DE69925865D1 - 4-(aminomethyl)-piperidinbenzamide zur behandlung von gastrointestinalen störungen - Google Patents

4-(aminomethyl)-piperidinbenzamide zur behandlung von gastrointestinalen störungen

Info

Publication number
DE69925865D1
DE69925865D1 DE69925865T DE69925865T DE69925865D1 DE 69925865 D1 DE69925865 D1 DE 69925865D1 DE 69925865 T DE69925865 T DE 69925865T DE 69925865 T DE69925865 T DE 69925865T DE 69925865 D1 DE69925865 D1 DE 69925865D1
Authority
DE
Germany
Prior art keywords
piperidinbenzamides
aminomethyl
treatment
gastrointestinal disorder
gastrointestinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69925865T
Other languages
English (en)
Other versions
DE69925865T2 (de
Inventor
Rene Bosmans
Louise Meulemans
Cleyn Anna De
Jacobus Gijsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE69925865D1 publication Critical patent/DE69925865D1/de
Application granted granted Critical
Publication of DE69925865T2 publication Critical patent/DE69925865T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69925865T 1998-12-22 1999-12-14 4-(aminomethyl)-piperidinbenzamide zur behandlung von gastrointestinalen störungen Expired - Lifetime DE69925865T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98204411 1998-12-22
EP98204411 1998-12-22
PCT/EP1999/010064 WO2000037461A1 (en) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders

Publications (2)

Publication Number Publication Date
DE69925865D1 true DE69925865D1 (de) 2005-07-21
DE69925865T2 DE69925865T2 (de) 2006-05-11

Family

ID=8234539

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69925865T Expired - Lifetime DE69925865T2 (de) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidinbenzamide zur behandlung von gastrointestinalen störungen

Country Status (34)

Country Link
US (2) US6544997B1 (de)
EP (1) EP1140915B1 (de)
JP (1) JP4615725B2 (de)
KR (1) KR100633680B1 (de)
CN (1) CN1150190C (de)
AR (1) AR024240A1 (de)
AT (1) ATE297917T1 (de)
AU (1) AU770397B2 (de)
BG (1) BG64953B1 (de)
BR (1) BR9916491A (de)
CA (1) CA2355857C (de)
CZ (1) CZ300851B6 (de)
DE (1) DE69925865T2 (de)
DK (1) DK1140915T3 (de)
EA (1) EA003608B1 (de)
EE (1) EE200100335A (de)
ES (1) ES2245131T3 (de)
HK (1) HK1039114B (de)
HR (1) HRP20010445A2 (de)
HU (1) HUP0104838A3 (de)
ID (1) ID28953A (de)
IL (1) IL143858A (de)
MY (1) MY121852A (de)
NO (1) NO321324B1 (de)
NZ (1) NZ512871A (de)
PL (1) PL197409B1 (de)
PT (1) PT1140915E (de)
SI (1) SI1140915T1 (de)
SK (1) SK285829B6 (de)
TR (1) TR200101962T2 (de)
TW (1) TW570920B (de)
UA (1) UA71591C2 (de)
WO (1) WO2000037461A1 (de)
ZA (1) ZA200105135B (de)

Families Citing this family (24)

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Publication number Priority date Publication date Assignee Title
WO2004024143A1 (ja) * 2002-09-12 2004-03-25 Nagase Chemtex Corporation 医薬組成物
WO2005003122A1 (en) 2003-06-19 2005-01-13 Janssen Pharmaceutica N.V. 5ht4-antagonistic 4-(aminomethyl)-piperidine benzamides
AU2004251823B2 (en) * 2003-06-19 2010-06-03 Janssen Pharmaceutica N.V. Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists
ES2336448T3 (es) 2003-06-19 2010-04-13 Janssen Pharmaceutica Nv 4-(aminometil)-piperidina-benzamidas con sustituyentes heterociclicos como antagonistas de 5ht4.
JO2478B1 (en) * 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
EP1641782B1 (de) * 2003-06-19 2010-11-03 Janssen Pharmaceutica NV Hydroxycarbonylphenyl substituierte 4-(aminomethyl)-piperidinbenzamide als 5ht4-antagonisten
BRPI0414105B8 (pt) * 2003-09-03 2021-05-25 Askat Inc compostos de benzimidazolona com atividade agonista do receptor 5-ht4
EP1689742B1 (de) * 2003-11-24 2010-03-17 Pfizer, Inc. Chinoloncarbonsäureverbindungen mit 5-ht4-rezeptoragonistischer wirkung
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
EP1758891A2 (de) 2004-06-15 2007-03-07 Pfizer Japan Inc. Benzimidazoloncarbonsäurederivate
US20060035890A1 (en) * 2004-08-10 2006-02-16 Amit Banerjee Compounds and methods for the treatment of ubiquitin conjugating disorders
ATE431824T1 (de) * 2004-11-05 2009-06-15 Theravance Inc Chinolinon-carboxamid-verbindungen
DE602005016446D1 (de) * 2004-11-05 2009-10-15 Theravance Inc 5-HT4-Rezeptoragonistenverbindungen
ES2347265T3 (es) * 2004-12-22 2010-10-27 Theravance, Inc. Compuestos de indazol-carboxamida.
KR20070107807A (ko) * 2005-03-02 2007-11-07 세라밴스 인코포레이티드 5-ｈｔ4 수용체 아고니스트인 퀴놀리논 화합물
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US8377968B2 (en) * 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
US10208023B2 (en) 2013-03-01 2019-02-19 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel
WO2017066705A1 (en) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
MX2022000492A (es) 2019-07-11 2022-07-04 Praxis Prec Medicines Inc Formulaciones de moduladores de canal de calcio tipo t y metodos de uso de estos.

