DK150304C - Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf - Google Patents

Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf

Info

Publication number
DK150304C
DK150304C DK227782A DK227782A DK150304C DK 150304 C DK150304 C DK 150304C DK 227782 A DK227782 A DK 227782A DK 227782 A DK227782 A DK 227782A DK 150304 C DK150304 C DK 150304C
Authority
DK
Denmark
Prior art keywords
propoxymethyl
guanine
dihydroxy
analogue
preparation
Prior art date
Application number
DK227782A
Other languages
Danish (da)
English (en)
Other versions
DK150304B (da
DK227782A (da
Inventor
Julien P Verheyden
John C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK150304(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DK227782A publication Critical patent/DK227782A/da
Priority to DK504183A priority Critical patent/DK149001C/da
Publication of DK150304B publication Critical patent/DK150304B/da
Application granted granted Critical
Publication of DK150304C publication Critical patent/DK150304C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK227782A 1981-05-21 1982-05-19 Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf DK150304C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK504183A DK149001C (da) 1981-05-21 1983-11-03 9-substituerede n2-acylguaniner eller syreadditionssalte eller uorganiske metalsalte deraf

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
US26721081 1981-05-21

Publications (3)

Publication Number Publication Date
DK227782A DK227782A (da) 1982-11-22
DK150304B DK150304B (da) 1987-02-02
DK150304C true DK150304C (da) 1988-01-04

Family

ID=23017790

Family Applications (2)

Application Number Title Priority Date Filing Date
DK227782A DK150304C (da) 1981-05-21 1982-05-19 Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf
DK504183A DK149001C (da) 1981-05-21 1983-11-03 9-substituerede n2-acylguaniner eller syreadditionssalte eller uorganiske metalsalte deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK504183A DK149001C (da) 1981-05-21 1983-11-03 9-substituerede n2-acylguaniner eller syreadditionssalte eller uorganiske metalsalte deraf

Country Status (33)

Country Link
US (1) US4355032B2 (no)
EP (1) EP0066208B1 (no)
JP (2) JPS57203086A (no)
KR (1) KR890004663B1 (no)
AR (1) AR244227A1 (no)
AT (1) ATE15899T1 (no)
AU (1) AU572086B2 (no)
BR (1) BR8202931A (no)
CA (3) CA1305140C (no)
CS (4) CS235018B2 (no)
DD (2) DD213218A5 (no)
DE (1) DE3266644D1 (no)
DK (2) DK150304C (no)
ES (7) ES512414A0 (no)
FI (1) FI73682C (no)
GR (1) GR76459B (no)
HK (1) HK67088A (no)
HU (2) HU186514B (no)
IE (1) IE53731B1 (no)
IL (1) IL65836A (no)
IN (1) IN156469B (no)
LU (1) LU88334I2 (no)
MY (1) MY8700793A (no)
NL (2) NL930022I1 (no)
NO (2) NO161740C (no)
NZ (1) NZ200691A (no)
PH (1) PH17975A (no)
PL (4) PL136579B1 (no)
PT (1) PT74934B (no)
RO (2) RO84860B (no)
SG (1) SG81687G (no)
SU (1) SU1176841A3 (no)
ZA (1) ZA823532B (no)

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US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
AU569462B2 (en) * 1981-08-11 1988-02-04 Wellcome Foundation Limited, The Antiviral purine derivatives
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
IE830186L (en) * 1982-02-01 1983-08-01 Syntex Inc Purines
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
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IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
EP0190123A1 (en) * 1984-07-20 1986-08-13 GAUNTT, Charles, O. Immunoregulatory and anti-viral compound
EP0187297B1 (en) * 1984-12-12 1991-08-21 Syntex (U.S.A.) Inc. Alkoxy methyl ether and alkoxy methyl ester derivatives
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
US5043339A (en) * 1988-12-19 1991-08-27 Burroughs Wellcome Co. Antiviral compounds
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
HUT73410A (en) * 1993-06-23 1996-07-29 Merrell Pharma Inc Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents
US5856481A (en) * 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5565565A (en) * 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
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US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
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IN179493B (no) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
EP0806425B1 (en) * 1996-04-09 2001-08-29 Lupin Laboratories Limited An improved regiospecific process for synthesis of acyclic nucleosides
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CN1091445C (zh) * 1999-12-29 2002-09-25 湖北省医药工业研究院 抗病毒药物中间体、它们的制备及应用
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
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GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
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Also Published As

