DK166324C - Oprenset, rekombineret interleukin-2-sammensaetning og fremgangsmaade til udvinding af samme fra en transformeret mikroorganisme - Google Patents
Oprenset, rekombineret interleukin-2-sammensaetning og fremgangsmaade til udvinding af samme fra en transformeret mikroorganismeInfo
- Publication number
- DK166324C DK166324C DK135985A DK135985A DK166324C DK 166324 C DK166324 C DK 166324C DK 135985 A DK135985 A DK 135985A DK 135985 A DK135985 A DK 135985A DK 166324 C DK166324 C DK 166324C
- Authority
- DK
- Denmark
- Prior art keywords
- extraction
- purified
- procedure
- composition
- same
- Prior art date
Links
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 6
- 238000000605 extraction Methods 0.000 title abstract 3
- 244000005700 microbiome Species 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 102000000588 Interleukin-2 Human genes 0.000 title 1
- MSXVEPNJUHWQHW-UHFFFAOYSA-N 2-methylbutan-2-ol Chemical compound CCC(C)(C)O MSXVEPNJUHWQHW-UHFFFAOYSA-N 0.000 abstract 3
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 abstract 3
- 230000001413 cellular effect Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 230000003196 chaotropic effect Effects 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000001641 gel filtration chromatography Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000004007 reversed phase HPLC Methods 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59422384 | 1984-03-28 | ||
| US06/594,223 US4569790A (en) | 1984-03-28 | 1984-03-28 | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK135985D0 DK135985D0 (da) | 1985-03-26 |
| DK135985A DK135985A (da) | 1985-09-29 |
| DK166324B DK166324B (da) | 1993-04-05 |
| DK166324C true DK166324C (da) | 1993-08-23 |
Family
ID=24378044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK135985A DK166324C (da) | 1984-03-28 | 1985-03-26 | Oprenset, rekombineret interleukin-2-sammensaetning og fremgangsmaade til udvinding af samme fra en transformeret mikroorganisme |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US4569790A (da) |
| EP (2) | EP0156373B1 (da) |
| JP (2) | JP2599903B2 (da) |
| KR (1) | KR850007083A (da) |
| AT (1) | ATE81674T1 (da) |
| AU (1) | AU592751B2 (da) |
| CA (1) | CA1341083C (da) |
| DE (2) | DE3588189T2 (da) |
| DK (1) | DK166324C (da) |
| ES (1) | ES8609362A1 (da) |
| FI (1) | FI94960C (da) |
| GR (1) | GR850741B (da) |
| IE (1) | IE59100B1 (da) |
| IL (1) | IL74733A (da) |
| IN (1) | IN162903B (da) |
| NO (1) | NO851235L (da) |
| NZ (1) | NZ211569A (da) |
| PH (1) | PH21012A (da) |
| PT (1) | PT80172B (da) |
| ZA (1) | ZA852347B (da) |
Families Citing this family (90)
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|---|---|---|---|---|
| US4925919A (en) * | 1984-04-25 | 1990-05-15 | Roland Mertelsmann | Purified interleukin 2 |
| US4992271A (en) * | 1982-09-23 | 1991-02-12 | Cetus Corporation | Formulation for lipophilic IL-2 proteins |
| US4853332A (en) * | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
| JPS60115528A (ja) * | 1983-11-28 | 1985-06-22 | Takeda Chem Ind Ltd | ヒトインタ―ロイキン―2蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物 |
| CA1340853C (en) * | 1983-12-23 | 1999-12-21 | Hsiang-Fu Kung | Purification of recombinant interleukin-2 |
| US4656132A (en) * | 1984-03-28 | 1987-04-07 | Cetus Corporation | Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria |
| US4569790A (en) * | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
| US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
| EP0158487B1 (en) * | 1984-04-09 | 1991-08-28 | Takeda Chemical Industries, Ltd. | Stable composition of interleukin-2 |
| US4908434A (en) * | 1984-04-25 | 1990-03-13 | Sloan-Kettering Institute For Cancer Research | Process for preparing purified interleukin-2 |
| US4908433A (en) * | 1984-04-25 | 1990-03-13 | Sloan-Kettering Institute For Cancer Research | Uses of interleukin-2 |
| US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
| DE3500681A1 (de) * | 1985-01-11 | 1986-07-17 | Hoechst Ag, 6230 Frankfurt | Verfahren zur isolierung und reinigung von lymphokinen |
| JPH0646957B2 (ja) * | 1985-03-11 | 1994-06-22 | 武田薬品工業株式会社 | インタ−ロイキン−2の製造方法 |
| US5523215A (en) * | 1985-03-28 | 1996-06-04 | Chiron Corporation | Enhanced purification and expression of insoluble recombinant proteins |
| US5248769A (en) * | 1985-06-26 | 1993-09-28 | Cetus Oncology Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
| US4748234A (en) * | 1985-06-26 | 1988-05-31 | Cetus Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
| US4788144A (en) * | 1985-06-28 | 1988-11-29 | International Minerals & Chemical Corp. | Fermentation process for the high level production of swine growth |
