EE200100335A - 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid - Google Patents

4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid

Info

Publication number
EE200100335A
EE200100335A EEP200100335A EEP200100335A EE200100335A EE 200100335 A EE200100335 A EE 200100335A EE P200100335 A EEP200100335 A EE P200100335A EE P200100335 A EEP200100335 A EE P200100335A EE 200100335 A EE200100335 A EE 200100335A
Authority
EE
Estonia
Prior art keywords
aminomethyl
intermediates
preparation
methods
pharmaceutical composition
Prior art date
Application number
EEP200100335A
Other languages
English (en)
Estonian (et)
Inventor
Ren Marie Andr Bosmans Jean-Paul
Louise Gabri�lle Meulemans Ann
Anna Jozef De Cleyn Michel
Jacobus Maria Gijsen Henricus
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200100335A publication Critical patent/EE200100335A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EEP200100335A 1998-12-22 1999-12-14 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid EE200100335A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204411 1998-12-22
PCT/EP1999/010064 WO2000037461A1 (en) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders

Publications (1)

Publication Number Publication Date
EE200100335A true EE200100335A (et) 2002-08-15

Family

ID=8234539

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100335A EE200100335A (et) 1998-12-22 1999-12-14 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid

Country Status (34)

Country Link
US (2) US6544997B1 (es)
EP (1) EP1140915B1 (es)
JP (1) JP4615725B2 (es)
KR (1) KR100633680B1 (es)
CN (1) CN1150190C (es)
AR (1) AR024240A1 (es)
AT (1) ATE297917T1 (es)
AU (1) AU770397B2 (es)
BG (1) BG64953B1 (es)
BR (1) BR9916491A (es)
CA (1) CA2355857C (es)
CZ (1) CZ300851B6 (es)
DE (1) DE69925865T2 (es)
DK (1) DK1140915T3 (es)
EA (1) EA003608B1 (es)
EE (1) EE200100335A (es)
ES (1) ES2245131T3 (es)
HK (1) HK1039114B (es)
HR (1) HRP20010445A2 (es)
HU (1) HUP0104838A3 (es)
ID (1) ID28953A (es)
IL (1) IL143858A (es)
MY (1) MY121852A (es)
NO (1) NO321324B1 (es)
NZ (1) NZ512871A (es)
PL (1) PL197409B1 (es)
PT (1) PT1140915E (es)
SI (1) SI1140915T1 (es)
SK (1) SK285829B6 (es)
TR (1) TR200101962T2 (es)
TW (1) TW570920B (es)
UA (1) UA71591C2 (es)
WO (1) WO2000037461A1 (es)
ZA (1) ZA200105135B (es)

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US7485665B2 (en) * 2002-09-12 2009-02-03 Nagase Chemtex Corporation Medicinal composition
DE602004024200D1 (de) 2003-06-19 2009-12-31 Janssen Pharmaceutica Nv Heterocyclisch substituierte 4-(aminomethyl)-piperidinbenzamide als 5ht4-antagonisten
JP4688798B2 (ja) * 2003-06-19 2011-05-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５ｈｔ４−アンタゴニストとしてのヒドロキシカルボニルフェニル置換４−（アミノメチル）−ピペリジンベンズアミド
WO2005000837A1 (en) * 2003-06-19 2005-01-06 Janssen Pharmaceutica N.V. Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
PL1638959T3 (pl) * 2003-06-19 2008-02-29 Janssen Pharmaceutica Nv 4-(Aminometylo)piperydynobenzamidy antagonistyczne względem 5HT4
JO2478B1 (en) * 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
PL1664036T3 (pl) * 2003-09-03 2012-04-30 Pfizer Związki benzimidazolonu wykazujące działanie agonistyczne względem receptora 5-ht4
DK1689742T3 (da) * 2003-11-24 2010-05-17 Pfizer Quinoloncarboxylsyreforbindelser med 5-HT-receptor-agonistisk aktivitet
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
WO2005123718A2 (en) 2004-06-15 2005-12-29 Pfizer Japan Inc. Benzimidazolone carboxylic acid derivatives
US20060035890A1 (en) * 2004-08-10 2006-02-16 Amit Banerjee Compounds and methods for the treatment of ubiquitin conjugating disorders
EP1807423B1 (en) * 2004-11-05 2009-05-20 Theravance, Inc. Quinolinone-carboxamide compounds
WO2006052640A1 (en) * 2004-11-05 2006-05-18 Theravance, Inc. 5-ht4 receptor agonist compounds
US7419989B2 (en) * 2004-12-22 2008-09-02 Theravance, Inc. Indazole-carboxamide compounds
MX2007010769A (es) * 2005-03-02 2008-03-07 Theravance Inc Compuestos de quinolina como agonistas de receptor 5-ht4.
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
EP2961403A4 (en) 2013-03-01 2016-11-30 Zalicus Pharmaceuticals Ltd HETEROCYCLIC INHIBITORS OF SODIUM CHANNEL
WO2017066705A1 (en) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
TW202116314A (zh) 2019-07-11 2021-05-01 美商普雷西斯精密藥品公司 T型鈣離子通道調節劑之調配物及其使用方法

