PL206255B1
(pl)
*
|
2000-07-21 |
2010-07-30 |
Dendreon Corporationdendreon Corporation |
Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii
|
MY134070A
(en)
|
2001-01-22 |
2007-11-30 |
Isis Pharmaceuticals Inc |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
US6867185B2
(en)
*
|
2001-12-20 |
2005-03-15 |
Bristol-Myers Squibb Company |
Inhibitors of hepatitis C virus
|
CA2369711A1
(en)
*
|
2002-01-30 |
2003-07-30 |
Boehringer Ingelheim (Canada) Ltd. |
Macrocyclic peptides active against the hepatitis c virus
|
US7119072B2
(en)
|
2002-01-30 |
2006-10-10 |
Boehringer Ingelheim (Canada) Ltd. |
Macrocyclic peptides active against the hepatitis C virus
|
US6642204B2
(en)
|
2002-02-01 |
2003-11-04 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
CA2369970A1
(en)
*
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
US7091184B2
(en)
|
2002-02-01 |
2006-08-15 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
US6828301B2
(en)
|
2002-02-07 |
2004-12-07 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for hepatitis C viral protease inhibitors
|
NZ561851A
(en)
|
2002-04-11 |
2009-05-31 |
Vertex Pharma |
Inhibitors of serine proteases, particularly hepatitis C virus NS3 - NS4 protease
|
WO2004043339A2
(en)
|
2002-05-20 |
2004-05-27 |
Bristol-Myers Squibb Company |
Substituted cycloalkyl p1' hepatitis c virus inhibitors
|
EP1506000B9
(en)
|
2002-05-20 |
2011-08-31 |
Bristol-Myers Squibb Company |
Heterocyclicsulfonamide hepatitis c virus inhibitors
|
AU2003299519A1
(en)
|
2002-05-20 |
2004-05-04 |
Bristol-Myers Squibb Company |
Hepatitis c virus inhibitors
|
MY140680A
(en)
|
2002-05-20 |
2010-01-15 |
Bristol Myers Squibb Co |
Hepatitis c virus inhibitors
|
US20040138109A1
(en)
*
|
2002-09-30 |
2004-07-15 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Potent inhibitor of HCV serine protease
|
EP1408031A1
(en)
*
|
2002-10-09 |
2004-04-14 |
3 D Gene Pharma |
Pyrolidine derivatives useful in treatment of hepatitis C virus infection
|
US20050075279A1
(en)
|
2002-10-25 |
2005-04-07 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis C virus
|
CA2498653C
(en)
|
2002-10-29 |
2010-12-14 |
Boehringer Ingelheim International Gmbh |
Inhibitor-resistant hcv ns3 protease
|
US20050159345A1
(en)
*
|
2002-10-29 |
2005-07-21 |
Boehringer Ingelheim International Gmbh |
Composition for the treatment of infection by Flaviviridae viruses
|
US7601709B2
(en)
|
2003-02-07 |
2009-10-13 |
Enanta Pharmaceuticals, Inc. |
Macrocyclic hepatitis C serine protease inhibitors
|
KR100940619B1
(ko)
*
|
2003-02-07 |
2010-02-05 |
이난타 파마슈티칼스, 인코포레이티드 |
마크로사이클릭 씨형 간염 세린 단백효소 억제제
|
UY28240A1
(es)
*
|
2003-03-27 |
2004-11-08 |
Boehringer Ingelheim Pharma |
Fases cristalinas de un potente inhibidor de la hcv
|
CA2520886A1
(en)
|
2003-04-02 |
2004-11-04 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for hepatitis c viral protease inhibitors
|
JP2007523833A
(ja)
*
|
2003-04-10 |
2007-08-23 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
ルテニウム錯体触媒メタセシス反応による大環状化合物の製造方法
|
JP4231524B2
(ja)
|
2003-04-10 |
2009-03-04 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
大環状化合物の製造方法
|
ES2386161T3
(es)
*
|
2003-04-16 |
2012-08-10 |
Bristol-Myers Squibb Company |
Proceso para separar una mezcla de enantiómeros de éster alquílico usando una enzima
|
EP2143727B1
(en)
*
|
2003-04-18 |
2015-01-21 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
|
US7176208B2
(en)
|
2003-04-18 |
2007-02-13 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
|
MXPA05012545A
(es)
|
2003-05-21 |
2006-02-08 |
Boehringer Ingelheim Int |
Compuestos inhibidores de la hepatitis c.
|
US7273851B2
(en)
|
2003-06-05 |
2007-09-25 |
Enanta Pharmaceuticals, Inc. |
Tri-peptide hepatitis C serine protease inhibitors
|
US7125845B2
(en)
|
2003-07-03 |
2006-10-24 |
Enanta Pharmaceuticals, Inc. |
Aza-peptide macrocyclic hepatitis C serine protease inhibitors
|
PE20050374A1
(es)
|
2003-09-05 |
2005-05-30 |
Vertex Pharma |
Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc
|
MXPA06003141A
(es)
*
|
2003-09-22 |
2006-06-05 |
Boehringer Ingelheim Int |
Peptidos macrociclicos activos contra el virus de la hepatitis c.
