DE69938129D1 - Verbesserte in vivo-produktion von cephalosporinen - Google Patents
Verbesserte in vivo-produktion von cephalosporinenInfo
- Publication number
- DE69938129D1 DE69938129D1 DE69938129T DE69938129T DE69938129D1 DE 69938129 D1 DE69938129 D1 DE 69938129D1 DE 69938129 T DE69938129 T DE 69938129T DE 69938129 T DE69938129 T DE 69938129T DE 69938129 D1 DE69938129 D1 DE 69938129D1
- Authority
- DE
- Germany
- Prior art keywords
- improved
- vivo production
- cephalosporines
- host cell
- host cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004027 cell Anatomy 0.000 abstract 4
- 101710104123 Deacetoxycephalosporin C synthase Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 210000000172 cytosol Anatomy 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000002500 microbody Anatomy 0.000 abstract 1
- 210000002824 peroxisome Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98201655 | 1998-05-19 | ||
| PCT/EP1999/003455 WO1999060102A2 (en) | 1998-05-19 | 1999-05-19 | Improved in vivo production of cephalosporins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69938129D1 true DE69938129D1 (de) | 2008-03-27 |
Family
ID=8233737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69938129T Expired - Lifetime DE69938129D1 (de) | 1998-05-19 | 1999-05-19 | Verbesserte in vivo-produktion von cephalosporinen |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6995003B1 (enExample) |
| EP (2) | EP1078069B1 (enExample) |
| JP (1) | JP2003527069A (enExample) |
| KR (1) | KR100648480B1 (enExample) |
| CN (2) | CN101353660A (enExample) |
| AT (1) | ATE386123T1 (enExample) |
| AU (1) | AU4144999A (enExample) |
| BR (1) | BR9910532A (enExample) |
| DE (1) | DE69938129D1 (enExample) |
| ES (1) | ES2302379T3 (enExample) |
| ID (1) | ID27054A (enExample) |
| MX (1) | MXPA00011223A (enExample) |
| PL (1) | PL344863A1 (enExample) |
| RU (1) | RU2230790C2 (enExample) |
| WO (1) | WO1999060102A2 (enExample) |
| ZA (1) | ZA200006308B (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011185D0 (en) * | 2000-05-09 | 2000-06-28 | Synpac Pharmaceuticals Limited | Protein |
| CN1796537B (zh) * | 2004-12-23 | 2010-09-08 | 华北制药集团有限责任公司 | 一种新的产黄青霉菌株以及利用此菌株发酵制备青霉素 |
| US20060217971A1 (en) * | 2005-03-28 | 2006-09-28 | Tellabs Operations, Inc. | Method and apparatus for modifying an encoded signal |
| EP2220234B1 (en) | 2007-11-20 | 2012-06-27 | DSM IP Assets B.V. | Dicarboxylic acid production in a recombinant yeast |
| WO2009065777A1 (en) | 2007-11-20 | 2009-05-28 | Dsm Ip Assets B.V. | Dicarboxylic acid production in a filamentous fungus |
| CN104818224A (zh) | 2007-11-20 | 2015-08-05 | 帝斯曼知识产权资产管理有限公司 | 在真核细胞中生产琥珀酸 |
| EP2116136A1 (en) | 2008-05-08 | 2009-11-11 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Novel phytases |
| EP2408907B8 (en) | 2009-03-17 | 2018-04-18 | Dutch DNA Biotech B.V. | Use of cellulose and ligno-cellulose active proteins |
| WO2010118932A1 (en) | 2009-04-15 | 2010-10-21 | Dsm Ip Assets B.V. | Dicarboxylic acid production process |
| UA108853C2 (uk) | 2009-07-10 | 2015-06-25 | Спосіб ферментації галактози | |
| EA201201449A1 (ru) | 2010-04-21 | 2013-03-29 | ДСМ АйПи АССЕТС Б.В. | Способ получения клеток, способных преобразовывать арабинозу |
| EP2388331A1 (en) | 2010-05-21 | 2011-11-23 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Constitutive promoter |
| MY160995A (en) | 2010-10-13 | 2017-03-28 | Dsm Ip Assets Bv | Polypeptides with permease activity |
| EA201301193A1 (ru) | 2011-04-22 | 2014-02-28 | ДСМ АйПи АССЕТС Б.В. | Дрожжевые клетки, способные к превращению сахаров, содержащих арабинозу и ксилозу |
