FI94960C - Menetelmä ihmisen interleukiini-2:n talteensaamiseksi - Google Patents

Menetelmä ihmisen interleukiini-2:n talteensaamiseksi

Info

Publication number
FI94960C
FI94960C FI851231A FI851231A FI94960C FI 94960 C FI94960 C FI 94960C FI 851231 A FI851231 A FI 851231A FI 851231 A FI851231 A FI 851231A FI 94960 C FI94960 C FI 94960C
Authority
FI
Finland
Prior art keywords
method
human interleukin
recovering human
recovering
interleukin
Prior art date
Application number
FI851231A
Other languages
English (en)
Swedish (sv)
Other versions
FI851231A0 (fi
FI94960B (fi
FI851231L (fi
Inventor
Kriston Edward Koths
James William Thomson
Michael Kunitani
Kenneth Wilson
Wolfgang Helmut Hanisch
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US06/594,223 priority Critical patent/US4569790A/en
Priority to US59422384 priority
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Publication of FI851231A0 publication Critical patent/FI851231A0/fi
Publication of FI851231L publication Critical patent/FI851231L/fi
Application granted granted Critical
Publication of FI94960B publication Critical patent/FI94960B/fi
Publication of FI94960C publication Critical patent/FI94960C/fi
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24378044&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI94960(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/55IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
FI851231A 1984-03-28 1985-03-27 Menetelmä ihmisen interleukiini-2:n talteensaamiseksi FI94960C (fi)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US06/594,223 US4569790A (en) 1984-03-28 1984-03-28 Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
US59422384 1984-03-28

Publications (4)

Publication Number Publication Date
FI851231A0 FI851231A0 (fi) 1985-03-27
FI851231L FI851231L (fi) 1985-09-29
FI94960B FI94960B (fi) 1995-08-15
FI94960C true FI94960C (fi) 1995-11-27

Family

ID=24378044

Family Applications (1)

Application Number Title Priority Date Filing Date
FI851231A FI94960C (fi) 1984-03-28 1985-03-27 Menetelmä ihmisen interleukiini-2:n talteensaamiseksi

Country Status (21)

