DK0693475T3 - 1-Phenyl-3-dimethylamino-propan forbindelser med farmakologisk virkning - Google Patents
1-Phenyl-3-dimethylamino-propan forbindelser med farmakologisk virkningInfo
- Publication number
- DK0693475T3 DK0693475T3 DK95110864T DK95110864T DK0693475T3 DK 0693475 T3 DK0693475 T3 DK 0693475T3 DK 95110864 T DK95110864 T DK 95110864T DK 95110864 T DK95110864 T DK 95110864T DK 0693475 T3 DK0693475 T3 DK 0693475T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- meta
- phenyl
- dimethylamino
- para
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/62—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
- C07C225/08—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
- C07C225/10—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings with doubly-bound oxygen atoms bound to carbon atoms not being part of rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
- C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
- C07C323/36—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Adhesive Tapes (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4426245A DE4426245A1 (de) | 1994-07-23 | 1994-07-23 | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0693475T3 true DK0693475T3 (da) | 1998-09-23 |
Family
ID=6524045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95110864T DK0693475T3 (da) | 1994-07-23 | 1995-07-12 | 1-Phenyl-3-dimethylamino-propan forbindelser med farmakologisk virkning |
Country Status (31)
Country | Link |
---|---|
US (3) | US6248737B1 (da) |
EP (1) | EP0693475B1 (da) |
JP (2) | JP4034366B2 (da) |
KR (1) | KR100364465B1 (da) |
CN (1) | CN1077566C (da) |
AT (1) | ATE163176T1 (da) |
AU (1) | AU685644B2 (da) |
BR (1) | BR9502390A (da) |
CA (1) | CA2154424C (da) |
CO (1) | CO4410179A1 (da) |
CZ (1) | CZ286441B6 (da) |
DE (3) | DE4426245A1 (da) |
DK (1) | DK0693475T3 (da) |
ES (1) | ES2115298T3 (da) |
FI (1) | FI114704B (da) |
FR (1) | FR12C0016I2 (da) |
GR (1) | GR3026326T3 (da) |
HK (1) | HK1005062A1 (da) |
HU (1) | HU218481B (da) |
IL (1) | IL113901A (da) |
LT (1) | LTPA2011007I1 (da) |
LU (1) | LU91793I2 (da) |
MY (1) | MY114889A (da) |
NZ (1) | NZ272623A (da) |
PE (1) | PE34896A1 (da) |
PL (1) | PL181169B1 (da) |
RU (1) | RU2150465C1 (da) |
SI (1) | SI0693475T1 (da) |
UA (1) | UA41345C2 (da) |
UY (1) | UY23992A1 (da) |
ZA (1) | ZA956118B (da) |
Families Citing this family (171)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2182680A1 (en) * | 1994-02-08 | 1995-08-17 | Alan L. Mueller | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
JP2000506157A (ja) * | 1996-03-08 | 2000-05-23 | サンテラボ | (2―アミノエチル)ベンゾフラン誘導体、その製造およびその治療的使用 |
FR2745815B1 (fr) * | 1996-03-08 | 1998-06-26 | Synthelabo | Derives de benzofurane, leur preparations et compositions pharmaceutiques les comprenant |
DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
DE19732928C2 (de) * | 1997-07-31 | 2000-05-18 | Gruenenthal Gmbh | Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel |
DE19933421A1 (de) | 1999-07-16 | 2001-01-25 | Gruenenthal Gmbh | 2-Benzyl-3-dimethylamino-1-phenyl-propanderi- vate |
PE20010623A1 (es) * | 1999-10-05 | 2001-07-07 | Gruenenthal Chemie | Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria |
DE10000312A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Aminomethyl-Phenyl-Cyclohexanderivate |
DE10059412A1 (de) * | 2000-11-30 | 2002-06-13 | Gruenenthal Gmbh | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie der Harninkontinenz |
US20050176790A1 (en) | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
DE10109763A1 (de) * | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
DE10146275A1 (de) * | 2001-09-18 | 2003-04-24 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz |
PE20030527A1 (es) * | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
US20080057011A1 (en) * | 2001-12-12 | 2008-03-06 | L'oreal S.A., | Composition structured with a polymer containing a heteroatom and an Organogelator |
