BRPI0518101A - métodos de produção e sìntese de composições nanoparticuladas, composições obtidas e seu uso - Google Patents
métodos de produção e sìntese de composições nanoparticuladas, composições obtidas e seu usoInfo
- Publication number
- BRPI0518101A BRPI0518101A BRPI0518101-1A BRPI0518101A BRPI0518101A BR PI0518101 A BRPI0518101 A BR PI0518101A BR PI0518101 A BRPI0518101 A BR PI0518101A BR PI0518101 A BRPI0518101 A BR PI0518101A
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- nanoparticulate
- present
- synthesis
- nanoparticulate compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
MéTODOS DE PRODUçãO E SìNTESE DE COMPOSIçõES NANOPARTICULADAS. Trata-se a presente invenção de composições m icroestruturais melhoradas de nanocompósitos terapeuticamente ativos, que incluem composições nanoparticuladas e preparações nanoparticuladas. As modalidades preferidas da presente invenção incluem composições nanoparticuladas, que compreendem nanopartículas de um agente terapeuticamente ativo dispersas em uma matriz carreadora. A presente invenção também se refere a um método para o preparo das ditas composições nanoparticuladas e preparações nanoparticuladas, por meio do uso da sintese mecanoquímica no estado sólido. Adicionalmente, a presente invenção também se refere aos produtos terapêuticos produzidos por meio do uso das ditas composições nanoparticuladas, bem como a métodos de tratamento, por meio do uso das ditas composições nanoparticuladas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2004907377A AU2004907377A0 (en) | 2004-12-31 | Nano-Particle Composition(s) and Method for Synthesis Thereof | |
PCT/AU2005/001977 WO2006069419A1 (en) | 2004-12-31 | 2005-12-30 | Nanoparticle composition and methods for synthesis thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0518101A true BRPI0518101A (pt) | 2008-10-28 |
Family
ID=36614419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0518101-1A BRPI0518101A (pt) | 2004-12-31 | 2005-12-30 | métodos de produção e sìntese de composições nanoparticuladas, composições obtidas e seu uso |
Country Status (10)
Country | Link |
---|---|
US (3) | US20090028948A1 (pt) |
EP (1) | EP1830824B1 (pt) |
JP (2) | JP6091041B2 (pt) |
CN (2) | CN101094659A (pt) |
BR (1) | BRPI0518101A (pt) |
CA (2) | CA2858733C (pt) |
IL (1) | IL183843A (pt) |
NZ (1) | NZ555719A (pt) |
WO (1) | WO2006069419A1 (pt) |
ZA (1) | ZA200704613B (pt) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2378233T3 (es) * | 2004-09-21 | 2012-04-10 | G & I Irtech S.L. | Proceso y máquina para la aglomeración y/o secado de materiales en polvo usando radiación infrarroja |
AU2007264418B2 (en) | 2006-06-30 | 2012-05-03 | Iceutica Pty Ltd | Methods for the preparation of biologically active compounds in nanoparticulate form |
AU2016203251B2 (en) * | 2006-06-30 | 2017-11-16 | Iceutica Pty Ltd | Methods for the Preparation of Biologically Active Compounds in Nanoparticle Form |
TWI564033B (zh) * | 2006-06-30 | 2017-01-01 | 艾修提卡股份有限公司 | 製造奈米微粒形式生物活性化合物之方法 |
EP2231169B1 (en) * | 2007-12-06 | 2016-05-04 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
JP2009203102A (ja) * | 2008-02-27 | 2009-09-10 | Nagoya Institute Of Technology | セラミックス粉体の固化方法及びセラミックス固化体 |
NZ722319A (en) * | 2009-04-24 | 2018-01-26 | Iceutica Pty Ltd | A novel formulation of meloxicam |
AU2014208310C1 (en) * | 2009-04-24 | 2020-01-23 | Iceutica Pty Ltd | A Novel Formulation of Diclofenac |
WO2010121320A1 (en) * | 2009-04-24 | 2010-10-28 | Iceutica Pty Ltd | Production of encapsulated nanoparticles at high volume fractions |
CN104825396A (zh) * | 2009-04-24 | 2015-08-12 | 伊休蒂卡有限公司 | 用于改善生物活性物质溶出度特征的方法 |
SG175767A1 (en) * | 2009-04-24 | 2011-12-29 | Iceutica Pty Ltd | A novel formulation of naproxen |
NZ595984A (en) * | 2009-04-24 | 2014-04-30 | Iceutica Pty Ltd | Production of encapsulated nanoparticles at commercial scale |
