DK1140915T3 - 4-(aminomethyl)-piperidinbenzamider til behandling af gastrointestinale forstyrrelser - Google Patents

4-(aminomethyl)-piperidinbenzamider til behandling af gastrointestinale forstyrrelser

Info

Publication number
DK1140915T3
DK1140915T3 DK99967956T DK99967956T DK1140915T3 DK 1140915 T3 DK1140915 T3 DK 1140915T3 DK 99967956 T DK99967956 T DK 99967956T DK 99967956 T DK99967956 T DK 99967956T DK 1140915 T3 DK1140915 T3 DK 1140915T3
Authority
DK
Denmark
Prior art keywords
aminomethyl
treatment
gastrointestinal disorders
piperidine benzamides
benzamides
Prior art date
Application number
DK99967956T
Other languages
Danish (da)
English (en)
Inventor
Jean-Paul Rene Marie A Bosmans
Cleyn Michel Anna Jozef De
Henricus Jacobus Maria Gijsen
Ann Louise Gabrielle Meulemans
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK1140915T3 publication Critical patent/DK1140915T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK99967956T 1998-12-22 1999-12-14 4-(aminomethyl)-piperidinbenzamider til behandling af gastrointestinale forstyrrelser DK1140915T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204411 1998-12-22
PCT/EP1999/010064 WO2000037461A1 (en) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders

Publications (1)

Publication Number Publication Date
DK1140915T3 true DK1140915T3 (da) 2005-10-10

Family

ID=8234539

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99967956T DK1140915T3 (da) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidinbenzamider til behandling af gastrointestinale forstyrrelser

Country Status (34)

