HRP20010445A2 - 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders - Google Patents

4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders Download PDF

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Publication number
HRP20010445A2
HRP20010445A2 HR20010445A HRP20010445A HRP20010445A2 HR P20010445 A2 HRP20010445 A2 HR P20010445A2 HR 20010445 A HR20010445 A HR 20010445A HR P20010445 A HRP20010445 A HR P20010445A HR P20010445 A2 HRP20010445 A2 HR P20010445A2
Authority
HR
Croatia
Prior art keywords
formula
alkyl
hydroxy
hydrogen
image
Prior art date
Application number
HR20010445A
Other languages
English (en)
Croatian (hr)
Inventor
Jean-Paul Rene Marie A Bosmans
Ann
Michel Anna Josef De Cleyn
Henricus
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HRP20010445A2 publication Critical patent/HRP20010445A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR20010445A 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders HRP20010445A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204411 1998-12-22
PCT/EP1999/010064 WO2000037461A1 (en) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders

Publications (1)

Publication Number Publication Date
HRP20010445A2 true HRP20010445A2 (en) 2002-06-30

Family

ID=8234539

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010445A HRP20010445A2 (en) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders

Country Status (34)

Country Link
US (2) US6544997B1 (cs)
EP (1) EP1140915B1 (cs)
JP (1) JP4615725B2 (cs)
KR (1) KR100633680B1 (cs)
CN (1) CN1150190C (cs)
AR (1) AR024240A1 (cs)
AT (1) ATE297917T1 (cs)
AU (1) AU770397B2 (cs)
BG (1) BG64953B1 (cs)
BR (1) BR9916491A (cs)
CA (1) CA2355857C (cs)
CZ (1) CZ300851B6 (cs)
DE (1) DE69925865T2 (cs)
DK (1) DK1140915T3 (cs)
EA (1) EA003608B1 (cs)
EE (1) EE200100335A (cs)
ES (1) ES2245131T3 (cs)
HK (1) HK1039114B (cs)
HR (1) HRP20010445A2 (cs)
HU (1) HUP0104838A3 (cs)
ID (1) ID28953A (cs)
IL (1) IL143858A (cs)
MY (1) MY121852A (cs)
NO (1) NO321324B1 (cs)
NZ (1) NZ512871A (cs)
PL (1) PL197409B1 (cs)
PT (1) PT1140915E (cs)
SI (1) SI1140915T1 (cs)
SK (1) SK285829B6 (cs)
TR (1) TR200101962T2 (cs)
TW (1) TW570920B (cs)
UA (1) UA71591C2 (cs)
WO (1) WO2000037461A1 (cs)
ZA (1) ZA200105135B (cs)

Families Citing this family (24)

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Publication number Priority date Publication date Assignee Title
US7485665B2 (en) * 2002-09-12 2009-02-03 Nagase Chemtex Corporation Medicinal composition
PL1641783T3 (pl) 2003-06-19 2012-08-31 Janssen Pharmaceutica Nv 4-(aminometylo)-piperydyno-benzamidy podstawione aminosulfonylem jako antagoniści 5HT₄
PT1638959E (pt) * 2003-06-19 2007-12-12 Janssen Pharmaceutica Nv 4-(aminometil)piperidinobenzamidas antagonistas de 5ht4
JO2478B1 (en) * 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
JP4688798B2 (ja) * 2003-06-19 2011-05-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５ｈｔ４−アンタゴニストとしてのヒドロキシカルボニルフェニル置換４−（アミノメチル）−ピペリジンベンズアミド
US7732464B2 (en) * 2003-06-19 2010-06-08 Janssen Pharmaceutica, N.V. Heterocyclic substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists
ATE539077T1 (de) * 2003-09-03 2012-01-15 Pfizer Benzimidazolonverbindungen mit agonistischer wirkung am 5-ht4 rezeptor
DE602004026095D1 (de) * 2003-11-24 2010-04-29 Pfizer Chinoloncarbonsäureverbindungen mit 5-ht4-rezeptoragonistischer wirkung
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
EA200801608A1 (ru) 2004-06-15 2008-10-30 Пфайзер Инк. Производные бензимидазолонкарбоновой кислоты
US20060035890A1 (en) * 2004-08-10 2006-02-16 Amit Banerjee Compounds and methods for the treatment of ubiquitin conjugating disorders
DE602005016446D1 (de) * 2004-11-05 2009-10-15 Theravance Inc 5-HT4-Rezeptoragonistenverbindungen
WO2006052889A2 (en) * 2004-11-05 2006-05-18 Theravance, Inc. Quinolinone-carboxamide compounds
CN101080406A (zh) * 2004-12-22 2007-11-28 施万制药 吲唑－甲酰胺化合物
MX2007010769A (es) * 2005-03-02 2008-03-07 Theravance Inc Compuestos de quinolina como agonistas de receptor 5-ht4.
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US8377968B2 (en) * 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
WO2014134306A1 (en) 2013-03-01 2014-09-04 Zalicus Pharmaceuticals, Ltd. Heterocyclic inhibitors of the sodium channel
US20180305334A1 (en) * 2015-10-14 2018-10-25 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
WO2021007487A1 (en) 2019-07-11 2021-01-14 Praxis Precision Medicines, Inc. Formulations of t-type calcium channel modulators and methods of use thereof

