BRPI0908686B8 - método de produção de nanopartículas não-imunogênicas, nanopartícula não-imunogênica terapeuticamente ativa, composição terapêutica, uso de uma nanopartícula não-imunogênica e kit para a produção de nanopartículas não-imunogênicas - Google Patents
método de produção de nanopartículas não-imunogênicas, nanopartícula não-imunogênica terapeuticamente ativa, composição terapêutica, uso de uma nanopartícula não-imunogênica e kit para a produção de nanopartículas não-imunogênicasInfo
- Publication number
- BRPI0908686B8 BRPI0908686B8 BRPI0908686A BRPI0908686A BRPI0908686B8 BR PI0908686 B8 BRPI0908686 B8 BR PI0908686B8 BR PI0908686 A BRPI0908686 A BR PI0908686A BR PI0908686 A BRPI0908686 A BR PI0908686A BR PI0908686 B8 BRPI0908686 B8 BR PI0908686B8
- Authority
- BR
- Brazil
- Prior art keywords
- immunogenic
- nanoparticles
- nanoparticle
- production
- kit
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/721—Dextrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
método de produção de nanopartículas não-imunogênicas, nanopartícula não-imunogênica terapeuticamente ativa, composição terapêutica, uso de uma substância que compreende uma quantidade farmacologicamente terapêutica de uma nanopartícula não-imunogênica e kit para a produção de nanopartículas não-imunogênicas são decritos métodos para a produção de nanopartículas não-imunogênicas a partir de fontes de proteínas mediante o controle de ph em um processo de nanopreciitação. as nanopartículas que são produzidas pelos métodos descritos variam no tamanho do diâmetro de aproximadamente 100 nm a aproximadamente 400 nm, com um tamanho de diâmetro preferido de aproximadamente 100 nm a aproximadamente 300 nm, desse modo tornando as mesmas não-imunogênicas. a invenção também apresenta métodos para a produção de nanoconjugados que são apropriados para uma variedade de usos terapêuticos, de diagnóstico e outros ainda.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12713408P | 2008-05-09 | 2008-05-09 | |
US61/127,134 | 2008-05-09 | ||
PCT/US2009/002935 WO2009137112A1 (en) | 2008-05-09 | 2009-05-11 | Method of forming non-immunogenic hydrophobic protein nanoparticles and uses therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0908686B1 BRPI0908686B1 (pt) | 2020-09-29 |
BRPI0908686B8 true BRPI0908686B8 (pt) | 2021-05-25 |
Family
ID=41264904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0908686A BRPI0908686B8 (pt) | 2008-05-09 | 2009-05-11 | método de produção de nanopartículas não-imunogênicas, nanopartícula não-imunogênica terapeuticamente ativa, composição terapêutica, uso de uma nanopartícula não-imunogênica e kit para a produção de nanopartículas não-imunogênicas |
Country Status (12)
Country | Link |
---|---|
US (2) | US8669225B2 (pt) |
EP (1) | EP2285825B1 (pt) |
JP (2) | JP5546532B2 (pt) |
KR (1) | KR101616771B1 (pt) |
CN (1) | CN102066399B (pt) |
AU (1) | AU2009244742B2 (pt) |
BR (1) | BRPI0908686B8 (pt) |
CA (1) | CA2723563C (pt) |
HK (1) | HK1158221A1 (pt) |
IL (1) | IL209155A (pt) |
RU (1) | RU2010146684A (pt) |
WO (1) | WO2009137112A1 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2170283B1 (en) | 2007-06-22 | 2019-01-09 | Board of Regents, The University of Texas System | Formation of stable submicron peptide or protein particles by thin film freezing |
