DK1430034T3 - Substituerede alkylaminopyridazinonderivater, fremgangsmåde til fremstilling deraf og en farmaceutisk sammensætning indeholdende disse - Google Patents

Substituerede alkylaminopyridazinonderivater, fremgangsmåde til fremstilling deraf og en farmaceutisk sammensætning indeholdende disse

Info

Publication number
DK1430034T3
DK1430034T3 DK02767729T DK02767729T DK1430034T3 DK 1430034 T3 DK1430034 T3 DK 1430034T3 DK 02767729 T DK02767729 T DK 02767729T DK 02767729 T DK02767729 T DK 02767729T DK 1430034 T3 DK1430034 T3 DK 1430034T3
Authority
DK
Denmark
Prior art keywords
sub
hydrogen
stands
alkyl
carbon atoms
Prior art date
Application number
DK02767729T
Other languages
Danish (da)
English (en)
Inventor
Gyula Simig
Hajnalka Kompagne
Csilla Leveleki
Janos Wellmann
Nagy Peter Kotay
Gyoergy Levay
Istvan Gacsalyi
Marko Bernadett Martonne
Eva Schmidt
Andras Egyed
Kovacs Anik Miklosne
Gabor Szenasi
Laszl Gabor Harsing
J Zsef Barkoczy
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Application granted granted Critical
Publication of DK1430034T3 publication Critical patent/DK1430034T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22Nitrogen and oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK02767729T 2001-09-27 2002-09-26 Substituerede alkylaminopyridazinonderivater, fremgangsmåde til fremstilling deraf og en farmaceutisk sammensætning indeholdende disse DK1430034T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0103912A HU227237B1 (en) 2001-09-27 2001-09-27 Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
PCT/HU2002/000097 WO2003027078A1 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Publications (1)

Publication Number Publication Date
DK1430034T3 true DK1430034T3 (da) 2005-05-30

Family

ID=89979721

Family Applications (2)

Application Number Title Priority Date Filing Date
DK02762620T DK1430047T3 (da) 2001-09-27 2002-09-26 Substituerede alkylaminopyridazinonderivater, fremgangsmåde til fremstilling deraf og en farmaceutisk sammensætning indeholdende disse
DK02767729T DK1430034T3 (da) 2001-09-27 2002-09-26 Substituerede alkylaminopyridazinonderivater, fremgangsmåde til fremstilling deraf og en farmaceutisk sammensætning indeholdende disse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK02762620T DK1430047T3 (da) 2001-09-27 2002-09-26 Substituerede alkylaminopyridazinonderivater, fremgangsmåde til fremstilling deraf og en farmaceutisk sammensætning indeholdende disse

Country Status (26)

Country Link
US (2) US20050043314A1 (hu)
EP (2) EP1430047B1 (hu)
JP (2) JP2005508914A (hu)
KR (2) KR100890667B1 (hu)
CN (3) CN100368404C (hu)
AT (2) ATE288899T1 (hu)
AU (2) AU2002328166B2 (hu)
BR (2) BR0212932A (hu)
CA (2) CA2461510C (hu)
CZ (2) CZ2004528A3 (hu)
DE (2) DE60202969T2 (hu)
DK (2) DK1430047T3 (hu)
EA (2) EA006392B1 (hu)
ES (2) ES2237696T3 (hu)
HK (3) HK1069816A1 (hu)
HU (1) HU227237B1 (hu)
MA (2) MA27137A1 (hu)
MX (2) MXPA04002838A (hu)
NO (2) NO326370B1 (hu)
NZ (2) NZ532103A (hu)
PL (2) PL369107A1 (hu)
PT (2) PT1430034E (hu)
SI (2) SI1430047T1 (hu)
SK (2) SK1902004A3 (hu)
WO (2) WO2003027097A1 (hu)
ZA (2) ZA200402545B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5080716B2 (ja) 2001-07-20 2012-11-21 サイコジェニックス・インコーポレーテッド 注意欠陥・多動性障害の治療
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
CL2008000725A1 (es) * 2007-03-15 2008-11-14 Schering Corp Compuestos derivados de heterociclos aromaticos; composicion farmaceutica; kit farmceuticos; uso de la composicion y de los compuestos como inhibidores de glucano sintasa para el tratamiento o prevencion del crecimiento de patogenos fungicos en planta y para tratar o prevenir infecciones producidas por hongos.
TW202344505A (zh) * 2018-04-30 2023-11-16 美商律幫治療股份有限公司 作為parp7抑制劑的嗒𠯤酮
CN109053693B (zh) 2018-09-20 2021-02-05 顺毅股份有限公司 哒嗪胺类化合物的制备及其应用
CN117425648A (zh) * 2021-03-12 2024-01-19 杭州英创医药科技有限公司 作为parp7抑制剂的化合物
CN115490671B (zh) * 2022-10-21 2024-05-14 水木未来(北京)科技有限公司 Parp7抑制剂及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH557820A (de) * 1970-11-12 1975-01-15 Sandoz Ag Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin (2h)-3-onen.
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
PL164079B1 (pl) * 1990-06-15 1994-06-30 Akad Medyczna posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu
HU209388B (en) * 1990-12-27 1994-05-30 Richter Gedeon Vegyeszet Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
HU224067B1 (hu) 1995-05-29 2005-05-30 Gyógyszerkutató Intézet Kft. 3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
CA2334220A1 (en) * 1998-06-05 1999-12-16 Egis Gyogyszergyar Rt. Process for the preparation of a 3(2h)-pyridazinone- 4-substituted amino- 5-chloro- derivative

