DK0820300T3 - Biologisk nedbrydelige nanopartikler med kontrolleret frigivelse indeholdende insulin - Google Patents

Biologisk nedbrydelige nanopartikler med kontrolleret frigivelse indeholdende insulin

Info

Publication number
DK0820300T3
DK0820300T3 DK96909320T DK96909320T DK0820300T3 DK 0820300 T3 DK0820300 T3 DK 0820300T3 DK 96909320 T DK96909320 T DK 96909320T DK 96909320 T DK96909320 T DK 96909320T DK 0820300 T3 DK0820300 T3 DK 0820300T3
Authority
DK
Denmark
Prior art keywords
insulin
nanoparticles
controlled release
nanoparticles containing
containing insulin
Prior art date
Application number
DK96909320T
Other languages
Danish (da)
English (en)
Inventor
Zebunnissa Ramtoola
Original Assignee
Elan Corp Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Corp Plc filed Critical Elan Corp Plc
Application granted granted Critical
Publication of DK0820300T3 publication Critical patent/DK0820300T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6933—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained by reactions only involving carbon to carbon, e.g. poly(meth)acrylate, polystyrene, polyvinylpyrrolidone or polyvinylalcohol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
DK96909320T 1995-04-04 1996-04-02 Biologisk nedbrydelige nanopartikler med kontrolleret frigivelse indeholdende insulin DK0820300T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IE950237A IE80468B1 (en) 1995-04-04 1995-04-04 Controlled release biodegradable nanoparticles containing insulin

Publications (1)

Publication Number Publication Date
DK0820300T3 true DK0820300T3 (da) 2004-04-26

Family

ID=11040701

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96909320T DK0820300T3 (da) 1995-04-04 1996-04-02 Biologisk nedbrydelige nanopartikler med kontrolleret frigivelse indeholdende insulin

Country Status (14)

Country Link
US (1) US5641515A (fr)
EP (1) EP0820300B1 (fr)
JP (1) JP3981152B2 (fr)
AT (1) ATE261311T1 (fr)
AU (1) AU704875B2 (fr)
CA (1) CA2217485C (fr)
DE (1) DE69631824T2 (fr)
DK (1) DK0820300T3 (fr)
ES (1) ES2213770T3 (fr)
IE (1) IE80468B1 (fr)
NZ (1) NZ304976A (fr)
PT (1) PT820300E (fr)
WO (1) WO1996031231A1 (fr)
ZA (1) ZA962671B (fr)

Families Citing this family (358)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US6368586B1 (en) 1996-01-26 2002-04-09 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US5985312A (en) * 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US6120806A (en) * 1997-06-25 2000-09-19 Whitmire; David R. Oral formulations for controlled release of alcohol deterrents
FR2775435B1 (fr) * 1998-02-27 2000-05-26 Bioalliance Pharma Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US6197340B1 (en) * 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US8236352B2 (en) * 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
CA2346001C (fr) * 1998-10-01 2003-12-30 Elan Pharma International, Limited Liberation regulee de compositions nanoparticulaires
US6984404B1 (en) 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
NZ552959A (en) * 1998-11-27 2008-06-30 Darwin Discovery Ltd Compositions and methods for increasing bone mineralization
JP3650582B2 (ja) 1998-11-30 2005-05-18 ナノスフェアー インコーポレイテッド ポリマー−ナノ粒子ハイブリッド粒子
US20040258763A1 (en) * 1999-02-03 2004-12-23 Bell Steve J.D. Methods of manufacture and use of calcium phosphate particles containing allergens
AU2753100A (en) 1999-02-03 2000-08-25 Biosante Pharmaceuticals, Inc. Therapeutic calcium phosphate particles and methods of manufacture and use
US20020054914A1 (en) * 1999-02-03 2002-05-09 Tulin Morcol Compositions and methods for therapuetic agents complexed with calcium phosphate and encased by casein
US6410255B1 (en) * 1999-05-05 2002-06-25 Aurora Biosciences Corporation Optical probes and assays
KR100840925B1 (ko) 1999-05-14 2008-06-24 니리어스 파마슈티컬즈, 인크. 신규한 인터루킨-1 및 종양사멸인자-α의 조절인자들, 상기조절인자들의 합성 및 상기 조절인자들의 사용 방법
EP1754488A1 (fr) 1999-05-24 2007-02-21 Introgen Therapeutics, Inc. Methodes et compositions de thérapie génique non-virale pour le traitement des maladies hyperprolifératives
US6406745B1 (en) 1999-06-07 2002-06-18 Nanosphere, Inc. Methods for coating particles and particles produced thereby
US20040115134A1 (en) * 1999-06-22 2004-06-17 Elan Pharma International Ltd. Novel nifedipine compositions
RU2155602C1 (ru) * 1999-11-30 2000-09-10 Оао "Куантум Сатис" Инсулинсодержащее лекарственное средство для перорального применения и способ его получения
KR100919916B1 (ko) 2000-02-23 2009-10-07 글락소스미스클라인 바이오로지칼즈 에스.에이. 종양 특이적 동물 단백질
DE60139544D1 (de) * 2000-02-23 2009-09-24 Life Technologies Corp Veränderte, fluoreszierende proteine
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
US6582713B2 (en) 2000-04-06 2003-06-24 Univ. Of Colorado - Colorado Springs Compositions and methods for promoting wound healing
US10293056B1 (en) 2000-05-24 2019-05-21 Board Of Regents, The University Of Texas System Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases
CA2309575A1 (fr) * 2000-05-26 2001-11-26 James E. Guillet Macromolecules a reticulation interne
SI1542732T1 (sl) 2000-06-20 2010-01-29 Corixa Corp Csc The United Sta Fuzijski proteini Mycobacterium tuberculosis
EP1319069B1 (fr) 2000-06-28 2008-05-21 Corixa Corporation Compositions et methodes pour le traitement et le diagnostic du cancer du poumon
US6602523B1 (en) 2000-08-17 2003-08-05 Technology Holding, Llc. Composite material and process for increasing bioavailability and activity of a beneficial agent
ES2402045T3 (es) * 2000-11-16 2013-04-26 The Regents Of The University Of California Taxón de actionomiceto marino para el descubrimiento de fármacos y de productos de fermentación
AU2002220257A1 (en) * 2000-12-07 2002-06-18 Board Of Regents, The University Of Texas System Methods of treatment involving human mda-7
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US8067032B2 (en) * 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20040022862A1 (en) * 2000-12-22 2004-02-05 Kipp James E. Method for preparing small particles
