DK1105096T3 - Injicerbare vandige propofoldispersioner - Google Patents

Injicerbare vandige propofoldispersioner

Info

Publication number
DK1105096T3
DK1105096T3 DK99942292T DK99942292T DK1105096T3 DK 1105096 T3 DK1105096 T3 DK 1105096T3 DK 99942292 T DK99942292 T DK 99942292T DK 99942292 T DK99942292 T DK 99942292T DK 1105096 T3 DK1105096 T3 DK 1105096T3
Authority
DK
Denmark
Prior art keywords
propofol
dispersions
injectable aqueous
water
aqueous propofol
Prior art date
Application number
DK99942292T
Other languages
English (en)
Inventor
Awadhesh K Mishra
Gary W Pace
Michael G Vachon
Original Assignee
Skyepharma Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skyepharma Canada Inc filed Critical Skyepharma Canada Inc
Application granted granted Critical
Publication of DK1105096T3 publication Critical patent/DK1105096T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DK99942292T 1998-08-19 1999-08-18 Injicerbare vandige propofoldispersioner DK1105096T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9707198P 1998-08-19 1998-08-19
PCT/US1999/018801 WO2000010531A1 (en) 1998-08-19 1999-08-18 Injectable aqueous dispersions of propofol

Publications (1)

Publication Number Publication Date
DK1105096T3 true DK1105096T3 (da) 2004-03-08

Family

ID=22260807

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99942292T DK1105096T3 (da) 1998-08-19 1999-08-18 Injicerbare vandige propofoldispersioner

Country Status (15)

Country Link
US (2) US7097849B2 (da)
EP (1) EP1105096B1 (da)
JP (1) JP4198318B2 (da)
KR (1) KR100777647B1 (da)
CN (1) CN1221249C (da)
AT (1) ATE252889T1 (da)
AU (1) AU759641B2 (da)
CA (1) CA2338703C (da)
DE (1) DE69912441T2 (da)
DK (1) DK1105096T3 (da)
ES (1) ES2211151T3 (da)
HK (1) HK1040195B (da)
IL (2) IL141095A0 (da)
SE (1) SE0100254L (da)
WO (1) WO2000010531A1 (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110243731A (zh) * 2019-07-03 2019-09-17 苏州新实医疗科技有限公司 抑菌圈直径动态测量方法、测量装置及可读存储介质