| AR087423A1 (es) | 2011-08-04 | 2014-03-19 | Dsm Ip Assets Bv | Celula capaz de fermentar azucares pentosas |
| EP2554668A1 (en) | 2011-08-04 | 2013-02-06 | DSM IP Assets B.V. | A pentose sugar fermenting cell |
| EA201400836A8 (ru) | 2012-01-23 | 2016-03-31 | ДСМ АйПи АССЕТС Б.В. | Получение дитерпена |
| CN104718280A (zh) | 2012-10-16 | 2015-06-17 | 帝斯曼知识产权资产管理有限公司 | 具有改善的戊糖转化的细胞 |
| EP2772545A1 (en) | 2013-03-01 | 2014-09-03 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Starch active proteins |
| EP2981610A1 (en) | 2013-04-05 | 2016-02-10 | Université du Luxembourg | Biotechnological production of itaconic acid |
| EP2992105A1 (en) | 2013-05-02 | 2016-03-09 | Dutch DNA Biotech B.V. | Novel organic acid pathway |
| CA2913876A1 (en) | 2013-05-31 | 2014-12-04 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
| AU2014292150B2 (en) | 2013-07-15 | 2019-04-04 | Dsm Ip Assets B.V. | Diterpene production |
| EP3536697A1 (en) | 2013-07-31 | 2019-09-11 | DSM IP Assets B.V. | Recovery of steviol glycosides |
| EP3259361A1 (en) | 2015-02-16 | 2017-12-27 | DSM IP Assets B.V. | Process for producing itaconic acid under anaerobic conditions |
| CA2979931A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| CA2979957A1 (en) | 2015-03-23 | 2016-09-29 | Dsm Ip Assets B.V. | Udp-glycosyltransferases from solanum lycopersicum |
| EP3718417B1 (en) | 2015-04-03 | 2025-09-03 | DSM IP Assets B.V. | Steviol glycosides |
| CN107532135A (zh) | 2015-04-21 | 2018-01-02 | 帝斯曼知识产权资产管理有限公司 | 萜类化合物的微生物生产 |
| MY186983A (en) | 2015-05-22 | 2021-08-26 | Dsm Ip Assets Bv | Acetate consuming yeast cell |
| EP3320104B1 (en) | 2015-07-10 | 2021-11-10 | DSM IP Assets B.V. | Method for preparing a steviol glycoside composition |
| CA2993744A1 (en) | 2015-08-13 | 2017-02-16 | Dsm Ip Assets B.V. | Steviol glycoside transport |
| WO2017050652A1 (en) | 2015-09-25 | 2017-03-30 | Dsm Ip Assets B.V. | Asparaginase |
| CA2999638A1 (en) | 2015-10-05 | 2017-04-13 | Dsm Ip Assets B.V. | Kaurenoic acid hydroxylases |
| EP3359655B1 (en) | 2015-10-06 | 2019-11-20 | DSM IP Assets B.V. | Eukaryotic cell with increased production of fermentation product |
| WO2017115323A2 (en) | 2015-12-30 | 2017-07-06 | Dsm Ip Assets B.V. | Partial enzymatic hydrolysis of triacylglycerols |
| WO2017115322A2 (en) | 2015-12-30 | 2017-07-06 | Dsm Ip Assets B.V. | Partial enzymatic hydrolysis of triacylglycerols |
| WO2017167847A1 (en) | 2016-03-31 | 2017-10-05 | Dsm Ip Assets B.V. | Production of milk with low lactose content |
| EP3435772A1 (en) | 2016-03-31 | 2019-02-06 | DSM IP Assets B.V. | Enzyme composition and preparation of a dairy product with improved properties |
| WO2017167848A1 (en) | 2016-03-31 | 2017-10-05 | Dsm Ip Assets B.V. | Enzyme composition and preparation of a dairy product with improved properties |
| CN109312296B (zh) | 2016-06-14 | 2023-05-05 | 帝斯曼知识产权资产管理有限公司 | 重组酵母细胞 |
| EP3919615A1 (en) | 2016-07-13 | 2021-12-08 | DSM IP Assets B.V. | Malate dehyrogenases |
| EP3497109A1 (en) | 2016-08-09 | 2019-06-19 | DSM IP Assets B.V. | Crystallization of steviol glycosides |
| EP3497110A1 (en) | 2016-08-09 | 2019-06-19 | DSM IP Assets B.V. | Crystallization of steviol glycosides |
| CN110036114B (zh) | 2016-08-26 | 2023-09-29 | 勒萨弗尔公司 | 提高的衣康酸生产 |
| WO2018073107A1 (en) | 2016-10-19 | 2018-04-26 | Dsm Ip Assets B.V. | Eukaryotic cell comprising xylose isomerase |
| WO2018078014A1 (en) | 2016-10-27 | 2018-05-03 | Dsm Ip Assets B.V. | Geranylgeranyl pyrophosphate synthases |