US6869617B2 (en) * 2000-12-22 2005-03-22 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20030072807A1 (en) * 2000-12-22 2003-04-17 Wong Joseph Chung-Tak Solid particulate antifungal compositions for pharmaceutical use
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
US20050048126A1 (en) * 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
EP1515982A4 (fr) 2001-05-09 2005-10-26 Corixa Corp Methodes et compositions pour la therapie et le diagnostic du cancer de la prostate
US20030185892A1 (en) * 2001-08-17 2003-10-02 Bell Steve J. D. Intraocular delivery compositions and methods
US20030095928A1 (en) * 2001-09-19 2003-05-22 Elan Pharma International Limited Nanoparticulate insulin
JP2005504090A (ja) * 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
DK1581119T3 (da) 2001-12-17 2013-05-13 Corixa Corp Sammensætninger og fremgangsmåder til terapi og diagnose af inflammatoriske tarmsygdomme
CA2477780A1 (fr) * 2002-03-05 2003-09-18 Board Of Regents, The University Of Texas System Procedes d'amelioration de l'induction de la reponse immunitaire impliquant mda-7
US7799523B2 (en) 2002-04-03 2010-09-21 Celltech R & D, Inc. Association of polymorphisms in the SOST gene region with bone mineral density
AU2003237798A1 (en) 2002-04-05 2003-10-27 Board Of Regents, The University Of Texas System Intrapleural single-chain urokinase alone or complexed to its soluble receptor protects against pleural adhesions
US7176232B2 (en) * 2002-06-24 2007-02-13 The Regents Of The University Of California Salinosporamides and methods for use thereof
EP2269618A1 (fr) 2002-08-12 2011-01-05 Jennerex Biotherapeutics ULC Virus de vaccinia oncolytique pour usage en combinaison aven une chémiothérapie pour le traitement du cancer
WO2004034970A2 (fr) * 2002-09-27 2004-04-29 Nereus Pharmaceuticals, Inc. Lactames macrocycliques
US20050051968A1 (en) * 2002-11-13 2005-03-10 Froesel David William Washer toss game
CN1849142A (zh) 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′－支链核苷和黄病毒突变
AU2003301064A1 (en) * 2002-12-17 2004-07-14 Massachusetts Institute Of Technology Stimuli-responsive systems for controlled drug delivery
ZA200505302B (en) 2003-01-06 2007-03-28 Corixa Corp Certain aminoalkyl glucosaminide phosphate compounds and their use
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
EP1596872B1 (fr) * 2003-01-24 2011-06-22 Flora Technology Inc. Compositions et procedes pour restaurer la flore bacterienne
WO2004078124A2 (fr) * 2003-03-03 2004-09-16 Board Of Regents, The University Of Texas System Procedes et compositions impliquant mda-7
ES2586401T3 (es) 2003-06-16 2016-10-14 Ucb Pharma S.A. Anticuerpos específicos para la esclerostina y métodos para aumentar la mineralización ósea
PL2441767T3 (pl) * 2003-06-20 2015-11-30 Univ California Salinosporamidy i sposoby ich stosowania
AU2004253478A1 (en) * 2003-06-20 2005-01-13 Nereus Pharmaceuticals, Inc. Use of [3.2.0] heterocyclic compounds and analogs thereof for the treatment of cancer, inflammation and infectious diseases
NZ544637A (en) 2003-07-16 2010-04-30 Protiva Biotherapeutics Inc Lipid encapsulated interfering RNA
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
EP1525890A1 (fr) * 2003-10-02 2005-04-27 Complex Biosystems GmbH Complexes protéine-protéophore
AU2004285468B2 (en) 2003-10-22 2011-02-24 Fred Hutchinson Cancer Research Center Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms
WO2005082396A2 (fr) * 2003-12-01 2005-09-09 Introgen Therapeutics, Inc. Utilisation de mda-7 pour inhiber des organismes infectieux pathogenes
JP2007519727A (ja) * 2004-01-23 2007-07-19 ネレアス ファーマシューティカルズ インコーポレイテッド 抗菌薬として有用なビス−インドールピロール
CA2555921A1 (fr) * 2004-02-13 2005-09-15 Nod Pharmaceuticals, Inc. Nouveaux procedes et nouvelle composition d'administration de macromolecules par voie orale
US20070281041A1 (en) * 2004-03-02 2007-12-06 Introgen Therapeutics, Inc. Compositions and Methods Involving MDA-7 for the Treatment of Cancer
MXPA06012421A (es) 2004-04-30 2007-01-31 Nereus Pharmaceuticals Inc Compuestos de heterociclicos y metodos para utilizar los mismos.
US7579371B2 (en) 2004-04-30 2009-08-25 Nereus Pharmaceuticals, Inc. Methods of using [3.2.0] heterocyclic compounds and analogs thereof
CA2837748C (fr) 2004-05-25 2016-03-08 Oregon Health And Science University Vaccination du virus de l'immunodeficience simienne (siv) et du virus de l'immunodeficience humaine (vih) utilisant des vecteurs de vaccin a base de rhcmv et hcmv
US20080280973A1 (en) * 2004-06-28 2008-11-13 Wender Paul A Laulimalide Analogues as Therapeutic Agents
FR2872703B1 (fr) * 2004-07-07 2006-10-06 Ethypharm Sa Nanoparticules polymeriques composites
CN1732962A (zh) * 2004-08-11 2006-02-15 张阳德 阿霉素－聚氰基丙烯酸正丁脂纳米粒的制备方法
CN1733313A (zh) * 2004-08-11 2006-02-15 张阳德 聚氰基丙烯酸正丁酯纳米颗粒的制备方法
US20060078622A1 (en) * 2004-08-13 2006-04-13 Emisphere Technologies, Inc. Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
US10583094B2 (en) 2004-09-18 2020-03-10 University Of Maryland Therapeutic methods that target the NCCA-ATP channel
JP5085326B2 (ja) 2004-09-18 2012-11-28 ユニバーシティ オブ メリーランド，ボルチモア ＮＣＣａ−ＡＴＰチャネルを標的とする処置剤およびその使用方法
US7282194B2 (en) * 2004-10-05 2007-10-16 Gp Medical, Inc. Nanoparticles for protein drug delivery
CA2586035A1 (fr) * 2004-11-01 2006-05-11 Biosante Pharmaceuticals, Inc. Particules therapeutiques de phosphate de calcium destinees a la medecine esthetique ou cosmetique, et procedes de fabrication et d'utilisation
DK1830838T3 (da) * 2004-12-03 2013-01-21 Dana Farber Cancer Inst Inc Sammensætninger og fremgangsmåder til behandling af neoplastiske sygdomme
JP2008531481A (ja) * 2005-02-08 2008-08-14 ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム 癌の治療のための、ｍｄａ−７を含む組成物および方法
US7507794B2 (en) 2005-02-08 2009-03-24 Research Development Foundation Isolated soluble corticotropin releasing factor receptor type 2 (sCRFR2)
ES2259914B1 (es) * 2005-03-14 2007-06-16 Advanced In Vitro Cell Technologies, S.L. Nanoparticulas de quitosano y polietilenglicol como sistema de administracion de moleculas biologicamente activas.