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100302A (en) * 1999-04-05 2000-08-08 Baxter International Inc. Propofol formulation with enhanced microbial characteristics
AU2006201100B2 (en) * 1999-09-21 2009-09-24 Jagotec Ag Surface modified particulate compositions of biologically active substances
ES2241663T3 (es) * 1999-09-21 2005-11-01 Skyepharma Canada Inc. Composiciones particuladas modificadas superficialmente de substancias biologicamente activas.
GB2359747B (en) 2000-02-29 2002-04-24 Maelor Pharmaceuticals Ltd Anaesthetic formulations
GB0012597D0 (en) * 2000-05-25 2000-07-12 Astrazeneca Ab Formulation
US6726919B2 (en) * 2000-06-16 2004-04-27 Rtp Pharma, Inc. Injectable dispersion of propofol
US6399087B1 (en) * 2000-12-20 2002-06-04 Amphastar Pharmaceuticals, Inc. Propofol formulation with enhanced microbial inhibition
RU2297216C2 (ru) * 2002-04-08 2007-04-20 Эм-Джи-Ай Джи-Пи,Инк. Фармацевтические композиции, содержащие растворимые в воде пролекарства пропофола, и способы их применения
WO2004039360A1 (en) * 2002-10-29 2004-05-13 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
US7550155B2 (en) * 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
JP2005538191A (ja) * 2002-07-29 2005-12-15 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 水性２，６―ジイソプロピルフェノール医薬組成物
AU2003286725B2 (en) * 2002-10-29 2007-07-12 Transform Pharmaceuticals, Inc. Propofol with cysteine
CA2508441A1 (en) * 2002-12-06 2004-06-24 Otsuka Pharmaceutical Factory, Inc. Propofol-containing fat emulsions
US20040225022A1 (en) * 2003-05-09 2004-11-11 Desai Neil P. Propofol formulation containing reduced oil and surfactants
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
BRPI0615292A8 (pt) * 2005-08-31 2018-03-06 Abraxis Bioscience Llc composições e métodos para preparação de fármacos de má solubilidade em água com estabilidade aumentada
DK3311805T3 (da) * 2005-08-31 2020-04-14 Abraxis Bioscience Llc Sammensætninger, der omfatter svært vandopløselige farmaceutiske midler og antimikrobielle midler
EA200802166A1 (ru) * 2006-04-20 2009-06-30 Эмджен Инк. Стабильная фармацевтическая композиция с защитным действием от раздражения (варианты), способ ее получения и способ лечения кальций-миметиком с ее помощью
BRPI0905725B8 (pt) 2008-01-11 2021-05-25 Univ Emory vacina e embalagem farmacêutica
WO2010082092A1 (en) * 2009-01-13 2010-07-22 Claris Lifesciences Limited Propofol based anesthetic with preservative
EP2461825B1 (en) 2009-08-04 2017-05-31 The Government of The United States of America, as represented by the Secretary, Department of Health and Human Services, Anti-rsv immunogens and methods of immunization
WO2011100408A2 (en) 2010-02-10 2011-08-18 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, Centers For Disease Control And Prevention Serologic correlates of protection against bacillis anthracis infection
US9102742B2 (en) 2010-02-10 2015-08-11 The United States Of America As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Serologic correlates of protection against Bacillus anthracis infection
US10045996B2 (en) 2010-03-17 2018-08-14 Novaliq Gmbh Pharmaceutical composition for treatment of increased intraocular pressure
JP5591603B2 (ja) * 2010-05-21 2014-09-17 富士フイルム株式会社 プロポフォール含有水中油型エマルション組成物
JP2012012331A (ja) * 2010-06-30 2012-01-19 Fujifilm Corp プロポフォール含有水中油型エマルション組成物
EP2444063A1 (en) 2010-10-20 2012-04-25 Novaliq GmbH Liquid pharmaceutical compositions for the delivery of active ingredients
EP2462921A1 (en) 2010-11-11 2012-06-13 Novaliq GmbH Liquid pharmaceutical compositions for the treatment of a posterior eye disease
CA2819988C (en) * 2011-01-04 2019-11-12 Novaliq Gmbh O/w-emulsions comprising semifluorinated alkanes
CA2824591C (en) 2011-02-02 2019-02-05 Nestec S.A. High protein nutritional compositions and methods of making and using same
US10130707B2 (en) 2011-05-25 2018-11-20 Novaliq Gmbh Topical pharmaceutical composition based on semifluorinated alkanes
ES2965828T3 (es) 2012-09-12 2024-04-17 Novaliq Gmbh Composiciones de alcano semifluorado
US9322558B2 (en) * 2013-06-27 2016-04-26 Siemens Aktiengesellschaft Combustor apparatus in a gas turbine engine
EP3331567B1 (en) 2015-07-24 2020-09-23 Neon Laboratories Ltd. Stabilized injectable emulsion of propofol and ketamine
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal
JP6602964B2 (ja) 2015-09-30 2019-11-06 ノバリック ゲーエムベーハー 半フッ素化化合物およびその組成物
EP3722274B1 (en) 2015-09-30 2023-06-07 Novaliq GmbH 2-perfluorobutyl pentane for ophthalmic administration
JP2019520357A (ja) 2016-06-23 2019-07-18 ノバリック ゲーエムベーハー 局所投与方法
KR102614858B1 (ko) 2016-09-22 2023-12-18 노바리크 게엠베하 안검염 치료에 사용되는 약제학적 조성물
EP3515467B1 (en) 2016-09-23 2023-11-29 Novaliq GmbH Ophthalmic compositions comprising ciclosporin
US11273174B2 (en) 2017-04-21 2022-03-15 Novaliq Gmbh Iodine compositions
EP3619186B1 (en) 2017-05-05 2021-02-17 Novaliq GmbH Process for the production of semifluorinated alkanes
US11278503B2 (en) 2017-05-12 2022-03-22 Novaliq Gmbh Pharmaceutical compositions comprising semifluorinated alkanes for the treatment of contact lense-related conditions
CN111372566A (zh) 2017-09-27 2020-07-03 诺瓦利克有限责任公司 用于治疗眼部疾病的包含拉坦前列素的眼科用组合物
WO2019068763A1 (en) 2017-10-04 2019-04-11 Novaliq Gmbh OPHTHALMIC COMPOSITIONS COMPRISING F6H8
EP3758676A1 (en) 2018-03-02 2021-01-06 Novaliq GmbH Pharmaceutical compositions comprising nebivolol
CA3112031A1 (en) 2018-10-12 2020-04-16 Novaliq Gmbh Ophthalmic composition for treatment of dry eye disease
US11198831B2 (en) 2019-01-31 2021-12-14 Kvi Llc Lubricant for a device
WO2023159295A1 (en) * 2022-02-22 2023-08-31 Deciem Beauty Group Inc. Stable, low viscosity oil-in-water emulsions for skin conditioning