| JP2020500520A (ja) | 2016-12-08 | 2020-01-16 | ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． | カウレン酸ヒドロキシラーゼ |
| WO2018114912A1 (en) | 2016-12-21 | 2018-06-28 | Dsm Ip Assets B.V. | Lipolytic enzyme variants |
| EP3559222A1 (en) | 2016-12-21 | 2019-10-30 | DSM IP Assets B.V. | Lipolytic enzyme variants |
| US10889807B2 (en) | 2016-12-21 | 2021-01-12 | Dsm Ip Assets B.V. | Lipolytic enzyme variants |
| WO2018114938A1 (en) | 2016-12-21 | 2018-06-28 | Dsm Ip Assets B.V. | Lipolytic enzyme variants |
| WO2018114995A1 (en) | 2016-12-22 | 2018-06-28 | Dsm Ip Assets B.V. | Fermentation process for producing steviol glycosides |
| CA3064143A1 (en) | 2017-06-13 | 2018-12-20 | Dsm Ip Assets B.V. | Recombinant yeast cell |
| EP4155400A1 (en) | 2017-06-27 | 2023-03-29 | DSM IP Assets B.V. | Udp-glycosyltransferases |
| CN111133111A (zh) | 2017-09-26 | 2020-05-08 | 帝斯曼知识产权资产管理有限公司 | 消耗乙酸的菌株 |
| EP3533878A1 (en) | 2018-02-28 | 2019-09-04 | Dutch DNA Biotech B.V. | Process for producing citramalic acid employing aspergillus |
| MX2020014191A (es) | 2018-06-19 | 2021-03-09 | Dsm Ip Assets Bv | Variantes de enzimas lipoliticas. |
| EP4232568A1 (en) | 2020-10-22 | 2023-08-30 | DSM IP Assets B.V. | Microorganisms for diterpene production |
| WO2022269549A2 (en) | 2021-06-24 | 2022-12-29 | Fonterra Co-Operative Group Limited | Recombinant proteins |
| US20250333768A1 (en) | 2021-07-12 | 2025-10-30 | Danisco Us Inc. | Recombinant yeast cell |
| WO2023285280A1 (en) | 2021-07-12 | 2023-01-19 | Dsm Ip Assets B.V. | Recombinant yeast cell |
| MX2024000606A (es) | 2021-07-12 | 2024-01-30 | Danisco Us Inc | Celula de levadura recombinante. |
| EP4370692A1 (en) | 2021-07-12 | 2024-05-22 | Danisco Us Inc | Recombinant yeast cell |
| MX2024000513A (es) | 2021-07-12 | 2024-03-27 | Danisco Us Inc | Celula de levadura recombinante. |
| CN117916381A (zh) | 2021-07-12 | 2024-04-19 | 丹尼斯科美国公司 | 重组酵母细胞 |
| EP4426824A1 (en) | 2021-11-04 | 2024-09-11 | Danisco US Inc. | Recombinant yeast cell |
| US20240425888A1 (en) | 2021-11-04 | 2024-12-26 | Danisco Us Inc. | Process for the production of ethanol and recombinant yeast cell |
| US20240409965A1 (en) | 2021-11-04 | 2024-12-12 | Danisco Us Inc. | Variant polypeptide and recombinant yeast cell |
| EP4430174A1 (en) | 2021-11-09 | 2024-09-18 | Amgen Inc. | Production of therapeutic proteins |
| JP2025520009A (ja) | 2022-05-16 | 2025-07-01 | ディーエスエム アイピー アセッツ ビー．ブイ． | 脂肪分解酵素変異体 |
| CN121127603A (zh) | 2023-04-20 | 2025-12-12 | 帝斯曼知识产权资产管理有限公司 | 用于产生罗汉果苷的菌株和方法 |
| WO2025012325A1 (en) | 2023-07-11 | 2025-01-16 | Dsm Ip Assets B.V. | Protein arginine deiminase |
| WO2025144785A2 (en) | 2023-12-28 | 2025-07-03 | Dsm Ip Assets B.V. | Cells and methods for the production of glycosylated compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4003894A (en) | 1971-08-17 | 1977-01-18 | Gist-Brocades N.V. | Preparation of 7-substituted amino-desacetoxycephalosporanic acid compounds |
| PT83746B (pt) | 1985-11-15 | 1988-08-17 | Gist Brocades Nv | Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao |
| US5070020A (en) * | 1988-05-09 | 1991-12-03 | Eli Lilly And Company | Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase |
| US5082772A (en) | 1988-10-24 | 1992-01-21 | Eli Lilly And Company | Process for preparing deacetylcephalosporin c |
| PT97116B (pt) * | 1990-03-23 | 1998-10-30 | Gist Brocades Nv | Processo para modular a producao de metabolitos secundarios nomeadamente derivados de beta-lactama |