|
JP4525982B2
(ja)
*
|
2003-09-26 |
2010-08-18 |
シェーリング コーポレイション |
C型肝炎ウイルスのns3セリンプロテアーゼの大環状インヒビター
|
KR20120010278A
(ko)
|
2003-10-10 |
2012-02-02 |
버텍스 파마슈티칼스 인코포레이티드 |
세린 프로테아제, 특히 hcv ns3-ns4a 프로테아제의 억제제
|
PL1680137T3
(pl)
*
|
2003-10-14 |
2013-04-30 |
F Hoffmann La Roche Ltd |
Makrocykliczny kwas karboksylowy i związek acylosulfonamidowy jako inhibitor replikacji HCV
|
CA2551074A1
(en)
|
2003-10-27 |
2005-05-12 |
Vertex Pharmaceuticals Incorporated |
Hcv ns3-ns4a protease resistance mutants
|
US8187874B2
(en)
|
2003-10-27 |
2012-05-29 |
Vertex Pharmaceuticals Incorporated |
Drug discovery method
|
EP1944042A1
(en)
|
2003-10-27 |
2008-07-16 |
Vertex Pharmceuticals Incorporated |
Combinations for HCV treatment
|
US7132504B2
(en)
|
2003-11-12 |
2006-11-07 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
US7309708B2
(en)
*
|
2003-11-20 |
2007-12-18 |
Birstol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
JP2007532479A
(ja)
*
|
2003-11-20 |
2007-11-15 |
シェーリング コーポレイション |
C型肝炎ウイルスns3プロテアーゼの脱ペプチド化インヒビター
|
WO2005053735A1
(en)
|
2003-11-20 |
2005-06-16 |
Boehringer Ingelheim International Gmbh |
Method of removing transition metals, especially from metathesis reaction products
|
US7135462B2
(en)
|
2003-11-20 |
2006-11-14 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
DE602004019973D1
(de)
*
|
2003-12-08 |
2009-04-23 |
Boehringer Ingelheim Int |
Abtrennung von ruthenium-nebenprodukten durch behandlung mit überkritischen flüssigkeiten
|
GB0500020D0
(en)
|
2005-01-04 |
2005-02-09 |
Novartis Ag |
Organic compounds
|
ES2358333T3
(es)
|
2004-01-21 |
2011-05-09 |
Boehringer Ingelheim International Gmbh |
Péptidos macrocíclicos con acción contra el virus de la hepatitis c.
|
EP1711514B1
(en)
*
|
2004-01-28 |
2008-12-03 |
Boehringer Ingelheim International GmbH |
Method of removing transition metals from reaction solutions comprising transition metal byproducts
|
ES2336009T3
(es)
*
|
2004-01-30 |
2010-04-07 |
Medivir Ab |
Inhibidores de la ns-3 serina proteasa del vhc.
|
AU2011203349B2
(en)
*
|
2004-01-30 |
2012-05-24 |
Medivir Ab |
HCV NS-3 serine protease inhibitors
|
WO2005077969A2
(en)
|
2004-02-04 |
2005-08-25 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
US20050182252A1
(en)
|
2004-02-13 |
2005-08-18 |
Reddy K. R. |
Novel 2'-C-methyl nucleoside derivatives
|
KR20120091276A
(ko)
|
2004-02-20 |
2012-08-17 |
베링거 인겔하임 인터내셔날 게엠베하 |
바이러스 폴리머라제 억제제
|
US20070049593A1
(en)
|
2004-02-24 |
2007-03-01 |
Japan Tobacco Inc. |
Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
|
EP1939213B1
(en)
|
2004-02-27 |
2010-08-25 |
Schering Corporation |
Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
|
US7635694B2
(en)
|
2004-02-27 |
2009-12-22 |
Schering Corporation |
Cyclobutenedione-containing compounds as inhibitors of hepatitis C virus NS3 serine protease
|
WO2005087730A1
(en)
|
2004-02-27 |
2005-09-22 |
Schering Corporation |
3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease
|
CA2557301A1
(en)
*
|
2004-02-27 |
2005-09-15 |
Schering Corporation |
Cyclobutenedione groups-containing compounds as inhibitors of hepatitis c virus ns3 serine protease
|
CA2557247A1
(en)
|
2004-02-27 |
2005-09-22 |
Schering Corporation |
Compounds as inhibitors of hepatitis c virus ns3 serine protease
|
KR20060124725A
(ko)
|
2004-02-27 |
2006-12-05 |
쉐링 코포레이션 |
C형 간염 바이러스 ns3 프로테아제의 억제제
|
AU2005224092A1
(en)
|
2004-03-15 |
2005-09-29 |
Boehringer Ingelheim International, Gmbh |
Process for preparing macrocyclic dipeptides which are suitable for the treatment of hepatitis C viral infections
|
WO2005095403A2
(en)
*
|
2004-03-30 |
2005-10-13 |
Intermune, Inc. |
Macrocyclic compounds as inhibitors of viral replication
|
CN1984922A
(zh)
|
2004-05-20 |
2007-06-20 |
先灵公司 |
用作丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的取代脯氨酸
|
WO2005123087A2
(en)
|
2004-06-15 |
2005-12-29 |
