EE200100335A - 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid - Google Patents

4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid

Info

Publication number
EE200100335A
EE200100335A EEP200100335A EEP200100335A EE200100335A EE 200100335 A EE200100335 A EE 200100335A EE P200100335 A EEP200100335 A EE P200100335A EE P200100335 A EEP200100335 A EE P200100335A EE 200100335 A EE200100335 A EE 200100335A
Authority
EE
Estonia
Prior art keywords
aminomethyl
intermediates
preparation
methods
pharmaceutical composition
Prior art date
Application number
EEP200100335A
Other languages
English (en)
Inventor
Ren Marie Andr Bosmans Jean-Paul
Louise Gabri�lle Meulemans Ann
Anna Jozef De Cleyn Michel
Jacobus Maria Gijsen Henricus
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200100335A publication Critical patent/EE200100335A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EEP200100335A 1998-12-22 1999-12-14 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid EE200100335A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204411 1998-12-22
PCT/EP1999/010064 WO2000037461A1 (en) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders

Publications (1)

Publication Number Publication Date
EE200100335A true EE200100335A (et) 2002-08-15

Family

ID=8234539

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100335A EE200100335A (et) 1998-12-22 1999-12-14 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid

Country Status (34)

Country Link
US (2) US6544997B1 (et)
EP (1) EP1140915B1 (et)
JP (1) JP4615725B2 (et)
KR (1) KR100633680B1 (et)
CN (1) CN1150190C (et)
AR (1) AR024240A1 (et)
AT (1) ATE297917T1 (et)
AU (1) AU770397B2 (et)
BG (1) BG64953B1 (et)
BR (1) BR9916491A (et)
CA (1) CA2355857C (et)
CZ (1) CZ300851B6 (et)
DE (1) DE69925865T2 (et)
DK (1) DK1140915T3 (et)
EA (1) EA003608B1 (et)
EE (1) EE200100335A (et)
ES (1) ES2245131T3 (et)
HK (1) HK1039114B (et)
HR (1) HRP20010445A2 (et)
HU (1) HUP0104838A3 (et)
ID (1) ID28953A (et)
IL (1) IL143858A (et)
MY (1) MY121852A (et)
NO (1) NO321324B1 (et)
NZ (1) NZ512871A (et)
PL (1) PL197409B1 (et)
PT (1) PT1140915E (et)
SI (1) SI1140915T1 (et)
SK (1) SK285829B6 (et)
TR (1) TR200101962T2 (et)
TW (1) TW570920B (et)
UA (1) UA71591C2 (et)
WO (1) WO2000037461A1 (et)
ZA (1) ZA200105135B (et)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100370983C (zh) * 2002-09-12 2008-02-27 长濑化成株式会社 药物组合物
AU2004254191B2 (en) * 2003-06-19 2010-03-11 Janssen Pharmaceutica N.V. Hydroxycarbonylphenyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists
EA009259B1 (ru) * 2003-06-19 2007-12-28 Янссен Фармацевтика Н.В. Аминосульфонилзамещенные 4-(аминометил)пиперидинбензамиды в качестве 5ht-антагонистов
EA008514B1 (ru) * 2003-06-19 2007-06-29 Янссен Фармацевтика Н.В. Гетероциклические замещенные 4-(аминометил)пиперидин бензамиды в качестве 5-нт-антагонистов
WO2005003122A1 (en) * 2003-06-19 2005-01-13 Janssen Pharmaceutica N.V. 5ht4-antagonistic 4-(aminomethyl)-piperidine benzamides
JO2478B1 (en) * 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
GEP20084527B (en) * 2003-09-03 2008-11-10 Pfizer Benzimidazolone compounds having 5-ht4 receptor agonistic activity
DK1689742T3 (da) * 2003-11-24 2010-05-17 Pfizer Quinoloncarboxylsyreforbindelser med 5-HT-receptor-agonistisk aktivitet
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
MXPA06014486A (es) 2004-06-15 2007-03-01 Pfizer Derivados de acido carboxilico de bencimidazolona.
US20060035890A1 (en) * 2004-08-10 2006-02-16 Amit Banerjee Compounds and methods for the treatment of ubiquitin conjugating disorders
EP1807422B1 (en) * 2004-11-05 2009-09-02 Theravance, Inc. 5-ht4 receptor agonist compounds
US7396933B2 (en) * 2004-11-05 2008-07-08 Theravance, Inc. Quinolinone-carboxamide compounds
ATE469897T1 (de) * 2004-12-22 2010-06-15 Theravance Inc Indazolcarbonsäureamidverbindungen
BRPI0608392A2 (pt) * 2005-03-02 2009-12-29 Theravance Inc compostos de quinolinona como agonistas do receptor 5-ht4
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
US10208023B2 (en) 2013-03-01 2019-02-19 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel
WO2017066705A1 (en) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
CN114340670A (zh) 2019-07-11 2022-04-12 普拉克西斯精密药物股份有限公司 T-型钙通道调节剂的制剂及其使用方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
NZ243993A (en) 1991-08-20 1994-10-26 Smithkline Beecham Plc Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
ATE182591T1 (de) * 1991-09-12 1999-08-15 Smithkline Beecham Plc 5-ht4 rezeptor antagonisten
ES2121988T3 (es) * 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.
NZ246915A (en) * 1992-02-06 1996-05-28 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives, preparation and pharmaceutical compositions thereof
US5708174A (en) 1992-03-12 1998-01-13 Smithkline Beecham P.L.C. Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists
GB9219163D0 (en) 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
MX9306311A (es) 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
AU680453B2 (en) 1992-11-05 1997-07-31 Smithkline Beecham Plc Piperidine derivatives as 5-HT4 receptor antagonists
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
ES2103675B1 (es) * 1995-01-10 1998-07-01 Almirall Lab Nuevas piperidinas sustituidas.
IT1275903B1 (it) 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
JP2000516198A (ja) * 1996-02-15 2000-12-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ セロトニンの再取り込み阻害剤の胃腸に対する作用を克服するための５ｈｔ４レセプター拮抗剤の使用
TW445263B (en) * 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
TW548103B (en) * 1997-07-11 2003-08-21 Janssen Pharmaceutica Nv Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
CA2340952C (en) * 1998-09-10 2009-12-08 F. Hoffmann-La Roche Ag Dihydrobenzodioxine carboxamide and ketone derivatives as 5-ht4 receptor antagonists
DE10217868A1 (de) * 2002-04-22 2003-10-30 Jomed N V Ballon-Katheter

