HUP0303811A2 - Eljárás 1,3-helyettesített indének és aril-kondenzált azapoliciklusos vegyületek előállítására - Google Patents

Eljárás 1,3-helyettesített indének és aril-kondenzált azapoliciklusos vegyületek előállítására

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Publication number
HUP0303811A2
HUP0303811A2 HU0303811A HUP0303811A HUP0303811A2 HU P0303811 A2 HUP0303811 A2 HU P0303811A2 HU 0303811 A HU0303811 A HU 0303811A HU P0303811 A HUP0303811 A HU P0303811A HU P0303811 A2 HUP0303811 A2 HU P0303811A2
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HU
Hungary
Prior art keywords
alkyl
aryl
group
general formula
carbon atoms
Prior art date
Application number
HU0303811A
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English (en)
Inventor
Jason Daniel Mckinley
Robert Alan Singer
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0303811A2 publication Critical patent/HUP0303811A2/hu
Publication of HUP0303811A3 publication Critical patent/HUP0303811A3/hu

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/47Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány eljárást nyújt az (Ia), (Ib) és (Ic) általános képletű1,3-szubsztituált indéneknek vagy ezek keverékeinek az előállítására.Az (Ia), (Ib) és (Ic) általános képletű vegyületek vagy ezek keverékeköztesanyagként használható fel a (II) általános képletű vegyületekelőállításánál. Az (Ia), (Ib) és (Ic) általános képletekben R2 és R3jelentése egymástól függetlenül hidrogén-, fluor-, klóratom, -SOq(1-6szénatomos akil) általános képletű csoport, melyen belül q jelentése0, 1 vagy 2; (1-6 szénatomos alkil)2-amino-, -CO2R7, -CONR8R9, -SO2NR10R11, aril-(0-3 szénatomos alkil)- vagy aril-(0-3 szénatomosalkil)-O- általános képletű csoport, melyen belül az arilcsoportjelentése fenil- vagy naftilcsoport; heteroaril-(0-3 szénatomosalkil)- vagy heteroaril-(0-3 szénatomos alkil)-O- általános képletűcsoport, melyen belül a nevezett heteroarilcsoport 1-4 heteroatomot,ami lehet oxigén-, nitrogén- vagy kénatom, tartalmazó, 5-7 tagú aromásgyűrű; X2(0-6 szénatomos) R5 jelentése 1-6 szénatomos alkilcsoportvagy Si(R12)3 általános képletű csoport; R1 jelentése elektronvonzócsoport, az alábbiakból kiválasztva: ciano-, alkoxi-karbonil-, alkil-karbonil-, aril-karbonil-, aril-, nitro-, trifluor-metil- vagyszulfonilcsoport; R4 jelentése egymástól függetlenül hidrogénatom, 1-6szénatomos alkilcsoport, H(L)3N+ általános képletű vagy fémkation,beleértve az alkálifémeket, mint amilyen a nátrium-, kálium-, lítium-vagy céziumkation; vagy a két R4 csoport egy 2-3 szénatomosalkilénhidat képez. Ó
HU0303811A 2001-04-20 2002-03-04 Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds HUP0303811A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28513101P 2001-04-20 2001-04-20
PCT/IB2002/000660 WO2002085843A2 (en) 2001-04-20 2002-03-04 Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds

Publications (2)

Publication Number Publication Date
HUP0303811A2 true HUP0303811A2 (hu) 2004-03-01
HUP0303811A3 HUP0303811A3 (en) 2008-05-28

Family

ID=23092860

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303811A HUP0303811A3 (en) 2001-04-20 2002-03-04 Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds

Country Status (25)

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US (2) US7091372B2 (hu)
EP (1) EP1383733B1 (hu)
JP (1) JP2004527545A (hu)
KR (1) KR100551183B1 (hu)
CN (1) CN1321107C (hu)
AR (2) AR035957A1 (hu)
AT (1) ATE388135T1 (hu)
AU (1) AU2002234836B2 (hu)
BR (1) BR0208992A (hu)
CA (1) CA2443946A1 (hu)
CZ (1) CZ20032814A3 (hu)
DE (1) DE60225433T2 (hu)
DK (1) DK1383733T3 (hu)
ES (1) ES2300430T3 (hu)
HK (1) HK1062170A1 (hu)
HU (1) HUP0303811A3 (hu)
IL (1) IL157881A0 (hu)
MX (1) MXPA03009527A (hu)
PL (1) PL366657A1 (hu)
PT (1) PT1383733E (hu)
RU (1) RU2282619C9 (hu)
TW (1) TWI244472B (hu)
WO (1) WO2002085843A2 (hu)
YU (1) YU78303A (hu)
ZA (1) ZA200307205B (hu)

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WO2005007630A2 (en) * 2003-07-21 2005-01-27 Pfizer Products Inc. Aryl fused azapolycyclic compounds
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Also Published As

Publication number Publication date
EP1383733A2 (en) 2004-01-28
YU78303A (sh) 2006-05-25
IL157881A0 (en) 2004-03-28
TWI244472B (en) 2005-12-01
US20060079707A1 (en) 2006-04-13
ATE388135T1 (de) 2008-03-15
JP2004527545A (ja) 2004-09-09
CA2443946A1 (en) 2002-10-31
US20030060624A1 (en) 2003-03-27
HUP0303811A3 (en) 2008-05-28
CZ20032814A3 (cs) 2004-08-18
US7186870B2 (en) 2007-03-06
EP1383733B1 (en) 2008-03-05
WO2002085843A3 (en) 2003-06-05
US7091372B2 (en) 2006-08-15
AU2002234836B2 (en) 2007-08-23
KR20030092087A (ko) 2003-12-03
AR043636A2 (es) 2005-08-03
PL366657A1 (en) 2005-02-07
ES2300430T3 (es) 2008-06-16
KR100551183B1 (ko) 2006-02-13
DE60225433T2 (de) 2008-06-12
AR035957A1 (es) 2004-07-28
ZA200307205B (en) 2004-09-15
DE60225433D1 (de) 2008-04-17
CN1503781A (zh) 2004-06-09
RU2003130751A (ru) 2005-03-27
HK1062170A1 (en) 2004-10-21
MXPA03009527A (es) 2004-02-12
WO2002085843A2 (en) 2002-10-31
PT1383733E (pt) 2008-04-15
RU2282619C9 (ru) 2006-12-20
BR0208992A (pt) 2004-04-27
DK1383733T3 (da) 2008-06-09
CN1321107C (zh) 2007-06-13
RU2282619C2 (ru) 2006-08-27

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