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2803582A (en) 1956-07-16 1957-08-20 Leonid S Cherney Local anesthetic composition
NL241476A (da) 1958-07-24
US3137631A (en) 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3216897A (en) 1961-11-02 1965-11-09 Air Reduction Injectable anesthetic
US3440318A (en) 1964-02-12 1969-04-22 Herbert S Polin Methods for enhancing the effectiveness of drugs,which employ an alkylated phenoxy (polyethanol)
DE1792410B2 (de) 1967-09-01 1980-03-13 Apoteksvarucentralen Vitrum Apotekareaktiebolaget, Stockholm Arzneimittelzubereitung zur intravenösen Injektion
US3594476A (en) 1969-05-12 1971-07-20 Massachusetts Inst Technology Submicron aqueous aerosols containing lecithin
US3937668A (en) 1970-07-15 1976-02-10 Ilse Zolle Method for incorporating substances into protein microspheres
NL7012832A (da) 1970-08-29 1972-03-02
US3715432A (en) 1971-01-22 1973-02-06 Massachusetts Inst Technology Submicron aqueous aerosols containing lecithin
US3885027A (en) * 1971-04-12 1975-05-20 West Laboratories Inc Orally administered drug composition for therapy in the treatment of narcotic drug addiction
US3776857A (en) 1971-09-24 1973-12-04 Witco Chemical Corp Water-in-oil emulsions
US4013100A (en) * 1972-12-08 1977-03-22 Institut Francais Du Petrole, Des Carburants Et Lubrifiants Et Entreprise De Recherches Et D'activities Petrolieres Elf Flexible elongated member comprising a reinforcing armouring
US3794476A (en) 1972-12-26 1974-02-26 Ppg Industries Inc Method for thermally tempering glass sheet by liquid quenching
GB1413186A (en) 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
GB1472793A (en) 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
US4798846A (en) 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions
US3965255A (en) 1974-05-01 1976-06-22 E. E. Eljim Ecology Ltd. Controlled drug releasing preparations
GB1502774A (en) 1974-06-25 1978-03-01 Nat Res Dev Immunological preparations
CH588887A5 (da) 1974-07-19 1977-06-15 Battelle Memorial Institute
US4073943A (en) 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
JPS5186117A (en) 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
JPS5231981A (en) 1975-08-18 1977-03-10 Takeda Chem Ind Ltd Microcapsule preparation method
CA1077842A (en) 1975-10-09 1980-05-20 Minnesota Mining And Manufacturing Company Albumin medicament carrier system
US4168308A (en) 1976-03-12 1979-09-18 Apoteksvarucentralen Vitrum Ab Composition for enhancing the administration of pharmacologically active agents
GB1523965A (en) 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
GB1578776A (en) 1976-06-10 1980-11-12 Univ Illinois Hemoglobin liposome and method of making the same
US4078052A (en) 1976-06-30 1978-03-07 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Large unilamellar vesicles (LUV) and method of preparing same
US4086257A (en) 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
US4320121A (en) 1976-10-12 1982-03-16 Sears Barry D Method of emulsifying cholesterol, cholesterol esters and triglyceride compounds
US4351831A (en) 1977-11-02 1982-09-28 Massachusetts Institute Of Technology Process and composition for treating disorders by administering isoxsurpine and choline
US4356167A (en) 1978-01-27 1982-10-26 Sandoz, Inc. Liposome drug delivery systems
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4529561A (en) 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4186183A (en) 1978-03-29 1980-01-29 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in chemotherapy of leishmaniasis
US4298594A (en) 1978-04-14 1981-11-03 Arthur D. Little, Inc. Xenobiotic delivery vehicles, method of forming them and method of using them
GB2026340B (en) 1978-07-03 1982-12-22 Ash P Stabilising microvesicles
EP0007895B1 (fr) 1978-07-19 1983-06-22 Patrick Couvreur Nanoparticules biodégradables, compositions pharmaceutiques les contenant et procédé pour leur préparation
US4219548A (en) 1978-09-01 1980-08-26 The Procter & Gamble Company Topical anti-inflammatory composition
US4369182A (en) 1978-09-27 1983-01-18 A. Nattermann & Cie Gmbh Inflammation-preventing pharmaceutical composition of oral administration
DE2856333C2 (de) 1978-12-27 1983-09-22 A. Nattermann & Cie GmbH, 5000 Köln Oral einnehmbare Arzneimittel mit entzündungshemmender Wirkung
IT1111367B (it) 1978-11-17 1986-01-13 Serono Ist Farm Processo per la preparazione estemporanea di liposomi e liposomi cosi' ottenuti
US4328222A (en) 1978-11-21 1982-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions for parenteral or local administration
GR73668B (da) 1978-11-21 1984-03-28 Hoffmann La Roche
US4241046A (en) 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4378354A (en) 1978-12-27 1983-03-29 A. Nattermann & Cie. Gmbh Inflammation-preventing pharmaceutical composition of oral administration
US4421747A (en) 1978-12-27 1983-12-20 A. Nattermann & Cie. Gmbh Inflammation-preventing pharmaceutical composition of oral administration
US4316884A (en) 1979-01-25 1982-02-23 Adria Laboratories, Inc. Sustained release pharmaceutical formulation
DE2914788A1 (de) 1979-04-11 1980-10-16 Nattermann A & Cie Parenteral applizierbare, stabile arzneimittelloesungen mit entzuendungshemmender wirkung
US4345588A (en) 1979-04-23 1982-08-24 Northwestern University Method of delivering a therapeutic agent to a target capillary bed
JPS6030652B2 (ja) 1979-05-07 1985-07-17 株式会社ミドリ十字 静脈注射用脂肪乳剤
JPS562353A (en) 1979-06-20 1981-01-12 Ricoh Co Ltd Novel disazo compound and its preparation
CA1173360A (en) 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
AR220263A1 (es) 1980-02-19 1980-10-15 Bago Lab Sa Procedimiento para obtener una preparacion inyectable de sulfonamida potenciada de baja irritabilidad
US4302459A (en) 1980-03-19 1981-11-24 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in leishmaniasis chemotherapy with 8-aminoquinoline derivatives
JPS56152739A (en) 1980-04-25 1981-11-26 Tanabe Seiyaku Co Ltd Production of microcapsule
JPS609726B2 (ja) 1980-05-15 1985-03-12 株式会社 ミドリ十字 ステロイド製剤
US4331654A (en) 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
DE3024416C2 (de) 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
US4394372A (en) 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
US4397372A (en) 1981-03-09 1983-08-09 Bell & Howell Company Pendulum suspended bumper assembly
US4397846A (en) 1981-05-15 1983-08-09 Murray Weiner Storage-stable lipid vesicles and method of preparation
US4394182A (en) 1981-10-14 1983-07-19 Rockwell International Corporation Microelectronic shadow masking process for reducing punchthrough
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
JPS59111636A (ja) 1982-12-17 1984-06-27 Fuji Photo Film Co Ltd 熱現像カラー感光材料およびそれを用いたカラー画像形成方法
US4588578A (en) 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4515736A (en) 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
US4474753A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Topical drug delivery system utilizing thermosetting gels
US4622219A (en) 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
US4725442A (en) 1983-06-17 1988-02-16 Haynes Duncan H Microdroplets of water-insoluble drugs and injectable formulations containing same
JPS601122A (ja) 1983-06-20 1985-01-07 Green Cross Corp:The ビフエニリルプロピオン酸誘導体脂肪乳剤
DE3339236A1 (de) 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
US4492720A (en) 1983-11-15 1985-01-08 Benjamin Mosier Method of preparing microspheres for intravascular delivery
US4532089A (en) 1984-01-14 1985-07-30 Northwestern University Method of preparing giant size liposomes
DE3406497A1 (de) 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4610868A (en) 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
JPS60208910A (ja) 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
FR2562421B1 (fr) 1984-04-09 1989-02-17 Sandoz Sa Perfectionnements a la therapie par l'interleukine
US5855908A (en) * 1984-05-01 1999-01-05 University Of Utah Research Foundation Non-dissolvable drug-containing dosage-forms for use in the transmucosal delivery of a drug to a patient
US5288498A (en) * 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
US4863737A (en) 1985-05-01 1989-09-05 University Of Utah Compositions and methods of manufacture of compressed powder medicaments
DE3421468A1 (de) 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
US4761228A (en) 1984-06-08 1988-08-02 Weisenbarger Gale M Magnetic fluid conditioner
JPS6176414A (ja) 1984-09-21 1986-04-18 Shionogi & Co Ltd リポソーム製剤の製法
JPS61174940A (ja) 1985-01-29 1986-08-06 Oogawara Kakoki Kk ワックス類コーテイング単核状マイクロカプセルおよびその製造方法
US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
JPH0688911B2 (ja) 1985-06-06 1994-11-09 国立予防衛生研究所長 インフルエンザワクチン及びその製造方法
US4766046A (en) 1985-09-27 1988-08-23 Liposome Technology, Inc. Stabilized liposome/amphotericin composition and method
JPH0617309B2 (ja) 1985-11-29 1994-03-09 株式会社ビタミン研究所 アドリアマイシン包埋リポソ−ム製剤
US4803070A (en) 1986-04-15 1989-02-07 Ribi Immunochem Research Inc. Immunological emulsion adjuvants for polysaccharide vaccines
US4806352A (en) 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
US4806350A (en) 1986-04-18 1989-02-21 Norden Laboratories, Inc. Vaccine formulation
DE3623376A1 (de) 1986-07-11 1988-01-21 Behringwerke Ag Pharmazeutische formulierung und verfahren zu deren herstellung
FR2602423B1 (fr) 1986-08-08 1989-05-05 Ethypharm Sa Procede de preparation d'un medicament a base de fenofibrate, medicament obtenu par ce procede
US4776991A (en) 1986-08-29 1988-10-11 The United States Of America As Represented By The Secretary Of The Navy Scaled-up production of liposome-encapsulated hemoglobin
US5179079A (en) * 1986-12-16 1993-01-12 Novo Nordisk A/S Nasal formulation and intranasal administration therewith
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4839111A (en) 1987-02-02 1989-06-13 The University Of Tennessee Research Corporation Preparation of solid core liposomes
KR880012221A (ko) * 1987-04-13 1988-11-26 사노 가즈오 에스테르 또는 아미드를 활성성분으로 함유하는 약제 조성물
US4798860A (en) 1987-08-21 1989-01-17 Akzo America Inc. Flame resistant organic substances containing polymeric flame retardants
FR2627696B1 (fr) 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
US5656286A (en) * 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5719197A (en) * 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US4937078A (en) 1988-08-26 1990-06-26 Mezei Associates Limited Liposomal local anesthetic and analgesic products
FR2651680B1 (fr) * 1989-09-14 1991-12-27 Medgenix Group Sa Nouveau procede de preparation de microparticules lipidiques.
IL95952A0 (en) * 1989-10-19 1991-07-18 Sterling Drug Inc Aerosol composition for topical medicament
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
JP2785981B2 (ja) * 1989-11-20 1998-08-13 株式会社資生堂 乳化組成物
US5294604A (en) * 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
US5389377A (en) * 1989-12-22 1995-02-14 Molecular Bioquest, Inc. Solid care therapeutic compositions and methods for making same
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5091187A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
DE4015108A1 (de) * 1990-05-11 1991-11-14 Leopold Pharma Gmbh Stabile emulsion zur applikation pharmakologisch aktiver wirkstoffe
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5498420A (en) * 1991-04-12 1996-03-12 Merz & Co. Gmbh & Co. Stable small particle liposome preparations, their production and use in topical cosmetic, and pharmaceutical compositions
EP0656779B1 (en) * 1992-08-28 2000-04-12 Pharmos Corporation Submicron emulsions as ocular drug delivery vehicles
US5298262A (en) * 1992-12-04 1994-03-29 Sterling Winthrop Inc. Use of ionic cloud point modifiers to prevent particle aggregation during sterilization
US5302401A (en) * 1992-12-09 1994-04-12 Sterling Winthrop Inc. Method to reduce particle size growth during lyophilization
WO1994018954A1 (en) * 1993-02-22 1994-09-01 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of biologics and compositions useful therefor
US6190894B1 (en) * 1993-03-19 2001-02-20 The Regents Of The University Of California Method and compositions for disrupting the epithelial barrier function
JP3591837B2 (ja) * 1994-02-17 2004-11-24 ニューヨーク・ブラッド・センター・インコーポレイテッド フィブリン膠およびリポソームを含有する生物学的生体接着剤組成物、その製造方法および使用
GB9405593D0 (en) * 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
US5731356A (en) * 1994-03-22 1998-03-24 Zeneca Limited Pharmaceutical compositions of propofol and edetate
US5858398A (en) * 1994-11-03 1999-01-12 Isomed Inc. Microparticular pharmaceutical compositions