US20140234420A1 (en) * | 2008-05-09 | 2014-08-21 | Omathanu P. Perumal | Method of Treating Skin Disorders using Nanoscale Delivery Devices and Transdermal Enhancing Compositions |
BRPI0908686B8 (pt) * | 2008-05-09 | 2021-05-25 | South Dakota State Univ | método de produção de nanopartículas não-imunogênicas, nanopartícula não-imunogênica terapeuticamente ativa, composição terapêutica, uso de uma nanopartícula não-imunogênica e kit para a produção de nanopartículas não-imunogênicas |
US8697098B2 (en) | 2011-02-25 | 2014-04-15 | South Dakota State University | Polymer conjugated protein micelles |
CA2743789C (en) | 2008-11-16 | 2017-10-31 | Board Of Regents, The Univesity Of Texas System | Low viscosity highly concentrated suspensions |
EP2587940B1 (en) | 2010-06-30 | 2014-08-06 | Unilever N.V. | Particles comprising hydrophobic polymer and hydrophobic phenolic compound |
WO2012007628A1 (es) | 2010-07-16 | 2012-01-19 | Instituto Científico Y Tecnológico De Navarra, S.A. | Nanopartículas para encapsulación de compuestos, su obtención y usos |
CN102120823B (zh) * | 2011-01-06 | 2016-08-03 | 鲁传华 | 水溶性玉米朊的合成及在药物制剂中的运用 |
CA2828253C (en) * | 2011-02-25 | 2016-10-18 | South Dakota State University | Polymer conjugated protein micelles |
CA2828255A1 (en) * | 2011-02-25 | 2012-08-30 | South Dakota State University | Protein nanocarriers for topical delivery |
WO2012122544A2 (en) * | 2011-03-10 | 2012-09-13 | Board Of Regents, The University Of Texas System | Protein nanoparticle dispersions |
US20140341975A1 (en) * | 2011-08-26 | 2014-11-20 | Vicoy Nanomedicines Ltd | Pathogen and substance traps |
EP2625966A1 (en) | 2012-02-13 | 2013-08-14 | Bionanoplus, S.L. | Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof |
US20150323530A1 (en) * | 2012-07-04 | 2015-11-12 | Empire Technology Development Llc | Quantum dot-protein complexes, films, and methods of use |
KR102045732B1 (ko) * | 2012-12-28 | 2019-11-18 | 엘지디스플레이 주식회사 | 온도감응형 계면활성제를 이용한 수용성 나노입자의 제조방법 |
US20150150822A1 (en) * | 2013-06-04 | 2015-06-04 | South Dakota State University | Novel core-shell nanoparticles for oral drug delivery |
IL228528A (en) | 2013-09-17 | 2015-01-29 | Technion Res & Dev Foundation | Potato-based nanoparticles |
EP3204046A4 (en) * | 2014-10-09 | 2018-08-08 | Andreas Voigt | Use of meso-and nanoporous material for surfactant trapping in nanoparticle suspensions |
WO2018071864A1 (en) | 2016-10-13 | 2018-04-19 | Thomas Jefferson University | Delivery compositions, and methods of making and using same |
TWI778069B (zh) * | 2017-06-02 | 2022-09-21 | 日商特一華製藥股份有限公司 | 難水溶性成分經可溶化之微膠粒及含有該微膠粒之液劑 |
TWI642685B (zh) * | 2017-07-26 | 2018-12-01 | 中原大學 | 新穎胜肽及其應用 |
CN109432433A (zh) * | 2018-10-30 | 2019-03-08 | 中国药科大学 | 一种纳米载体的制备方法和用途 |
CN109730976B (zh) * | 2018-12-24 | 2020-06-09 | 华中科技大学 | 一种基于自由基氧化制备白蛋白纳米粒的方法 |
CN110251487B (zh) * | 2019-08-01 | 2021-11-02 | 郑州大学 | 一种提高多西他赛载药量和口服生物利用度的醇溶蛋白纳米粒的制备方法及其应用 |
CN112121019B (zh) * | 2020-09-23 | 2022-05-31 | 合肥工业大学 | 抗氧化型淀粉基糊精复合纳米颗粒及其制备方法与应用 |
CN115025054B (zh) * | 2022-06-09 | 2023-12-22 | 四川普锐特药业有限公司 | 一种以乳铁蛋白为载体的纳米组合物的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
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US2236521A (en) | 1937-08-12 | 1941-04-01 | Zein Corp Of America | Ink |