Country Link
US (3) US4569790A (fi)
EP (2) EP0156373B1 (fi)
JP (2) JP2599903B2 (fi)
KR (1) KR850007083A (fi)
AT (1) AT81674T (fi)
AU (1) AU592751B2 (fi)
CA (1) CA1341083C (fi)
DE (4) DE3586762D1 (fi)
DK (1) DK166324C (fi)
ES (1) ES8609362A1 (fi)
FI (1) FI94960C (fi)
GR (1) GR850741B (fi)
HK (1) HK1004474A1 (fi)
IE (1) IE59100B1 (fi)
IL (1) IL74733A (fi)
IN (1) IN162903B (fi)
NO (1) NO851235L (fi)
NZ (1) NZ211569A (fi)
PH (1) PH21012A (fi)
PT (1) PT80172B (fi)
ZA (1) ZA8502347B (fi)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908434A (en) * 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Process for preparing purified interleukin-2
US4925919A (en) * 1984-04-25 1990-05-15 Roland Mertelsmann Purified interleukin 2
US4908433A (en) * 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Uses of interleukin-2
US4992271A (en) * 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
US4853332A (en) * 1982-10-19 1989-08-01 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
JPH0542413B2 (fi) * 1983-11-28 1993-06-28 Takeda Chemical Industries Ltd
CA1340853C (en) * 1983-12-23 1999-12-21 Hsiang-Fu Kung Purification of recombinant interleukin-2
US4530787B1 (fi) * 1984-03-28 1993-07-20 Cetus Corp
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
US4656132A (en) * 1984-03-28 1987-04-07 Cetus Corporation Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
DE3583880D1 (de) * 1984-04-09 1991-10-02 Takeda Chemical Industries Ltd Stabile interleukin-2-zusammensetzung.
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
DE3500681A1 (de) * 1985-01-11 1986-07-17 Hoechst Ag Verfahren zur isolierung und reinigung von lymphokinen
JPH0646957B2 (ja) * 1985-03-11 1994-06-22 武田薬品工業株式会社 インタ−ロイキン−2の製造方法
US5523215A (en) * 1985-03-28 1996-06-04 Chiron Corporation Enhanced purification and expression of insoluble recombinant proteins
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
US5248769A (en) * 1985-06-26 1993-09-28 Cetus Oncology Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
US4788144A (en) * 1985-06-28 1988-11-29 International Minerals & Chemical Corp. Fermentation process for the high level production of swine growth
US4762784A (en) * 1985-07-15 1988-08-09 International Minerals & Chemical Corp. Fermemtation process for the high level production of bovine growth hormone
US4690915A (en) * 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
CA1297003C (en) * 1985-09-20 1992-03-10 Jack H. Nunberg Composition and method for treating animals
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
US4933433A (en) * 1986-01-31 1990-06-12 E. I. Du Pont De Nemours And Company Recombinant interleukin-2 composition and process for making it
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
US4931544A (en) * 1986-09-04 1990-06-05 Cetus Corporation Succinylated interleukin-2 for pharmaceutical compositions
US4683293A (en) * 1986-10-20 1987-07-28 Phillips Petroleum Company Purification of pichia produced lipophilic proteins
JPS6463395A (en) 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
US4894330A (en) * 1986-12-23 1990-01-16 Cetus Corporation Purification of recombinant beta-interferon incorporating RP-HPLC
US4879374A (en) * 1987-03-13 1989-11-07 Immunex Corporation Bovine interleukin-1β DNA sequence
US5108911A (en) * 1987-03-13 1992-04-28 Immunex Corporation Process for preparing bovine interleukin-Iβ
CA1339757C (en) * 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
EP0368857B1 (en) * 1987-05-11 1997-08-06 Chiron Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
US5162507A (en) * 1987-05-11 1992-11-10 Cetus Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
US4801691A (en) * 1987-05-15 1989-01-31 International Minerals & Chemical Corp. Method for removing sodium dodecyl sulfate from sodium dodecyl sulfate solubilized protein solutions
WO1989001046A1 (en) * 1987-07-29 1989-02-09 Schering Biotech Corporation Purification of human interleukin-4 expressed in escherichia coli
JP2669859B2 (ja) * 1987-08-04 1997-10-29 協和醗酵工業株式会社 タンパク質の再活性化法
EP0337243A1 (en) * 1988-04-14 1989-10-18 F. Hoffmann-La Roche Ag Process for purifying recombinant human interleukin-2
FR2635527B1 (fr) * 1988-07-28 1992-06-12 Roussel Uclaf Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament
US4923967A (en) * 1988-09-26 1990-05-08 Eli Lilly And Company Purification and refolding of recombinant proteins
