DK1109558T3 - Ranolazinformuleringer med langvarig frigivelse - Google Patents

Ranolazinformuleringer med langvarig frigivelse

Info

Publication number
DK1109558T3
DK1109558T3 DK99968627T DK99968627T DK1109558T3 DK 1109558 T3 DK1109558 T3 DK 1109558T3 DK 99968627 T DK99968627 T DK 99968627T DK 99968627 T DK99968627 T DK 99968627T DK 1109558 T3 DK1109558 T3 DK 1109558T3
Authority
DK
Denmark
Prior art keywords
sustained release
release formulations
ranolazine sustained
ranolazine
formulations
Prior art date
Application number
DK99968627T
Other languages
Danish (da)
English (en)
Inventor
Andrew A Wolff
Fiona Baker
John Langridge
Original Assignee
Cv Therapeutics Inc
Syntex Inc
Syntex Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26796494&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1109558(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cv Therapeutics Inc, Syntex Inc, Syntex Llc filed Critical Cv Therapeutics Inc
Application granted granted Critical
Publication of DK1109558T3 publication Critical patent/DK1109558T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
DK99968627T 1998-09-10 1999-09-09 Ranolazinformuleringer med langvarig frigivelse DK1109558T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9980498P 1998-09-10 1998-09-10
US09/321,522 US6303607B1 (en) 1998-09-10 1999-05-27 Method for administering a sustained release ranolanolazine formulation
PCT/US1999/020967 WO2000013686A2 (en) 1998-09-10 1999-09-09 Sustained release ranolazine formulations

Publications (1)

Publication Number Publication Date
DK1109558T3 true DK1109558T3 (da) 2002-08-26

Family

ID=26796494

Family Applications (2)

Application Number Title Priority Date Filing Date
DK99948196T DK1096937T3 (da) 1998-09-10 1999-09-09 Ranolazinformuleringer med langvarig frigivelse
DK99968627T DK1109558T3 (da) 1998-09-10 1999-09-09 Ranolazinformuleringer med langvarig frigivelse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK99948196T DK1096937T3 (da) 1998-09-10 1999-09-09 Ranolazinformuleringer med langvarig frigivelse

Country Status (33)

Country Link
US (14) US6303607B1 (no)
EP (3) EP1109558B1 (no)
JP (2) JP3745621B2 (no)
KR (1) KR100475759B1 (no)
CN (2) CN1211086C (no)
AR (3) AR022085A1 (no)
AT (2) ATE285774T1 (no)
AU (4) AU744071B2 (no)
BR (2) BR9913553A (no)
CA (2) CA2342390C (no)
CY (1) CY2008020I1 (no)
CZ (2) CZ301341B6 (no)
DE (3) DE69901570T2 (no)
DK (2) DK1096937T3 (no)
ES (2) ES2234302T3 (no)
FR (1) FR09C0001I2 (no)
GE (1) GEP20053420B (no)
HK (2) HK1040060A1 (no)
HU (2) HU224215B1 (no)
IL (6) IL141892A0 (no)
LU (1) LU91504I2 (no)
MX (2) MXPA01002598A (no)
NL (1) NL300371I2 (no)
NO (4) NO319434B1 (no)
NZ (2) NZ510386A (no)
PL (3) PL196668B1 (no)
PT (2) PT1109558E (no)
RU (2) RU2207856C2 (no)
SI (2) SI1096937T1 (no)
TR (2) TR200101261T2 (no)
TW (1) TWI241911B (no)
UA (2) UA67793C2 (no)
WO (2) WO2000013687A2 (no)

