CN110251487B - 一种提高多西他赛载药量和口服生物利用度的醇溶蛋白纳米粒的制备方法及其应用 - Google Patents
一种提高多西他赛载药量和口服生物利用度的醇溶蛋白纳米粒的制备方法及其应用 Download PDFInfo
- Publication number
- CN110251487B CN110251487B CN201910709057.1A CN201910709057A CN110251487B CN 110251487 B CN110251487 B CN 110251487B CN 201910709057 A CN201910709057 A CN 201910709057A CN 110251487 B CN110251487 B CN 110251487B
- Authority
- CN
- China
- Prior art keywords
- dtx
- zein
- ethanol
- solution
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910709057.1A CN110251487B (zh) | 2019-08-01 | 2019-08-01 | 一种提高多西他赛载药量和口服生物利用度的醇溶蛋白纳米粒的制备方法及其应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910709057.1A CN110251487B (zh) | 2019-08-01 | 2019-08-01 | 一种提高多西他赛载药量和口服生物利用度的醇溶蛋白纳米粒的制备方法及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110251487A CN110251487A (zh) | 2019-09-20 |
CN110251487B true CN110251487B (zh) | 2021-11-02 |
Family
ID=67912576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910709057.1A Active CN110251487B (zh) | 2019-08-01 | 2019-08-01 | 一种提高多西他赛载药量和口服生物利用度的醇溶蛋白纳米粒的制备方法及其应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110251487B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110947005A (zh) * | 2020-01-09 | 2020-04-03 | 广州立达尔生物科技股份有限公司 | 一种叶黄素纳米粒子的制备方法及应用 |
CN114831947A (zh) * | 2022-05-23 | 2022-08-02 | 郑州大学 | 一种提高2-甲氧基雌二醇载药量和口服生物利用度的纳米制剂的制备方法及其应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1476825A (zh) * | 2003-07-04 | 2004-02-25 | 中国科学院上海有机化学研究所 | 谷物类醇溶蛋白微球和制备方法 |
CN102066399A (zh) * | 2008-05-09 | 2011-05-18 | 南达科他州立大学 | 形成非免疫原性疏水蛋白纳米颗粒的方法及其用途 |
WO2012168882A1 (en) * | 2011-06-07 | 2012-12-13 | SPAI Group Ltd. | Compositions and methods for improving stability and extending shelf life of sensitive food additives and food products thereof |
CN103813786A (zh) * | 2011-02-25 | 2014-05-21 | 南达科他州立大学 | 用于局部递送的蛋白纳米载体 |
CN105456200A (zh) * | 2015-12-08 | 2016-04-06 | 郑州大学 | 一种提高难溶性药物口服生物利用度的纳米粒微球的制备方法及应用 |
-
2019
- 2019-08-01 CN CN201910709057.1A patent/CN110251487B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1476825A (zh) * | 2003-07-04 | 2004-02-25 | 中国科学院上海有机化学研究所 | 谷物类醇溶蛋白微球和制备方法 |
CN102066399A (zh) * | 2008-05-09 | 2011-05-18 | 南达科他州立大学 | 形成非免疫原性疏水蛋白纳米颗粒的方法及其用途 |
CN103813786A (zh) * | 2011-02-25 | 2014-05-21 | 南达科他州立大学 | 用于局部递送的蛋白纳米载体 |
WO2012168882A1 (en) * | 2011-06-07 | 2012-12-13 | SPAI Group Ltd. | Compositions and methods for improving stability and extending shelf life of sensitive food additives and food products thereof |
CN105456200A (zh) * | 2015-12-08 | 2016-04-06 | 郑州大学 | 一种提高难溶性药物口服生物利用度的纳米粒微球的制备方法及应用 |
Non-Patent Citations (1)
Title |
---|
The Interaction between Zein and Lecithin in Ethanol-Water Solution and Characterization of Zein±Lecithin Composite Colloidal Nanoparticles;Lei Dai et al;《PLoS One》;20161128;第11卷(第11期);第e0167172页 * |
Also Published As
Publication number | Publication date |
---|---|
CN110251487A (zh) | 2019-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20180353463A1 (en) | Cannabinoid Formulations | |
CN102188377B (zh) | 包载药物脂质体的制备方法 | |
CN102824356A (zh) | 一种黄芩苷纳晶混悬剂、纳晶干粉及其制备方法 | |
CN102008439A (zh) | 一种姜黄素包覆脂质体制剂及其制备方法 | |
CN106727336B (zh) | 冬凌草甲素立方液晶纳米粒及其制备方法 | |
CN110251487B (zh) | 一种提高多西他赛载药量和口服生物利用度的醇溶蛋白纳米粒的制备方法及其应用 | |
CN1951400A (zh) | 蟾酥纳米脂质体及其制备方法 | |
Guo et al. | High oral bioavailability of 2-methoxyestradiol in PEG-PLGA micelles-microspheres for cancer therapy | |
CN114917362B (zh) | 一种脂质纳米粒及其制备方法及用途 | |
CN101984958A (zh) | 纳米级阿苯达唑微粉及其制备方法 | |
CN105748437A (zh) | 囊泡、囊泡制剂及其制备方法 | |
WO2014005363A1 (zh) | 2,2',6,6'-四异丙基-4,4'-二联苯酚软胶囊制剂及其制备方法 | |
CN108498455B (zh) | 一种油性水溶药物纳米晶及其制备方法 | |
CN102872002B (zh) | 羟基红花黄色素a油溶液及其制备方法和应用 | |
CN103315961A (zh) | 新藤黄酸自微乳制剂及其制备方法 | |
CN100544738C (zh) | 一种抗肿瘤的中药制剂 | |
KR101218428B1 (ko) | 막유화법을 이용한 실리마린 경구용 고형제제 조성물 및 그 제조방법 | |
CN101554371A (zh) | 水飞蓟宾和水飞蓟素聚合物胶束的制备和应用 | |
CN112121028B (zh) | 一种辛伐他汀固体纳米粒制剂及其制备方法 | |
CN111297876B (zh) | 一种塞来昔布胶束和和厚朴酚胶束药物联用控释系统及其制备方法 | |
CN103690482A (zh) | 以磷脂复合物为中间体的甘草酸自乳化制剂用浓缩液及制备方法 | |
CN107281163B (zh) | 羧基化合物在促进载药纳米粒微球口服吸收方面的应用 | |
CN102727440A (zh) | 一种青蒿素超细粉体及其制备方法 | |
CN102274274B (zh) | 可自微乳化的葛根黄酮口服微丸组合物及其制备方法 | |
CN114632072B (zh) | 一种人参皂苷Rg5脂质纳米粒缓释制剂的制备及应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Zhenzhong Inventor after: Guo Xinhong Inventor after: Li Xiao Inventor after: Cai Qingqing Inventor after: Fan Shuting Inventor after: Lian Xinjie Inventor after: Hu Wen Tao Inventor before: Guo Xinhong Inventor before: Li Xiao Inventor before: Cai Qingqing Inventor before: Fan Shuting Inventor before: Lian Xinjie Inventor before: Hu Wen Tao Inventor before: Zhang Zhenzhong |
|
GR01 | Patent grant | ||
GR01 | Patent grant |