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NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
AU2435092A (en) 1991-08-20 1993-03-16 Smithkline Beecham Plc 5-ht4 receptor antagonists
ATE182591T1 (de) * 1991-09-12 1999-08-15 Smithkline Beecham Plc 5-ht4 rezeptor antagonisten
US6323212B1 (en) * 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
AU667874B2 (en) * 1992-02-06 1996-04-18 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists
WO1994008994A1 (en) 1992-10-13 1994-04-28 Smithkline Beecham Plc Heterocyclic -esters or -amides used as 5-ht4 receptor antagonists
GB9219163D0 (en) 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
MX9306311A (es) 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
US5705498A (en) * 1992-11-05 1998-01-06 Smithkline Beecham Plc. Piperidine derivatives as 5-HT4 receptor antagonists
GB9301660D0 (en) 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
ES2103675B1 (es) * 1995-01-10 1998-07-01 Almirall Lab Nuevas piperidinas sustituidas.
IT1275903B1 (it) 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
JP2000516198A (ja) * 1996-02-15 2000-12-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ セロトニンの再取り込み阻害剤の胃腸に対する作用を克服するための５ｈｔ４レセプター拮抗剤の使用
TW445263B (en) 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
TR200100698T2 (tr) * 1998-09-10 2001-07-23 F.Hoffmann-La Roche Ag 5-HT4 alıcı-Antagonistleri olarak Dihidrobenzodioksin Karboksamit ve Keton türevleri
DE10217868A1 (de) * 2002-04-22 2003-10-30 Jomed N V Ballon-Katheter

Also Published As

Publication number Publication date
CN1331690A (zh) 2002-01-16
HRP20010445A2 (en) 2002-06-30
SK8592001A3 (en) 2002-02-05
CZ20012117A3 (cs) 2001-10-17
EA003608B1 (ru) 2003-06-26
PT1140915E (pt) 2005-11-30
KR20010080293A (ko) 2001-08-22
MY121852A (en) 2006-02-28
NO20012858L (no) 2001-06-08
DE69925865D1 (de) 2005-07-21
CZ300851B6 (cs) 2009-08-26
JP4615725B2 (ja) 2011-01-19
WO2000037461A1 (en) 2000-06-29
AU770397B2 (en) 2004-02-19
HUP0104838A2 (hu) 2002-07-29
ZA200105135B (en) 2002-06-21
BG105571A (en) 2002-01-31
BG64953B1 (bg) 2006-10-31
EP1140915A1 (en) 2001-10-10
EP1140915B1 (en) 2005-06-15
US7205410B2 (en) 2007-04-17
NO321324B1 (no) 2006-04-24
IL143858A0 (en) 2002-04-21
KR100633680B1 (ko) 2006-10-11
JP2002533337A (ja) 2002-10-08
SI1140915T1 (sl) 2005-12-31
HUP0104838A3 (en) 2003-05-28
PL197409B1 (pl) 2008-03-31
ATE297917T1 (de) 2005-07-15
UA71591C2 (en) 2004-12-15
EA200100710A1 (ru) 2001-12-24
DE69925865T2 (de) 2006-05-11
AU2432800A (en) 2000-07-12
ID28953A (id) 2001-07-19
BR9916491A (pt) 2001-09-04
HK1039114B (zh) 2005-08-19
PL348417A1 (en) 2002-05-20
AR024240A1 (es) 2002-09-25
SK285829B6 (sk) 2007-09-06
CA2355857C (en) 2008-10-28
HK1039114A1 (en) 2002-04-12
CN1150190C (zh) 2004-05-19
US6544997B1 (en) 2003-04-08
ES2245131T3 (es) 2005-12-16
IL143858A (en) 2005-03-20
US20030181456A1 (en) 2003-09-25
TR200101962T2 (tr) 2002-04-22
CA2355857A1 (en) 2000-06-29
NZ512871A (en) 2002-11-26
DK1140915T3 (da) 2005-10-10
NO20012858D0 (no) 2001-06-08
TW570920B (en) 2004-01-11

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