Publication number Publication date
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
DK149001C (da) 1988-11-28
ES8505681A1 (es) 1985-06-16
PL136579B1 (en) 1986-02-28
RO84860A (ro) 1984-09-29
AR244227A1 (es) 1993-10-29
CS235042B2 (en) 1985-04-16
NL930139I2 (nl) 1997-07-01
IN156469B (no) 1985-08-10
PL246770A1 (en) 1984-08-27
NO821676L (no) 1982-11-22
JPH0529399B2 (no) 1993-04-30
JPH04217983A (ja) 1992-08-07
CS235043B2 (en) 1985-04-16
ES8507549A1 (es) 1985-09-16
ES529383A0 (es) 1986-05-16
ES8701496A1 (es) 1987-01-01
ES8500276A1 (es) 1984-11-01
US4355032B1 (no) 1983-06-14
ES524899A0 (es) 1985-09-16
IL65836A0 (en) 1982-08-31
DK227782A (da) 1982-11-22
DD213218A5 (de) 1984-09-05
DD203052A5 (de) 1983-10-12
CA1305140C (en) 1992-07-14
ES520849A0 (es) 1984-11-01
CA1305141C (en) 1992-07-14
FI821794A0 (fi) 1982-05-20
RO87387A (ro) 1985-08-31
ES8601204A1 (es) 1985-11-16
SU1176841A3 (ru) 1985-08-30
NL930139I1 (nl) 1993-11-01
IE53731B1 (en) 1989-02-01
AU8389282A (en) 1982-11-25
ZA823532B (en) 1983-03-30
BR8202931A (pt) 1983-05-03
ES8404355A1 (es) 1984-05-01
ES533821A0 (es) 1985-06-16
LU88334I2 (fr) 1994-09-09
AU572086B2 (en) 1988-05-05
FI73682B (fi) 1987-07-31
NZ200691A (en) 1986-11-12
ES512414A0 (es) 1984-05-01
JPH046195B2 (no) 1992-02-05
HU186514B (en) 1985-08-28
ATE15899T1 (de) 1985-10-15
KR890004663B1 (ko) 1989-11-24
RO87387B (ro) 1985-08-31
NO1994005I1 (no) 1994-07-29
US4355032A (en) 1982-10-19
US4355032B2 (en) 1990-10-30
NO161740C (no) 1989-09-20
NL930022I1 (nl) 1993-05-03
PL136332B1 (en) 1986-02-28
FI73682C (fi) 1987-11-09
PT74934B (en) 1984-05-08
RO84860B (ro) 1984-10-30
PH17975A (en) 1985-02-22
KR830010112A (ko) 1983-12-26
EP0066208A1 (en) 1982-12-08
DK149001B (da) 1985-12-16
HU188000B (en) 1986-03-28
JPS57203086A (en) 1982-12-13
HK67088A (en) 1988-09-02
NO161740B (no) 1989-06-12
PT74934A (en) 1982-06-01
CS235044B2 (en) 1985-04-16
PL136637B1 (en) 1986-03-31
MY8700793A (en) 1987-12-31
PL236521A1 (en) 1984-01-02
IE821210L (en) 1982-11-21
PL242101A1 (en) 1984-07-16
IL65836A (en) 1991-04-15
CS235018B2 (en) 1985-04-16
CA1305139C (en) 1992-07-14
ES529384A0 (es) 1987-01-01
DE3266644D1 (en) 1985-11-07
DK504183A (da) 1983-11-03
PL136004B1 (en) 1986-01-31
ES8606869A1 (es) 1986-05-16
GR76459B (no) 1984-08-10
SG81687G (en) 1989-07-07
PL242100A1 (en) 1984-04-24
DK504183D0 (da) 1983-11-03
ES524900A0 (es) 1985-11-16

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