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
NZ243993A (en) 1991-08-20 1994-10-26 Smithkline Beecham Plc Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
US5580885A (en) * 1991-09-12 1996-12-03 Smithkline Beecham P.L.C. 5-HT4 receptor antagonists
DK0577847T3 (da) * 1992-01-23 1999-06-23 Toray Industries Morphinanderivat og medicinsk anvendelse deraf
JPH07503480A (ja) * 1992-02-06 1995-04-13 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４拮抗薬としてのベンゾピラン，ベンゾチオピランおよびベンゾフラン誘導体
US5708174A (en) 1992-03-12 1998-01-13 Smithkline Beecham P.L.C. Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists
GB9219163D0 (en) 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
MX9306311A (es) 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
NZ257545A (en) * 1992-11-05 1997-01-29 Smithkline Beecham Plc Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
ES2103675B1 (es) * 1995-01-10 1998-07-01 Almirall Lab Nuevas piperidinas sustituidas.
IT1275903B1 (it) 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
EP0977558B1 (en) * 1996-02-15 2003-10-01 Janssen Pharmaceutica N.V. Use of 5ht4 receptor antagonists for overcoming gastrointestinal effects of serotonin reuptake inhibitors
TW445263B (en) * 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
AU758807B2 (en) * 1998-09-10 2003-03-27 F. Hoffmann-La Roche Ag Dihydrobenzodioxine carboxamide and ketone derivatives as 5-HT4 receptor antagonists
DE10217868A1 (de) * 2002-04-22 2003-10-30 Jomed N V Ballon-Katheter

Also Published As

Publication number Publication date
JP4615725B2 (ja) 2011-01-19
HUP0104838A3 (en) 2003-05-28
DK1140915T3 (da) 2005-10-10
BR9916491A (pt) 2001-09-04
EP1140915A1 (en) 2001-10-10
WO2000037461A1 (en) 2000-06-29
SK8592001A3 (en) 2002-02-05
NZ512871A (en) 2002-11-26
IL143858A0 (en) 2002-04-21
ZA200105135B (en) 2002-06-21
HUP0104838A2 (hu) 2002-07-29
BG64953B1 (bg) 2006-10-31
JP2002533337A (ja) 2002-10-08
HK1039114A1 (en) 2002-04-12
DE69925865T2 (de) 2006-05-11
NO20012858L (no) 2001-06-08
US6544997B1 (en) 2003-04-08
IL143858A (en) 2005-03-20
ES2245131T3 (es) 2005-12-16
ATE297917T1 (de) 2005-07-15
CA2355857C (en) 2008-10-28
CN1150190C (zh) 2004-05-19
PT1140915E (pt) 2005-11-30
PL348417A1 (en) 2002-05-20
EA003608B1 (ru) 2003-06-26
BG105571A (en) 2002-01-31
US7205410B2 (en) 2007-04-17
MY121852A (en) 2006-02-28
CZ20012117A3 (cs) 2001-10-17
TR200101962T2 (tr) 2002-04-22
NO20012858D0 (no) 2001-06-08
AR024240A1 (es) 2002-09-25
CA2355857A1 (en) 2000-06-29
EP1140915B1 (en) 2005-06-15
US20030181456A1 (en) 2003-09-25
EA200100710A1 (ru) 2001-12-24
HK1039114B (en) 2005-08-19
AU770397B2 (en) 2004-02-19
PL197409B1 (pl) 2008-03-31
SI1140915T1 (sl) 2005-12-31
ID28953A (id) 2001-07-19
SK285829B6 (sk) 2007-09-06
KR20010080293A (ko) 2001-08-22
TW570920B (en) 2004-01-11
DE69925865D1 (de) 2005-07-21
KR100633680B1 (ko) 2006-10-11
AU2432800A (en) 2000-07-12
CN1331690A (zh) 2002-01-16
NO321324B1 (no) 2006-04-24
UA71591C2 (en) 2004-12-15
CZ300851B6 (cs) 2009-08-26
EE200100335A (et) 2002-08-15

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