Merck & Co., Inc. |
C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase
|
US20070265222A1
(en)
|
2004-06-24 |
2007-11-15 |
Maccoss Malcolm |
Nucleoside Aryl Phosphoramidates for the Treatment of Rna-Dependent Rna Viral Infection
|
AP2461A
(en)
|
2004-07-16 |
2012-09-14 |
Gilead Sciences Inc |
Antiviral compounds
|
JP4914355B2
(ja)
|
2004-07-20 |
2012-04-11 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
C型肝炎インヒビターペプチド類似体
|
UY29016A1
(es)
|
2004-07-20 |
2006-02-24 |
Boehringer Ingelheim Int |
Analogos de dipeptidos inhibidores de la hepatitis c
|
CN101068828A
(zh)
|
2004-08-27 |
2007-11-07 |
先灵公司 |
用作丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的酰基磺酰胺化合物
|
EP1794179A1
(en)
*
|
2004-09-17 |
2007-06-13 |
Boehringer Ingelheim International Gmbh |
Ring-closing metathesis process in supercritical fluid
|
CA2577831A1
(en)
*
|
2004-09-17 |
2006-03-30 |
Boehringer Ingelheim International Gmbh |
Process for preparing macrocyclic hcv protease inhibitors
|
US20060068007A1
(en)
*
|
2004-09-24 |
2006-03-30 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Class of surfactant-like materials
|
CA2583152A1
(en)
*
|
2004-10-21 |
2006-04-27 |
Pfizer Inc. |
Inhibitors of hepatitis c virus protease, and compositions and treatments using the same
|
US7659263B2
(en)
|
2004-11-12 |
2010-02-09 |
Japan Tobacco Inc. |
Thienopyrrole compound and use thereof as HCV polymerase inhibitor
|
PT1835951E
(pt)
|
2004-12-20 |
2011-05-02 |
Tibotec Pharm Ltd |
Inibidor de vhc para utiliza??o num m?todo de tratamento da hepatite c
|
DE102005002336A1
(de)
|
2005-01-17 |
2006-07-20 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Durchführung von kontinuierlichen Olefin-Ringschluss-Metathesen in komprimiertem Kohlendioxid
|
US7323447B2
(en)
|
2005-02-08 |
2008-01-29 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
KR101514953B1
(ko)
*
|
2005-03-08 |
2015-04-24 |
베링거 인겔하임 인터내셔날 게엠베하 |
매크로사이클릭 화합물의 제조방법
|
CA2606195C
(en)
|
2005-05-02 |
2015-03-31 |
Merck And Co., Inc. |
Hcv ns3 protease inhibitors
|
US7592336B2
(en)
|
2005-05-10 |
2009-09-22 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
ES2415742T3
(es)
|
2005-05-13 |
2013-07-26 |
Vertex Pharmaceuticals (Canada) Incorporated |
Compuestos y procedimientos para el tratamiento o prevención de infecciones por flavivirus
|
PL1891089T3
(pl)
|
2005-06-02 |
2015-05-29 |
Merck Sharp & Dohme |
Inhibitory proteazy HCV w połączeniu z pokarmem
|
US20060276404A1
(en)
*
|
2005-06-02 |
2006-12-07 |
Anima Ghosal |
Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
|
AU2006252553B2
(en)
|
2005-06-02 |
2012-03-29 |
Merck Sharp & Dohme Corp. |
Combination of HCV protease inhibitors with a surfactant
|
US7608592B2
(en)
|
2005-06-30 |
2009-10-27 |
Virobay, Inc. |
HCV inhibitors
|
US7601686B2
(en)
|
2005-07-11 |
2009-10-13 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
TWI387603B
(zh)
|
2005-07-20 |
2013-03-01 |
Merck Sharp & Dohme |
Hcv ns3蛋白酶抑制劑
|
EP2305696A3
(en)
|
2005-07-25 |
2011-10-12 |
Intermune, Inc. |
Macrocyclic inhibitors of Hepatitis C virus replication
|
PL1919904T3
(pl)
*
|
2005-07-29 |
2014-06-30 |
Janssen R&D Ireland |
Makrocykliczne inhibitory wirusa zapalenia wątroby typu C
|
PE20070211A1
(es)
|
2005-07-29 |
2007-05-12 |
Medivir Ab |
Compuestos macrociclicos como inhibidores del virus de hepatitis c
|
CN101273028B
(zh)
*
|
2005-07-29 |
2013-08-21 |
泰博特克药品有限公司 |
丙型肝炎病毒的大环抑制剂
|
DK1919898T3
(da)
*
|
2005-07-29 |
2011-05-02 |
Tibotec Pharm Ltd |
Makrocykliske inhibitorer af hepatitis-C-virus
|
JO2768B1
(en)
*
|
2005-07-29 |
2014-03-15 |
تيبوتيك فارماسيوتيكالز ليمتد |
Large cyclic inhibitors of hepatitis C virus
|
PE20070343A1
(es)
|
2005-07-29 |
2007-05-12 |
Medivir Ab |
Inhibidores macrociclicos del virus de la hepatitis c
|
AP2387A
(en)
*
|
2005-07-29 |
2012-03-26 |
Tibotec Pharm Ltd |
Macrocyclic inhibitors of hepatitis C virus.