US5603951A (en) * 1994-11-09 1997-02-18 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin-containing soft capsule compositions
DE4440337A1 (de) * 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
US5589177A (en) * 1994-12-06 1996-12-31 Helene Curtis, Inc. Rinse-off water-in-oil-in-water compositions
GB9426104D0 (en) * 1994-12-23 1995-02-22 Merck Sharp & Dohme Use of surfactants and emulsions
US5885172A (en) * 1997-05-27 1999-03-23 Acushnet Company Multilayer golf ball with a thin thermoset outer layer
FR2730231B1 (fr) * 1995-02-02 1997-04-04 Fournier Sca Lab Association de fenofibrate et de vitamine e, utilisation en therapeutique
US6282712B1 (en) * 1995-03-10 2001-08-28 Microsoft Corporation Automatic software installation on heterogeneous networked computer systems
US5496537A (en) * 1995-03-23 1996-03-05 Henry; Richard A. Propofol hydrofluorocarbon propellant formulations
US5882676A (en) * 1995-05-26 1999-03-16 Alza Corporation Skin permeation enhancer compositions using acyl lactylates
GB9514878D0 (en) * 1995-07-20 1995-09-20 Danbiosyst Uk Vitamin E as a solubilizer for drugs contained in lipid vehicles
US5705039A (en) * 1995-10-13 1998-01-06 Albemarle Corporation Process for purifying a 2,6-dialkylphenol
US5591311A (en) * 1995-10-26 1997-01-07 Albemarle Corporation Process for purifying a 2,6-dialkylphenol
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
US5637625A (en) * 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations
SE9601421D0 (sv) * 1996-04-12 1996-04-12 Astra Ab New composition
US5804585A (en) * 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
US6096291A (en) * 1996-12-27 2000-08-01 Biovector Therapeutics, S.A. Mucosal administration of substances to mammals
US6019997A (en) * 1997-01-09 2000-02-01 Minnesota Mining And Manufacturing Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents
US5990176A (en) * 1997-01-27 1999-11-23 Abbott Laboratories Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid
DE19709704C2 (de) * 1997-03-10 1999-11-04 Michael Georgieff Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US5885597A (en) * 1997-10-01 1999-03-23 Medical Research Industries,Inc. Topical composition for the relief of pain
US6013665A (en) * 1997-12-16 2000-01-11 Abbott Laboratories Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides
DE69937558T2 (de) * 1998-06-03 2008-03-06 Scott Laboratories, Inc., Lubbock Gerät zur linderung von schmerz bei bewusstsein und angstzuständen im zusammenhang mit medizinischen und chirurgischen eingriffen
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US6025362A (en) * 1998-08-31 2000-02-15 Fukunaga; Atsuo F. Uses of xanthine compounds
US6028108A (en) * 1998-10-22 2000-02-22 America Home Products Corporation Propofol composition comprising pentetate
US6180136B1 (en) * 1998-11-10 2001-01-30 Idexx Laboratories, Inc. Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use
FR2787322B1 (fr) * 1998-12-18 2002-10-18 Galderma Res & Dev Emulsion huile-dans-eau comprenant un agent actif micronise et un systeme emulsionnant approprie
US6761903B2 (en) * 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6177477B1 (en) * 1999-03-24 2001-01-23 American Home Products Corporation Propofol formulation containing TRIS
US6011067A (en) * 1999-06-11 2000-01-04 Thione International, Inc. Antioxidant composition for the treatment of psoriasis and related diseases
US6350480B1 (en) * 1999-12-30 2002-02-26 Wm. Wrigley Jr. Company Chewing gum product including a hydrophilic gum base and method of producing
ES2303527T3 (es) * 2000-05-10 2008-08-16 Jagotec Ag Procedimiento de molienda.
SE0001865D0 (sv) * 2000-05-19 2000-05-19 Astrazeneca Ab Management of septic shock
US6938619B1 (en) * 2000-06-13 2005-09-06 Scott Laboratories, Inc. Mask free delivery of oxygen and ventilatory monitoring
US6726919B2 (en) * 2000-06-16 2004-04-27 Rtp Pharma, Inc. Injectable dispersion of propofol
US6362234B1 (en) * 2000-08-15 2002-03-26 Vyrex Corporation Water-soluble prodrugs of propofol for treatment of migrane
US6552064B2 (en) * 2000-09-19 2003-04-22 University Of Iowa Research Foundation Use of melatonin for induction of general anesthesia

