HUP0302258A2 - Fenoxifenil-alkánszulfonátok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Fenoxifenil-alkánszulfonátok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0302258A2
HUP0302258A2 HU0302258A HUP0302258A HUP0302258A2 HU P0302258 A2 HUP0302258 A2 HU P0302258A2 HU 0302258 A HU0302258 A HU 0302258A HU P0302258 A HUP0302258 A HU P0302258A HU P0302258 A2 HUP0302258 A2 HU P0302258A2
Authority
HU
Hungary
Prior art keywords
group
phenoxyphenyl
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU0302258A
Other languages
English (en)
Inventor
Jean-Marie-Viktor De Vry
Dirk Denzer
Markus Heil
Jan-Bernd Lenfers
Klemens Lustig
Frank Mauler
Heinrich Meier
Paul Naab
Arnd Voerste
Original Assignee
Bayer Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag. filed Critical Bayer Ag.
Publication of HUP0302258A2 publication Critical patent/HUP0302258A2/hu
Publication of HUP0302258A3 publication Critical patent/HUP0302258A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/20—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C309/22—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing carboxyl groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány szerinti vegyületek (I) általános képletében R1 jelentésehidrogénatom, 1-4 szénatomos alkilcsoport, halogénatom,trifluormetilcsoport, trifluormetoxicsoport, cianocsoport vagynitrocsoport, R2 jelentése halogénatom, trifluormetilcsoport,trifluormetoxicsoport, cianocsoport vagy nitrocsoport, R3 jelentése 4-7 szénatomos alkilcsoport, amely egy vagy több fluoratommal vagyklóratommal szubsztituálva lehet, R4 jelentése hidrogénatom vagyhalogénatom, A jelentése oxigénatom vagy NH. A találmány kiterjed afenti vegyületek előállítására és ezeket tartalmazógyógyszerkészítményekre. Ó
HU0302258A 2000-09-26 2001-09-13 Phenoxyphenyl alkane sulfonates, process for their preparation and pharmaceutical compositions containing them HUP0302258A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10047486A DE10047486A1 (de) 2000-09-26 2000-09-26 Phenoxyphenyl Alkansulfonate
PCT/EP2001/010564 WO2002026702A1 (de) 2000-09-26 2001-09-13 Phenoxyphenyl alkansulfonate

Publications (2)

Publication Number Publication Date
HUP0302258A2 true HUP0302258A2 (hu) 2003-11-28
HUP0302258A3 HUP0302258A3 (en) 2006-02-28

Family

ID=7657564

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302258A HUP0302258A3 (en) 2000-09-26 2001-09-13 Phenoxyphenyl alkane sulfonates, process for their preparation and pharmaceutical compositions containing them

Country Status (34)

Country Link
US (2) US6756409B2 (hu)
EP (1) EP1334086B1 (hu)
JP (1) JP2004509946A (hu)
KR (1) KR20030039372A (hu)
CN (1) CN1476427A (hu)
AR (1) AR033575A1 (hu)
AT (1) ATE292621T1 (hu)
AU (2) AU2002220547B2 (hu)
BG (1) BG107634A (hu)
BR (1) BR0114182A (hu)
CA (1) CA2423171A1 (hu)
DE (2) DE10047486A1 (hu)
EE (1) EE200300117A (hu)
ES (1) ES2240543T3 (hu)
GT (1) GT200100193A (hu)
HN (1) HN2001000214A (hu)
HR (1) HRP20030326A2 (hu)
HU (1) HUP0302258A3 (hu)
IL (1) IL154968A0 (hu)
MA (1) MA26053A1 (hu)
MX (1) MXPA03002546A (hu)
NO (1) NO20031357L (hu)
NZ (1) NZ524886A (hu)
PE (1) PE20020408A1 (hu)
PL (1) PL361015A1 (hu)
PT (1) PT1334086E (hu)
RU (1) RU2278853C2 (hu)
SI (1) SI1334086T1 (hu)
SK (1) SK3442003A3 (hu)
SV (1) SV2002000639A (hu)
UA (1) UA75369C2 (hu)
UY (1) UY26945A1 (hu)
WO (1) WO2002026702A1 (hu)
ZA (1) ZA200302275B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003061699A1 (fr) * 2001-12-27 2003-07-31 Japan Tobacco, Inc. Remedes pour affections allergiques
CA2767331A1 (en) 2008-07-10 2010-01-14 Angion Biomedica Corp. Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity
US10709497B2 (en) * 2017-09-22 2020-07-14 Covidien Lp Electrosurgical tissue sealing device with non-stick coating
SG11202110406SA (en) 2019-04-11 2021-10-28 Angion Biomedica Corp Solid forms of (e)-3-[2-(2-thienyl)vinyl]-1h-pyrazole