AU2014201967B2 (en) * | 2009-04-24 | 2015-09-17 | Iceutica Pty Ltd | A Novel Formulation of Naproxen |
US20120160944A1 (en) * | 2009-04-24 | 2012-06-28 | Aaron Dodd | Method for the production of commercial nanoparticle and micro particle powders |
KR101743847B1 (ko) | 2009-04-24 | 2017-06-05 | 아이슈티카 피티와이 리미티드 | 신규 인도메타신 제제 |
KR101580656B1 (ko) | 2009-04-24 | 2015-12-30 | 아이슈티카 피티와이 리미티드 | 디클로페낙의 신규 제형 |
AU2010261510A1 (en) | 2009-06-19 | 2012-02-09 | Nanoform Hungary Ltd. | Nanostructured Sildenafil base, its pharmaceutically acceptable salts and co-crystals, compositions of them, process for the preparation thereof and pharmaceutical compositions containing them |
HUP1000299A2 (hu) | 2010-06-08 | 2012-02-28 | Nanoform Cardiovascular Therapeutics Ltd | Nanostrukturált Atorvastatint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás elõállításukra |
EP2672959A1 (en) | 2011-02-10 | 2013-12-18 | Synthon BV | Granulated composition comprising tadalafil and a disintegrant |
WO2012107092A1 (en) | 2011-02-10 | 2012-08-16 | Synthon Bv | Pharmaceutical composition comprising tadalafil and a cyclodextrin |
WO2012107541A1 (en) | 2011-02-10 | 2012-08-16 | Synthon Bv | Pharmaceutical composition comprising tadalafil and a cyclodextrin |
US20120301498A1 (en) | 2011-04-29 | 2012-11-29 | Selecta Biosciences, Inc. | Controlled release of immunosuppressants from synthetic nanocarriers |
JP6073545B2 (ja) * | 2011-10-04 | 2017-02-01 | 横浜油脂工業株式会社 | リグナン類含有微粒子及び組成物 |
WO2014168845A1 (en) * | 2013-04-08 | 2014-10-16 | Igdrasol | Method of engineering nanoparticle |
BR122020023215B1 (pt) | 2013-05-03 | 2022-11-22 | Selecta Biosciences, Inc | Composição e kit de nanocarreadores sintéticos tolerogênicos para reduzir ou prevenir anafilaxia em resposta a um antígeno não alergênico |
CN104624132B (zh) * | 2013-11-07 | 2017-02-08 | 中国科学院化学研究所 | 环氧树脂自修复微胶囊及其制备方法 |
US9526734B2 (en) | 2014-06-09 | 2016-12-27 | Iceutica Pty Ltd. | Formulation of meloxicam |
IL292574A (en) | 2014-09-07 | 2022-06-01 | Selecta Biosciences Inc | Methods and preparations for attenuating immune responses in an antiviral transfer system |
CN105241793B (zh) * | 2015-09-07 | 2016-10-26 | 国家纳米科学中心 | 一种载药胶束形态粒径的测定方法 |
CA3013123A1 (en) | 2016-02-04 | 2017-08-10 | Cinrx Pharma, Llc | Deuterated domperidone compositions and methods for therapy of disorders |
KR102061179B1 (ko) * | 2016-11-09 | 2019-12-31 | 한밭대학교 산학협력단 | 고흡착성을 가진 고분자브러시 발포체 복합소재 및 이의 제조방법 |
WO2018142189A1 (en) * | 2017-02-02 | 2018-08-09 | Dukebox Sp. Z O. O. | A method of manufacturing a suspension of nanoparticles of tadalafil or sildenafil citrate |
JP2020510687A (ja) | 2017-03-11 | 2020-04-09 | セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. | 抗炎症剤および免疫抑制剤を含む合成ナノキャリアによる組み合わせ処置に関連する方法および組成物 |
DE102017108611A1 (de) * | 2017-04-21 | 2018-10-25 | Technische Universität Clausthal | Energie-effizientes lösungsmittelfreies Verfahren zur Herstellung von Aminosäure-Metallchelaten |
US11364226B2 (en) | 2017-06-30 | 2022-06-21 | Cinrx Pharma, Llc | Deuterated domperidone compositions, methods, and preparation |
BR112020013750A8 (pt) | 2018-01-05 | 2022-10-18 | Impel Neuropharma Inc | Dispensação intranasal de olanzapina por dispositivo olfativo de precisão |
DE102018000418A1 (de) | 2018-01-20 | 2019-07-25 | Bürkle Consulting Gmbh | Mechanochemisches Verfahren zur Herstellung von von persistenten organischen Schadstoffen und anderen Organohalogenverbindungen freien Wertprodukten aus Abfällen von Kunststoffen und Kunststofflaminaten |
CN108715442B (zh) * | 2018-08-01 | 2021-11-12 | 广西零到壹科技有限责任公司 | 机械活化连续反应制备高纯磷酸锌的设备及其应用 |
US20210369720A1 (en) * | 2018-11-02 | 2021-12-02 | Rutgers, The State University Of New Jersey | Synergistic composition having neuroprotective properties and methods of use thereof |
DE102019006084A1 (de) | 2019-02-12 | 2020-08-13 | Elke Münch | Mechanochemisches Verfahren |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2642486B2 (ja) * | 1989-08-04 | 1997-08-20 | 田辺製薬株式会社 | 難溶性薬物の超微粒子化法 |