| US5318896A (en) | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
| UA47385C2 (uk) * | 1991-10-15 | 2002-07-15 | Гіст-Брокейдс Б.В. | Спосіб одержання 7-амінодеацетилцефалоспоранової кислоти, спосіб одержання 7-аміноцефалоспоранової кислоти, вектор експресії рекомбінантної днк (варіанти), клітина-хазяїн penicillium chrysogenum (варіанти), спосіб культивування рекомбінантної клітини-хазяїна penicillium chrysogenum (варіанти) |
| EP1321523A3 (en) | 1993-07-23 | 2004-03-03 | DSM IP Assets B.V. | Selection marker gene free recombinant strains; a method for obtaining them and the use of these strains |
| PL180565B1 (pl) * | 1993-07-30 | 2001-02-28 | Gist Brocades Bv | Sposób wytwarzaniai wydzielania kwasu 7-aminodezacetoksycefalosporanowego (7-ADCA) PL PL |
| WO1995004148A1 (en) | 1993-07-30 | 1995-02-09 | Gist-Brocades B.V. | Process for the efficient production of 7-adca via 2-(carboxyethylthio)acetyl-7-adca and 3-(carboxymethylthio)propionyl-7-adca |
| WO1997020053A2 (en) | 1995-11-27 | 1997-06-05 | Gist-Brocades B.V. | Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin g |
| AU4114697A (en) | 1996-07-16 | 1998-02-09 | Gist-Brocades B.V. | Improved process for the production of adipoyl cephalosporins |
-
1999
- 1999-05-19 WO PCT/EP1999/003455 patent/WO1999060102A2/en not_active Ceased
- 1999-05-19 AU AU41449/99A patent/AU4144999A/en not_active Abandoned
- 1999-05-19 JP JP2000549710A patent/JP2003527069A/ja not_active Withdrawn
- 1999-05-19 EP EP99925015A patent/EP1078069B1/en not_active Expired - Lifetime
- 1999-05-19 PL PL99344863A patent/PL344863A1/xx not_active Application Discontinuation
- 1999-05-19 AT AT99925015T patent/ATE386123T1/de not_active IP Right Cessation
- 1999-05-19 CN CNA2008100875582A patent/CN101353660A/zh active Pending
- 1999-05-19 RU RU2000131687/13A patent/RU2230790C2/ru not_active IP Right Cessation
- 1999-05-19 ID IDW20002338A patent/ID27054A/id unknown
- 1999-05-19 CN CNB998063142A patent/CN100390285C/zh not_active Expired - Lifetime
- 1999-05-19 US US09/700,080 patent/US6995003B1/en not_active Expired - Fee Related
- 1999-05-19 KR KR1020007012957A patent/KR100648480B1/ko not_active Expired - Fee Related
- 1999-05-19 EP EP08101461A patent/EP1953230A1/en not_active Withdrawn
- 1999-05-19 DE DE69938129T patent/DE69938129D1/de not_active Expired - Lifetime
- 1999-05-19 ES ES99925015T patent/ES2302379T3/es not_active Expired - Lifetime
- 1999-05-19 BR BR9910532-2A patent/BR9910532A/pt not_active Application Discontinuation
- 1999-05-19 MX MXPA00011223A patent/MXPA00011223A/es unknown
-
2000
- 2000-11-03 ZA ZA200006308A patent/ZA200006308B/en unknown
-
2006
- 2006-02-07 US US11/349,381 patent/US20060127972A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101353660A (zh) | 2009-01-28 |
| JP2003527069A (ja) | 2003-09-16 |
| US20060127972A1 (en) | 2006-06-15 |
| ES2302379T3 (es) | 2008-07-01 |
| RU2230790C2 (ru) | 2004-06-20 |
| WO1999060102A3 (en) | 2000-02-03 |
| AU4144999A (en) | 1999-12-06 |
| EP1078069B1 (en) | 2008-02-13 |
| CN1301303A (zh) | 2001-06-27 |
| EP1078069A2 (en) | 2001-02-28 |
| ATE386123T1 (de) | 2008-03-15 |
| ZA200006308B (en) | 2001-05-23 |
| KR100648480B1 (ko) | 2006-11-24 |
| EP1953230A1 (en) | 2008-08-06 |
| PL344863A1 (en) | 2001-11-19 |
| US6995003B1 (en) | 2006-02-07 |
| ID27054A (id) | 2001-02-22 |
| BR9910532A (pt) | 2001-10-16 |
| WO1999060102A2 (en) | 1999-11-25 |
| MXPA00011223A (es) | 2002-04-17 |
| CN100390285C (zh) | 2008-05-28 |
| KR20010025039A (ko) | 2001-03-26 |
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