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
JPH06510283A (ja) 1991-08-20 1994-11-17 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４レセプター拮抗薬
SG49153A1 (en) * 1991-09-12 1998-05-18 Smithkline Beecham Plc 5-HT4 receptor antagonists
DE69321525T2 (de) * 1992-01-23 1999-03-04 Toray Industries Morphinan-derivate und medizinische verwendung
AU667874B2 (en) * 1992-02-06 1996-04-18 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists
GB9219163D0 (en) 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
MX9306311A (es) 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
JPH08502273A (ja) 1992-10-13 1996-03-12 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ▲下４▼レセプターアンタゴニスト用複素環式エステルまたはアミド
AU680453B2 (en) 1992-11-05 1997-07-31 Smithkline Beecham Plc Piperidine derivatives as 5-HT4 receptor antagonists
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
ES2103675B1 (es) * 1995-01-10 1998-07-01 Almirall Lab Nuevas piperidinas sustituidas.
IT1275903B1 (it) 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
KR100469029B1 (ko) * 1996-02-15 2005-05-27 얀센 파마슈티카 엔.브이. 세로토닌재흡수억제제의위장효과를극복하기위한5ht4수용체길항제의용도
TW445263B (en) * 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
TW548103B (en) * 1997-07-11 2003-08-21 Janssen Pharmaceutica Nv Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
EP1112270B1 (de) * 1998-09-10 2007-03-21 F. Hoffmann-La Roche Ag Dihydrobenzodioxincarbonsäureamid- und ketonderivate als 5-ht4-rezeptorantagonisten
DE10217868A1 (de) * 2002-04-22 2003-10-30 Jomed N V Ballon-Katheter

Also Published As

Publication number Publication date
EA003608B1 (ru) 2003-06-26
TW570920B (en) 2004-01-11
ATE297917T1 (de) 2005-07-15
TR200101962T2 (tr) 2002-04-22
KR100633680B1 (ko) 2006-10-11
PL348417A1 (en) 2002-05-20
BG64953B1 (bg) 2006-10-31
SK285829B6 (sk) 2007-09-06
UA71591C2 (en) 2004-12-15
US20030181456A1 (en) 2003-09-25
CA2355857A1 (en) 2000-06-29
ID28953A (id) 2001-07-19
CZ300851B6 (cs) 2009-08-26
JP2002533337A (ja) 2002-10-08
BR9916491A (pt) 2001-09-04
US7205410B2 (en) 2007-04-17
WO2000037461A1 (en) 2000-06-29
MY121852A (en) 2006-02-28
AR024240A1 (es) 2002-09-25
PT1140915E (pt) 2005-11-30
IL143858A (en) 2005-03-20
NO20012858L (no) 2001-06-08
CN1331690A (zh) 2002-01-16
NZ512871A (en) 2002-11-26
EA200100710A1 (ru) 2001-12-24
HUP0104838A3 (en) 2003-05-28
CZ20012117A3 (cs) 2001-10-17
SK8592001A3 (en) 2002-02-05
EE200100335A (et) 2002-08-15
ZA200105135B (en) 2002-06-21
CN1150190C (zh) 2004-05-19
EP1140915A1 (de) 2001-10-10
IL143858A0 (en) 2002-04-21
CA2355857C (en) 2008-10-28
HUP0104838A2 (hu) 2002-07-29
SI1140915T1 (sl) 2005-12-31
AU770397B2 (en) 2004-02-19
JP4615725B2 (ja) 2011-01-19
AU2432800A (en) 2000-07-12
HK1039114B (zh) 2005-08-19
BG105571A (en) 2002-01-31
ES2245131T3 (es) 2005-12-16
HRP20010445A2 (en) 2002-06-30
HK1039114A1 (en) 2002-04-12
KR20010080293A (ko) 2001-08-22
US6544997B1 (en) 2003-04-08
DE69925865T2 (de) 2006-05-11
DK1140915T3 (da) 2005-10-10
PL197409B1 (pl) 2008-03-31
NO20012858D0 (no) 2001-06-08
NO321324B1 (no) 2006-04-24
EP1140915B1 (de) 2005-06-15

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