DK142413B - Analogifremgangsmåde til fremstilling af 1-acyloxymethyl-5-fluoruracilderivater. - Google Patents
Analogifremgangsmåde til fremstilling af 1-acyloxymethyl-5-fluoruracilderivater. Download PDFInfo
- Publication number
- DK142413B DK142413B DK394477AA DK394477A DK142413B DK 142413 B DK142413 B DK 142413B DK 394477A A DK394477A A DK 394477AA DK 394477 A DK394477 A DK 394477A DK 142413 B DK142413 B DK 142413B
- Authority
- DK
- Denmark
- Prior art keywords
- fluorouracil
- product
- general formula
- reaction
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10571476A JPS5331676A (en) | 1976-09-06 | 1976-09-06 | Uracil derivatives and their preparation |
| JP10571476 | 1976-09-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK394477A DK394477A (de) | 1978-03-07 |
| DK142413B true DK142413B (da) | 1980-10-27 |
| DK142413C DK142413C (de) | 1981-03-23 |
Family
ID=14414993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK394477AA DK142413B (da) | 1976-09-06 | 1977-09-05 | Analogifremgangsmåde til fremstilling af 1-acyloxymethyl-5-fluoruracilderivater. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4267326A (de) |
| JP (1) | JPS5331676A (de) |
| AU (1) | AU513153B2 (de) |
| CH (1) | CH634567A5 (de) |
| DE (1) | DE2739912A1 (de) |
| DK (1) | DK142413B (de) |
| FI (1) | FI62071C (de) |
| FR (1) | FR2363563A1 (de) |
| GB (1) | GB1543467A (de) |
| HU (1) | HU177482B (de) |
| NL (1) | NL7709808A (de) |
| PH (1) | PH14000A (de) |
| PL (1) | PL108914B1 (de) |
| SE (1) | SE438856B (de) |
| SU (1) | SU795468A3 (de) |
| ZA (1) | ZA775361B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5379879A (en) * | 1976-12-23 | 1978-07-14 | Mitsui Toatsu Chem Inc | 1,3-substituted-5-fluorouracils and process for their preparation |
| JPS54122281A (en) * | 1978-03-13 | 1979-09-21 | Mitsui Toatsu Chem Inc | 5-fluorouracil derivative and its preparation |
| JPS5668674A (en) * | 1979-11-08 | 1981-06-09 | Shionogi & Co Ltd | 5-fluorouracil derivative |
| JPS5724369A (en) * | 1980-07-19 | 1982-02-08 | Tokyo Kinzoku Kogyo Kk | Pyrimidine derivative and its preparation |
| JPS5738774A (en) * | 1980-08-19 | 1982-03-03 | Chugai Pharmaceut Co Ltd | Uracil derivative and its preparation |
| EP0162924B1 (de) * | 1983-10-20 | 1989-12-13 | Terumo Kabushiki Kaisha | 5-fluoruracilabkömmlinge sowie medizinische zusammensetzungen die diese enthalten |
| DK197486A (da) * | 1986-04-30 | 1987-10-31 | Ferring Farma Lab | 5-fluoruracilprodug |
| US6051576A (en) * | 1994-01-28 | 2000-04-18 | University Of Kentucky Research Foundation | Means to achieve sustained release of synergistic drugs by conjugation |
| JP5732453B2 (ja) | 2009-06-25 | 2015-06-10 | アルカーメス ファーマ アイルランド リミテッド | Ｎｈ酸性化合物のプロドラッグ |
| US8431576B2 (en) | 2009-06-25 | 2013-04-30 | Alkermes Pharma Ireland Limited | Heterocyclic compounds for the treatment of neurological and psychological disorders |
| NZ730571A (en) | 2012-09-19 | 2018-12-21 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions having improved storage stability |
| EP3119399A4 (de) | 2014-03-20 | 2017-09-27 | Alkermes Pharma Ireland Limited | Aripiprazolformulierungen mit erhöhten injektionsgeschwindigkeiten |
| US11273158B2 (en) | 2018-03-05 | 2022-03-15 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| CN109761915B (zh) * | 2019-03-05 | 2021-12-21 | 沈阳药科大学 | 靶向mct1转运体的5-氟尿嘧啶成酯前药 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5324952B2 (de) * | 1973-11-28 | 1978-07-24 | ||
| JPS603071B2 (ja) * | 1975-02-17 | 1985-01-25 | 三井製薬工業株式会社 | １−（α−アシロキシアルキル）−５−フルオロウラシル類の製造方法 |
-
1976
- 1976-09-06 JP JP10571476A patent/JPS5331676A/ja active Granted
-
1977
- 1977-09-01 FI FI772594A patent/FI62071C/fi not_active IP Right Cessation
- 1977-09-02 HU HU77MI623A patent/HU177482B/hu unknown
- 1977-09-05 DK DK394477AA patent/DK142413B/da not_active IP Right Cessation
- 1977-09-05 SE SE7709942A patent/SE438856B/xx unknown
- 1977-09-05 GB GB36964/77A patent/GB1543467A/en not_active Expired
- 1977-09-05 DE DE19772739912 patent/DE2739912A1/de not_active Ceased
- 1977-09-06 SU SU772521748A patent/SU795468A3/ru active
- 1977-09-06 AU AU28571/77A patent/AU513153B2/en not_active Expired
- 1977-09-06 FR FR7726980A patent/FR2363563A1/fr active Granted
- 1977-09-06 CH CH1087377A patent/CH634567A5/de not_active IP Right Cessation
- 1977-09-06 PL PL1977200685A patent/PL108914B1/pl unknown
- 1977-09-06 PH PH20206A patent/PH14000A/en unknown
- 1977-09-06 ZA ZA00775361A patent/ZA775361B/xx unknown
- 1977-09-06 NL NL7709808A patent/NL7709808A/xx not_active Application Discontinuation
-
1979
- 1979-02-26 US US06/015,149 patent/US4267326A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI62071B (fi) | 1982-07-30 |
| FR2363563A1 (fr) | 1978-03-31 |
| FI62071C (fi) | 1982-11-10 |
| PL108914B1 (en) | 1980-05-31 |
| SE438856B (sv) | 1985-05-13 |
| PL200685A1 (pl) | 1978-10-09 |
| SU795468A3 (ru) | 1981-01-07 |
| PH14000A (en) | 1980-11-28 |
| GB1543467A (en) | 1979-04-04 |
| AU513153B2 (en) | 1980-11-20 |
| DK142413C (de) | 1981-03-23 |
| FI772594A (fi) | 1978-03-07 |
| ZA775361B (en) | 1978-07-26 |
| US4267326A (en) | 1981-05-12 |
| HU177482B (en) | 1981-10-28 |
| JPS5331676A (en) | 1978-03-25 |
| NL7709808A (nl) | 1978-03-08 |
| DK394477A (de) | 1978-03-07 |
| DE2739912A1 (de) | 1978-03-09 |
| JPS6114148B2 (de) | 1986-04-17 |
| SE7709942L (sv) | 1978-03-07 |
| FR2363563B1 (de) | 1980-06-20 |
| CH634567A5 (de) | 1983-02-15 |
| AU2857177A (en) | 1979-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |