DK0722434T3 - Salpetersyreestere, der har anti-inflammatorisk og/eller analgetisk aktivitet og fremgangsmåder til deres fremstilling - Google Patents

Salpetersyreestere, der har anti-inflammatorisk og/eller analgetisk aktivitet og fremgangsmåder til deres fremstilling

Info

Publication number
DK0722434T3
DK0722434T3 DK94928801T DK94928801T DK0722434T3 DK 0722434 T3 DK0722434 T3 DK 0722434T3 DK 94928801 T DK94928801 T DK 94928801T DK 94928801 T DK94928801 T DK 94928801T DK 0722434 T3 DK0722434 T3 DK 0722434T3
Authority
DK
Denmark
Prior art keywords
pct
inflammatory
analgesic activity
preparation
methods
Prior art date
Application number
DK94928801T
Other languages
Danish (da)
English (en)
Inventor
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9320599A external-priority patent/GB2283238B/en
Priority claimed from ITMI940916A external-priority patent/IT1269735B/it
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of DK0722434T3 publication Critical patent/DK0722434T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK94928801T 1993-10-06 1994-09-23 Salpetersyreestere, der har anti-inflammatorisk og/eller analgetisk aktivitet og fremgangsmåder til deres fremstilling DK0722434T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9320599A GB2283238B (en) 1993-10-06 1993-10-06 Nitric esters of derivatives of propionic acid and process for their preparation
ITMI940916A IT1269735B (it) 1994-05-10 1994-05-10 Prodotti provvisti di un gruppo nitroestere terminale dotati di attivita' anti-infiammatoria e/o analgesica
PCT/EP1994/003182 WO1995009831A1 (en) 1993-10-06 1994-09-23 Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation

Publications (1)

Publication Number Publication Date
DK0722434T3 true DK0722434T3 (da) 1998-11-16

Family

ID=26303642

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94928801T DK0722434T3 (da) 1993-10-06 1994-09-23 Salpetersyreestere, der har anti-inflammatorisk og/eller analgetisk aktivitet og fremgangsmåder til deres fremstilling

Country Status (15)

Country Link
US (2) US5700947A (ru)
EP (1) EP0722434B1 (ru)
JP (1) JP3775796B2 (ru)
KR (1) KR100343243B1 (ru)
AT (1) ATE168986T1 (ru)
AU (1) AU678063B2 (ru)
BR (1) BR9407749A (ru)
CA (1) CA2173582C (ru)
DE (1) DE69412109T2 (ru)
DK (1) DK0722434T3 (ru)
ES (1) ES2120070T3 (ru)
HU (1) HU218923B (ru)
RU (1) RU2136653C1 (ru)
SI (1) SI0722434T1 (ru)
WO (1) WO1995009831A1 (ru)

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US6310052B1 (en) 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
US7115661B1 (en) 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
IT1288123B1 (it) 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
IT1285770B1 (it) 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
IT1295694B1 (it) 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
FR2757159B1 (fr) * 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments
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US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
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CN100486573C (zh) 1999-12-23 2009-05-13 硝化医药股份有限公司 硝基化的和亚硝基化的环加氧酶-2抑制剂、组合物及其用途
SE0000773D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
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IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
US6706724B2 (en) 2000-12-21 2004-03-16 Nitromed, Inc. Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
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GB0111872D0 (en) 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
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ITMI20011744A1 (it) * 2001-08-09 2003-02-09 Nicox Sa Farmaci per le vasculopatie
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US20050234123A1 (en) * 2001-11-27 2005-10-20 Aldo Belli Process
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
RU2004126950A (ru) 2002-02-04 2005-06-27 АЛФАМА-Инвестигасау и Дезенволвименту де Продутош Фармасеутикуш Лда. (PT) Использование выделяющих co соединений при изготовлении лекарственного средства для лечения воспалительных заболеваний
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
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Also Published As

Publication number Publication date
JPH09503214A (ja) 1997-03-31
HU218923B (hu) 2000-12-28
ES2120070T3 (es) 1998-10-16
HUT74446A (en) 1996-12-30
EP0722434A1 (en) 1996-07-24
WO1995009831A1 (en) 1995-04-13
US5780495A (en) 1998-07-14
RU2136653C1 (ru) 1999-09-10
BR9407749A (pt) 1997-02-12
DE69412109D1 (de) 1998-09-03
CA2173582A1 (en) 1995-04-13
HU9600874D0 (en) 1996-06-28
US5700947A (en) 1997-12-23
AU7809294A (en) 1995-05-01
KR100343243B1 (ko) 2003-02-14
JP3775796B2 (ja) 2006-05-17
ATE168986T1 (de) 1998-08-15
SI0722434T1 (en) 1998-12-31
EP0722434B1 (en) 1998-07-29
DE69412109T2 (de) 1999-01-21
CA2173582C (en) 2006-11-28
KR960704834A (ko) 1996-10-09
AU678063B2 (en) 1997-05-15

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