EE200100335A - 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid - Google Patents

4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid

Info

Publication number
EE200100335A
EE200100335A EEP200100335A EEP200100335A EE200100335A EE 200100335 A EE200100335 A EE 200100335A EE P200100335 A EEP200100335 A EE P200100335A EE P200100335 A EEP200100335 A EE P200100335A EE 200100335 A EE200100335 A EE 200100335A
Authority
EE
Estonia
Prior art keywords
aminomethyl
intermediates
preparation
methods
pharmaceutical composition
Prior art date
Application number
EEP200100335A
Other languages
English (en)
Estonian (et)
Inventor
Ren Marie Andr Bosmans Jean-Paul
Louise Gabri�lle Meulemans Ann
Anna Jozef De Cleyn Michel
Jacobus Maria Gijsen Henricus
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200100335A publication Critical patent/EE200100335A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EEP200100335A 1998-12-22 1999-12-14 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid EE200100335A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204411 1998-12-22
PCT/EP1999/010064 WO2000037461A1 (en) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders

Publications (1)

Publication Number Publication Date
EE200100335A true EE200100335A (et) 2002-08-15

Family

ID=8234539

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100335A EE200100335A (et) 1998-12-22 1999-12-14 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid

Country Status (34)

Country Link
US (2) US6544997B1 (cs)
EP (1) EP1140915B1 (cs)
JP (1) JP4615725B2 (cs)
KR (1) KR100633680B1 (cs)
CN (1) CN1150190C (cs)
AR (1) AR024240A1 (cs)
AT (1) ATE297917T1 (cs)
AU (1) AU770397B2 (cs)
BG (1) BG64953B1 (cs)
BR (1) BR9916491A (cs)
CA (1) CA2355857C (cs)
CZ (1) CZ300851B6 (cs)
DE (1) DE69925865T2 (cs)
DK (1) DK1140915T3 (cs)
EA (1) EA003608B1 (cs)
EE (1) EE200100335A (cs)
ES (1) ES2245131T3 (cs)
HK (1) HK1039114B (cs)
HR (1) HRP20010445A2 (cs)
HU (1) HUP0104838A3 (cs)
ID (1) ID28953A (cs)
IL (1) IL143858A (cs)
MY (1) MY121852A (cs)
NO (1) NO321324B1 (cs)
NZ (1) NZ512871A (cs)
PL (1) PL197409B1 (cs)
PT (1) PT1140915E (cs)
SI (1) SI1140915T1 (cs)
SK (1) SK285829B6 (cs)
TR (1) TR200101962T2 (cs)
TW (1) TW570920B (cs)
UA (1) UA71591C2 (cs)
WO (1) WO2000037461A1 (cs)
ZA (1) ZA200105135B (cs)

