AR024240A1 - COMPUESTOS DE 4-(AMINOMETIL)-PIPERIDIN BENZAMIDA uTILES PARA TRATAR TRASTORNOS GASTROINTESTINALES, COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE, PROCESO PARA PREPARAR DICHA COMPOSICIoN FARMACÉUTICA, COMPUESTO INTERMEDIARIO uTIL PARA PREPARA DICHOS COMPUESTOS DE BENZAMIDA, PROCESO PARA PREPARAR DICHOS - Google Patents

COMPUESTOS DE 4-(AMINOMETIL)-PIPERIDIN BENZAMIDA uTILES PARA TRATAR TRASTORNOS GASTROINTESTINALES, COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE, PROCESO PARA PREPARAR DICHA COMPOSICIoN FARMACÉUTICA, COMPUESTO INTERMEDIARIO uTIL PARA PREPARA DICHOS COMPUESTOS DE BENZAMIDA, PROCESO PARA PREPARAR DICHOS

Info

Publication number
AR024240A1
AR024240A1 ARP990106644A ARP990106644A AR024240A1 AR 024240 A1 AR024240 A1 AR 024240A1 AR P990106644 A ARP990106644 A AR P990106644A AR P990106644 A ARP990106644 A AR P990106644A AR 024240 A1 AR024240 A1 AR 024240A1
Authority
AR
Argentina
Prior art keywords
preparation
pharmaceutical composition
prepare
compounds
gastrointestinal disorders
Prior art date
Application number
ARP990106644A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR024240A1 publication Critical patent/AR024240A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compuestos de formula (1) su forma estereoquímicamente isomérica, su forma de N-oxido o su sal de adicion de ácido farmacéuticamente aceptable, en donde R1R2, R3, R4, R5, L tienen los significados dados en la memoria descriptiva. Se describen ademásun proceso para su preparacion , composiciones farmacéuticas, enparticular para el tratamiento o prevencion de trastornos gastrointestinales, que comprenden dichos compuestos intermediarios.
ARP990106644A 1998-12-22 1999-12-21 COMPUESTOS DE 4-(AMINOMETIL)-PIPERIDIN BENZAMIDA uTILES PARA TRATAR TRASTORNOS GASTROINTESTINALES, COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE, PROCESO PARA PREPARAR DICHA COMPOSICIoN FARMACÉUTICA, COMPUESTO INTERMEDIARIO uTIL PARA PREPARA DICHOS COMPUESTOS DE BENZAMIDA, PROCESO PARA PREPARAR DICHOS AR024240A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98204411 1998-12-22

Publications (1)

Publication Number Publication Date
AR024240A1 true AR024240A1 (es) 2002-09-25

Family

ID=8234539

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990106644A AR024240A1 (es) 1998-12-22 1999-12-21 COMPUESTOS DE 4-(AMINOMETIL)-PIPERIDIN BENZAMIDA uTILES PARA TRATAR TRASTORNOS GASTROINTESTINALES, COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE, PROCESO PARA PREPARAR DICHA COMPOSICIoN FARMACÉUTICA, COMPUESTO INTERMEDIARIO uTIL PARA PREPARA DICHOS COMPUESTOS DE BENZAMIDA, PROCESO PARA PREPARAR DICHOS

Country Status (34)

Country Link
US (2) US6544997B1 (es)
EP (1) EP1140915B1 (es)
JP (1) JP4615725B2 (es)
KR (1) KR100633680B1 (es)
CN (1) CN1150190C (es)
AR (1) AR024240A1 (es)
AT (1) ATE297917T1 (es)
AU (1) AU770397B2 (es)
BG (1) BG64953B1 (es)
BR (1) BR9916491A (es)
CA (1) CA2355857C (es)
CZ (1) CZ300851B6 (es)
DE (1) DE69925865T2 (es)
DK (1) DK1140915T3 (es)
EA (1) EA003608B1 (es)
EE (1) EE200100335A (es)
ES (1) ES2245131T3 (es)
HK (1) HK1039114B (es)
HR (1) HRP20010445A2 (es)
HU (1) HUP0104838A3 (es)
ID (1) ID28953A (es)
IL (1) IL143858A (es)
MY (1) MY121852A (es)
NO (1) NO321324B1 (es)
NZ (1) NZ512871A (es)
PL (1) PL197409B1 (es)
PT (1) PT1140915E (es)
SI (1) SI1140915T1 (es)
SK (1) SK285829B6 (es)
TR (1) TR200101962T2 (es)
TW (1) TW570920B (es)
UA (1) UA71591C2 (es)
WO (1) WO2000037461A1 (es)
ZA (1) ZA200105135B (es)

Families Citing this family (24)