Also Published As

Publication number Publication date
EA006942B1 (ru) 2006-06-30
AU2002328166A2 (en) 2003-04-07
HK1115728A1 (en) 2008-12-05
SI1430034T1 (en) 2005-08-31
MA27137A1 (fr) 2005-01-03
CN101099740B (zh) 2010-09-08
SI1430047T1 (en) 2005-08-31
EP1430034A1 (en) 2004-06-23
EP1430047B1 (en) 2005-02-09
HUP0103912A3 (en) 2004-03-01
HU0103912D0 (en) 2001-12-28
NZ532104A (en) 2005-10-28
HU227237B1 (en) 2010-12-28
CN1571783A (zh) 2005-01-26
ZA200402545B (en) 2005-04-26
KR20040039445A (ko) 2004-05-10
PT1430034E (pt) 2005-06-30
EP1430034B1 (en) 2005-02-09
HK1069817A1 (en) 2005-06-03
US20050043314A1 (en) 2005-02-24
MXPA04002838A (es) 2004-07-05
KR20040039446A (ko) 2004-05-10
US6930110B2 (en) 2005-08-16
ES2237690T3 (es) 2005-08-01
NO326370B1 (no) 2008-11-17
EP1430047A1 (en) 2004-06-23
MXPA04002836A (es) 2004-07-05
ES2237696T3 (es) 2005-08-01
JP2005503437A (ja) 2005-02-03
ATE288899T1 (de) 2005-02-15
AU2002330656B2 (en) 2009-04-09
BR0212932A (pt) 2004-10-13
PL369256A1 (en) 2005-04-18
CZ2004528A3 (cs) 2004-08-18
AU2002330656A2 (en) 2003-04-07
EA006392B1 (ru) 2005-12-29
NO20041704L (no) 2004-04-26
CZ2004532A3 (cs) 2004-08-18
US20040242873A1 (en) 2004-12-02
AU2002330656B9 (en) 2009-09-03
PT1430047E (pt) 2005-06-30
DE60202969D1 (de) 2005-03-17
SK1892004A3 (en) 2004-10-05
ZA200402544B (en) 2005-04-26
NO325080B1 (no) 2008-01-28
NZ532103A (en) 2005-08-26
KR100890667B1 (ko) 2009-03-26
KR100911069B1 (ko) 2009-08-06
CN101099740A (zh) 2008-01-09
JP4472337B2 (ja) 2010-06-02
AU2002328166B2 (en) 2008-04-17
CN100368404C (zh) 2008-02-13
NO20041551L (no) 2004-06-10
DE60202970D1 (de) 2005-03-17
EA200400469A1 (ru) 2004-08-26
CA2461510C (en) 2009-07-07
CN1558904A (zh) 2004-12-29
DE60202969T2 (de) 2006-01-19
CA2461467A1 (en) 2003-04-03
CN1325489C (zh) 2007-07-11
BR0212839A (pt) 2004-10-13
ATE288910T1 (de) 2005-02-15
SK1902004A3 (en) 2004-10-05
DE60202970T2 (de) 2006-02-16
MA27068A1 (fr) 2004-12-20
EA200400470A1 (ru) 2004-08-26
WO2003027097A1 (en) 2003-04-03
HK1069816A1 (en) 2005-06-03
WO2003027078A1 (en) 2003-04-03
PL369107A1 (en) 2005-04-18
DK1430047T3 (da) 2005-06-06
HUP0103912A2 (hu) 2003-07-28
CA2461510A1 (en) 2003-04-03
JP2005508914A (ja) 2005-04-07

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