Also Published As

Publication number Publication date
CN1150190C (zh) 2004-05-19
EA003608B1 (ru) 2003-06-26
CA2355857C (en) 2008-10-28
EA200100710A1 (ru) 2001-12-24
PL197409B1 (pl) 2008-03-31
UA71591C2 (en) 2004-12-15
US20030181456A1 (en) 2003-09-25
KR100633680B1 (ko) 2006-10-11
JP2002533337A (ja) 2002-10-08
PT1140915E (pt) 2005-11-30
ID28953A (id) 2001-07-19
IL143858A (en) 2005-03-20
HRP20010445A2 (en) 2002-06-30
HK1039114A1 (en) 2002-04-12
JP4615725B2 (ja) 2011-01-19
ATE297917T1 (de) 2005-07-15
KR20010080293A (ko) 2001-08-22
EP1140915A1 (en) 2001-10-10
BR9916491A (pt) 2001-09-04
HUP0104838A3 (en) 2003-05-28
DK1140915T3 (da) 2005-10-10
NO321324B1 (no) 2006-04-24
US6544997B1 (en) 2003-04-08
AR024240A1 (es) 2002-09-25
ES2245131T3 (es) 2005-12-16
AU2432800A (en) 2000-07-12
DE69925865T2 (de) 2006-05-11
DE69925865D1 (de) 2005-07-21
CN1331690A (zh) 2002-01-16
PL348417A1 (en) 2002-05-20
HK1039114B (zh) 2005-08-19
SI1140915T1 (sl) 2005-12-31
CZ300851B6 (cs) 2009-08-26
NO20012858D0 (no) 2001-06-08
TR200101962T2 (tr) 2002-04-22
SK285829B6 (sk) 2007-09-06
MY121852A (en) 2006-02-28
HUP0104838A2 (hu) 2002-07-29
NZ512871A (en) 2002-11-26
BG64953B1 (bg) 2006-10-31
US7205410B2 (en) 2007-04-17
IL143858A0 (en) 2002-04-21
AU770397B2 (en) 2004-02-19
EP1140915B1 (en) 2005-06-15
CA2355857A1 (en) 2000-06-29
BG105571A (en) 2002-01-31
TW570920B (en) 2004-01-11
SK8592001A3 (en) 2002-02-05
NO20012858L (no) 2001-06-08
WO2000037461A1 (en) 2000-06-29
ZA200105135B (en) 2002-06-21
CZ20012117A3 (cs) 2001-10-17

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