|
WO2007014924A1
(en)
|
2005-07-29 |
2007-02-08 |
Tibotec Pharmaceuticals Ltd. |
Macrocyclic inhibitors of hepatitis c virus
|
PE20070210A1
(es)
*
|
2005-07-29 |
2007-04-16 |
Tibotec Pharm Ltd |
Compuestos macrociclicos como inhibidores del virus de hepatitis c
|
DK1912997T3
(da)
*
|
2005-07-29 |
2012-01-02 |
Tibotec Pharm Ltd |
Makrocycliske inhibitorer af hepatitis C virus
|
MY144895A
(en)
*
|
2005-07-29 |
2011-11-30 |
Tibotec Pharm Ltd |
Macrocylic inhibitors of hepatitis c virus
|
AU2006275605B2
(en)
|
2005-08-01 |
2011-01-06 |
Merck Sharp & Dohme Corp. |
Macrocyclic peptides as HCV NS3 protease inhibitors
|
CA2617679A1
(en)
|
2005-08-02 |
2007-02-08 |
Steve Lyons |
Inhibitors of serine proteases
|
JP2009513564A
(ja)
|
2005-08-09 |
2009-04-02 |
メルク エンド カムパニー インコーポレーテッド |
Rna依存性rnaウイルス感染の治療用のリボヌクレオシド環状アセタール誘導体
|
CA2618682C
(en)
|
2005-08-12 |
2011-06-21 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
NZ566049A
(en)
|
2005-08-19 |
2011-07-29 |
Vertex Pharma |
Processes and intermediates
|
AR055395A1
(es)
|
2005-08-26 |
2007-08-22 |
Vertex Pharma |
Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
|
KR20080056295A
(ko)
|
2005-10-11 |
2008-06-20 |
인터뮨, 인크. |
C형 간염 바이러스 복제를 억제하기 위한 화합물 및 방법
|
US7772183B2
(en)
|
2005-10-12 |
2010-08-10 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
US7741281B2
(en)
|
2005-11-03 |
2010-06-22 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
US7705138B2
(en)
|
2005-11-11 |
2010-04-27 |
Vertex Pharmaceuticals Incorporated |
Hepatitis C virus variants
|
EP2392588A3
(en)
|
2005-11-11 |
2012-03-07 |
Vertex Pharmaceuticals Incorporated |
Hepatitis C virus variants
|
US7816348B2
(en)
|
2006-02-03 |
2010-10-19 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
GB0609492D0
(en)
|
2006-05-15 |
2006-06-21 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
US9526769B2
(en)
|
2006-06-06 |
2016-12-27 |
Enanta Pharmaceuticals, Inc. |
Macrocylic oximyl hepatitis C protease inhibitors
|
US8268776B2
(en)
|
2006-06-06 |
2012-09-18 |
Enanta Pharmaceuticals, Inc. |
Macrocylic oximyl hepatitis C protease inhibitors
|
GB0612423D0
(en)
|
2006-06-23 |
2006-08-02 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
UY30437A1
(es)
|
2006-06-26 |
2008-01-31 |
Enanta Pharm Inc |
Quinoxalinil macroceclicos inhibidores de serina proteasa del virus de la hepatitis c
|
RU2008152171A
(ru)
|
2006-07-05 |
2010-08-10 |
Интермьюн, Инк. (Us) |
Новые ингибиторы вирусной репликации гепатита с
|
EP2049474B1
(en)
|
2006-07-11 |
2015-11-04 |
Bristol-Myers Squibb Company |
Hepatitis c virus inhibitors
|
ES2448494T3
(es)
*
|
2006-07-13 |
2014-03-14 |
Achillion Pharmaceuticals, Inc. |
Péptidos de 4-amino-4-oxobutanoilo en calidad de inhibidores de la replicación viral
|
EP1886685A1
(en)
|
2006-08-11 |
2008-02-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition
|
MX2009000882A
(es)
|
2006-08-17 |
2009-02-04 |
Boehringer Ingelheim Int |
Inhibidores de la polimerasa virica.
