner fra uoploeselige inklusionslegemer
DK394786D0 (da) Fremgangsmaade til rensning og aktivering af proteiner fra uoploeselige inklusionslegemer
AU580276B2 (en) Purification of recombinant interleukin-2
ES2061434T3 (es) Procedimiento para la activacion de proteinas eucarioticas heterologas que contienen puentes de disulfuro, preparadas mediante tecnologia genetica, despues de su expresion en procariotas.
DE3855899D1 (de) Prozess zur gewinnung von mikrobiell produziertem interleukin-2
DK10189D0 (da) Fremgangsmaade til indvinding af renset, oxideret, renatureret interleukin-2 fra mikroorganismer
BR9810650A (pt) Vetor para expressão de proteìna heteróloga e métodos para extrair proteìna recombinante e para purificar insulina recombinante isolada
AU5894886A (en) High performance liquid chromatography mobile phase
ZA845434B (en) Complexable heterogeneous oligosaccharides and alpha-hydosanes having therapeutical activity,process for their preparation and related pharmaceutical compositions
Koths et al. Purified, reduced recombinant interleukin-2 compositions
KR920002771A (ko) 돼지콜레라 바이러스의 외피 당단백질을 추출정제하는 방법

Legal Events

Date Code Title Description
PBP Patent lapsed
PUP Patent expired