| US4762784A (en) * | 1985-07-15 | 1988-08-09 | International Minerals & Chemical Corp. | Fermemtation process for the high level production of bovine growth hormone |
| US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| CA1297003C (en) * | 1985-09-20 | 1992-03-10 | Jack H. Nunberg | Composition and method for treating animals |
| US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
| US4933433A (en) * | 1986-01-31 | 1990-06-12 | E. I. Du Pont De Nemours And Company | Recombinant interleukin-2 composition and process for making it |
| US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| US4931544A (en) * | 1986-09-04 | 1990-06-05 | Cetus Corporation | Succinylated interleukin-2 for pharmaceutical compositions |
| US4683293A (en) * | 1986-10-20 | 1987-07-28 | Phillips Petroleum Company | Purification of pichia produced lipophilic proteins |
| US4894330A (en) * | 1986-12-23 | 1990-01-16 | Cetus Corporation | Purification of recombinant beta-interferon incorporating RP-HPLC |
| US4879374A (en) * | 1987-03-13 | 1989-11-07 | Immunex Corporation | Bovine interleukin-1β DNA sequence |
| US5108911A (en) * | 1987-03-13 | 1992-04-28 | Immunex Corporation | Process for preparing bovine interleukin-Iβ |
| CA1339757C (en) | 1987-04-16 | 1998-03-17 | Robert F. Halenbeck | Production of purified biologically active, bacterially produced recombinant human csf-1 |
| US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
| JPS6463395A (en) | 1987-05-04 | 1989-03-09 | Oncogen | Oncostatin m and novel composition having antitumor activity |
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| AU622860B2 (en) * | 1987-05-11 | 1992-04-30 | Novartis Vaccines And Diagnostics, Inc. | Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms |
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| US4801691A (en) * | 1987-05-15 | 1989-01-31 | International Minerals & Chemical Corp. | Method for removing sodium dodecyl sulfate from sodium dodecyl sulfate solubilized protein solutions |
| EP0301835A1 (en) * | 1987-07-29 | 1989-02-01 | Schering Biotech Corporation | Purification of human interleukin-4 expressed in Escherichia Coli |
| JP2669859B2 (ja) * | 1987-08-04 | 1997-10-29 | 協和醗酵工業株式会社 | タンパク質の再活性化法 |
| EP0337243A1 (en) * | 1988-04-14 | 1989-10-18 | F. Hoffmann-La Roche Ag | Process for purifying recombinant human interleukin-2 |
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| JP6941561B2 (ja) | 2014-10-09 | 2021-09-29 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 免疫障害を処置するための複数の可変il−2用量レジメン |
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| JP7235772B2 (ja) | 2018-05-21 | 2023-03-08 | ネクター セラピューティクス | 選択的Treg刺激因子RUR20kD-IL-2及び関連組成物 |
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-
1984
- 1984-03-28 US US06/594,223 patent/US4569790A/en not_active Expired - Lifetime
-
1985
- 1985-02-26 CA CA000475151A patent/CA1341083C/en not_active Expired - Lifetime
- 1985-03-25 PH PH32035A patent/PH21012A/en unknown
- 1985-03-25 IN IN220/CAL/85A patent/IN162903B/en unknown
- 1985-03-26 DK DK135985A patent/DK166324C/da not_active IP Right Cessation
- 1985-03-26 NZ NZ211569A patent/NZ211569A/en unknown
- 1985-03-26 GR GR850741A patent/GR850741B/el unknown
- 1985-03-27 PT PT80172A patent/PT80172B/pt unknown
- 1985-03-27 AT AT85103649T patent/ATE81674T1/de not_active IP Right Cessation
- 1985-03-27 EP EP85103649A patent/EP0156373B1/en not_active Expired - Lifetime
- 1985-03-27 FI FI851231A patent/FI94960C/fi not_active IP Right Cessation
- 1985-03-27 EP EP91113235A patent/EP0470586B1/en not_active Expired - Lifetime
- 1985-03-27 DE DE3588189T patent/DE3588189T2/de not_active Expired - Lifetime
- 1985-03-27 IL IL74733A patent/IL74733A/xx not_active IP Right Cessation
- 1985-03-27 DE DE8585103649T patent/DE3586762T2/de not_active Expired - Lifetime
- 1985-03-27 ES ES541608A patent/ES8609362A1/es not_active Expired
- 1985-03-27 NO NO851235A patent/NO851235L/no unknown
- 1985-03-28 IE IE79985A patent/IE59100B1/en not_active IP Right Cessation
- 1985-03-28 KR KR1019850002078A patent/KR850007083A/ko not_active Ceased
- 1985-03-28 JP JP60062195A patent/JP2599903B2/ja not_active Expired - Lifetime
- 1985-03-28 ZA ZA852347A patent/ZA852347B/xx unknown
- 1985-03-28 AU AU40467/85A patent/AU592751B2/en not_active Expired
-
1992
- 1992-05-06 US US07/879,753 patent/US5419899A/en not_active Expired - Lifetime
-
1995
- 1995-04-25 US US08/428,895 patent/US5614185A/en not_active Expired - Lifetime
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1996
- 1996-05-15 JP JP8143485A patent/JP2648587B2/ja not_active Expired - Lifetime
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| PUP | Patent expired |