CA2602637A1 (fr) 2005-03-31 2006-10-05 Glaxosmithkline Biologicals Sa Vaccins destines a lutter contre une infection a chlamydia
ITMI20050739A1 (it) * 2005-04-22 2006-10-23 Effebi Spa Piastrina di connsessione valvola-attuatore
PT1883665T (pt) 2005-04-22 2017-11-14 Univ Geneve Composições polilactídeo e usos das mesmas
DK1877426T3 (da) 2005-04-29 2012-05-14 Glaxosmithkline Biolog Sa Fremgangsmåde til forebyggelse eller behandling af M Tuberculosis-infektion.
US8003108B2 (en) * 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
US7592429B2 (en) * 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
AU2006259594A1 (en) * 2005-06-14 2006-12-28 Baxter Healthcare S.A. Pharmaceutical formulations for minimizing drug-drug interactions
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
WO2007015757A2 (fr) 2005-07-21 2007-02-08 Nereus Pharmaceuticals, Inc. Modulateurs de facteur de necrose tumorale alpha et d'interleukine-1; syntheses de ces modulateurs et procedes d'utilisation de ceux-ci
WO2007016597A2 (fr) * 2005-07-29 2007-02-08 The Regents Of The University Of California Ciblage de secretion de facteur de croissance dependant d'enzyme de conversion de tnf-alpha (tace) dans une therapie anticancereuse
KR20080047395A (ko) 2005-08-25 2008-05-28 다이호야쿠힌고교 가부시키가이샤 Ｔ세포 인식 에피토프 펩티드를 고정화 또는 내포화한생분해성 나노입자
KR20090004839A (ko) * 2005-09-07 2009-01-12 제네렉스, 인코포레이티드 Ｇｍ-ｃｓｆ를 발현하는 폭스바이러스를 사용한 전이성및/또는 전신 파종성 암의 전신 치료법
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
CA2628300C (fr) 2005-11-02 2018-04-17 Protiva Biotherapeutics, Inc. Molecules d'arnsi modifiees et utilisations de celles-ci
US20070134341A1 (en) * 2005-11-15 2007-06-14 Kipp James E Compositions of lipoxygenase inhibitors
EP1956910B1 (fr) 2005-11-23 2014-09-17 The Board of Regents of The University of Texas System Compose cytotoxique speficique du ras oncogene et ses procedes d'utilisation
CN102702013B (zh) 2005-11-28 2016-02-10 Gtx公司 核受体结合剂
US20090081157A1 (en) 2006-01-09 2009-03-26 Richard Syd Kornbluth Immunostimulatory Combinations for Vaccine Adjuvants
WO2007092944A2 (fr) * 2006-02-08 2007-08-16 Introgen Therapeutics, Inc. Compositions et procedes impliquant une therapie de gene et une modulation de proteasome
EP1876188A1 (fr) * 2006-07-04 2008-01-09 NanoDel Technologies GmbH Polymerisation en miniemulsion en deux étapes
CL2007002567A1 (es) 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.
US8652782B2 (en) 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US8481023B2 (en) 2006-09-15 2013-07-09 Ottawa Hospital Research Institute Oncolytic rhabdovirus
CA2663962A1 (fr) 2006-09-19 2008-03-27 Asuragen, Inc. Genes regules mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p et voies de signalisation utiles comme cibles dans une intervention therapeutique
WO2008070350A2 (fr) 2006-10-27 2008-06-12 The Board Of Regents Of The University Of Texas System Procédés et compositions liés aux enveloppements de déshydrons
WO2008133722A2 (fr) * 2006-11-10 2008-11-06 Ucb Pharma S.A. Anticorps et diagnostics
EP2423226A3 (fr) 2006-11-10 2012-05-30 Amgen Inc. Diagnostic à base d'anticorps et thérapeutique
WO2008140587A2 (fr) 2006-11-21 2008-11-20 The Regents Of The University Of California Rhamm, co-récepteur et interactions avec d'autres récepteurs dans la motilité des cellules cancéreuses et identification de populations cellulaires de progéniteurs cancéreux
US20080138418A1 (en) * 2006-12-07 2008-06-12 Tong Shen Enterprise Co., Ltd. Nanoparticles composed of alkyl-cyanoacrylate polymers
EP3103451A1 (fr) 2007-01-12 2016-12-14 University of Maryland, Baltimore Ciblage de canal ncca-atp destiné à protéger les organes après un épisode ischémique
US8679539B2 (en) * 2007-01-31 2014-03-25 Tong Shen Enterprise Co., Ltd. Drug-loaded poly (alkyl-cyanoacrylate) nanoparticles and process for the preparation thereof
WO2008095195A2 (fr) * 2007-02-02 2008-08-07 Nereus Pharmaceuticals, Inc. Formulations lyophilisées de salinosporamide a
CN101674730B (zh) 2007-02-02 2014-09-10 贝勒医学院 用于治疗代谢疾病的组合物和方法
CA2618099C (fr) 2007-02-09 2016-09-20 University Of Maryland, Baltimore Antagonistes d'un canal cationique non selectif dans des cellules neuronales
KR20080084528A (ko) 2007-03-15 2008-09-19 제네렉스 바이오테라퓨틱스 인크. 종양살상형 백시니아 바이러스 암 치료
MX351247B (es) * 2007-04-04 2017-10-05 Infectious Disease Res Institute Star Composiciones inmunogenicas que comprenden polipeptidos de mycobacterium tuberculosis y fusiones de los mismos.
US9725485B2 (en) 2012-05-15 2017-08-08 University Of Florida Research Foundation, Inc. AAV vectors with high transduction efficiency and uses thereof for gene therapy
EP3492596A1 (fr) 2007-04-09 2019-06-05 University of Florida Research Foundation, Inc. Compositions de vecteur raav comprenant des protéines de capside à tyrosine modifié et procédés d'utilisation
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
MX2009013354A (es) 2007-06-04 2010-07-06 Univ Ben Gurion Compuestos de triarilo y composiciones que los contienen.
CA2691199C (fr) 2007-06-22 2017-09-12 Marc J. Simard Inhibiteurs de canaux nc<sb>ca-atp</sb> pour therapie
US20090017167A1 (en) * 2007-07-11 2009-01-15 Herbalife International Inc. Mixture and beverage made therefrom for protecting cellular hydration
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
US9683256B2 (en) 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
EP2772267B1 (fr) 2007-08-27 2016-04-27 Longhorn Vaccines and Diagnostics, LLC Compositions immunogènes et procédés
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
DK2535428T3 (en) 2007-10-01 2015-11-23 Longhorn Vaccines & Diagnostics Llc Biological prøvesamlings- and transport system, and methods of using
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
US8394816B2 (en) * 2007-12-07 2013-03-12 Irene Ghobrial Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia
US20110044978A1 (en) * 2007-12-14 2011-02-24 Amgen Inc. Method for treating bone fracture
JP5618284B2 (ja) 2007-12-27 2014-11-05 昇一 城武 グラム陽性細菌用抗菌剤
WO2009082817A1 (fr) 2007-12-27 2009-07-09 Protiva Biotherapeutics, Inc. Silençage de l'expression de la polo-like kinase à l'aide d'un arn interférent
EP2281041B1 (fr) 2008-04-15 2014-07-02 Protiva Biotherapeutics Inc. Réduction au silence de l'expression du gène csn5 au moyen d'arn interférant
PL2279254T3 (pl) 2008-04-15 2017-11-30 Protiva Biotherapeutics Inc. Nowe preparaty lipidowe do dostarczania kwasów nukleinowych
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
BRPI0908686B8 (pt) * 2008-05-09 2021-05-25 South Dakota State Univ método de produção de nanopartículas não-imunogênicas, nanopartícula não-imunogênica terapeuticamente ativa, composição terapêutica, uso de uma nanopartícula não-imunogênica e kit para a produção de nanopartículas não-imunogênicas
KR20110011645A (ko) * 2008-05-12 2011-02-08 니리어스 파마슈티컬즈, 인코퍼레이션 프로테아좀 저해제로서의 살리노스포라마이드 유도체
US8404471B2 (en) 2008-06-26 2013-03-26 Atyr Pharma, Inc. Compositions and methods comprising glycyl-tRNA synthetases having non-canonical biological activities
EP2719380A3 (fr) 2008-09-16 2014-07-30 University of Maryland, Baltimore Inhibiteurs de SUR1 pour la thérapie
US8349899B1 (en) 2008-12-03 2013-01-08 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
US8765817B1 (en) 2008-12-03 2014-07-01 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
WO2010099477A2 (fr) 2009-02-27 2010-09-02 Atyr Pharma, Inc. Motifs structuraux de polypeptides associés à une activité de signalisation cellulaire
ES2742251T3 (es) 2009-03-16 2020-02-13 Pangu Biopharma Ltd Composiciones y procedimientos que comprenden variantes de splicing de histidil-tarn sintetasa que tienen actividades biológicas no canónicas
CA2757289A1 (fr) 2009-03-31 2010-10-21 Atyr Pharma, Inc. Compositions et procedes impliquant des aspartyl-arnt synthetases presentant des activites biologiques non canoniques
ES2702049T3 (es) 2009-04-24 2019-02-27 Univ Vanderbilt Inducción anti-TGF-beta de crecimiento óseo
WO2010135714A2 (fr) 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Méthodes de modulation de l'expression des adipocytes utilisant des compositions de micro-arn
WO2010138263A2 (fr) 2009-05-28 2010-12-02 University Of Massachusetts Nouveaux virus adéno-associés (aav) et leurs utilisations
JP5766188B2 (ja) 2009-07-01 2015-08-19 プロチバ バイオセラピューティクス インコーポレイティッド 固形腫瘍に治療剤を送達するための脂質製剤
US8716464B2 (en) 2009-07-20 2014-05-06 Thomas W. Geisbert Compositions and methods for silencing Ebola virus gene expression
WO2011011781A1 (fr) 2009-07-24 2011-01-27 Baylor College Of Medicine Procédés de modulation d'acides à chaînes ramifiées et leurs utilisations
CA2771769C (fr) 2009-08-28 2019-10-29 Research Development Foundation Analogues d'urocortine 2 et leurs utilisations
DK2477499T3 (en) 2009-09-14 2018-06-06 Sillajen Biotherapeutics Inc COMBINATION CANCER THERAPY WITH ONCOLYTIC VACCINIA VIRUS
CA2775092A1 (fr) 2009-09-23 2011-03-31 Protiva Biotherapeutics, Inc. Compositions et procedes pour reduire au silence des genes exprimes dans le cancer
AU2010329551B2 (en) 2009-12-10 2016-02-11 Turnstone Limited Partnership Oncolytic rhabdovirus
US9127268B2 (en) 2009-12-11 2015-09-08 Atyr Pharma, Inc. Aminoacyl tRNA synthetases for modulating inflammation
WO2011072266A2 (fr) 2009-12-11 2011-06-16 Atyr Pharma, Inc. Aminoacyl-arnt synthétases destinées à moduler l'hématopoïèse
TW201132353A (en) 2009-12-18 2011-10-01 Amgen Inc WISE binding agents and epitopes
HUE031184T2 (en) 2010-01-27 2017-06-28 Glaxosmithkline Biologicals Sa Modified tuberculosis antigens
EP2826860B1 (fr) 2010-04-23 2018-08-22 University of Massachusetts Vecteurs AAV de ciblage du système nerveux central et leurs procédés d'utilisation
ES2689520T3 (es) 2010-04-23 2018-11-14 Kempharm, Inc. Formulación terapéutica para reducir los efectos secundarios de fármacos
EP3444346B1 (fr) 2010-04-23 2022-07-27 University of Massachusetts Traitement de troubles liés au cholestérol basé sur aav
EP2561067B1 (fr) 2010-04-23 2018-11-14 University of Florida Research Foundation, Inc. Compositions de guanylate cyclase raav et méthodes de traitement de l'amaurose-1 congénitale de leber (lca1)
AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ， インコーポレイテッド イソロイシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2563911B1 (fr) 2010-04-28 2021-07-21 aTyr Pharma, Inc. Compositions thérapeutiques, diagnostiques et d'anticorps à base de fragments de protéines d'aminoacyl-arnt synthétases
WO2011139907A2 (fr) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Découverte innovatrice de compositions thérapeutiques, diagnostiques, et d'anticorps associées aux fragments protéiques des valyle arnt synthésases