|
AU2007309488B2
(en)
|
2006-10-24 |
2012-10-11 |
Merck Sharp & Dohme Corp. |
HCV NS3 protease inhibitors
|
CA2667165A1
(en)
|
2006-10-24 |
2008-05-02 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
US8138164B2
(en)
|
2006-10-24 |
2012-03-20 |
Merck Sharp & Dohme Corp. |
HCV NS3 protease inhibitors
|
WO2008057209A1
(en)
|
2006-10-27 |
2008-05-15 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
WO2008057208A2
(en)
|
2006-10-27 |
2008-05-15 |
Merck & Co., Inc. |
Hcv ns3 protease inhibitors
|
US8343477B2
(en)
|
2006-11-01 |
2013-01-01 |
Bristol-Myers Squibb Company |
Inhibitors of hepatitis C virus
|
US7772180B2
(en)
|
2006-11-09 |
2010-08-10 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
EA201101492A1
(ru)
|
2006-11-15 |
2012-09-28 |
Вирокем Фарма Инк. |
Аналоги тиофена для лечения или предупреждения флавивирусных инфекций
|
US7763584B2
(en)
|
2006-11-16 |
2010-07-27 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
US8003604B2
(en)
|
2006-11-16 |
2011-08-23 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
US7888464B2
(en)
|
2006-11-16 |
2011-02-15 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
MX2009005219A
(es)
|
2006-11-17 |
2009-05-27 |
Tibotec Pharm Ltd |
Inhibidores macrociclicos del virus de hepatitis c.
|
GB0625349D0
(en)
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
GB0625345D0
(en)
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
US8101595B2
(en)
|
2006-12-20 |
2012-01-24 |
Istituto di Ricerche di Biologia Molecolare P. Angletti SpA |
Antiviral indoles
|
AU2008209697B2
(en)
|
2007-02-01 |
2014-02-20 |
Janssen Sciences Ireland Uc |
Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV
|
JP5554570B2
(ja)
|
2007-02-08 |
2014-07-23 |
ヤンセン・アールアンドデイ・アイルランド |
Hcv阻害大環状フェニルカルバメート
|
EP2118091B1
(en)
*
|
2007-02-08 |
2015-04-15 |
Janssen Sciences Ireland UC |
Pyrimidine substituted macrocyclic hcv inhibitors
|
EP2495249A1
(en)
*
|
2007-02-26 |
2012-09-05 |
Achillion Pharmaceuticals, Inc. |
Tertiary amine substituted peptides useful as inhibitors of HCV replication
|
ATE548044T1
(de)
|
2007-05-04 |
2012-03-15 |
Vertex Pharma |
Kombinationstherapie zur behandlung von hiv- infektionen
|
AP2009005057A0
(en)
|
2007-05-10 |
2009-12-31 |
Array Biopharma Inc |
Novel peptide inhibitors of hepatitis c virus replication
|
AR067442A1
(es)
*
|
2007-06-29 |
2009-10-14 |
Gilead Sciences Inc |
Compuestos antivirales
|
US8513186B2
(en)
|
2007-06-29 |
2013-08-20 |
Gilead Sciences, Inc. |
Antiviral compounds
|
AU2008277440A1
(en)
|
2007-07-17 |
2009-01-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Macrocyclic indole derivatives for the treatment of hepatitis C infections
|
JP5433573B2
(ja)
|
2007-07-19 |
2014-03-05 |
イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ |
抗ウイルス剤としての大環状化合物
|
EP2188274A4
(en)
|
2007-08-03 |
2011-05-25 |
Boehringer Ingelheim Int |
VIRAL POLYMERASE HEMMER
|
GB0718575D0
(en)
|
2007-09-24 |
2007-10-31 |
Angeletti P Ist Richerche Bio |
Nucleoside derivatives as inhibitors of viral polymerases
|
US8383583B2
(en)
|
2007-10-26 |
2013-02-26 |
Enanta Pharmaceuticals, Inc. |
Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
|
EP2224942A4
(en)
|
2007-12-05 |
2012-01-25 |
Enanta Pharm Inc |
FLUORATED TRIPEPTIDE HCV SERINE PROTEASE INHIBITORS
|
US8193346B2
(en)
|
2007-12-06 |
2012-06-05 |
Enanta Pharmaceuticals, Inc. |
Process for making macrocyclic oximyl hepatitis C protease inhibitors
|
US8476257B2
(en)
|
2007-12-19 |
2013-07-02 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
