FI94960C - Menetelmä ihmisen interleukiini-2:n talteensaamiseksi - Google Patents
Menetelmä ihmisen interleukiini-2:n talteensaamiseksiInfo
- Publication number
- FI94960C FI94960C FI851231A FI851231A FI94960C FI 94960 C FI94960 C FI 94960C FI 851231 A FI851231 A FI 851231A FI 851231 A FI851231 A FI 851231A FI 94960 C FI94960 C FI 94960C
- Authority
- FI
- Finland
- Prior art keywords
- cellular material
- solubilizing
- butanol
- agent
- produced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/594,223 US4569790A (en) | 1984-03-28 | 1984-03-28 | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
US59422384 | 1984-03-28 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI851231A0 FI851231A0 (fi) | 1985-03-27 |
FI851231L FI851231L (fi) | 1985-09-29 |
FI94960B FI94960B (fi) | 1995-08-15 |
FI94960C true FI94960C (fi) | 1995-11-27 |
Family
ID=24378044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI851231A FI94960C (fi) | 1984-03-28 | 1985-03-27 | Menetelmä ihmisen interleukiini-2:n talteensaamiseksi |
Country Status (21)
Country | Link |
---|---|
US (3) | US4569790A (fi) |
EP (2) | EP0470586B1 (fi) |
JP (2) | JP2599903B2 (fi) |
KR (1) | KR850007083A (fi) |
AT (1) | ATE81674T1 (fi) |
AU (1) | AU592751B2 (fi) |
CA (1) | CA1341083C (fi) |
DE (2) | DE3588189T2 (fi) |
DK (1) | DK166324C (fi) |
ES (1) | ES8609362A1 (fi) |
FI (1) | FI94960C (fi) |
GR (1) | GR850741B (fi) |
HK (1) | HK1004474A1 (fi) |
IE (1) | IE59100B1 (fi) |
IL (1) | IL74733A (fi) |
IN (1) | IN162903B (fi) |
NO (1) | NO851235L (fi) |
NZ (1) | NZ211569A (fi) |
PH (1) | PH21012A (fi) |
PT (1) | PT80172B (fi) |
ZA (1) | ZA852347B (fi) |
Families Citing this family (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4925919A (en) * | 1984-04-25 | 1990-05-15 | Roland Mertelsmann | Purified interleukin 2 |
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US4656132A (en) * | 1984-03-28 | 1987-04-07 | Cetus Corporation | Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria |
US4569790A (en) * | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
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US4908433A (en) * | 1984-04-25 | 1990-03-13 | Sloan-Kettering Institute For Cancer Research | Uses of interleukin-2 |
US4908434A (en) * | 1984-04-25 | 1990-03-13 | Sloan-Kettering Institute For Cancer Research | Process for preparing purified interleukin-2 |
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DE3500681A1 (de) * | 1985-01-11 | 1986-07-17 | Hoechst Ag, 6230 Frankfurt | Verfahren zur isolierung und reinigung von lymphokinen |
JPH0646957B2 (ja) * | 1985-03-11 | 1994-06-22 | 武田薬品工業株式会社 | インタ−ロイキン−2の製造方法 |
US5523215A (en) * | 1985-03-28 | 1996-06-04 | Chiron Corporation | Enhanced purification and expression of insoluble recombinant proteins |
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US5248769A (en) * | 1985-06-26 | 1993-09-28 | Cetus Oncology Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
US4788144A (en) * | 1985-06-28 | 1988-11-29 | International Minerals & Chemical Corp. | Fermentation process for the high level production of swine growth |
US4762784A (en) * | 1985-07-15 | 1988-08-09 | International Minerals & Chemical Corp. | Fermemtation process for the high level production of bovine growth hormone |
US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
CA1297003C (en) * | 1985-09-20 | 1992-03-10 | Jack H. Nunberg | Composition and method for treating animals |
US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
US4933433A (en) * | 1986-01-31 | 1990-06-12 | E. I. Du Pont De Nemours And Company | Recombinant interleukin-2 composition and process for making it |
US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
US4931544A (en) * | 1986-09-04 | 1990-06-05 | Cetus Corporation | Succinylated interleukin-2 for pharmaceutical compositions |
US4683293A (en) * | 1986-10-20 | 1987-07-28 | Phillips Petroleum Company | Purification of pichia produced lipophilic proteins |
US4894330A (en) * | 1986-12-23 | 1990-01-16 | Cetus Corporation | Purification of recombinant beta-interferon incorporating RP-HPLC |
US5108911A (en) * | 1987-03-13 | 1992-04-28 | Immunex Corporation | Process for preparing bovine interleukin-Iβ |
US4879374A (en) * | 1987-03-13 | 1989-11-07 | Immunex Corporation | Bovine interleukin-1β DNA sequence |
CA1339757C (en) | 1987-04-16 | 1998-03-17 | Robert F. Halenbeck | Production of purified biologically active, bacterially produced recombinant human csf-1 |
US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
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DE3855986T2 (de) * | 1987-05-11 | 1998-02-05 | Chiron Corp | Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen |
