DK142413B - Analogifremgangsmåde til fremstilling af 1-acyloxymethyl-5-fluoruracilderivater. - Google Patents

Analogifremgangsmåde til fremstilling af 1-acyloxymethyl-5-fluoruracilderivater. Download PDF

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Publication number
DK142413B
DK142413B DK394477AA DK394477A DK142413B DK 142413 B DK142413 B DK 142413B DK 394477A A DK394477A A DK 394477AA DK 394477 A DK394477 A DK 394477A DK 142413 B DK142413 B DK 142413B
Authority
DK
Denmark
Prior art keywords
fluorouracil
product
general formula
reaction
group
Prior art date
Application number
DK394477AA
Other languages
Danish (da)
English (en)
Other versions
DK394477A (nl
DK142413C (nl
Inventor
Yoshimasa Ike
Shoichiro Ozaki
Katsutoshi Ishikawa
Haruki Tamura
Original Assignee
Mitsui Toatsu Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals
Publication of DK394477A publication Critical patent/DK394477A/da
Publication of DK142413B publication Critical patent/DK142413B/da
Application granted granted Critical
Publication of DK142413C publication Critical patent/DK142413C/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK394477AA 1976-09-06 1977-09-05 Analogifremgangsmåde til fremstilling af 1-acyloxymethyl-5-fluoruracilderivater. DK142413B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10571476A JPS5331676A (en) 1976-09-06 1976-09-06 Uracil derivatives and their preparation
JP10571476 1976-09-06

Publications (3)

Publication Number Publication Date
DK394477A DK394477A (nl) 1978-03-07
DK142413B true DK142413B (da) 1980-10-27
DK142413C DK142413C (nl) 1981-03-23

Family

ID=14414993

Family Applications (1)

Application Number Title Priority Date Filing Date
DK394477AA DK142413B (da) 1976-09-06 1977-09-05 Analogifremgangsmåde til fremstilling af 1-acyloxymethyl-5-fluoruracilderivater.

Country Status (16)

Country Link
US (1) US4267326A (nl)
JP (1) JPS5331676A (nl)
AU (1) AU513153B2 (nl)
CH (1) CH634567A5 (nl)
DE (1) DE2739912A1 (nl)
DK (1) DK142413B (nl)
FI (1) FI62071C (nl)
FR (1) FR2363563A1 (nl)
GB (1) GB1543467A (nl)
HU (1) HU177482B (nl)
NL (1) NL7709808A (nl)
PH (1) PH14000A (nl)
PL (1) PL108914B1 (nl)
SE (1) SE438856B (nl)
SU (1) SU795468A3 (nl)
ZA (1) ZA775361B (nl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5379879A (en) * 1976-12-23 1978-07-14 Mitsui Toatsu Chem Inc 1,3-substituted-5-fluorouracils and process for their preparation
JPS54122281A (en) * 1978-03-13 1979-09-21 Mitsui Toatsu Chem Inc 5-fluorouracil derivative and its preparation
JPS5668674A (en) * 1979-11-08 1981-06-09 Shionogi & Co Ltd 5-fluorouracil derivative
JPS5724369A (en) * 1980-07-19 1982-02-08 Tokyo Kinzoku Kogyo Kk Pyrimidine derivative and its preparation
JPS5738774A (en) * 1980-08-19 1982-03-03 Chugai Pharmaceut Co Ltd Uracil derivative and its preparation
EP0162924B1 (en) * 1983-10-20 1989-12-13 Terumo Kabushiki Kaisha 5-fluorouracil derivatives and medicinal preparation containing same
DK197486A (da) * 1986-04-30 1987-10-31 Ferring Farma Lab 5-fluoruracilprodug
US6051576A (en) * 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
AU2010266018B2 (en) 2009-06-25 2014-01-09 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
EP2445343B1 (en) 2009-06-25 2021-08-04 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
CA2885196C (en) 2012-09-19 2021-06-22 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability
WO2015143145A1 (en) 2014-03-20 2015-09-24 Alkermes Pharma Ireland Limited Aripiprazole formulations having increased injection speeds
US11273158B2 (en) 2018-03-05 2022-03-15 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
CN109761915B (zh) * 2019-03-05 2021-12-21 沈阳药科大学 靶向mct1转运体的5-氟尿嘧啶成酯前药

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5324952B2 (nl) * 1973-11-28 1978-07-24
JPS603071B2 (ja) * 1975-02-17 1985-01-25 三井製薬工業株式会社 1−(α−アシロキシアルキル)−5−フルオロウラシル類の製造方法

Also Published As

Publication number Publication date
GB1543467A (en) 1979-04-04
AU513153B2 (en) 1980-11-20
AU2857177A (en) 1979-03-15
SE438856B (sv) 1985-05-13
FR2363563B1 (nl) 1980-06-20
JPS6114148B2 (nl) 1986-04-17
CH634567A5 (de) 1983-02-15
PL200685A1 (pl) 1978-10-09
PH14000A (en) 1980-11-28
US4267326A (en) 1981-05-12
SE7709942L (sv) 1978-03-07
DE2739912A1 (de) 1978-03-09
DK394477A (nl) 1978-03-07
JPS5331676A (en) 1978-03-25
HU177482B (en) 1981-10-28
SU795468A3 (ru) 1981-01-07
ZA775361B (en) 1978-07-26
FI62071B (fi) 1982-07-30
FI772594A (fi) 1978-03-07
FR2363563A1 (fr) 1978-03-31
FI62071C (fi) 1982-11-10
DK142413C (nl) 1981-03-23
NL7709808A (nl) 1978-03-08
PL108914B1 (en) 1980-05-31

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