WO2011139854A2 (fr) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques et à based'anticorps associées à des fragments protéiques d'asparaginyl-arnt-synthétases
WO2011140135A2 (fr) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques et à base d'anticorps liées des fragments protéiques de méthionyl-arnt-synthétases
ES2623805T3 (es) 2010-05-03 2017-07-12 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de fenilalanil-alfa-ARNt sintetasas
WO2011139986A2 (fr) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, de diagnostic et d'anticorps liées à des fragments protéiques d'arginyle-arnt synthétases
EP2566499B1 (fr) 2010-05-04 2017-01-25 aTyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques et à base d'anticorps liées à des fragments protéiques de complexe multi-arnt synthétase p38
WO2011141704A1 (fr) 2010-05-12 2011-11-17 Protiva Biotherapeutics, Inc Nouveaux lipides cationiques cycliques et procédés d'utilisation
EP2569276B1 (fr) 2010-05-12 2021-02-24 Arbutus Biopharma Corporation Nouveaux lipides cationiques et procédés d'utilisation de ceux-ci
US8945541B2 (en) 2010-05-14 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
EA037392B1 (ru) 2010-05-14 2021-03-23 Эмджен Инк. Композиции с высокой концентрацией антител
CN103096914B (zh) 2010-05-17 2015-08-12 Atyr医药公司 与亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
JP6046607B2 (ja) 2010-05-27 2016-12-21 エータイアー ファーマ， インコーポレイテッド グルタミニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP5906237B2 (ja) 2010-06-01 2016-04-20 エータイアー ファーマ， インコーポレイテッド リジルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CA2804416C (fr) 2010-07-12 2020-04-28 Atyr Pharma, Inc. Decouverte innovante de compositions therapeutiques, de diagnostic et d'anticorps se rapportant a des fragments proteiques de glycyl-arnt synthetases
US10865445B2 (en) 2010-08-18 2020-12-15 Fred Hutchinson Cancer Research Center Methods for alleviating facioscapulohumeral dystrophy (FSHD) by N siRNA molecule inhibiting the expression of DUX4-FL
CN103108650A (zh) 2010-08-25 2013-05-15 Atyr医药公司 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2012057904A1 (fr) 2010-10-27 2012-05-03 Infectious Disease Research Institute Antigènes du mycobacterium tuberculosis et leurs combinaisons présentant une séroréactivité élevée
US20120114688A1 (en) 2010-11-08 2012-05-10 Infectious Disease Research Institute Vaccines comprising non-specific nucleoside hydrolase and sterol 24-c-methyltransferase (smt) polypeptides for the treatment and diagnosis of leishmaniasis
JP6121910B2 (ja) 2011-01-04 2017-04-26 シラジェン バイオセラピューティクス インコーポレイテッド 腫瘍溶解性ワクシニアウイルスの投与による腫瘍抗原に対する抗体の生成および腫瘍特異的補体依存性細胞傷害の生成
US9403885B2 (en) 2011-01-11 2016-08-02 Fate Therapeutics, Inc. Wnt compositions and therapeutic uses of such compositions
WO2012103328A1 (fr) 2011-01-26 2012-08-02 The Methodist Hospital Research Institute Antagonistes polyvalents non peptidiques marqués de l'intégrine alpha-ν bêta-3, compositions les renfermant et leur utilisation
CN103476931A (zh) 2011-02-03 2013-12-25 米尔纳医疗股份有限公司 Mir-34的合成模拟物
JP2014506789A (ja) 2011-02-03 2014-03-20 マーナ セラピューティクス インコーポレイテッド ｍｉＲ−１２４の合成模倣体
US8986739B2 (en) 2011-02-28 2015-03-24 Nicholas V. Perricone Treatment of urinary incontinence using nitrone spin traps
MX2013010011A (es) 2011-03-01 2014-10-24 Amgen Inc Agentes de unión biespecífica.
AU2012236962B2 (en) 2011-03-25 2017-05-11 Amgen Inc. Anti-sclerostin antibody crystals and formulations thereof
EP2692742A4 (fr) 2011-03-31 2014-10-01 Nanocame Co Ltd Nouvelle technique de préparation d'une structure d'ordre supérieur présentant un effet anti-cellulaire
RS57877B1 (sr) 2011-04-19 2018-12-31 Amgen Inc Metoda za lečenje osteoporoze
EP2718427B1 (fr) 2011-06-08 2017-01-11 Children's Hospital of Eastern Ontario Research Institute Inc. Compositions pour le traitement du glioblastome
US8858928B2 (en) 2011-06-10 2014-10-14 Bluebird Bio, Inc. Gene therapy vectors for adrenoleukodystrophy and adrenomyeloneuropathy
CA2837651A1 (fr) 2011-06-21 2012-12-27 Oncofactor Corporation Compositions et methodes pour la therapie et le diagnostic du cancer
AU2012287120B2 (en) 2011-07-22 2017-02-23 The University Of Chicago Treatments for migraine and related disorders
PT2739311T (pt) 2011-08-04 2018-03-26 Amgen Inc Método para tratamento de defeitos de lacunas ósseas
US9655905B2 (en) 2011-09-14 2017-05-23 King Abdullah University Of Science And Technology Treatment of sickle cell disease
WO2013041969A2 (fr) 2011-09-21 2013-03-28 King Abdullah University Of Science And Technology Famille de gènes de biosynthèse de la didemnine chez tistrella mobilis
CA2849720C (fr) 2011-09-23 2019-06-25 Bluebird Bio, Inc. Procedes de therapie genique ameliores
WO2013095736A2 (fr) 2011-09-27 2013-06-27 The Methodist Hospital Research Institute Nanoassemblage d'or-en-silicium pour une thérapie thermique et procédés d'utilisation
EP4095236A1 (fr) 2011-09-30 2022-11-30 Bluebird Bio, Inc. Composés permettant d'améliorer la transduction virale
EP2768481A4 (fr) 2011-10-21 2015-07-08 Subhash Desai Compositions pour la réduction d'effets secondaires
EP3815685A3 (fr) 2011-10-31 2021-10-13 The Methodist Hospital Research Institute Composé comprenant un fragment de ciblage/recherche de mao pour le traitement de gliomes humains
EP2776451B1 (fr) 2011-11-11 2018-07-18 Fred Hutchinson Cancer Research Center Immunothérapie par des lymphocytes t ciblant la cycline a1 pour le traitement du cancer
EP3750544A3 (fr) 2011-11-30 2021-03-24 Emory University Inhibiteurs jak destinées à la prévention ou au traitement des infections virales
US9546367B2 (en) 2011-12-07 2017-01-17 Jenny Chee Ning Chang siRNA compositions and methods for inhibiting gene expression in tumor initiating cells of breast cancer