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US6479496B1 (en) * 1998-09-10 2002-11-12 Cv Therapeutics, Inc. Methods for treating angina with ranolazine
US6303607B1 (en) * 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
IL151014A0 (en) 2000-02-18 2003-02-12 Cv Therapeutics Inc Partial fatty acid oxidation inhibitors in the treatment of congestive heart failure
US20020052377A1 (en) * 2000-07-21 2002-05-02 Wolff Andrew A. Method for treating angina
AU2001211213A1 (en) * 2000-10-20 2002-04-29 Galephar M/F Stable oral formulation containing benzimidazole derivative
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
US20030220344A1 (en) * 2002-04-04 2003-11-27 Luiz Belardinelli Method of treating arrhythmias
US20080109040A1 (en) * 2002-04-04 2008-05-08 Luiz Belardinelli Method of treating arrhythmias
WO2003084518A2 (fr) 2002-04-09 2003-10-16 Flamel Technologies Suspension orale de microcapsules de principes actifs
CA2480824A1 (fr) * 2002-04-09 2003-10-16 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee d'amoxicilline
US20040063717A1 (en) 2002-05-21 2004-04-01 Andrew Wolff Method of treating diabetes
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FI20060501L (fi) * 2006-05-22 2007-11-23 Biohit Oyj Koostumus ja menetelmä asetaldehydin sitomiseksi vatsassa
US20090111826A1 (en) * 2007-02-13 2009-04-30 Louis Lange Use of ranolazine for the treatment of cardiovascular diseases
US20090312340A1 (en) * 2007-02-13 2009-12-17 Whedy Wang Use of ranolazine for the treatment of cardiovascular diseases
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US20080193530A1 (en) * 2007-02-13 2008-08-14 Brent Blackburn Use of ranolazine for the treatment of non-coronary microvascular diseases
WO2008100992A1 (en) * 2007-02-13 2008-08-21 Cv Therapeutics, Inc. Intravenous solutions comprising ranolazine
EP2139877B1 (en) * 2007-03-07 2011-05-11 Concert Pharmaceuticals Inc. Deuterated piperazine derivatives as anti-anginal compounds
WO2008116083A1 (en) * 2007-03-22 2008-09-25 Cv Therapeutics, Inc. Use of ranolazine for elevated brain-type natriuretic peptide
CN101896181A (zh) * 2007-05-31 2010-11-24 吉利德帕洛阿尔托股份有限公司 用于升高的脑钠肽的雷诺嗪
CN101066253B (zh) * 2007-06-07 2011-01-05 北京本草天源药物研究院 一种雷诺嗪缓释片
JP2010529994A (ja) * 2007-06-13 2010-09-02 オースペックス・ファーマシューティカルズ・インコーポレイテッド 置換ピペラジン
US20090012103A1 (en) * 2007-07-05 2009-01-08 Matthew Abelman Substituted heterocyclic compounds
US20090076018A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched ranolazine
EP2252294A1 (en) * 2008-02-06 2010-11-24 Gilead Sciences, Inc. Use of ranolazine for treating pain
MX2011012140A (es) * 2009-05-14 2012-02-28 Gilead Sciences Inc Ranolazina para el tratamiento de problemas del snc.
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Also Published As