US8202996B2
(en)
|
2007-12-21 |
2012-06-19 |
Bristol-Myers Squibb Company |
Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
|
WO2009099596A2
(en)
|
2008-02-04 |
2009-08-13 |
Idenix Pharamaceuticals, Inc. |
Macrocyclic serine protease inhibitors
|
EP2268619A4
(en)
|
2008-03-20 |
2012-04-04 |
Enanta Pharm Inc |
FLUORINATED MACROCYCLIC COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS
|
AU2009249443A1
(en)
|
2008-04-15 |
2009-11-26 |
Intermune, Inc. |
Novel macrocyclic inhibitors of hepatitis C virus replication
|
US8163921B2
(en)
|
2008-04-16 |
2012-04-24 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
AU2009241445A1
(en)
|
2008-04-28 |
2009-11-05 |
Merck Sharp & Dohme Corp. |
HCV NS3 protease inhibitors
|
US7964560B2
(en)
|
2008-05-29 |
2011-06-21 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
WO2009148923A1
(en)
*
|
2008-05-29 |
2009-12-10 |
Bristol-Myers Squibb Company |
Hepatitis c virus inhibitors
|
EP2310095B1
(en)
|
2008-07-22 |
2012-08-29 |
Merck Sharp & Dohme Corp. |
Macrocyclic quinoxaline compounds as hcv ns3 protease inhibitors
|
US8207341B2
(en)
|
2008-09-04 |
2012-06-26 |
Bristol-Myers Squibb Company |
Process or synthesizing substituted isoquinolines
|
UY32099A
(es)
|
2008-09-11 |
2010-04-30 |
Enanta Pharm Inc |
Inhibidores macrocíclicos de serina proteasas de hepatitis c
|
KR101653550B1
(ko)
|
2008-09-16 |
2016-09-02 |
베링거 인겔하임 인터내셔날 게엠베하 |
강력한 hcv 억제제인 2-티아졸릴-4-퀴놀리닐-옥시 유도체의 결정 형태
|
US8044087B2
(en)
|
2008-09-29 |
2011-10-25 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
US8563505B2
(en)
|
2008-09-29 |
2013-10-22 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
EP3025727A1
(en)
|
2008-10-02 |
2016-06-01 |
The J. David Gladstone Institutes |
Methods of treating liver disease
|
KR101634833B1
(ko)
|
2008-10-22 |
2016-06-29 |
어레이 바이오파마 인크. |
TRK 키나아제 억제제로서 치환된 피라졸로[1,5a] 피리미딘 화합물
|
NZ592110A
(en)
|
2008-11-20 |
2012-06-29 |
Achillion Pharmaceuticals Inc |
Cyclic carboxamide compounds and analogues thereof as of hepatitis c virus
|
EP2364309B1
(en)
|
2008-12-10 |
2014-10-01 |
Achillion Pharmaceuticals, Inc. |
New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
|
EP2364310B1
(en)
*
|
2008-12-10 |
2015-07-29 |
Achillion Pharmaceuticals, Inc. |
4-amino-4-oxobutanoyl peptide cyclic analogues, inhibitors of viral replication
|
US8283310B2
(en)
|
2008-12-15 |
2012-10-09 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
SG172848A1
(en)
|
2009-01-07 |
2011-08-29 |
Scynexis Inc |
Cyclosporine derivative for use in the treatment of hcv and hiv infection
|
WO2010082050A1
(en)
|
2009-01-16 |
2010-07-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections
|
GB0900914D0
(en)
|
2009-01-20 |
2009-03-04 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
AR075584A1
(es)
|
2009-02-27 |
2011-04-20 |
Intermune Inc |
COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
|
EP2403860B1
(en)
|
2009-03-04 |
2015-11-04 |
IDENIX Pharmaceuticals, Inc. |
Phosphothiophene and phosphothiazole as hcv polymerase inhibitors
|
US8975247B2
(en)
|
2009-03-18 |
2015-03-10 |
The Board Of Trustees Of The Leland Stanford Junion University |
Methods and compositions of treating a flaviviridae family viral infection
|
EP2417134B1
(en)
|
2009-04-08 |
2017-05-17 |
Idenix Pharmaceuticals LLC. |
Macrocyclic serine protease inhibitors
|
MX2011012155A
(es)
|
2009-05-13 |
2012-02-28 |
Enanta Pharm Inc |
Compuestos macrociclicos como inhibidores del virus de hepatitis c.