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Publication number Priority date Publication date Assignee Title
WO2004024143A1 (ja) * 2002-09-12 2004-03-25 Nagase Chemtex Corporation 医薬組成物
PL1638959T3 (pl) 2003-06-19 2008-02-29 Janssen Pharmaceutica Nv 4-(Aminometylo)piperydynobenzamidy antagonistyczne względem 5HT4
JO2478B1 (en) 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
ES2336448T3 (es) * 2003-06-19 2010-04-13 Janssen Pharmaceutica Nv 4-(aminometil)-piperidina-benzamidas con sustituyentes heterociclicos como antagonistas de 5ht4.
WO2005000837A1 (en) * 2003-06-19 2005-01-06 Janssen Pharmaceutica N.V. Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
CA2528653C (en) 2003-06-19 2012-01-10 Janssen Pharmaceutica N.V. Hydroxycarbonylphenyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
OA13248A (en) * 2003-09-03 2007-01-31 Pfizer Benzimidazolone coumpounds having 5-HT4 receptor agonistic activity.
BRPI0416813A (pt) * 2003-11-24 2007-03-06 Pfizer compostos de ácido quinolonacarboxìlico com atividade agonista do receptor 5-ht4
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
EA200801607A1 (ru) 2004-06-15 2008-10-30 Пфайзер Инк. Производные бензимидазолонкарбоновой кислоты
US20060035890A1 (en) * 2004-08-10 2006-02-16 Amit Banerjee Compounds and methods for the treatment of ubiquitin conjugating disorders
EP1807423B1 (en) * 2004-11-05 2009-05-20 Theravance, Inc. Quinolinone-carboxamide compounds
DE602005016446D1 (de) * 2004-11-05 2009-10-15 Theravance Inc 5-HT4-Rezeptoragonistenverbindungen
CN101080406A (zh) * 2004-12-22 2007-11-28 施万制药 吲唑－甲酰胺化合物
EA013567B1 (ru) * 2005-03-02 2010-06-30 Тереванс, Инк. Хинолиноновые соединения в качестве агонистов рецептора 5-ht
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US8377968B2 (en) * 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
WO2014134306A1 (en) 2013-03-01 2014-09-04 Zalicus Pharmaceuticals, Ltd. Heterocyclic inhibitors of the sodium channel
CA3001857A1 (en) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
AU2020311942A1 (en) 2019-07-11 2022-02-24 Praxis Precision Medicines, Inc. Formulations of T-type calcium channel modulators and methods of use thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
EP0600955A1 (en) 1991-08-20 1994-06-15 Smithkline Beecham Plc 5-ht4 receptor antagonists
SG49153A1 (en) * 1991-09-12 1998-05-18 Smithkline Beecham Plc 5-HT4 receptor antagonists
CA2105072C (en) * 1992-01-23 1998-07-28 Hiroshi Nagase Morphinan derivative and its pharmaceutical applications
CA2129112A1 (en) * 1992-02-06 1993-08-19 Francis David King Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
US5708174A (en) 1992-03-12 1998-01-13 Smithkline Beecham P.L.C. Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists
GB9219163D0 (en) 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
MX9306311A (es) 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
KR950704328A (ko) * 1992-11-05 1995-11-17 데이비드 로버츠 5-HT₄ 수용체 길항제로서의 피페리딘 유도체(Piperidine Derivatives as 5-HT₄ Receptor Antagonists)
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
ES2103675B1 (es) * 1995-01-10 1998-07-01 Almirall Lab Nuevas piperidinas sustituidas.
IT1275903B1 (it) 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
GB9507882D0 (en) 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
DE69725345T2 (de) * 1996-02-15 2004-08-19 Janssen Pharmaceutica N.V. Verwendung von 5-ht4 antagonisten zur überwindung der gastrointestinalen beschädigung, die durch inhibitoren der serotonin-wiederaufnahme hervorgerufen werden
TW445263B (en) * 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
ATE357443T1 (de) * 1998-09-10 2007-04-15 Hoffmann La Roche Dihydrobenzodioxincarbonsäureamid- und ketonderivate als 5-ht4-rezeptorantagonisten
DE10217868A1 (de) * 2002-04-22 2003-10-30 Jomed N V Ballon-Katheter

Also Published As

Publication number Publication date
JP2002533337A (ja) 2002-10-08
DK1140915T3 (da) 2005-10-10
IL143858A (en) 2005-03-20
CA2355857A1 (en) 2000-06-29
HRP20010445A2 (en) 2002-06-30
TW570920B (en) 2004-01-11
AU770397B2 (en) 2004-02-19
BR9916491A (pt) 2001-09-04
WO2000037461A1 (en) 2000-06-29
NO321324B1 (no) 2006-04-24
JP4615725B2 (ja) 2011-01-19
NO20012858L (no) 2001-06-08
UA71591C2 (en) 2004-12-15
EA003608B1 (ru) 2003-06-26
EP1140915A1 (en) 2001-10-10
HK1039114B (en) 2005-08-19
AR024240A1 (es) 2002-09-25
US6544997B1 (en) 2003-04-08
KR100633680B1 (ko) 2006-10-11
NO20012858D0 (no) 2001-06-08
TR200101962T2 (tr) 2002-04-22
MY121852A (en) 2006-02-28
US20030181456A1 (en) 2003-09-25
EA200100710A1 (ru) 2001-12-24
BG105571A (en) 2002-01-31
HUP0104838A2 (hu) 2002-07-29
DE69925865D1 (de) 2005-07-21
CN1150190C (zh) 2004-05-19
CZ20012117A3 (cs) 2001-10-17
PT1140915E (pt) 2005-11-30
PL348417A1 (en) 2002-05-20
SK285829B6 (sk) 2007-09-06
BG64953B1 (bg) 2006-10-31
PL197409B1 (pl) 2008-03-31
AU2432800A (en) 2000-07-12
HK1039114A1 (en) 2002-04-12
KR20010080293A (ko) 2001-08-22
ES2245131T3 (es) 2005-12-16
CZ300851B6 (cs) 2009-08-26
ZA200105135B (en) 2002-06-21
IL143858A0 (en) 2002-04-21
CN1331690A (zh) 2002-01-16
ATE297917T1 (de) 2005-07-15
HUP0104838A3 (en) 2003-05-28
SI1140915T1 (sl) 2005-12-31
NZ512871A (en) 2002-11-26
US7205410B2 (en) 2007-04-17
EP1140915B1 (en) 2005-06-15
SK8592001A3 (en) 2002-02-05
CA2355857C (en) 2008-10-28
DE69925865T2 (de) 2006-05-11
ID28953A (id) 2001-07-19

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