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110243731A (zh) * 2019-07-03 2019-09-17 苏州新实医疗科技有限公司 抑菌圈直径动态测量方法、测量装置及可读存储介质
CN110243731B (zh) * 2019-07-03 2021-09-24 苏州新实医疗科技有限公司 抑菌圈直径动态测量方法、测量装置及可读存储介质

Also Published As

Publication number Publication date
EP1105096B1 (en) 2003-10-29
US20020006442A1 (en) 2002-01-17
DE69912441D1 (de) 2003-12-04
DE69912441T2 (de) 2004-08-19
ATE252889T1 (de) 2003-11-15
JP4198318B2 (ja) 2008-12-17
HK1040195B (zh) 2006-06-02
AU759641B2 (en) 2003-04-17
US7097849B2 (en) 2006-08-29
CA2338703C (en) 2009-03-24
AU5570599A (en) 2000-03-14
JP2002523356A (ja) 2002-07-30
KR20010099624A (ko) 2001-11-09
CA2338703A1 (en) 2000-03-02
SE0100254D0 (sv) 2001-01-30
SE0100254L (sv) 2001-04-04
KR100777647B1 (ko) 2007-11-19
CN1221249C (zh) 2005-10-05
ES2211151T3 (es) 2004-07-01
WO2000010531A1 (en) 2000-03-02
CN1313758A (zh) 2001-09-19
US20030165544A1 (en) 2003-09-04
IL141095A0 (en) 2002-02-10
IL141095A (en) 2008-04-13
EP1105096A1 (en) 2001-06-13
HK1040195A1 (en) 2002-05-31
US7041705B2 (en) 2006-05-09

Similar Documents

Publication Publication Date Title
DE69912441D1 (de) Injizierbare wässerige propofoldispersionen
NO942155D0 (no) Legemiddelformuleringer for parenteral anvendelse
JP2015038216A (ja) 圧縮ガスエアロゾルとして投与するのに適した溶媒和活性剤を含有する組成物
JP2003183157A (ja) 眼科用組成物
HU198123B (en) Deodorant and antibacterial cosmetic
ATE537812T1 (de) Zusammensetzungen und verfahren zur verbesserten verabreichung hydrophober therapeutischer wirkstoffe
JPH0892011A (ja) 脱臭性化粧品
DE69418468T2 (de) Viskoelastische zusammensetzungen aus organischen fluorierten verbindungen
US20170105417A1 (en) Skin disinfectant composition and methods for using
KR100260061B1 (en) Vitamin e drop
JP2002506820A (ja) 局所用防腐組成物および方法
WO2001070270A3 (en) Base compositions for preparing surfactant free topical compositions
JP4098093B2 (ja) エアゾール製品
US20010003003A1 (en) Preservative for emulsion and emulsion containing same
JPH08133911A (ja) 抗菌組成物
KR100332615B1 (ko) 구강용겔조성물
KR930001903A (ko) 유비데카레논 경구용 수용액 제제
JP4801300B2 (ja) 外用液状組成物
CA2141703C (en) Mouthwash
JP2004203824A (ja) 鼻腔用組成物及びその使用方法
PT862433E (pt) Composicao farmaceutica espumante topica para o tratamento de dermatoses induzidas por pityrosporum oval
CA2001568A1 (en) Medicament for treating toxoplasmosis
KR900018051A (ko) 트리아졸 화합물, 이를 함유하는 항진균제 및 이를 사용한 만성 진균증의 예방 및/또는 치료법
ATE355825T1 (de) Amphotericin b enthaltende strukturierte emulsion
WO2002049433A3 (fr) Composition cosmetique repulsive active contre les furcocercaires de schistosomes