|
US8232246B2
(en)
|
2009-06-30 |
2012-07-31 |
Abbott Laboratories |
Anti-viral compounds
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
US8828930B2
(en)
|
2009-07-30 |
2014-09-09 |
Merck Sharp & Dohme Corp. |
Hepatitis C virus NS3 protease inhibitors
|
WO2011017389A1
(en)
|
2009-08-05 |
2011-02-10 |
Idenix Pharmaceuticals, Inc. |
Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv
|
US20110117055A1
(en)
|
2009-11-19 |
2011-05-19 |
Macdonald James E |
Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds
|
JP2013511562A
(ja)
*
|
2009-11-24 |
2013-04-04 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
C型肝炎阻害化合物
|
EP2504343A4
(en)
*
|
2009-11-24 |
2013-04-17 |
Boehringer Ingelheim Int |
HEPATITIS C INHIBITOR COMPOUNDS
|
WO2011068715A1
(en)
|
2009-11-25 |
2011-06-09 |
Vertex Pharmaceuticals Incorporated |
5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections
|
CN102822175A
(zh)
|
2009-12-18 |
2012-12-12 |
埃迪尼克斯医药公司 |
5,5-稠合的亚芳基或亚杂芳基丙型肝炎病毒抑制剂
|
JP2013515746A
(ja)
|
2009-12-24 |
2013-05-09 |
ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド |
フラビウイルス感染症の治療又は予防のための類似体
|
WO2011119853A1
(en)
|
2010-03-24 |
2011-09-29 |
Vertex Pharmaceuticals Incorporated |
Analogues for the treatment or prevention of flavivirus infections
|
JP2013522377A
(ja)
|
2010-03-24 |
2013-06-13 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
フラビウイルス感染を処置または予防するためのアナログ
|
TW201141857A
(en)
|
2010-03-24 |
2011-12-01 |
Vertex Pharma |
Analogues for the treatment or prevention of flavivirus infections
|
EP2550262A1
(en)
|
2010-03-24 |
2013-01-30 |
Vertex Pharmaceuticals Incorporated |
Analogues for the treatment or prevention of flavivirus infections
|
EP2918588B1
(en)
*
|
2010-05-20 |
2017-05-03 |
Array Biopharma, Inc. |
Macrocyclic compounds as TRK kinase inhibitors
|
WO2011156545A1
(en)
|
2010-06-09 |
2011-12-15 |
Vertex Pharmaceuticals Incorporated |
Viral dynamic model for hcv combination therapy
|
EP2582717A2
(en)
|
2010-06-15 |
2013-04-24 |
Vertex Pharmaceuticals Incorporated |
Hcv ns5b polymerase mutants
|
WO2012006060A1
(en)
|
2010-06-28 |
2012-01-12 |
Vertex Pharmaceuticals Incorporated |
Compounds and methods for the treatment or prevention of flavivirus infections
|
EP2585447A2
(en)
|
2010-06-28 |
2013-05-01 |
Vertex Pharmaceuticals Incorporated |
Compounds and methods for the treatment or prevention of flavivirus infections
|
WO2012006070A1
(en)
|
2010-06-28 |
2012-01-12 |
Vertex Pharmaceuticals Incorporated |
Compounds and methods for the treatment or prevention of flavivirus infections
|
CN103153978A
(zh)
|
2010-08-17 |
2013-06-12 |
沃泰克斯药物股份有限公司 |
用于治疗或预防黄病毒科病毒感染的化合物和方法
|
WO2012040167A1
(en)
|
2010-09-21 |
2012-03-29 |
Enanta Pharmaceuticals, Inc. |
Macrocyclic proline derived hcv serine protease inhibitors
|
CN103534256B
(zh)
|
2010-12-30 |
2016-08-10 |
益安药业 |
大环丙型肝炎丝氨酸蛋白酶抑制剂
|
WO2012092411A2
(en)
*
|
2010-12-30 |
2012-07-05 |
Enanta Pharmaceuticals, Inc. |
Phenanthridine macrocyclic hepatitis c serine protease inhibitors
|
AR085352A1
(es)
|
2011-02-10 |
2013-09-25 |
Idenix Pharmaceuticals Inc |
Inhibidores macrociclicos de serina proteasa, sus composiciones farmaceuticas y su uso para tratar infecciones por hcv
|
WO2012107589A1
(en)
|
2011-02-11 |
2012-08-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment and prevention of hcv infections
|
US20120252721A1
(en)
|
2011-03-31 |
2012-10-04 |
Idenix Pharmaceuticals, Inc. |
Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
|
US8957203B2
(en)
*
|
2011-05-05 |
2015-02-17 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
US10201584B1
(en)
|
2011-05-17 |
2019-02-12 |
Abbvie Inc. |
Compositions and methods for treating HCV
|
US8691757B2
(en)
|
2011-06-15 |
2014-04-08 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
WO2013016491A1
(en)
|
2011-07-26 |
2013-01-31 |
Vertex Pharmaceuticals Incorporated |
Thiophene compounds
|
WO2013016499A1
(en)
|
2011-07-26 |
2013-01-31 |
Vertex Pharmaceuticals Incorporated |
Methods for preparation of thiophene compounds
|
US9328138B2
(en)
|
2011-11-15 |
2016-05-03 |
Msd Italia S.R.L. |
HCV NS3 protease inhibitors
|
WO2013086133A1
(en)
|
2011-12-06 |
2013-06-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for treating viral diseases
|
MX352654B
(es)
*
|
2012-01-11 |
2017-12-04 |
Hoffmann La Roche |
Amidas macrociclicas como inhibidores de proteasas.