DE10161809A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | Arzneimittel enthaltend N,N'-disubstituierte Piperazin-Verbindungen |
DE10161644A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | N,N'-disubstituierte Piperazin-Verbindungen |
DE10163421A1 (de) * | 2001-12-21 | 2003-07-31 | Gruenenthal Gmbh | Verwendung von (+)-(1S,2S)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)phenol als Antiemetikum |
US20050137194A1 (en) * | 2002-05-29 | 2005-06-23 | Gruenenthal Gmbh | Combination of selected opioids with other active compounds for treatment of urinary incontinence |
US7410965B2 (en) * | 2002-05-29 | 2008-08-12 | Gruenenthal Gmbh | Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol |
DE10224108A1 (de) * | 2002-05-29 | 2004-01-29 | Grünenthal GmbH | 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol enthaltendes Arzneimiitel mit verzögerter Wirkstofffreisetzung |
US20050137145A1 (en) * | 2002-05-30 | 2005-06-23 | Gruenenthal Gmbh | Metabolites of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol and their use in the treatment of urinary incontinence |
DE10224624A1 (de) * | 2002-05-30 | 2003-12-11 | Gruenenthal Gmbh | Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol |
DE10224556A1 (de) * | 2002-05-31 | 2004-01-08 | Grünenthal GmbH | 1-Dimethylamino- 3-(3-methoxy-phenyl)2-methyl-pentan-3-ol entaltendes Arzneimittel in verschiedenen Formulierungen |
US7550624B2 (en) * | 2002-06-06 | 2009-06-23 | Gruenenthal Gmbh | Pharmaceutically active salts and esters of 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol and 3- (3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)-phenol and methods of using same |
DE10225315A1 (de) * | 2002-06-06 | 2003-12-24 | Gruenenthal Gmbh | Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE10228192A1 (de) * | 2002-06-24 | 2004-01-15 | Grünenthal GmbH | Darreichungsform zur oralen Verabreichung von Wirkstoffen, Vitaminen und/oder Nährstoffen |
CA2492468A1 (en) * | 2002-09-24 | 2004-04-08 | Virginia Commonwealth University | .beta.-hydroxyphenylalkylamines and their use for treating glaucoma |
ES2819854T3 (es) | 2002-11-22 | 2021-04-19 | Gruenenthal Gmbh | Uso de (1R,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenol para tratar el dolor inflamatorio |
DE10326097A1 (de) * | 2003-06-06 | 2005-01-05 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen |
DE10328316A1 (de) | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
DE102004020220A1 (de) * | 2004-04-22 | 2005-11-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
US8075872B2 (en) * | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102004032051A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
DE102004019916A1 (de) * | 2004-04-21 | 2005-11-17 | Grünenthal GmbH | Gegen Missbrauch gesichertes wirkstoffhaltiges Pflaster |
US7244866B2 (en) * | 2004-05-14 | 2007-07-17 | Janssen Pharmaceutical N.V. | Carboxamido opioid compounds |
EP1612203B1 (en) * | 2004-06-28 | 2007-08-01 | Grünenthal GmbH | Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride |
DE102004032049A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
US20060160905A1 (en) * | 2005-01-18 | 2006-07-20 | Bergeron Raymond J Jr | Compositions and methods for inhibiting pain |
WO2006078239A1 (en) * | 2005-01-18 | 2006-07-27 | University Of Florida | Compositions and methods for inhibiting pain |
DE102005005449A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102005033732B4 (de) * | 2005-05-27 | 2014-02-13 | Grünenthal GmbH | Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane |
DE202005014347U1 (de) * | 2005-09-09 | 2007-01-18 | Grünenthal GmbH | Applikationssystem für ein wirkstoffhaltiges Pflaster und Wirkstoffabgaberegulierungsmittel |
US20090104266A1 (en) * | 2005-09-15 | 2009-04-23 | Tobias Jung | 3-(2-dimethylaminomethylcy clohexyl)phenol retard formulation |
DE102005052588A1 (de) * | 2005-11-02 | 2007-05-10 | Grünenthal GmbH | Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse |
US20070254960A1 (en) * | 2006-04-28 | 2007-11-01 | Gruenenthal Gmbh | Pharmaceutical combination |
DK2012763T3 (da) * | 2006-04-28 | 2011-05-02 | Gruenenthal Gmbh | Farmaceutisk kombination omfattende 3-(3-dimethylamono-1-ethyl-2-methyl-propyl) phenol og et NSAID |
RU2442576C2 (ru) * | 2006-04-28 | 2012-02-20 | Грюненталь Гмбх | Фармацевтическая комбинация, содержащая 3-(3-диметиламино-1-этил-2-метилпропил)фенол и парацетамол |
TWI401237B (zh) * | 2006-07-24 | 2013-07-11 | 3-〔(1r,2r)-3-(二甲基氨基)-1-乙基-2-甲基丙基〕酚之製備 | |
TWI496762B (zh) | 2006-07-24 | 2015-08-21 | 製備(1r,2r)-3-(3-二甲胺基-1-乙基-2-甲基-丙基)-酚之方法 | |
EA015003B1 (ru) * | 2006-07-24 | 2011-04-29 | Янссен Фармацевтика Нв | Получение (2r,3r)-3-(3-метоксифенил)-n,n,2-триметилпентанамина |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
DE102007012165A1 (de) | 2007-03-12 | 2008-09-18 | Grünenthal GmbH | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes |
DE102007019417A1 (de) * | 2007-04-23 | 2008-11-13 | Grünenthal GmbH | Tapentadol zur Schmerzbehandlung bei Arthrose |
EP1985292A1 (en) | 2007-04-23 | 2008-10-29 | Grünenthal GmbH | Titration of tapentadol |
US20090076164A1 (en) * | 2007-09-15 | 2009-03-19 | Protia, Llc | Deuterium-enriched tapentadol |
CN102065852B (zh) * | 2007-11-23 | 2015-06-17 | 格吕伦塔尔有限公司 | 他喷他多组合物 |
CN104447360B (zh) | 2007-12-07 | 2017-04-12 | 格吕伦塔尔有限公司 | (1r,2r)‑3‑(3‑二甲基氨基‑1‑乙基‑2‑甲基‑丙基)‑苯酚的结晶变体 |
US8383152B2 (en) | 2008-01-25 | 2013-02-26 | Gruenenthal Gmbh | Pharmaceutical dosage form |
HUE030803T2 (en) | 2008-05-09 | 2017-06-28 | Gruenenthal Gmbh | Process for the preparation of an intermediate powder formulation and a final solid dosage form using a spraying step \ t |
MX2011002339A (es) | 2008-09-05 | 2011-04-04 | Gruenenthal Gmbh | Combinacion farmaceutica de 3-(3-dimetilamino-1-etil-2-metil-propi l)-fenol y un antiepileptico. |
US20100190752A1 (en) * | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
PE20142368A1 (es) | 2008-10-30 | 2015-02-04 | Gruenenthal Chemie | Formas de dosificacion del tapentadol novedosas y potentes |
US20100272815A1 (en) * | 2009-04-28 | 2010-10-28 | Actavis Group Ptc Ehf | Amorphous form of tapentadol hydrochloride |
EP2424514B1 (en) | 2009-04-30 | 2017-02-22 | Grünenthal GmbH | Tapentadol for treating rheumatoid arthritic pain |
AR077420A1 (es) | 2009-07-22 | 2011-08-24 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion para opiaceos sensibles a la oxidacion |
EP2456427B1 (en) | 2009-07-22 | 2015-03-04 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
CN102002065B (zh) * | 2009-09-02 | 2014-09-10 | 上海特化医药科技有限公司 | 他喷他多的制备方法及其中间体 |
US8288592B2 (en) | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
IT1397189B1 (it) | 2009-12-01 | 2013-01-04 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
MX2012007759A (es) * | 2009-12-29 | 2012-08-01 | Mapi Pharma Ltd | Compuestos intermedios y procesos para la preparacion de tapentadol y compuestos relacionados. |
WO2011080756A1 (en) * | 2009-12-29 | 2011-07-07 | Ind-Swift Laboratories Limited | Process for the preparation of 1-phenyl-3-dimethylaminopropane derivatives |
WO2011092719A2 (en) * | 2010-02-01 | 2011-08-04 | Ind-Swift Laboratories Limited | Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives |
EP2531176B1 (en) | 2010-02-03 | 2016-09-07 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of an extruder |
WO2011107876A2 (en) | 2010-03-05 | 2011-09-09 | Actavis Group Ptc Ehf | Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
CA2793948A1 (en) | 2010-04-05 | 2011-10-20 | Actavis Group Ptc Ehf | Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof |
JP5905872B2 (ja) | 2010-04-07 | 2016-04-20 | ルピン・リミテッド | タペンタドールの制御放出医薬組成物 |
EP2383255A1 (en) | 2010-04-28 | 2011-11-02 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
US20130116333A1 (en) | 2010-05-05 | 2013-05-09 | Ratiopharm Gmbh | Solid tapentadol in non-crystalline form |
ITMI20100924A1 (it) * | 2010-05-21 | 2011-11-22 | Fidia Farmaceutici | Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol |
US8846765B2 (en) * | 2010-06-15 | 2014-09-30 | Gruenenthal Gmbh | Pharmaceutical combination |
CN104725246B (zh) | 2010-06-15 | 2017-05-03 | 格吕伦塔尔有限公司 | 用于制备取代的3‑(1‑氨基‑2‑甲基戊烷‑3‑基)苯基化合物的方法 |
SI2588093T1 (sl) | 2010-06-30 | 2016-10-28 | Gruenenthal Gmbh | Tapentadol za uporabo pri zdravljenju sindroma razdražljivega črevesja |
IT1401109B1 (it) | 2010-07-02 | 2013-07-12 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
PT3656765T (pt) * | 2010-07-23 | 2021-05-25 | Gruenenthal Gmbh | Sais ou cocristais de 3-(3-dimetilamino-1-etil-2- metilpropil)fenol |
WO2012023147A1 (en) | 2010-08-16 | 2012-02-23 | Indoco Remedies Limited | Process for the preparation of tapentadol |
JP5933553B2 (ja) | 2010-09-02 | 2016-06-15 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | アニオン性ポリマーを含む不正使用抵抗性剤形 |
ES2486791T3 (es) | 2010-09-02 | 2014-08-19 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación que comprende una sal inorgánica |
CN101948397A (zh) * | 2010-09-07 | 2011-01-19 | 天津泰普药品科技发展有限公司 | 镇痛药他喷他多重要中间体的制备方法 |
WO2012038974A1 (en) | 2010-09-20 | 2012-03-29 | Ind-Swift Laboratories Limited | Process for preparing l-phenyl-3-dimethylaminopropane derivative |
WO2012051246A1 (en) | 2010-10-12 | 2012-04-19 | Ratiopharm Gmbh | Tapentadol hydrobromide and crystalline forms thereof |
CZ2010995A3 (cs) * | 2010-12-30 | 2012-04-11 | Zentiva, K.S. | Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu |
CZ302992B6 (cs) * | 2010-12-30 | 2012-02-08 | Zentiva, K.S. | Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu) |
EP2545028A4 (en) | 2011-01-27 | 2013-07-03 | Symed Labs Ltd | STEREOSPECIFIC SYNTHESIS OF (-) (2S, 3S) -1-DIMETHYLAMINO-3- (3-METHOXYPHENYL) -2-METHYLPENTAN-3-OLE |
CN102617501A (zh) | 2011-01-31 | 2012-08-01 | 中国科学院上海药物研究所 | 取代正戊酰胺类化合物、其制备方法及用途 |
PT3287123T (pt) | 2011-03-04 | 2020-05-22 | Gruenenthal Gmbh | Formulação farmacêutica aquosa de tapentadol para administração oral |
RS54711B1 (en) | 2011-03-04 | 2016-08-31 | Grünenthal GmbH | PARENTERAL TAPENTADOL ADMINISTRATION |
KR102039320B1 (ko) | 2011-03-04 | 2019-11-01 | 그뤼넨탈 게엠베하 | 타펜타돌을 함유하는 반고체 수성 약제학적 조성물 |
US20120309840A1 (en) | 2011-04-05 | 2012-12-06 | Gruenenthal Gmbh | Treatment of Pain Associated with Trigeminal Neuralgia |
DK2694049T3 (da) | 2011-04-05 | 2019-01-02 | Gruenenthal Gmbh | Tapentadol til forebyggelse af kronificering af smerte |
CN102206164A (zh) * | 2011-04-11 | 2011-10-05 | 中国药科大学 | 一种他喷他多中间体的制备方法 |
WO2012146978A2 (en) | 2011-04-28 | 2012-11-01 | Actavis Group Ptc Ehf | A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof |
US20120277319A1 (en) | 2011-04-29 | 2012-11-01 | Gruenenthal Gmbh | Use of Tapentadol for Inhibiting and/or Treating Depression and Anxiety |
EP2530072A1 (en) | 2011-06-03 | 2012-12-05 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
US11413239B2 (en) | 2011-07-20 | 2022-08-16 | Torrent Pharmaceuticals Ltd. | Pharmaceutical composition of tapentadol for nasal administration |
US8853393B2 (en) | 2011-07-29 | 2014-10-07 | Anhui New Star Pharmaceutical Development Co., Ltd. | Intermediate for preparing tapentadol or analogues thereof |
MX353456B (es) * | 2011-07-29 | 2018-01-15 | Gruenenthal Gmbh | Administracion intratecal o epidural de 3-[(1s,2s)-3-(dimetilamino )-1-etil-2-metilpropil]fenol. |
RS56527B1 (sr) | 2011-07-29 | 2018-02-28 | Gruenenthal Gmbh | Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu |
LT2736495T (lt) | 2011-07-29 | 2017-11-10 | Grünenthal GmbH | Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu |
WO2013105109A1 (en) | 2011-11-09 | 2013-07-18 | Indoco Remedies Limited | Process for the preparation of tapentadol |
US20130150622A1 (en) | 2011-12-12 | 2013-06-13 | Boehringer Ingelheim International Gmbh | Stereoselective synthesis of tapentadol and its salts |
CN102557851B (zh) * | 2011-12-13 | 2014-03-26 | 安徽省新星药物开发有限责任公司 | 一种盐酸他喷他多及其类似物的合成方法 |
WO2013111161A2 (en) * | 2012-01-10 | 2013-08-01 | Msn Laboratories Limited | Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof |
WO2013120466A1 (en) | 2012-02-17 | 2013-08-22 | Zentiva, K.S. | A new solid form of tapentadol and a method of its preparation |
CA2864949A1 (en) | 2012-02-28 | 2013-09-06 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
EP2838512B1 (en) | 2012-04-18 | 2018-08-22 | Grünenthal GmbH | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
EP2674414A1 (en) | 2012-06-15 | 2013-12-18 | Siegfried AG | Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds |
CN103159633B (zh) * | 2012-07-06 | 2015-08-12 | 江苏恩华药业股份有限公司 | 他喷他多的制备方法及用于制备他喷他多的化合物 |
ES2661911T3 (es) | 2012-07-16 | 2018-04-04 | Grünenthal GmbH | Parche farmacéutico para la administración transdérmica de tapentadol |
CZ304576B6 (cs) * | 2012-07-24 | 2014-07-16 | Zentiva, K.S. | Oxalát TAPENTADOLU a způsob jeho přípravy |
WO2014068372A1 (en) | 2012-11-01 | 2014-05-08 | Torrent Pharmaceuticals Ltd | Pharmaceutical composition of tapentadol for parenteral administration |
US9090539B2 (en) | 2013-05-24 | 2015-07-28 | Ampac Fine Chemicals Llc | Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds |
JP6466417B2 (ja) | 2013-05-29 | 2019-02-06 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形 |
MX371432B (es) | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
EP2808319A1 (en) | 2013-05-31 | 2014-12-03 | Arevipharma GmbH | 3-[3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol resin complex |
MX368846B (es) | 2013-07-12 | 2019-10-18 | Gruenenthal Gmbh | Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo. |
EP2845625A1 (en) | 2013-09-04 | 2015-03-11 | Grünenthal GmbH | Tapentadol for use in the treatment of fibromyalgia and chronic fatigue syndrome |
RU2016120002A (ru) | 2013-11-01 | 2017-12-04 | Сан Фарма Адвансед Ресёрч Компани | Новое промежуточное соединение тапентадола |
WO2015071248A1 (en) | 2013-11-15 | 2015-05-21 | Synthon B.V. | Abuse-proofed extended release pharmaceutical composition comprising tapentadol |
IN2013MU03670A (da) | 2013-11-21 | 2015-07-31 | Unimark Remedies Ltd | |
EP3073994A1 (en) | 2013-11-26 | 2016-10-05 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
SI3083551T1 (en) | 2013-12-16 | 2018-04-30 | Farma Grs, D.O.O. | CRYSTAL FORM INTERMEDIATE TAPENTADOL |
CN104803861B (zh) * | 2014-01-27 | 2017-05-24 | 上海博邦医药科技有限公司 | 一种合成盐酸他喷他多的方法 |
CZ307492B6 (cs) | 2014-02-04 | 2018-10-17 | Zentiva, K.S. | Pevná forma maleátu tapentadolu a způsob její přípravy |
GB2523089A (en) * | 2014-02-12 | 2015-08-19 | Azad Pharmaceutical Ingredients Ag | Stable polymorph form B of tapentadol hydrochloride |
EP2942054A1 (en) | 2014-05-09 | 2015-11-11 | G.L. Pharma GmbH | Slow-release pharmaceutical formulation |
EP3142646A1 (en) | 2014-05-12 | 2017-03-22 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
AU2015266117A1 (en) | 2014-05-26 | 2016-11-24 | Grunenthal Gmbh | Multiparticles safeguarded against ethanolic dose-dumping |
US9556108B2 (en) | 2014-07-10 | 2017-01-31 | Mallinckrodt Llc | Process for preparing substituted phenylalkanes |
PL3273953T3 (pl) | 2015-03-27 | 2019-07-31 | Grünenthal GmbH | Stabilny preparat do pozajelitowego podawania tapentadolu |
EA035434B1 (ru) | 2015-04-24 | 2020-06-15 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями |
US10421050B2 (en) * | 2015-05-22 | 2019-09-24 | Digi-Star, Llc | Utilization of a mobile agricultural weighing system to monitor and store ancillary operational data for diagnostic purposes on trailed and truck-mounted equipment |
WO2016190766A1 (en) | 2015-05-26 | 2016-12-01 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa | Compositions for use in treating parkinson's disease and related disorders |
AU2016292797B2 (en) | 2015-07-10 | 2018-05-31 | SpecGx LLC | A two-step process for preparing 3-substituted phenylalkylamines |
JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
ES2860907T3 (es) | 2015-11-17 | 2021-10-05 | Msn Laboratories Private Ltd | Formas cristalinas de sales de tapentadol y procedimiento para la preparación de las mismas |