Country Link
US (2) US6544997B1 (cs)
EP (1) EP1140915B1 (cs)
JP (1) JP4615725B2 (cs)
KR (1) KR100633680B1 (cs)
CN (1) CN1150190C (cs)
AR (1) AR024240A1 (cs)
AT (1) ATE297917T1 (cs)
AU (1) AU770397B2 (cs)
BG (1) BG64953B1 (cs)
BR (1) BR9916491A (cs)
CA (1) CA2355857C (cs)
CZ (1) CZ300851B6 (cs)
DE (1) DE69925865T2 (cs)
DK (1) DK1140915T3 (cs)
EA (1) EA003608B1 (cs)
EE (1) EE200100335A (cs)
ES (1) ES2245131T3 (cs)
HK (1) HK1039114B (cs)
HR (1) HRP20010445A2 (cs)
HU (1) HUP0104838A3 (cs)
ID (1) ID28953A (cs)
IL (1) IL143858A (cs)
MY (1) MY121852A (cs)
NO (1) NO321324B1 (cs)
NZ (1) NZ512871A (cs)
PL (1) PL197409B1 (cs)
PT (1) PT1140915E (cs)
SI (1) SI1140915T1 (cs)
SK (1) SK285829B6 (cs)
TR (1) TR200101962T2 (cs)
TW (1) TW570920B (cs)
UA (1) UA71591C2 (cs)
WO (1) WO2000037461A1 (cs)
ZA (1) ZA200105135B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002335161A1 (en) * 2002-09-12 2004-04-30 Nagase Chemtex Corporation Medicinal composition
DE602004029888D1 (en) 2003-06-19 2010-12-16 Janssen Pharmaceutica Nv Hydroxycarbonylphenyl substituierte 4-(aminomethyl)-piperidinbenzamide als 5ht4-antagonisten
EP2305254A1 (en) 2003-06-19 2011-04-06 Janssen Pharmaceutica NV Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists for the treatment of gatrointestinal conditions
JP4688799B2 (ja) * 2003-06-19 2011-05-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 5ht4−拮抗性4−(アミノメチル)−ピペリジンベンズアミド
JP4767844B2 (ja) * 2003-06-19 2011-09-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 5ht4−アンタゴニストとしての複素環式置換4−(アミノメチル)−ピペリジンベンズアミド
JO2478B1 (en) * 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
EA009457B1 (ru) * 2003-09-03 2007-12-28 Пфайзер Инк. Бензимидазолоновые соединения, обладающие агонистической активностью в отношении 5-нтрецепторов
JP4704353B2 (ja) * 2003-11-24 2011-06-15 ファイザー株式会社 5−ht4受容体アゴニスト活性を有するキノリンカルボン酸化合物
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
GEP20094638B (en) 2004-06-15 2009-03-10 Pfizer Benzimidazolone carboxylic acid derivatives
US20060035890A1 (en) * 2004-08-10 2006-02-16 Amit Banerjee Compounds and methods for the treatment of ubiquitin conjugating disorders
US7399862B2 (en) * 2004-11-05 2008-07-15 Theravance, Inc. 5-HT4 receptor agonist compounds
ES2327142T3 (es) * 2004-11-05 2009-10-26 Theravance, Inc. Compuestos de quinolinona-carboxamida.
DE602005021696D1 (de) * 2004-12-22 2010-07-15 Theravance Inc Indazolcarbonsäureamidverbindungen
EA013567B1 (ru) * 2005-03-02 2010-06-30 Тереванс, Инк. Хинолиноновые соединения в качестве агонистов рецептора 5-ht
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
WO2014134306A1 (en) 2013-03-01 2014-09-04 Zalicus Pharmaceuticals, Ltd. Heterocyclic inhibitors of the sodium channel
CA3001857A1 (en) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
EP3996746A4 (en) 2019-07-11 2023-08-23 Praxis Precision Medicines, Inc. FORMULATIONS OF T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
AU2435092A (en) 1991-08-20 1993-03-16 Smithkline Beecham Plc 5-ht4 receptor antagonists
ATE182591T1 (de) * 1991-09-12 1999-08-15 Smithkline Beecham Plc 5-ht4 rezeptor antagonisten
AU666702B2 (en) * 1992-01-23 1996-02-22 Toray Industries, Inc. Morphinan derivative and medicinal use
EP0625149A1 (en) * 1992-02-06 1994-11-23 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
GB9219163D0 (en) 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
JPH08502273A (ja) 1992-10-13 1996-03-12 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 5−ht▲下4▼レセプターアンタゴニスト用複素環式エステルまたはアミド
MX9306311A (es) 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
JPH08502741A (ja) * 1992-11-05 1996-03-26 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 5−ht▲下4▼レセプターアンタゴニスト用のピペリジン誘導体
GB9301660D0 (en) 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
ES2103675B1 (es) * 1995-01-10 1998-07-01 Almirall Lab Nuevas piperidinas sustituidas.
IT1275903B1 (it) 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
GB9507882D0 (en) 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
ES2208870T3 (es) * 1996-02-15 2004-06-16 Janssen Pharmaceutica N.V. Uso de antagonistas del receptor 5ht4 para resolver los efectos gastrointestinales de los inhibidores de la reabsorcion de serotonina.
TW445263B (en) 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
TW548103B (en) * 1997-07-11 2003-08-21 Janssen Pharmaceutica Nv Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
EP1112270B1 (en) * 1998-09-10 2007-03-21 F. Hoffmann-La Roche Ag Dihydrobenzodioxine carboxamide and ketone derivatives as 5-ht4 receptor antagonists
DE10217868A1 (de) * 2002-04-22 2003-10-30 Jomed N V Ballon-Katheter

Also Published As

Publication number Publication date
JP2002533337A (ja) 2002-10-08
UA71591C2 (en) 2004-12-15
DE69925865D1 (de) 2005-07-21
NZ512871A (en) 2002-11-26
JP4615725B2 (ja) 2011-01-19
MY121852A (en) 2006-02-28
US6544997B1 (en) 2003-04-08
BG105571A (en) 2002-01-31
CA2355857A1 (en) 2000-06-29
SK285829B6 (sk) 2007-09-06
HK1039114A1 (en) 2002-04-12
ES2245131T3 (es) 2005-12-16
NO321324B1 (no) 2006-04-24
TW570920B (en) 2004-01-11
AU2432800A (en) 2000-07-12
BR9916491A (pt) 2001-09-04
CN1331690A (zh) 2002-01-16
CZ20012117A3 (cs) 2001-10-17
CZ300851B6 (cs) 2009-08-26
US7205410B2 (en) 2007-04-17
WO2000037461A1 (en) 2000-06-29
HRP20010445A2 (en) 2002-06-30
PL197409B1 (pl) 2008-03-31
IL143858A (en) 2005-03-20
DE69925865T2 (de) 2006-05-11
US20030181456A1 (en) 2003-09-25
PT1140915E (pt) 2005-11-30
ID28953A (id) 2001-07-19
KR100633680B1 (ko) 2006-10-11
SI1140915T1 (sl) 2005-12-31
SK8592001A3 (en) 2002-02-05
CA2355857C (en) 2008-10-28
HUP0104838A2 (hu) 2002-07-29
EA003608B1 (ru) 2003-06-26
BG64953B1 (bg) 2006-10-31
NO20012858L (no) 2001-06-08
ATE297917T1 (de) 2005-07-15
CN1150190C (zh) 2004-05-19
EE200100335A (et) 2002-08-15
EP1140915A1 (en) 2001-10-10
PL348417A1 (en) 2002-05-20
AR024240A1 (es) 2002-09-25
EA200100710A1 (ru) 2001-12-24
TR200101962T2 (tr) 2002-04-22
IL143858A0 (en) 2002-04-21
EP1140915B1 (en) 2005-06-15
NO20012858D0 (no) 2001-06-08
AU770397B2 (en) 2004-02-19
HK1039114B (en) 2005-08-19
KR20010080293A (ko) 2001-08-22
ZA200105135B (en) 2002-06-21
HUP0104838A3 (en) 2003-05-28

Similar Documents

Publication Publication Date Title
DK1140915T3 (da) 4-(aminomethyl)-piperidinbenzamider til behandling af gastrointestinale forstyrrelser
ID24161A (id) Gastrokinetik benzamida bisiklik dari derivat-derivat 3-atau 4-tersubstitusi 4-(aminometil) - piperidin
DK1423381T3 (da) 17beta-hydroxysteroid-dehydrogenase type 3-inhibitorer til behandling af androgenafhængige sygdomme
IS7099A (is) Efnasambönd til að meðhöndla bólgutruflanir
DK1443955T3 (da) PDGF-BB til behandling af Parkinsons sygdom
DK1063990T3 (da) Anvendelse af Biochanin-beriget ekstrakt til behandling af östrogen-associerede lidelser
DK1343773T3 (da) Thiazolderivater til behandling af PPAR-beslægtede forstyrrelser
DK1474416T3 (da) Dihydrobenzodiazepin-2-on-derivater til behandlingen af neurologiske lidelser
DK1562932T3 (da) 4 tetrazolyl-4-phenylpiperidinderivater til behandling af smerter
DK1362857T3 (da) (S)-4-amino-5-chlor-2-methoxy-N-[1-[1-(2-tetrahydrofurylcarbonyl)-4-piperidinylmethyl]-4-piperidinyl]benzamid til behandling af gastrointestinale motilitetslidelser
DK0967214T3 (da) Intranasale formuleringer til behandling af seksuelle forstyrrelser
DK1231920T3 (da) Anvendelse af epinastin til behandling af allergisk rhinitis/conjunctivitis
DK1165510T3 (da) 1-arensulfonyl-2-aryl-pyrrolidin- og -piperidinderivater til behandling af CNS-lidelser
NO20033803D0 (no) Karbamat for behandling av bevegelseslidelser
NO20033417L (no) Anvendelse av CD23-antagonister for behandling av neoplastiske forstyrrelser
DE60222693D1 (de) Nk1-antagonisten
DK1344526T3 (da) Midler til forebyggelse/behandling af inflammatoriske luftvejslidelser
DE60236863D1 (de) Elektrisch beheizte einbaubohle
NO20042613L (no) Ny anvendelse for behandling av gastroosofagial refluks
DK1309322T3 (da) Anvendelse af 3-benzoylphenyleddikesyrederivater til behandling af retinale lidelser
DK1268482T3 (da) Pyranoindoler til behandling af glaukom
DK1373232T3 (da) Fremgangsmåde til fremstilling af N-substituerede 2,6-dialkylmorpholiner
NO20005216D0 (no) Sammensetning for behandling av eksterne sekresjonssykdommer unntatt hypolakrimasjon
DK1468686T3 (da) S-methyl-dihydro-ziprasidon til behandling af psykiatriske lidelser
NO20030717L (no) Forbindelser for behandling av avhengighetsforstyrrelser