|
US20140356325A1
(en)
|
2012-01-12 |
2014-12-04 |
Ligand Pharmaceuticals Incorporated |
Novel 2'-c-methyl nucleoside derivative compounds
|
WO2013142157A1
(en)
|
2012-03-22 |
2013-09-26 |
Alios Biopharma, Inc. |
Pharmaceutical combinations comprising a thionucleotide analog
|
JP6154474B2
(ja)
*
|
2012-10-19 |
2017-06-28 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
C型肝炎ウイルス阻害剤
|
US9643999B2
(en)
*
|
2012-11-02 |
2017-05-09 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
US9598433B2
(en)
|
2012-11-02 |
2017-03-21 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
WO2014071007A1
(en)
|
2012-11-02 |
2014-05-08 |
Bristol-Myers Squibb Company |
Hepatitis c virus inhibitors
|
WO2014070974A1
(en)
|
2012-11-05 |
2014-05-08 |
Bristol-Myers Squibb Company |
Hepatitis c virus inhibitors
|
WO2014121417A1
(en)
|
2013-02-07 |
2014-08-14 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
|
WO2014121418A1
(en)
|
2013-02-07 |
2014-08-14 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
|
US20150065439A1
(en)
|
2013-02-28 |
2015-03-05 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions
|
WO2014137869A1
(en)
|
2013-03-07 |
2014-09-12 |
Bristol-Myers Squibb Company |
Hepatitis c virus inhibitors
|
WO2014138374A1
(en)
|
2013-03-08 |
2014-09-12 |
Boehringer Ingelheim International Gmbh |
Oral combination therapy for treating hcv infection in specific patient sub-population
|
WO2014145600A1
(en)
|
2013-03-15 |
2014-09-18 |
Achillion Pharmaceuticals, Inc. |
Ach-0142684 sodium salt polymorphs, composition including the same, and method of manufacture thereof
|
US9006423B2
(en)
|
2013-03-15 |
2015-04-14 |
Achillion Pharmaceuticals Inc. |
Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
|
WO2015042375A1
(en)
|
2013-09-20 |
2015-03-26 |
Idenix Pharmaceuticals, Inc. |
Hepatitis c virus inhibitors
|
EP3089757A1
(en)
|
2014-01-03 |
2016-11-09 |
AbbVie Inc. |
Solid antiviral dosage forms
|
EP3114122A1
(en)
|
2014-03-05 |
2017-01-11 |
Idenix Pharmaceuticals LLC |
Solid forms of a flaviviridae virus inhibitor compound and salts thereof
|
WO2015134561A1
(en)
|
2014-03-05 |
2015-09-11 |
Idenix Pharmaceuticals, Inc. |
Pharmaceutical compositions comprising a 5,5-fused heteroarylene flaviviridae inhibitor and their use for treating or preventing flaviviridae infection
|
DK3699181T3
(da)
|
2014-11-16 |
2023-03-20 |
Array Biopharma Inc |
Krystallinsk form af (s)-n-(5-((r)-2-(2,5-difluorphenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidin-1-carboxamidhydrogensulfat
|
BR112018008357A2
(pt)
|
2015-10-26 |
2018-11-27 |
Array Biopharma Inc |
mutações de ponto em câncer resistente a inibidor de trk e métodos relacionados às mesmas
|
RU2751767C2
(ru)
|
2016-04-04 |
2021-07-16 |
Локсо Онколоджи, Инк. |
Жидкие составы (s)-n-(5-((r)-2-(2,5-дифторфенил)пирролидин-1-ил)пиразоло[1,5-a]пиримидин-3-ил)-3-гидроксипирролидин-1-карбоксамида
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
LT3458456T
(lt)
|
2016-05-18 |
2021-02-25 |
Loxo Oncology, Inc. |
(s)-n-(5-((r)-2-(2,5-difluorfenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamido gavimas
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
CN108059625A
(zh)
*
|
2016-11-09 |
2018-05-22 |
广东广康生化科技股份有限公司 |
一种由噻唑酸制备噻呋酰胺的新型工艺
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
SG11201908863VA
(en)
|
2017-03-24 |
2019-10-30 |
Agency Science Tech & Res |
Building blocks for stapled peptides
|
MX2023005983A
(es)
|
2020-11-23 |
2023-08-15 |
Enanta Pharm Inc |
Nuevos agentes antivirales derivados de la espiropirrolidina.
|
WO2022235605A1
(en)
|
2021-05-04 |
2022-11-10 |
Enanta Pharmaceuticals, Inc. |
Novel macrocyclic antiviral agents
|
WO2022240541A1
(en)
*
|
2021-05-11 |
2022-11-17 |
Enanta Pharmaceuticals, Inc. |
Novel macrocyclic spiropyrrolidine derived antiviral agents
|
US11858945B2
(en)
|
2021-11-12 |
2024-01-02 |
Enanta Pharmaceuticals, Inc. |
Alkyne-containing antiviral agents
|
US11919910B2
(en)
|
2021-11-12 |
2024-03-05 |
Enanta Pharmaceuticals, Inc. |
Spiropyrrolidine derived antiviral agents
|
WO2023086352A1
(en)
|
2021-11-12 |
2023-05-19 |
Enanta Pharmaceuticals, Inc. |
Novel spiropyrrolidine derived antiviral agents
|
US11993600B2
(en)
|
2021-12-08 |
2024-05-28 |
Enanta Pharmaceuticals, Inc. |
Saturated spirocyclics as antiviral agents
|