PL3653599T3 (pl) | 2016-04-19 | 2023-03-20 | Ratiopharm Gmbh | Krystaliczny fosforan tapentadolu |
MX2019003257A (es) | 2016-09-23 | 2019-06-10 | Gruenenthal Gmbh | Formulacion estable para la administracion parenteral de tapentadol. |
PL3568126T3 (pl) | 2017-01-11 | 2024-03-25 | Torrent Pharmaceuticals Limited | Donosowa kompozycja tapentadolu |
US10292948B2 (en) | 2017-01-11 | 2019-05-21 | Torrent Pharmaceuticals Limited | Tapentadol nasal composition |
WO2019195775A1 (en) * | 2018-04-06 | 2019-10-10 | Flex Pharma, Inc. | Tolperisone analogs and methods of use |
CN112262121A (zh) | 2018-06-15 | 2021-01-22 | 法尔玛赞公司 | 用于制备他喷他多的新方法 |
GR1009751B (el) | 2019-03-22 | 2020-05-29 | "Φαρματεν Α.Β.Ε.Ε." | Σκευασμα παρατεταμενης αποδεσμευσης που περιλαμβανει οξαλικη ταπενταδολη και μεθοδος παρασκευης αυτου |
GR1009791B (el) | 2019-03-26 | 2020-08-03 | Φαρματεν Α.Β.Ε.Ε. | Σκευασμα παρατεταμενης αποδεσμευσης που περιλαμβανει ταπενταδολη και μεθοδος παρασκευης αυτου |
KR102297806B1 (ko) * | 2019-11-11 | 2021-09-03 | 한국생산기술연구원 | 탄탈륨-구리 합금의 제조방법 및 이로부터 제조된 탄탈륨-구리 합금 |
CN111056961A (zh) * | 2019-11-13 | 2020-04-24 | 李晓强 | 3-((1s,2s)-3-二甲氨基-1-乙基-2-甲基丙基)苯酚盐酸盐的制备方法 |
BR112022017700A2 (pt) | 2020-03-02 | 2023-01-17 | Gruenenthal Gmbh | Forma de dosagem fornecendo liberação prolongada de sal de ácido fosfórico de tapentadol |
EP3875080A1 (en) | 2020-03-02 | 2021-09-08 | Grünenthal GmbH | Dosage form providing prolonged release of tapentadol phosphoric acid salt |
ES2968510T3 (es) | 2020-03-02 | 2024-05-10 | Gruenenthal Gmbh | Forma de dosificación que proporciona liberación prolongada de sal de ácido fosfórico de Tapentadol |
DE202020104285U1 (de) | 2020-07-24 | 2020-12-18 | Grünenthal GmbH | Ethylcellulose-beschichtete Partikel enthaltend ein Salz aus Tapentadol und Phosphorsäure |
EP3995135B1 (de) | 2020-11-10 | 2022-07-13 | Grünenthal GmbH | Darreichungsformen mit verlängerter freisetzung eines salzes von tapentadol mit l-(+)-weinsäure |
PE20240113A1 (es) | 2020-11-10 | 2024-01-22 | Gruenenthal Chemie | Formas de dosificacion de liberacion sostenida de una sal de tapentadol con acido l-(+)-tartarico |
DE202020005470U1 (de) | 2020-11-10 | 2022-01-25 | Grünenthal GmbH | Darreichungsformen mit verlängerter Freisetzung eines Salzes von Tapentadol mit L-(+)-Weinsäure |
EP4011369A1 (en) | 2020-12-14 | 2022-06-15 | G.L. Pharma GmbH | Aqueous pharmaceutical composition comprising tapentadol tartrate |
EP4269384A1 (en) | 2022-04-26 | 2023-11-01 | KRKA, d.d., Novo mesto | Method for crystallizing tapentadol intermediate, tapentadol intermediate of high purity, method of making tapentadol and tapentadol of high purity |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE124521C (da) | ||||
US2662886A (en) | 1949-01-28 | 1953-12-15 | Winthrop Stearns Inc | Substituted phenylpropylamines |
DE1051281B (de) * | 1955-07-05 | 1959-02-26 | Bayer Ag | Verfahren zur Herstellung von Derivaten der 1-Aryl-3-aminopropan-1-ole |
US3328249A (en) | 1965-06-21 | 1967-06-27 | Sterling Drug Inc | Process for counteracting depressive states |
NL7403348A (da) * | 1973-03-19 | 1974-09-23 | ||
DD124521A1 (da) | 1976-03-16 | 1977-03-02 | ||
US4608391A (en) | 1977-07-05 | 1986-08-26 | Cornell Research Foundation Inc. | Catecholamine derivatives, a process for their preparation and pharmaceutical compositions thereof |
DE2732750A1 (de) * | 1977-07-20 | 1979-02-08 | Merck Patent Gmbh | Basische thioaether und verfahren zu ihrer herstellung |
US4404222A (en) | 1980-08-25 | 1983-09-13 | American Cyanamid Company | Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization thereby |
US4336269A (en) | 1979-12-10 | 1982-06-22 | Eli Lilly And Company | Para-nitrophenylalkylamines |
DE3242922A1 (de) | 1982-11-20 | 1984-05-24 | Basf Ag, 6700 Ludwigshafen | Phenylpropanolamine, ihre herstellung und verwendung |
IT1213219B (it) | 1984-09-28 | 1989-12-14 | Consiglio Nazionale Ricerche | Derivati amminoalchilnaftalenici ad attivita' farmacologica. |
US4843160A (en) | 1984-10-01 | 1989-06-27 | The Dow Chemical Company | Preparation of alpha-aminoalkylphenols |
US5059422A (en) | 1985-07-29 | 1991-10-22 | American Cyanamid Company | Continuous release phenylethanolamine derivative compositions |
US5169633A (en) | 1985-07-29 | 1992-12-08 | American Cyanamid Company | Continuous release phenylethanolamine derivative compositions |
US4857553A (en) | 1987-08-06 | 1989-08-15 | A. H. Robins Company, Incorporated | Method of treating nausea and vomiting with certain substituted-phenylalkylamino (and aminoacid) derivatives and other serotonin depleting agents |
SE8800207D0 (sv) * | 1988-01-22 | 1988-01-22 | Kabivitrum Ab | Nya aminer, deras anvendning och framstellning |
US5135955A (en) | 1988-04-25 | 1992-08-04 | Eli Lilly And Company | Propanamine derivatives |
WO1990002126A1 (en) | 1988-08-24 | 1990-03-08 | Mochida Pharmaceutical Co., Ltd. | Hydantoin derivatives |
DK258389D0 (da) * | 1989-05-26 | 1989-05-26 | Ferrosan As | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
WO1991009594A1 (en) | 1989-12-28 | 1991-07-11 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
US5281623A (en) | 1990-08-27 | 1994-01-25 | Eli Lilly And Company | Method for treating inflammation |
CA2049481A1 (en) | 1990-08-27 | 1992-02-28 | Jill Ann Panetta | Method of treating inflammatory bowel disease |
US5280046A (en) | 1991-02-22 | 1994-01-18 | The University Of Colorado Foundation, Inc. | Method of treating type I diabetes |
US6031003A (en) * | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US6001884A (en) * | 1991-08-23 | 1999-12-14 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US6011068A (en) * | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US5419993A (en) | 1991-11-01 | 1995-05-30 | Canon Kabushiki Kaisha | Polyamide, electrophotographic photosensitive member employing the polyamide, and electrophotographic apparatus, device unit and facsimile machine employing the member |
US5322859A (en) | 1993-02-08 | 1994-06-21 | University Of Iowa Research Foundation | Antiglaucoma drug composition and method |
US6071970A (en) * | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
US6017965A (en) * | 1993-02-08 | 2000-01-25 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
US5387614A (en) | 1993-07-27 | 1995-02-07 | University Of Iowa Research Foundation | Use of sigma receptor ligands as salivary gland stimulants |
CA2182680A1 (en) * | 1994-02-08 | 1995-08-17 | Alan L. Mueller | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
ATE199829T1 (de) | 1994-06-03 | 2001-04-15 | Thejmde Trust | Meta substituierte arylalkylamine und therapeutische und diagnostische verwendung davon |
ATE287390T1 (de) | 1994-10-21 | 2005-02-15 | Nps Pharma Inc | Kalzium-rezeptor aktive verbindungen |
DE19525137C2 (de) | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
US5648541A (en) | 1995-09-28 | 1997-07-15 | Nps Pharmaceuticals, Inc. | Chiral reductions of imines leading to the syntheses of optically active amines |
US5830509A (en) | 1996-02-07 | 1998-11-03 | West; Daniel David | Microparticle complexes with 2-amino-1-phenylpropanol materials |
DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
NZ332068A (en) * | 1996-04-09 | 2001-03-30 | Smithkline Beecham | Alpha, alpha-disubstituted arylalkylamine derivatives as calcilytic compounds |
ATE430123T1 (de) * | 1996-05-01 | 2009-05-15 | Nps Pharma Inc | Inorganische am ionen-rezeptor aktive verbindungen |
US6052610A (en) * | 1998-01-09 | 2000-04-18 | International Business Machines Corporation | Magnetic catheter tracker and method therefor |
US6011066A (en) | 1998-02-02 | 2000-01-04 | Veterans General Hospital-Taipei | Method for treating septic shock |
DE19915601A1 (de) | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
US6828351B2 (en) | 2000-11-01 | 2004-12-07 | Sention, Inc. | Methods and compositions for regulating memory consolidation |
-
1994
- 1994-07-23 DE DE4426245A patent/DE4426245A1/de not_active Withdrawn
-
1995