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE216642C (hu) *
BE786644A (fr) * 1971-07-23 1973-01-24 Hoechst Ag Derives d'acides phenoxy-4 phenoxy-alcane-carboxyliques leur preparation et les medicaments qui en contiennent
US3914418A (en) * 1971-09-02 1975-10-21 Merck & Co Inc Methods of controlling liver fluke infections
GB8914660D0 (en) * 1989-06-26 1989-08-16 Fujisawa Pharmaceutical Co Aniline derivatives,processes for production thereof and pharmaceutical compositions comprising the same
MY117939A (en) * 1996-07-25 2004-08-30 Lg Chemical Ltd Composition for enhancing oral hygiene
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
DK0966436T3 (da) * 1997-02-21 2003-03-31 Bayer Ag Arylsulfonamider og analoger deraf og anvendelse deraf til behandling af neurodegenerative lidelser
US5925654A (en) * 1997-03-12 1999-07-20 G.D. Searle & Co. LTA4 , hydrolase inhibitors
DE69810960T2 (de) * 1997-10-20 2003-09-11 Taisho Pharmaceutical Co., Ltd. 2-phenoxyanilin-derivate
US6231875B1 (en) * 1998-03-31 2001-05-15 Johnson & Johnson Consumer Companies, Inc. Acidified composition for topical treatment of nail and skin conditions
NL1008795C2 (nl) * 1998-04-02 1999-10-05 Rene Werenfridus Lodewijk Vroo Samenstelling voor het behandelen van hoeven en werkwijze voor het vervaardigen van de samenstelling.
HN1998000027A (es) * 1998-08-19 1999-06-02 Bayer Ip Gmbh Arilsulfonamidas y analagos
DE19837627A1 (de) * 1998-08-19 2000-02-24 Bayer Ag Neue Aminosäureester von Arylsulfonamiden und Analoga
US6242422B1 (en) * 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases

Also Published As

Publication number Publication date
WO2002026702A1 (de) 2002-04-04
BG107634A (bg) 2003-12-31
EE200300117A (et) 2005-04-15
RU2278853C2 (ru) 2006-06-27
SI1334086T1 (en) 2005-10-31
JP2004509946A (ja) 2004-04-02
EP1334086A1 (de) 2003-08-13
NO20031357D0 (no) 2003-03-25
NZ524886A (en) 2005-09-30
DE10047486A1 (de) 2002-04-11
EP1334086B1 (de) 2005-04-06
SV2002000639A (es) 2002-10-24
HN2001000214A (es) 2001-10-25
GT200100193A (es) 2002-06-04
MA26053A1 (fr) 2004-04-01
AU2054702A (en) 2002-04-08
PL361015A1 (en) 2004-09-20
US20030022934A1 (en) 2003-01-30
ES2240543T3 (es) 2005-10-16
DE50105857D1 (de) 2005-05-12
US20040214886A1 (en) 2004-10-28
PT1334086E (pt) 2005-08-31
CA2423171A1 (en) 2003-03-21
KR20030039372A (ko) 2003-05-17
SK3442003A3 (en) 2003-10-07
CN1476427A (zh) 2004-02-18
AU2002220547B2 (en) 2006-11-02
ZA200302275B (en) 2004-03-24
UA75369C2 (en) 2006-04-17
HUP0302258A3 (en) 2006-02-28
AR033575A1 (es) 2003-12-26
IL154968A0 (en) 2003-10-31
US6756409B2 (en) 2004-06-29
UY26945A1 (es) 2002-04-26
HRP20030326A2 (en) 2005-02-28
ATE292621T1 (de) 2005-04-15
BR0114182A (pt) 2003-07-29
NO20031357L (no) 2003-03-25
PE20020408A1 (es) 2002-06-08
MXPA03002546A (es) 2004-04-20

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