US5830452A (en) * 1990-11-20 1998-11-03 Chiron Corporation Method for enhancing the anti-tumor therapeutic index of interleukin-2
DE69031596T2 (de) * 1990-11-23 1998-02-26 Roussel Uclaf Verfahren zur herstellung eines proteins gehörend zu der klasse der cytokine, das mindestens eine intramolekulare disulfidbrücke enthält, durch oxidation bei einem ph-wert kleiner als 5.0 des entsprechenden rekombinanten reduzierten proteins
US5939524A (en) * 1991-12-09 1999-08-17 The Scripps Research Institute Platelet GPIII P1A1 and P1A2 epitopes, their preparation and use
AU648214B2 (en) * 1991-12-31 1994-04-14 Lucky Limited Recombinant gene coding for human alpha interferon and expression vector thereof, etc.
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US20030171292A1 (en) * 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
EP0672144A1 (en) * 1992-10-20 1995-09-20 Central Laboratory Of The Netherlands Red Cross Blood Transfusion Service Interleukin-6 receptor antagonists
CN1051092C (zh) * 1993-05-21 2000-04-05 沈阳军区后勤部军事医学研究所 一种重组大肠杆菌培养液中分离和纯化重组人白细胞介素2的方法
US5912327A (en) * 1996-09-30 1999-06-15 Human Genome Sciences, Inc. Method of purifying chemokines from inclusion bodies
US5632983A (en) 1994-11-17 1997-05-27 University Of South Florida Method for treating secondary immunodeficiency
US6632425B1 (en) 1997-03-20 2003-10-14 Human Genome Sciences, Inc. Chemokine compositions
EP1935431A3 (en) 2000-05-15 2008-08-13 Health Research, Inc. Cancer treatments by using a combination of an antibody against her2 and interleukin-2
DE60230491D1 (de) 2001-03-29 2009-02-05 Schering Corp Als ccr5-antagonisten verwendbare aryloxim-piperazine
MXPA04003547A (es) * 2001-10-15 2004-07-22 Chiron Corp Tratamiento de sepsis mediante administracion de dosis bajas de inhibidor de via factor de tejido.
AU2002304965A1 (en) 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
EP1608629A1 (en) 2003-03-24 2005-12-28 F. Hoffmann-La Roche Ag Benzyl-pyridazinons as reverse transcriptase inhibitors
ES2335017T3 (es) * 2003-09-09 2010-03-18 Novartis Vaccines And Diagnostics, Inc. Separacion cromatografica de polipeptidos terapeuticos.
AU2004283294B2 (en) 2003-10-23 2011-03-17 Kineta Two, Llc Detection of mutations in a gene associated with resistance to viral infection, OAS1
PT1682178E (pt) 2003-11-04 2010-10-21 Novartis Vaccines & Diagnostic Métodos de terapêutica para cancros que expressam o antigénio cd40
SG150552A1 (en) * 2004-03-17 2009-03-30 Chiron Corp Treatment of severe community-acquired pneumonia by administration of tissue factor pathway inhibitor (tfpi)
CU23297A1 (es) 2004-11-16 2008-07-24 Ct De Inmunologa A Molecular Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer
DE102005005542A1 (de) * 2005-02-07 2006-08-10 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Herstellung von Aldesleukin für die pharmazeutische Verwendung
EP1940781A1 (en) 2005-10-19 2008-07-09 F.Hoffmann-La Roche Ag Phenyl-acetamide nnrt inhibitors
RU2304586C1 (ru) * 2006-03-27 2007-08-20 Михаил Николаевич Смирнов Препарат интерлейкина-2 и способ его получения
CA2658984C (en) 2006-08-16 2014-12-02 Joshua Kennedy-Smith Non-nucleoside reverse transcriptase inhibitors
MX2009005881A (es) 2006-12-13 2009-06-12 Hoffmann La Roche Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida.
EP2155692B1 (en) 2007-05-30 2015-06-17 F. Hoffmann-La Roche AG Non-nucleoside reverse transcriptase inhibitors
BRPI0821349A2 (pt) 2007-12-21 2019-09-24 Hoffmann La Roche compostos antivirais heterocíclicos
JP2011529707A (ja) * 2008-08-04 2011-12-15 カイ バイオエナジー 光合成培養物の連続的培養、採取、および油抽出
EP2637694A4 (en) 2010-11-12 2016-10-19 Nektar Therapeutics Conjugates of an il-2 moiety and a polymer
EP2655409A4 (en) 2010-12-22 2015-07-01 Univ Leland Stanford Junior Superagonists and antagonists of interleukin-2
CN104507953B (zh) * 2012-05-31 2018-05-18 新加坡科技研究局 通过用正电性有机添加剂处理来降低蛋白质制剂中蛋白质-污染物复合物和聚集物水平的方法
JP6592505B2 (ja) 2014-04-24 2019-10-16 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー インターロイキン−2のスーパーアンタゴニスト、パーシャルアゴニスト及びアンタゴニスト
AU2018309172A1 (en) 2017-08-03 2020-02-27 Synthorx, Inc. Cytokine conjugates for the treatment of autoimmune diseases
WO2019226538A1 (en) 2018-05-21 2019-11-28 Nektar Therapeutics SELECTIVE TREG STIMULATOR RUR20kD-IL-2 AND RELATED COMPOSITIONS
WO2019241534A1 (en) * 2018-06-13 2019-12-19 Akron Biotechnology, LLC. Method to prepare therapeutically active aldesleukin highly stable in liquid pharmaceutical compositions