US5330778A (en) | 1988-09-19 | 1994-07-19 | Opta Food Ingredients, Inc. | Hydrophobic protein microparticles |
CA2071867A1 (en) | 1989-11-06 | 1991-05-07 | Edith Mathiowitz | Method for producing protein microspheres |
US5254673A (en) | 1991-12-26 | 1993-10-19 | Opta Food Ingredients, Inc. | Purification of zein from corn gluten meal |
IE80468B1 (en) * | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
MY153295A (en) * | 2004-09-29 | 2015-01-29 | Nestec Sa | Nanoparticulated whey proteins |
US20070148251A1 (en) * | 2005-12-22 | 2007-06-28 | Hossainy Syed F A | Nanoparticle releasing medical devices |
KR20080111033A (ko) * | 2006-03-29 | 2008-12-22 | 후지필름 가부시키가이샤 | 카제인 나노입자 |
EP2054036B1 (en) * | 2006-07-24 | 2019-12-18 | Singh-Broemer and Company, Inc. | Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening |
CN101485629B (zh) * | 2008-01-16 | 2013-01-23 | 沈阳药科大学 | 一种给药系统及其制备方法 |
BRPI0908686B8 (pt) * | 2008-05-09 | 2021-05-25 | South Dakota State Univ | método de produção de nanopartículas não-imunogênicas, nanopartícula não-imunogênica terapeuticamente ativa, composição terapêutica, uso de uma nanopartícula não-imunogênica e kit para a produção de nanopartículas não-imunogênicas |
CA2828255A1 (en) * | 2011-02-25 | 2012-08-30 | South Dakota State University | Protein nanocarriers for topical delivery |
-
2009
- 2009-05-11 BR BRPI0908686A patent/BRPI0908686B8/pt active IP Right Grant
- 2009-05-11 JP JP2011508521A patent/JP5546532B2/ja active Active
- 2009-05-11 US US12/991,872 patent/US8669225B2/en active Active
- 2009-05-11 CA CA2723563A patent/CA2723563C/en active Active
- 2009-05-11 EP EP09743099.5A patent/EP2285825B1/en active Active
- 2009-05-11 CN CN200980123704.5A patent/CN102066399B/zh active Active
- 2009-05-11 KR KR1020107027648A patent/KR101616771B1/ko active IP Right Grant
- 2009-05-11 AU AU2009244742A patent/AU2009244742B2/en active Active
- 2009-05-11 WO PCT/US2009/002935 patent/WO2009137112A1/en active Application Filing
- 2009-05-11 RU RU2010146684/10A patent/RU2010146684A/ru not_active Application Discontinuation
-
2010
- 2010-11-04 IL IL209155A patent/IL209155A/en active IP Right Grant
-
2011
- 2011-11-18 HK HK11112508.7A patent/HK1158221A1/xx unknown
-
2014
- 2014-03-10 US US14/203,476 patent/US9616021B2/en active Active
- 2014-05-13 JP JP2014099344A patent/JP5851550B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
EP2285825B1 (en) | 2020-07-15 |
JP2011519932A (ja) | 2011-07-14 |
EP2285825A1 (en) | 2011-02-23 |
JP5851550B2 (ja) | 2016-02-03 |
CN102066399A (zh) | 2011-05-18 |
CA2723563C (en) | 2017-12-12 |
HK1158221A1 (en) | 2012-07-13 |
US9616021B2 (en) | 2017-04-11 |
EP2285825A4 (en) | 2012-11-28 |
US20140308351A1 (en) | 2014-10-16 |
AU2009244742A1 (en) | 2009-11-12 |
IL209155A (en) | 2016-07-31 |
CN102066399B (zh) | 2014-11-26 |
US20110091565A1 (en) | 2011-04-21 |
CA2723563A1 (en) | 2009-11-12 |
KR101616771B1 (ko) | 2016-04-29 |
RU2010146684A (ru) | 2012-06-20 |
KR20110036704A (ko) | 2011-04-08 |
BRPI0908686B1 (pt) | 2020-09-29 |
WO2009137112A1 (en) | 2009-11-12 |
US8669225B2 (en) | 2014-03-11 |
JP5546532B2 (ja) | 2014-07-09 |
JP2014177474A (ja) | 2014-09-25 |
IL209155A0 (en) | 2011-01-31 |
AU2009244742B2 (en) | 2014-11-06 |
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