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
SG10201509629QA (en) 2011-12-28 2015-12-30 Amgen Inc Method Of Treating Alveolar Bone Loss Through The Use Of Anti-Sclerostin Antibodies
EP2805617A4 (fr) * 2012-01-19 2015-08-12 Shoichi Shirotake Agent antibactérien dirigé contre des bactéries provoquant une maladie des plantes
CA3207612A1 (fr) 2012-01-26 2013-08-01 Longhorn Vaccines And Diagnostics, Llc Sequences et vaccins antigeniques composites
WO2013123282A1 (fr) 2012-02-16 2013-08-22 The University Of Toledo Vaccins anticancéreux présentant un xéno-antigène et leur procédé de fabrication
WO2013126803A1 (fr) 2012-02-24 2013-08-29 Protiva Biotherapeutics Inc. Lipides cationiques trialkylés et leurs procédés d'utilisation
AR092821A1 (es) 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
US20150342897A1 (en) * 2012-05-16 2015-12-03 Glaxo Group Limited Polypeptide loaded poca nanoparticles for oral administration
CN104428005B (zh) 2012-05-23 2019-05-10 俄亥俄州立大学 用于反义寡核苷酸递送的脂质纳米颗粒组合物
EP3626267A1 (fr) 2012-07-05 2020-03-25 UCB Pharma, S.A. Traitement pour maladies osseuses
ES2969734T3 (es) 2012-08-03 2024-05-22 Access To Advanced Health Inst Composiciones y métodos para tratar una infección activa por Mycobacterium tuberculosis
US20150258198A1 (en) * 2012-08-14 2015-09-17 Wockhardt Limited Pharmaceutical microparticulate compositions of polypeptides
US20150224176A1 (en) * 2012-08-14 2015-08-13 Wockhardt Limited Pharmaceutical microparticulate compositions of polypeptides
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
JP2016508504A (ja) 2013-02-01 2016-03-22 サンタ マリア バイオセラピューティクス インコーポレイテッド 対象に対する抗アクチビン−ａ化合物の投与
ES2741147T3 (es) 2013-02-21 2020-02-10 Turnstone Lp Composición de vacuna
US10208012B2 (en) 2013-03-13 2019-02-19 Board Of Regents, The University Of Texas System Compounds for treating inflammatory and hyperproliferative diseases
BR112015024860B1 (pt) 2013-03-28 2023-11-07 Access To Advanced Health Institute Polipeptídeo de fusão, polinucleotídeo isolado, composição compreendendo dito polipeptídeo, uso da dita composição para estimular uma resposta imune contra leishmania e método in vitro e kit de diagnóstico para detectar infecção por leishmania em uma amostra biológica
US10006049B2 (en) 2013-05-16 2018-06-26 University Of Florida Research Foundation, Incorporated Hairpin mRNA elements and methods for the regulation of protein translation
WO2015011633A1 (fr) 2013-07-23 2015-01-29 Protiva Biotherapeutics, Inc. Compositions et procédés pour l'administration d'arn messager
AU2014347668A1 (en) 2013-11-05 2016-05-19 Ben-Gurion University Of The Negev Research And Development Authority Compounds for the treatment of diabetes and disease complications arising from same
US10328127B2 (en) 2013-12-02 2019-06-25 Baylor College Of Medicine Methods for stimulation of appetite and increase in weight by administration of asprosin
JP6533213B2 (ja) 2014-02-27 2019-06-19 昇一 城武 抗ウイルス剤
CN111620830A (zh) 2014-03-14 2020-09-04 北卡罗来纳大学教堂山分校 用于抑制雄性生育力的小分子
KR20160143775A (ko) 2014-04-08 2016-12-14 더 메서디스트 하스피틀 iNOS-억제 조성물들 및 이들의 유방암 치료제로서의 용도
US9693994B2 (en) 2014-04-09 2017-07-04 Research Development Foundation Class IIa HDAC inhibitors for the treatment of infection
WO2015164786A1 (fr) 2014-04-25 2015-10-29 University Of Massachusetts Vecteurs de virus adéno-associés recombinants utiles pour réduire une immunité contre des produits transgéniques
WO2015196142A1 (fr) 2014-06-20 2015-12-23 Aveo Pharmaceuticals, Inc. Traitement de l'insuffisance cardiaque congestive et d'autres dysfonctionnements cardiaques à l'aide d'un modulateur gdf15
US20170137506A1 (en) 2014-06-20 2017-05-18 Aveo Pharmaceuticals, Inc. Treatment of chronic kidney disease and other renal dysfunction using a gdf15 modulator
US10278986B2 (en) 2014-08-14 2019-05-07 The Regents Of The University Of Colorado, A Body Corporate Antibody-siRNA conjugates and uses therefor
TWI691597B (zh) 2014-09-01 2020-04-21 中央研究院 延長壽命與抑制腫瘤發生的動物模型
MX2017002750A (es) 2014-09-02 2017-08-02 Singh Bhupinder Metodo para marcar una molecula deuterada o no deuterada y formulaciones farmaceuticas para tratamiento.
EP3189143B1 (fr) 2014-09-04 2019-08-07 Memorial Sloan-Kettering Cancer Center Thérapie génique globale destinée à traiter les hémoglobinopathies
WO2016049470A1 (fr) 2014-09-25 2016-03-31 Aveo Pharmaceuticals, Inc. Procédés d'inversion de la cachexie et de prolongation de la survie, comprenant l'administration d'un modulateur de gdf15 et d'un agent anticancéreux
EP3201338B1 (fr) 2014-10-02 2021-11-03 Arbutus Biopharma Corporation Compositions et méthodes d'extinction de l'expression du gène du virus de l'hépatite b
US10711270B2 (en) 2014-10-03 2020-07-14 University Of Massachusetts High efficiency library-identified AAV vectors
IL251588B1 (en) 2014-10-08 2024-05-01 Pacific Northwest Res Institute Methods and preparations for increasing the potency of antifungal agents
RU2020140209A (ru) 2014-10-21 2021-01-25 Юниверсити Оф Массачусетс Варианты рекомбинантных aav и их применения
WO2016073184A1 (fr) 2014-11-04 2016-05-12 Dana Farber Cancer Institute, Inc. Compositions et procédés pour le traitement d'un myélome multiple
MA41142A (fr) 2014-12-12 2017-10-17 Amgen Inc Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
EP3233131A1 (fr) 2014-12-16 2017-10-25 Board of Regents of the University of Nebraska Thérapie génique pour la maladie de steinert juvénile
CN107635575A (zh) 2015-03-10 2018-01-26 纽约市哥伦比亚大学理事会 重组glut1腺相关病毒载体构建体以及用于恢复glut1表达的相关方法
US11285190B2 (en) 2015-04-20 2022-03-29 The Board Of Regents Of The University Of Texas System CLEC11a is a bone growth agent