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3897309A (en) * 1974-02-15 1975-07-29 Merck & Co Inc Process for removing pyrogenic material from aqueous solutions
JPS6030291B2 (fi) * 1978-03-20 1985-07-16 Morinaga Nyugyo Kk
IN150740B (fi) * 1978-11-24 1982-12-04 Hoffmann La Roche
JPS55148098A (en) * 1979-05-10 1980-11-18 Toray Ind Inc Concentration and purification of interferon
ZA8003943B (en) * 1979-07-31 1981-06-24 Hoffmann La Roche Homogeneous fibroblast interferon and method for manufacture thereof
US4390623A (en) * 1980-10-02 1983-06-28 Hooper Trading Company Serum-free and mitogen-free T-cell growth factor and process for making same
US4464355A (en) * 1981-03-26 1984-08-07 Hooper Trading Co. Serum-free and mitogen-free T-cell growth factor and process for making same
US4448879A (en) * 1981-03-26 1984-05-15 Hooper Trading Company High yield process for in vitro production of serum-free and mitogen-free interleukin-2
US4315852A (en) * 1980-11-26 1982-02-16 Schering Corporation Extraction of interferon from bacteria
US4401756A (en) * 1981-04-14 1983-08-30 Immunex Corporation Process for preparing human interleukin 2
JPS6326993B2 (fi) * 1981-12-28 1988-06-01 Takeda Chemical Industries Ltd
US4450103A (en) * 1982-03-01 1984-05-22 Cetus Corporation Process for recovering human IFN-β from a transformed microorganism
CA1341562C (en) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
EP0091539B2 (en) * 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells
US4925919A (en) * 1984-04-25 1990-05-15 Roland Mertelsmann Purified interleukin 2
US4778879A (en) * 1982-04-20 1988-10-18 Sloan-Kettering Institute For Cancer Research Highly purified human interleukin 2 and method
DE3378128D1 (en) * 1982-04-20 1988-11-03 Sloan Kettering Inst Cancer Purification of interleukin 2
JPS58198293A (en) * 1982-05-12 1983-11-18 Shionogi & Co Ltd Production of immunoregulator such as interleukin
US4490289A (en) * 1982-09-16 1984-12-25 Hoffmann-La Roche Inc. Homogeneous human interleukin 2
US4992271A (en) * 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
US4462940A (en) * 1982-09-23 1984-07-31 Cetus Corporation Process for the recovery of human β-interferon-like polypeptides
DE3242851A1 (de) * 1982-11-19 1984-05-24 Biotechnolog Forschung Gmbh Verfahren zur reinigung von menschlichen lymphokinen
EP0111344A2 (en) * 1982-12-13 1984-06-20 Sloan-Kettering Institute For Cancer Research Anti-interleukin-2 monoclonal antibodies
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides
IL71275D0 (en) * 1983-03-21 1984-06-29 Sparamedica Ag Human interleukin-2-and its preparation
GB8308483D0 (en) * 1983-03-28 1983-05-05 Health Lab Service Board Secretion of gene products
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US4582799A (en) * 1983-04-15 1986-04-15 Damon Biotech, Inc. Process for recovering nonsecreted substances produced by cells
DK265384A (da) * 1983-06-01 1984-12-02 Hoffmann La Roche Polypeptider med interferonaktivitet
WO1985000606A1 (en) * 1983-07-19 1985-02-14 Takeda Chemical Industries, Ltd. Human il-2 and process for its preparation
US4464295A (en) * 1983-08-17 1984-08-07 The United States Of America As Represented By The Secretary Of Agriculture Simple and rapid method for extraction of proteins from bacteria
US4476049A (en) * 1983-09-20 1984-10-09 Hoffmann-La Roche Inc. Method for the extraction of immune interferon
GB8327880D0 (en) * 1983-10-18 1983-11-16 Ajinomoto Kk Saccharomyces cerevisiae
US4675383A (en) * 1983-11-15 1987-06-23 The Salk Institute For Biological Studies Purification of T-cell growth factor
JPH0542413B2 (fi) * 1983-11-28 1993-06-28 Takeda Chemical Industries Ltd
CA1340853C (en) * 1983-12-23 1999-12-21 Hsiang-Fu Kung Purification of recombinant interleukin-2
US4530787B1 (fi) * 1984-03-28 1993-07-20 Cetus Corp
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
EP0211835B1 (en) * 1984-03-28 1990-01-03 Cetus Corporation Pharmaceutical compositions of microbially produced interleukin-2
EP0158198A1 (en) * 1984-03-29 1985-10-16 Takeda Chemical Industries, Ltd. DNA and use thereof
DE3583880D1 (de) * 1984-04-09 1991-10-02 Takeda Chemical Industries Ltd Stabile interleukin-2-zusammensetzung.
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
US4782139A (en) * 1985-10-28 1988-11-01 Eli Lilly And Company Selective chemical removal of a protein amino-terminal residue
US4787658A (en) * 1986-07-29 1988-11-29 Harris Jr John Unibody bumper system
US5156968A (en) * 1988-06-24 1992-10-20 Genentech, Inc. Purified yeast ubiquitin hydrolase