Publication number Publication date
NL300371I1 (nl) 2009-02-02
IL141892A (en) 2006-08-20
CZ301375B6 (cs) 2010-02-03
CZ301341B6 (cs) 2010-01-20
PL347073A1 (en) 2002-03-11
WO2000013686A2 (en) 2000-03-16
AR052921A1 (es) 2007-04-11
CN1211086C (zh) 2005-07-20
US6617328B2 (en) 2003-09-09
EP1527779A1 (en) 2005-05-04
NZ510386A (en) 2003-08-29
RU2207856C2 (ru) 2003-07-10
US6864258B2 (en) 2005-03-08
CA2342390C (en) 2006-08-29
NO20011192L (no) 2001-04-30
CZ2001880A3 (cs) 2001-08-15
DK1096937T3 (da) 2005-05-09
SI1109558T1 (en) 2002-10-31
ES2234302T3 (es) 2005-06-16
JP2006096757A (ja) 2006-04-13
TR200101261T2 (tr) 2002-05-21
BR9913553A (pt) 2001-10-23
NZ510384A (en) 2002-10-25
HK1044284B (zh) 2005-07-15
KR20010089874A (ko) 2001-10-12
PT1096937E (pt) 2005-04-29
CA2343376C (en) 2007-01-09
US20050153982A1 (en) 2005-07-14
EP1096937B1 (en) 2004-12-29
CY2008020I2 (el) 2010-07-28
US20030166659A1 (en) 2003-09-04
US20050059667A1 (en) 2005-03-17
PL196668B1 (pl) 2008-01-31
IL175371A0 (en) 2006-09-05
HUP0104088A2 (hu) 2002-05-29
NL300371I2 (nl) 2009-10-01
NO320986B1 (no) 2006-02-20
US6369062B1 (en) 2002-04-09
AR053440A2 (es) 2007-05-09
WO2000013687A3 (en) 2000-06-29
HK1044284A1 (en) 2002-10-18
MXPA01002598A (es) 2002-04-08
PL196263B1 (pl) 2007-12-31
AU744071B2 (en) 2002-02-14
DE122008000065I1 (de) 2009-04-09
NO2009005I2 (no) 2010-06-28
ES2177346T3 (es) 2002-12-01
DE69901570T2 (de) 2003-01-09
US20060147521A1 (en) 2006-07-06
SI1096937T1 (en) 2005-04-30
US6503911B2 (en) 2003-01-07
LU91504I9 (no) 2019-01-02
AU2008207707A1 (en) 2008-09-25
DE69922964D1 (de) 2005-02-03
NO2009005I1 (no) 2009-03-16
HK1040060A1 (en) 2002-05-24
AU2008207703A1 (en) 2008-09-25
RU2214233C2 (ru) 2003-10-20
WO2000013687A2 (en) 2000-03-16
NO20011191L (no) 2001-04-30
NO319434B1 (no) 2005-08-15
AR022085A1 (es) 2002-09-04
IL180864A0 (en) 2007-07-04
HUP0104088A3 (en) 2002-12-28
TR200101262T2 (tr) 2001-12-21
CA2343376A1 (en) 2000-03-16
IL141892A0 (en) 2002-03-10
AU760435B2 (en) 2003-05-15
EP1109558A2 (en) 2001-06-27
US6525057B2 (en) 2003-02-25
NO20011191D0 (no) 2001-03-08
EP1109558B1 (en) 2002-05-22
EP1096937B9 (en) 2007-02-28
HUP0103844A3 (en) 2002-11-28
FR09C0001I1 (no) 2009-02-27
PT1109558E (pt) 2002-10-31
CN1193757C (zh) 2005-03-23
WO2000013686A3 (en) 2000-07-06
US6620814B2 (en) 2003-09-16
US6562826B1 (en) 2003-05-13
PL348249A1 (en) 2002-05-20
ATE285774T1 (de) 2005-01-15
JP3745621B2 (ja) 2006-02-15
KR100475759B1 (ko) 2005-03-10
US20030099705A1 (en) 2003-05-29
US20030100566A1 (en) 2003-05-29
US20060217397A1 (en) 2006-09-28
AU6142599A (en) 2000-03-27
US6303607B1 (en) 2001-10-16
EP1096937A2 (en) 2001-05-09
BR9913626A (pt) 2001-12-04
IL141893A0 (en) 2002-03-10
IL141893A (en) 2008-08-07
ATE217794T1 (de) 2002-06-15
LU91504I2 (fr) 2009-02-03
US20040029890A1 (en) 2004-02-12
DE69901570D1 (de) 2002-06-27
CY2008020I1 (el) 2010-07-28
UA75027C2 (uk) 2006-03-15
US20040097514A1 (en) 2004-05-20
FR09C0001I2 (no) 2009-12-18
NO20054324L (no) 2001-04-30
CZ2001879A3 (cs) 2001-08-15
GEP20053420B (en) 2005-01-25
DE69922964T2 (de) 2005-12-08
CN1321088A (zh) 2001-11-07
MXPA01002599A (es) 2005-02-17
US20020004506A1 (en) 2002-01-10
UA67793C2 (uk) 2004-07-15
PL202207B1 (pl) 2009-06-30
HUP0103844A2 (hu) 2002-04-29
TWI241911B (en) 2005-10-21
JP2002524416A (ja) 2002-08-06
AU6036499A (en) 2000-03-27
US6852724B2 (en) 2005-02-08
NO20011192D0 (no) 2001-03-08
CN1354665A (zh) 2002-06-19
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HU224215B1 (hu) 2005-06-28
US20020090396A1 (en) 2002-07-11

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