- 1995-05-29 IL IL11390195A patent/IL113901A/xx active Protection Beyond IP Right Term
- 1995-06-06 US US08/466,911 patent/US6248737B1/en not_active Ceased
- 1995-07-06 UY UY23992A patent/UY23992A1/es not_active IP Right Cessation
- 1995-07-12 AT AT95110864T patent/ATE163176T1/de active
- 1995-07-12 EP EP95110864A patent/EP0693475B1/de not_active Expired - Lifetime
- 1995-07-12 DE DE59501431T patent/DE59501431D1/de not_active Expired - Lifetime
- 1995-07-12 DE DE122011000007C patent/DE122011000007I1/de active Pending
- 1995-07-12 SI SI9530043T patent/SI0693475T1/xx unknown
- 1995-07-12 ES ES95110864T patent/ES2115298T3/es not_active Expired - Lifetime
- 1995-07-12 DK DK95110864T patent/DK0693475T3/da active
- 1995-07-14 UA UA95073330A patent/UA41345C2/uk unknown
- 1995-07-17 HU HU9502146A patent/HU218481B/hu active Protection Beyond IP Right Term
- 1995-07-19 PE PE1995274181A patent/PE34896A1/es not_active IP Right Cessation
- 1995-07-19 RU RU95113154/04A patent/RU2150465C1/ru active
- 1995-07-20 NZ NZ272623A patent/NZ272623A/en not_active IP Right Cessation
- 1995-07-20 MY MYPI95002089A patent/MY114889A/en unknown
- 1995-07-21 PL PL95309734A patent/PL181169B1/pl unknown
- 1995-07-21 AU AU27138/95A patent/AU685644B2/en not_active Expired
- 1995-07-21 CZ CZ19951904A patent/CZ286441B6/cs not_active IP Right Cessation
- 1995-07-21 CA CA002154424A patent/CA2154424C/en not_active Expired - Lifetime
- 1995-07-21 ZA ZA956118A patent/ZA956118B/xx unknown
- 1995-07-21 JP JP18603195A patent/JP4034366B2/ja not_active Expired - Lifetime
- 1995-07-21 CO CO95032376A patent/CO4410179A1/es unknown
- 1995-07-21 CN CN95108919A patent/CN1077566C/zh not_active Expired - Lifetime
- 1995-07-21 BR BR9502390A patent/BR9502390A/pt not_active IP Right Cessation
- 1995-07-21 FI FI953523A patent/FI114704B/fi not_active IP Right Cessation
- 1995-07-22 KR KR1019950021738A patent/KR100364465B1/ko active Protection Beyond IP Right Term
-
1998
- 1998-03-11 GR GR980400517T patent/GR3026326T3/el unknown
- 1998-05-15 HK HK98104213A patent/HK1005062A1/xx not_active IP Right Cessation
-
2001
- 2001-04-20 US US09/838,192 patent/US6344558B1/en not_active Expired - Lifetime
-
2003
- 2003-06-17 US US10/462,844 patent/USRE39593E1/en not_active Expired - Lifetime
-
2006
- 2006-12-20 JP JP2006342354A patent/JP4846552B2/ja not_active Expired - Lifetime
-
2011
- 2011-03-01 LU LU91793C patent/LU91793I2/fr unknown
- 2011-07-14 LT LTPA2011007C patent/LTPA2011007I1/lt unknown
-
2012
- 2012-03-02 FR FR12C0016C patent/FR12C0016I2/fr active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0693475T3 (da) | 1-Phenyl-3-dimethylamino-propan forbindelser med farmakologisk virkning | |
EP0320118A3 (en) | Peptides with collagenase inhibiting activity | |
ATE118523T1 (de) | Flüssigkristall-racematmischung, flüssigkristallzusammensetzung und flüssigkristallelement, verfahren zur herstellung und verwendung. | |
DE69529624D1 (de) | Neue endiyn-chinonimine und verfahren zu deren herstellung und verwendung | |
ZA854205B (en) | Plant growth regulators | |
ES538933A0 (es) | Un procedimiento para preparar imidazo(1,2-c)pirimidinas | |
DE69119714D1 (de) | Verfahren zur Herstellung von Benzylphthalazinonderivaten und von deren Salzen | |
FR2263752A1 (en) | 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants | |
EP0145236A3 (en) | Thiadiazinone compounds, process for their preparation, and pharmaceutical compositions containing them | |
JPS6479181A (en) | Novel beta-lactam compound and production thereof | |
ZA86543B (en) | 2-alkoxycarbonylalkyl-3-oxo-5,6-diaryl-as-triazines having utility as therapeutics | |
GB1042206A (en) | Benzo[a]quinolizine amides and the preparation thereof | |
HUT37382A (en) | New salts of cyclopropanecarboxylic acid and their application | |
TH15143A (th) | การยับยั้งไนโทรซามีน | |
PT84061A (en) | Process for the preparation of monosulfactams | |
ES8306020A1 (es) | Un procedimiento para la preparacion de un derivado de fenetilamina. |