Also Published As

Publication number Publication date
IE59100B1 (en) 1994-01-12
FI851231D0 (fi)
IE850799L (en) 1985-09-28
US5419899A (en) 1995-05-30
PT80172B (pt) 1987-06-17
JPH08332089A (ja) 1996-12-17
DK135985D0 (da) 1985-03-26
CA1341083C (en) 2000-08-15
AT81674T (de) 1992-11-15
NZ211569A (en) 1988-05-30
EP0156373A3 (en) 1987-09-02
EP0470586B1 (en) 1998-07-15
ZA8502347B (en) 1986-11-26
HK1004474A1 (en) 2000-03-17
DE3588189T2 (de) 1998-11-19
FI851231A0 (fi) 1985-03-27
ES541608A0 (es) 1986-09-01
EP0470586A1 (en) 1992-02-12
IL74733D0 (en) 1985-06-30
DE3586762T2 (de) 1993-02-25
DK135985A (da) 1985-09-29
US4569790A (en) 1986-02-11
DE3588189D1 (de) 1998-08-20
PT80172A (en) 1985-04-01
JP2599903B2 (ja) 1997-04-16
EP0156373A2 (en) 1985-10-02
US5614185A (en) 1997-03-25
GR850741B (fi) 1985-06-26
NO851235L (no) 1985-09-30
DE3586762D1 (de) 1992-11-26
AU4046785A (en) 1985-10-03
DK166324C (da) 1993-08-23
AU592751B2 (en) 1990-01-25
IL74733A (en) 1990-11-05
KR850007083A (ko) 1985-10-30
JP2648587B2 (ja) 1997-09-03
FI94960B (fi) 1995-08-15
JPS611393A (en) 1986-01-07
FI851231L (fi) 1985-09-29
FI851231A (fi)
IN162903B (fi) 1988-07-23
ES541608D0 (fi)
ES8609362A1 (es) 1986-09-01
EP0156373B1 (en) 1992-10-21
DK166324B (da) 1993-04-05
PH21012A (en) 1987-06-23

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