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WO2004024143A1 (ja) * 2002-09-12 2004-03-25 Nagase Chemtex Corporation 医薬組成物
JO2478B1 (en) * 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
EA008514B1 (ru) * 2003-06-19 2007-06-29 Янссен Фармацевтика Н.В. Гетероциклические замещенные 4-(аминометил)пиперидин бензамиды в качестве 5-нт-антагонистов
EP1641782B1 (en) 2003-06-19 2010-11-03 Janssen Pharmaceutica NV Hydroxycarbonylphenyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
WO2005003122A1 (en) * 2003-06-19 2005-01-13 Janssen Pharmaceutica N.V. 5ht4-antagonistic 4-(aminomethyl)-piperidine benzamides
AU2004251823B2 (en) * 2003-06-19 2010-06-03 Janssen Pharmaceutica N.V. Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists
ES2377484T3 (es) * 2003-09-03 2012-03-28 Pfizer, Inc. Compuestos de bencimidazolona que tiene actividad agonista del receptor 5-HT
JP4704353B2 (ja) * 2003-11-24 2011-06-15 ファイザー株式会社 ５−ｈｔ４受容体アゴニスト活性を有するキノリンカルボン酸化合物
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
GEP20094638B (en) 2004-06-15 2009-03-10 Pfizer Benzimidazolone carboxylic acid derivatives
US20060035890A1 (en) * 2004-08-10 2006-02-16 Amit Banerjee Compounds and methods for the treatment of ubiquitin conjugating disorders
WO2006052889A2 (en) * 2004-11-05 2006-05-18 Theravance, Inc. Quinolinone-carboxamide compounds
EP1807422B1 (en) * 2004-11-05 2009-09-02 Theravance, Inc. 5-ht4 receptor agonist compounds
US7419989B2 (en) * 2004-12-22 2008-09-02 Theravance, Inc. Indazole-carboxamide compounds
CN101163701A (zh) * 2005-03-02 2008-04-16 施万制药 作为5-ht4受体激动剂的喹啉酮化合物
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
WO2014134306A1 (en) 2013-03-01 2014-09-04 Zalicus Pharmaceuticals, Ltd. Heterocyclic inhibitors of the sodium channel
CA3001857A1 (en) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
TW202116314A (zh) 2019-07-11 2021-05-01 美商普雷西斯精密藥品公司 T型鈣離子通道調節劑之調配物及其使用方法

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NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
AU2435092A (en) 1991-08-20 1993-03-16 Smithkline Beecham Plc 5-ht4 receptor antagonists
DK0604494T3 (da) * 1991-09-12 1999-11-29 Smithkline Beecham Plc 5-HT4-receptorantagonister
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AU667874B2 (en) * 1992-02-06 1996-04-18 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists
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CA2146930A1 (en) 1992-10-13 1994-04-28 Francis David King Heterocyclic -esters or -amides used as 5-ht4 receptor antagonists
MX9306311A (es) 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
KR950704328A (ko) 1992-11-05 1995-11-17 데이비드 로버츠 5-HT₄ 수용체 길항제로서의 피페리딘 유도체(Piperidine Derivatives as 5-HT₄ Receptor Antagonists)
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Also Published As

Publication number Publication date
DK1140915T3 (da) 2005-10-10
EP1140915A1 (en) 2001-10-10
PL348417A1 (en) 2002-05-20
CZ20012117A3 (cs) 2001-10-17
HK1039114A1 (en) 2002-04-12
AU770397B2 (en) 2004-02-19
CN1331690A (zh) 2002-01-16
BR9916491A (pt) 2001-09-04
CN1150190C (zh) 2004-05-19
WO2000037461A1 (en) 2000-06-29
CZ300851B6 (cs) 2009-08-26
SK8592001A3 (en) 2002-02-05
PT1140915E (pt) 2005-11-30
JP2002533337A (ja) 2002-10-08
NO20012858L (no) 2001-06-08
SI1140915T1 (sl) 2005-12-31
KR100633680B1 (ko) 2006-10-11
NO321324B1 (no) 2006-04-24
MY121852A (en) 2006-02-28
HK1039114B (zh) 2005-08-19
AU2432800A (en) 2000-07-12
EA200100710A1 (ru) 2001-12-24
KR20010080293A (ko) 2001-08-22
IL143858A0 (en) 2002-04-21
ES2245131T3 (es) 2005-12-16
CA2355857C (en) 2008-10-28
HRP20010445A2 (en) 2002-06-30
TR200101962T2 (tr) 2002-04-22
US20030181456A1 (en) 2003-09-25
ID28953A (id) 2001-07-19
ATE297917T1 (de) 2005-07-15
DE69925865T2 (de) 2006-05-11
NO20012858D0 (no) 2001-06-08
DE69925865D1 (de) 2005-07-21
SK285829B6 (sk) 2007-09-06
BG105571A (en) 2002-01-31
CA2355857A1 (en) 2000-06-29
UA71591C2 (en) 2004-12-15
TW570920B (en) 2004-01-11
IL143858A (en) 2005-03-20
ZA200105135B (en) 2002-06-21
EP1140915B1 (en) 2005-06-15
EE200100335A (et) 2002-08-15
HUP0104838A2 (hu) 2002-07-29
BG64953B1 (bg) 2006-10-31
PL197409B1 (pl) 2008-03-31
US6544997B1 (en) 2003-04-08
EA003608B1 (ru) 2003-06-26
JP4615725B2 (ja) 2011-01-19
US7205410B2 (en) 2007-04-17
HUP0104838A3 (en) 2003-05-28
NZ512871A (en) 2002-11-26

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