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
US5298262A (en) * | 1992-12-04 | 1994-03-29 | Sterling Winthrop Inc. | Use of ionic cloud point modifiers to prevent particle aggregation during sterilization |
WO1994014503A1 (en) * | 1992-12-18 | 1994-07-07 | Technological Resources Pty. Limited | Toxic material disposal |
US5718388A (en) * | 1994-05-25 | 1998-02-17 | Eastman Kodak | Continuous method of grinding pharmaceutical substances |
US5591456A (en) * | 1995-02-10 | 1997-01-07 | Nanosystems L.L.C. | Milled naproxen with hydroxypropyl cellulose as a dispersion stabilizer |
TW487582B (en) * | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
AUPP355798A0 (en) * | 1998-05-15 | 1998-06-11 | University Of Western Australia, The | Process for the production of ultrafine powders |
US6165506A (en) * | 1998-09-04 | 2000-12-26 | Elan Pharma International Ltd. | Solid dose form of nanoparticulate naproxen |
JP4541647B2 (ja) * | 2000-11-20 | 2010-09-08 | エラン ファーマ インターナショナル,リミティド | 表面安定剤として共重合体を含むナノ粒子組成物 |
FI20010115A0 (fi) * | 2001-01-18 | 2001-01-18 | Orion Corp | Menetelmä nanopartikkelien valmistamiseksi |
AU2003297151A1 (en) * | 2002-12-17 | 2004-07-22 | Elan Pharma International Ltd. | Milling microgram quantities of nanoparticulate candidate compounds |
US20050042177A1 (en) * | 2003-07-23 | 2005-02-24 | Elan Pharma International Ltd. | Novel compositions of sildenafil free base |
US9149440B2 (en) * | 2003-09-02 | 2015-10-06 | University Of South Florida | Nanoparticles for drug-delivery |
US20070071825A1 (en) * | 2003-10-01 | 2007-03-29 | Catherine Curdy | Device and method for making particles |
ES2366646T3 (es) * | 2003-11-05 | 2011-10-24 | Elan Pharma International Limited | Composiciones en forma de nanopartículas que tienen un péptido como estabilizante superficial. |
-
2005
- 2005-12-30 BR BRPI0518101-1A patent/BRPI0518101A/pt not_active Application Discontinuation
- 2005-12-30 EP EP05821508.8A patent/EP1830824B1/en active Active
- 2005-12-30 NZ NZ555719A patent/NZ555719A/en not_active IP Right Cessation
- 2005-12-30 CA CA2858733A patent/CA2858733C/en active Active
- 2005-12-30 CA CA2593862A patent/CA2593862C/en active Active
- 2005-12-30 JP JP2007548645A patent/JP6091041B2/ja active Active
- 2005-12-30 US US11/813,116 patent/US20090028948A1/en not_active Abandoned
- 2005-12-30 WO PCT/AU2005/001977 patent/WO2006069419A1/en active Application Filing
- 2005-12-30 CN CNA2005800455152A patent/CN101094659A/zh active Pending
- 2005-12-30 CN CN201410035148.9A patent/CN104083342A/zh active Pending
-
2007
- 2007-06-11 IL IL183843A patent/IL183843A/en active IP Right Grant
- 2007-06-27 ZA ZA200704613A patent/ZA200704613B/en unknown
-
2016
- 2016-02-25 JP JP2016034479A patent/JP6113878B2/ja active Active
-
2018
- 2018-01-08 US US15/865,119 patent/US20180169028A1/en not_active Abandoned
-
2020
- 2020-08-04 US US16/985,150 patent/US20200360294A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN101094659A (zh) | 2007-12-26 |
NZ555719A (en) | 2010-11-26 |
US20180169028A1 (en) | 2018-06-21 |
WO2006069419A1 (en) | 2006-07-06 |
EP1830824A1 (en) | 2007-09-12 |
CN104083342A (zh) | 2014-10-08 |
CA2858733A1 (en) | 2006-07-06 |
CA2858733C (en) | 2017-12-19 |
IL183843A (en) | 2017-01-31 |
JP2016106123A (ja) | 2016-06-16 |
EP1830824B1 (en) | 2016-01-13 |
IL183843A0 (en) | 2007-10-31 |
EP1830824A4 (en) | 2012-08-29 |
CA2593862C (en) | 2014-10-21 |
JP2008526689A (ja) | 2008-07-24 |
JP6091041B2 (ja) | 2017-03-08 |
CA2593862A1 (en) | 2006-07-06 |
ZA200704613B (en) | 2008-05-28 |
US20200360294A1 (en) | 2020-11-19 |
JP6113878B2 (ja) | 2017-04-12 |
US20090028948A1 (en) | 2009-01-29 |
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Legal Events
Date | Code | Title | Description |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B12B | Appeal against refusal [chapter 12.2 patent gazette] |