US5162507A (en) * | 1987-05-11 | 1992-11-10 | Cetus Corporation | Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms |
US4931543A (en) * | 1987-05-11 | 1990-06-05 | Cetus Corporation | Process for recovering microbially produced interleukin-2 |
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JP2669859B2 (ja) * | 1987-08-04 | 1997-10-29 | 協和醗酵工業株式会社 | タンパク質の再活性化法 |
EP0337243A1 (en) * | 1988-04-14 | 1989-10-18 | F. Hoffmann-La Roche Ag | Process for purifying recombinant human interleukin-2 |
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CN100469769C (zh) | 2003-03-24 | 2009-03-18 | 弗·哈夫曼-拉罗切有限公司 | 作为逆转录酶抑制剂的苄基-哒嗪酮 |
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KR101475091B1 (ko) | 2006-12-13 | 2014-12-22 | 에프. 호프만-라 로슈 아게 | 비뉴클레오시드 역전사 효소 억제제로서 2-(피페리딘-4-일)-4-페녹시- 또는 페닐아미노-피리미딘 유도체 |
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BRPI0821349A2 (pt) | 2007-12-21 | 2019-09-24 | Hoffmann La Roche | compostos antivirais heterocíclicos |
CN102186966A (zh) * | 2008-08-04 | 2011-09-14 | 凯生物能公司 | 光合培养物的连续培养、收获和油提取 |
KR20200070407A (ko) | 2010-11-12 | 2020-06-17 | 넥타르 테라퓨틱스 | Il-2 부분 및 중합체의 접합체 |
WO2012088446A1 (en) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
SG11201407812SA (en) | 2012-05-31 | 2014-12-30 | Agency Science Tech & Res | Methods for reducing levels of protein-contaminant complexes and aggregates in protein preparations by treatment with electropositive organic additives |
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US10150802B2 (en) | 2014-04-24 | 2018-12-11 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
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JP7433051B2 (ja) | 2017-06-19 | 2024-02-19 | メディシナ セラピューティクス インコーポレイテッド | Il-2スーパーアゴニスト、アゴニスト、およびそれらの融合体の使用および方法 |
SG11202000167SA (en) | 2017-07-11 | 2020-02-27 | Synthorx Inc | Incorporation of unnatural nucleotides and methods thereof |
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EP3713592A4 (en) | 2017-11-21 | 2022-01-12 | The Board of Trustees of the Leland Stanford Junior University | INTERLEUKIN-2 PARTIAL AGONISTS |
IL278528B1 (en) | 2018-05-21 | 2024-06-01 | Nektar Therapeutics | Selective TREG activator RUR20kD-IL-2 and related agents |
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CN114245802A (zh) | 2019-06-20 | 2022-03-25 | 石药集团巨石生物制药有限公司 | 修饰的il-2蛋白、peg偶联物及其用途 |
CA3166509A1 (en) | 2020-01-14 | 2021-07-22 | Synthekine, Inc. | Biased il2 muteins methods and compositions |
CN111793124A (zh) * | 2020-06-24 | 2020-10-20 | 宁波博睿瀚达生物科技有限公司 | 一种去除重组白介素-2内毒素的方法 |
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1984
- 1984-03-28 US US06/594,223 patent/US4569790A/en not_active Expired - Lifetime
-
1985
- 1985-02-26 CA CA000475151A patent/CA1341083C/en not_active Expired - Lifetime
- 1985-03-25 IN IN220/CAL/85A patent/IN162903B/en unknown
- 1985-03-25 PH PH32035A patent/PH21012A/en unknown
- 1985-03-26 DK DK135985A patent/DK166324C/da not_active IP Right Cessation
- 1985-03-26 NZ NZ211569A patent/NZ211569A/en unknown
- 1985-03-26 GR GR850741A patent/GR850741B/el unknown
- 1985-03-27 IL IL74733A patent/IL74733A/xx not_active IP Right Cessation
- 1985-03-27 EP EP91113235A patent/EP0470586B1/en not_active Expired - Lifetime
- 1985-03-27 FI FI851231A patent/FI94960C/fi not_active IP Right Cessation
- 1985-03-27 EP EP85103649A patent/EP0156373B1/en not_active Expired - Lifetime
- 1985-03-27 DE DE3588189T patent/DE3588189T2/de not_active Expired - Lifetime
- 1985-03-27 ES ES541608A patent/ES8609362A1/es not_active Expired
- 1985-03-27 DE DE8585103649T patent/DE3586762T2/de not_active Expired - Lifetime
- 1985-03-27 NO NO851235A patent/NO851235L/no unknown
- 1985-03-27 AT AT85103649T patent/ATE81674T1/de not_active IP Right Cessation
- 1985-03-27 PT PT80172A patent/PT80172B/pt unknown
- 1985-03-28 IE IE79985A patent/IE59100B1/en not_active IP Right Cessation
- 1985-03-28 KR KR1019850002078A patent/KR850007083A/ko not_active Application Discontinuation
- 1985-03-28 AU AU40467/85A patent/AU592751B2/en not_active Expired
- 1985-03-28 JP JP60062195A patent/JP2599903B2/ja not_active Expired - Lifetime
- 1985-03-28 ZA ZA852347A patent/ZA852347B/xx unknown
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1992
- 1992-05-06 US US07/879,753 patent/US5419899A/en not_active Expired - Lifetime
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1995
- 1995-04-25 US US08/428,895 patent/US5614185A/en not_active Expired - Lifetime
-
1996
- 1996-05-15 JP JP8143485A patent/JP2648587B2/ja not_active Expired - Lifetime
-
1998
- 1998-05-04 HK HK98103767A patent/HK1004474A1/xx not_active IP Right Cessation
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