WO2016172155A1 (fr) 2015-04-23 2016-10-27 University Of Massachusetts Modulation de l'expression d'un transgène du vecteur aav
WO2016183292A1 (fr) 2015-05-14 2016-11-17 Longhorn Vaccines And Diagnostics, Llc Procédés rapides pour l'extraction d'acides nucléiques provenant d'échantillons biologiques
WO2016197132A1 (fr) 2015-06-04 2016-12-08 Protiva Biotherapeutics Inc. Traitement d'une infection à virus de l'hépatite b à de l'aide de crispr
WO2016205615A1 (fr) 2015-06-17 2016-12-22 The Johns Hopkins University Tdp-43 dans une maladie dégénérative
EP3329003A2 (fr) 2015-07-29 2018-06-06 Arbutus Biopharma Corporation Compositions et méthodes de silençage de l'expression du gène du virus de l'hépatite b
US20170056485A1 (en) 2015-08-31 2017-03-02 Sciotec Diagnostic Technologies Gmbh Crystallized xylose isomerase in prevention of the development of non-alcoholic fatty liver disease
CA3002982A1 (fr) 2015-10-22 2017-04-27 University Of Massachusetts Procedes et compositions pour le traitement du desequilibre metabolique dans une maladie neurodegenerative
EP3371221A2 (fr) 2015-11-07 2018-09-12 MultiVir Inc. Méthodes et compositions comprenant une thérapie génique suppressive de tumeur et le blocage du point de contrôle immunitaire pour le traitement du cancer
CN108884448B (zh) 2016-01-27 2022-12-30 昂克诺斯公司 溶瘤病毒载体及其用途
WO2017132321A1 (fr) 2016-01-29 2017-08-03 The Johns Hopkins University Nouveaux inhibiteurs de la croissance bactérienne
US11060088B2 (en) 2016-02-12 2021-07-13 University Of Massachusetts Anti-angiogenic miRNA therapeutics for inhibiting corneal neovascularization
WO2017143112A2 (fr) 2016-02-17 2017-08-24 The Johns Hopkins University Oxazolidinone pour le traitement d'infections par un bacille de la tuberculose
US11149060B2 (en) 2016-02-19 2021-10-19 University Of Delaware Functionalized nanoparticles for enhanced affinity precipitation of proteins
EP3419602A1 (fr) 2016-02-22 2019-01-02 The Methodist Hospital Compositions de vésicules protéo-lipidiques biomimétiques et leurs utilisations
WO2017147370A1 (fr) 2016-02-24 2017-08-31 The Johns Hopkins University Nouvelles protéines antivirales et leur utilisations dans des méthodes thérapeutiques
KR20180114946A (ko) 2016-03-02 2018-10-19 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 면역요법을 위한 sting 활성화 나노백신
DK3423110T3 (da) 2016-03-03 2021-11-15 Univ Massachusetts Lineært duplex-dna med lukket ende til ikke-viral genoverførsel
WO2017155935A1 (fr) 2016-03-07 2017-09-14 The Johns Hopkins University Agents pharmaceutiques ciblant des cellules souches cancéreuses
US11965009B2 (en) 2016-03-10 2024-04-23 The Johns Hopkins University Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses
BR112018068055A2 (pt) 2016-03-10 2019-01-08 Univ Johns Hopkins métodos para produção de proteínas de fusão de toxina da difteria monoméricas livre de agregados e usos terapêuticas
US11203626B2 (en) 2016-03-10 2021-12-21 The Johns Hopkins University Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
JP2019510088A (ja) 2016-03-17 2019-04-11 ザ ジョンズ ホプキンス ユニバーシティーＴｈｅ Ｊｏｈｎｓ Ｈｏｐｋｉｎｓ Ｕｎｉｖｅｒｓｉｔｙ Ｐａｒｉｓのファルネシル化によってパーキンソン病を予防または治療する方法
EP3436609B1 (fr) 2016-03-30 2022-05-04 The Johns Hopkins University Spécificité du olfr90 et procédés de détection
WO2017189483A1 (fr) 2016-04-25 2017-11-02 The Johns Hopkins University Dosages du znt8 pour le développement de médicaments et compositions pharmaceutiques
JP2019521095A (ja) 2016-05-21 2019-07-25 インフェクシャス ディズィーズ リサーチ インスティチュート 二次性結核および非結核性マイコバクテリウム感染症を治療するための組成物および方法
EP3478838A1 (fr) 2016-06-30 2019-05-08 Arbutus Biopharma Corporation Compositions et procédés pour l'administration d'arn messager
JP7493334B2 (ja) 2016-07-05 2024-05-31 ユニバーシティ オブ マサチューセッツ 緑内障における神経保護療法としてのｓＦａｓＬのＡＡＶ２媒介遺伝子送達
KR102619496B1 (ko) 2016-07-19 2023-12-29 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 Stat3를 타겟으로 하는 종양용해성 바이러스
US9963498B2 (en) 2016-08-18 2018-05-08 Wisconsin Alumni Research Foundation Peptides that inhibit syndecan-1 activation of VLA-4 and IGF-1R
WO2018053294A1 (fr) 2016-09-16 2018-03-22 Infectious Disease Research Institute Vaccins comprenant des polypeptides de mycobacterium leprae pour la prévention, le traitement et le diagnostic de la lèpre
US10457940B2 (en) 2016-09-22 2019-10-29 University Of Massachusetts AAV treatment of Huntington's disease
US11149275B2 (en) 2016-10-10 2021-10-19 The Johns Hopkins University Device and method to treat esophageal disorders
US11491114B2 (en) 2016-10-12 2022-11-08 Curioralrx, Llc Formulations for enteric delivery of therapeutic agents
AU2017341849B2 (en) 2016-10-13 2024-03-21 University Of Massachusetts AAV capsid designs
JP2020510624A (ja) 2016-12-12 2020-04-09 マルチビア インコーポレイテッド がんおよび感染性疾患の治療および予防のための、ウイルス遺伝子治療および免疫チェックポイント阻害剤を含む方法および組成物
US10434089B2 (en) 2017-01-25 2019-10-08 The Johns Hopkins University Avibactam and carbapenems antibacterial agents
EP4309739A3 (fr) 2017-01-27 2024-04-17 The Methodist Hospital Plate-forme de structure c ur/écorce pour immunothérapie
WO2018146689A1 (fr) 2017-02-12 2018-08-16 Ben-Gurion University Of The Negev Research And Development Authority Composés activant la télomérase destinés à être utilisés dans la fertilité et applications associées
US20210139932A1 (en) 2017-05-03 2021-05-13 Biomarin Pharmaceutical Inc. Improved lentiviruses for transduction of hematopoietic stem cells
EP3635122A4 (fr) 2017-06-06 2021-03-31 University of Massachusetts Vecteurs aav à autorégulation pour l'expression sans risque de mecp2 dans le syndrome de rett
WO2019014044A1 (fr) 2017-07-12 2019-01-17 The Johns Hopkins University Auto-antigène znt8 à base de protéoliposomes pour le diagnostic du diabète de type 1
EP3658165A4 (fr) 2017-07-26 2021-09-01 Oncorus, Inc. Vecteurs viraux oncolytiques et leurs utilisations
WO2019028469A1 (fr) 2017-08-04 2019-02-07 The Methodist Hospital Compositions mitochondriales a polymère fonctionnalisé et procédés d'utilisation dans une transplantation cellulaire et pour modifier un phénotype métabolique
JP7339942B2 (ja) 2017-09-08 2023-09-06 アクセス ツー アドバンスト ヘルス インスティチュート サポニンを含むリポソーム製剤および使用方法
US20200330541A1 (en) 2017-11-16 2020-10-22 University Of Maine System Board Of Trustees Compositions and methods for modulating endothelial cell migration and angiogenesis
AU2018378683A1 (en) 2017-12-06 2020-07-02 Memorial Sloan-Kettering Cancer Center Globin gene therapy for treating hemoglobinopathies
WO2019118527A1 (fr) 2017-12-14 2019-06-20 The Johns Hopkins University Nouveaux inhibiteurs antifongiques
TW201936201A (zh) 2017-12-14 2019-09-16 美商堅固生物科技公司 基因之非病毒生產及遞送
BR112020013715A2 (pt) 2018-01-05 2020-12-01 Ottawa Hospital Research Institute vetores de vaccinia modificados
WO2020036635A2 (fr) 2018-03-19 2020-02-20 Multivir Inc. Procédés et compositions comprenant une thérapie génique suppressive de tumeur et des agonistes de cd122/cd132 pour le traitement du cancer
KR20200135433A (ko) 2018-03-23 2020-12-02 유니버시티 오브 매사추세츠 골 장애 치료를 위한 유전자 치료제
WO2019191119A1 (fr) 2018-03-28 2019-10-03 Herbalife International Of America, Inc. Acétylation de polysaccharides
EP3774879A1 (fr) 2018-03-30 2021-02-17 Amgen Inc. Variants d'anticorps anti-c-terminal
EP3784290A4 (fr) 2018-04-27 2022-03-23 University of Massachusetts Capsides de vaa identifiés par la sélection d'une bibliothèque in vivo
AU2019265663B2 (en) 2018-05-08 2024-06-13 Rutgers, The State University Of New Jersey AAV-compatible laminin-linker polymerization proteins
KR102167755B1 (ko) 2018-05-23 2020-10-19 주식회사 큐어바이오 단편화된 grs 폴리펩타이드, 이의 변이체 및 이들의 용도
AU2019347666A1 (en) 2018-09-28 2021-03-25 President And Fellows Of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
JP2022501060A (ja) 2018-09-28 2022-01-06 プレジデント アンド フェローズ オブ ハーバード カレッジ 遺伝子の発現のための変異体リバーステトラサイクリントランスアクチベーター
US20220033824A1 (en) 2018-11-29 2022-02-03 University Of Massachusetts Modulation of sptlc1 via recombinant adeno-associated vectors
CN113557035A (zh) 2019-01-12 2021-10-26 卫理公会医院 自组装肽纳米颗粒和其用途
EP3921029A4 (fr) 2019-02-07 2022-12-07 Baylor College of Medicine Cellules souches squelettiques périostales dans une réparation osseuse
US20220054655A1 (en) 2019-02-22 2022-02-24 University Of Massachusetts Oxr1 gene therapy
US11717506B2 (en) 2019-05-07 2023-08-08 The Johns Hopkins University Neuroprotective compounds for amyotrophic lateral sclerosis
CN114555814A (zh) 2019-09-13 2022-05-27 罗特格斯新泽西州立大学 Aav相容的层粘连蛋白-连接子聚合蛋白
US20220380735A1 (en) 2019-10-10 2022-12-01 Oncorus, Inc. Dual viruses and dual oncolytic viruses and methods of treatment
EP4045665A4 (fr) 2019-10-15 2023-11-15 University of Massachusetts Trans-épissage d'arn amélioré par éditeur d'arn
WO2021113644A1 (fr) 2019-12-05 2021-06-10 Multivir Inc. Combinaisons comprenant un activateur de lymphocytes t cd8+, un inhibiteur de point de contrôle immunitaire et une radiothérapie en vue d'obtenir des effets ciblés et abscopal pour le traitement du cancer
KR20220144377A (ko) 2020-01-30 2022-10-26 우모자 바이오파마 인코포레이티드 이중특이적 형질도입 촉진제
MX2022012279A (es) 2020-03-31 2023-02-23 Univ Massachusetts Variantes de capsides de aav y usos de los mismos.
US11965162B2 (en) 2020-04-16 2024-04-23 The Johns Hopkins University MicroRNA and inhibitors thereof and methods of treatment
AU2021321944A1 (en) 2020-08-07 2023-04-06 Access To Advanced Health Institute Purified saponins and chromatographic process for purification of same
EP4255457A1 (fr) 2020-12-03 2023-10-11 University of Massachusetts Développement de nouvelles thérapies géniques pour la fibrodysplasie ossifiante progressive
KR20220082558A (ko) 2020-12-10 2022-06-17 재단법인 의약바이오컨버젼스연구단 면역 증진 활성이 있는 신규 crs 단편 펩타이드 및 이의 용도
MX2023008831A (es) 2021-01-27 2023-10-19 Umoja Biopharma Inc Lentivirus para generar células que expresan receptores de antígeno quimérico anti-cd19.
US20240200078A1 (en) 2021-11-18 2024-06-20 Cornell University Microrna-dependent mrna switches for tissue-specific mrna-based therapies
GB2614309A (en) 2021-12-24 2023-07-05 Stratosvir Ltd Improved vaccinia virus vectors
WO2023144393A1 (fr) 2022-01-28 2023-08-03 Fundació Centre De Regulació Genòmica Cytokines thérapeutiques et méthodes
WO2023144792A1 (fr) 2022-01-31 2023-08-03 Genevant Sciences Gmbh Conjugués poly(alkyloxazoline)-lipide et particules lipidiques les contenant
WO2023144798A1 (fr) 2022-01-31 2023-08-03 Genevant Sciences Gmbh Lipides cationiques ionisables pour nanoparticules lipidiques
WO2023196851A1 (fr) 2022-04-06 2023-10-12 President And Fellows Of Harvard College Inversion du vieillissement du système nerveux central
WO2023215481A1 (fr) 2022-05-05 2023-11-09 The Board Of Trustees Of The Leland Stanford Junior University Thérapie par arn interférant pour la cardiomyopathie pln-r14del
WO2023225569A1 (fr) 2022-05-17 2023-11-23 Umoja Biopharma, Inc. Fabrication de particules virales
WO2024097992A2 (fr) 2022-11-04 2024-05-10 Umoja Biopharma, Inc. Particules présentant des fusions de molécules d'adhésion

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2504408B1 (fr) * 1981-04-24 1986-02-14 Couvreur Patrick Procede de preparation de particules submicroscopiques, particules ainsi obtenues et compositions pharmaceutiques les contenant
WO1994017789A1 (fr) * 1993-02-15 1994-08-18 Shield Research Limited Nanocapsules en polyalkylcyanoacrylate

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