BR9910532A - Produção melhorada in vivo de cefalosporina - Google Patents

Produção melhorada in vivo de cefalosporina

Info

Publication number
BR9910532A
BR9910532A BR9910532-2A BR9910532A BR9910532A BR 9910532 A BR9910532 A BR 9910532A BR 9910532 A BR9910532 A BR 9910532A BR 9910532 A BR9910532 A BR 9910532A
Authority
BR
Brazil
Prior art keywords
improved
vivo
host cell
host cells
localised
Prior art date
Application number
BR9910532-2A
Other languages
English (en)
Inventor
Maarten Nieboer
Roelof Ary Lans Bovenberg
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Publication of BR9910532A publication Critical patent/BR9910532A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PRODUçãO MELHORADA IN VIVO DE CEFALOSPORINA" A invenção apresenta DNA, células hospedeiras heterólogas, capazes de transcrever, traduzir, ou expressar o referido DNA e processos empregando tais células hospedeiras e suas culturas para uma produção melhorada in vivo de cefalosporinas aciladas com rendimento mais elevado. De acordo com a invenção, é apresentada uma célula hospedeira, que compreende uma enzima que possui atividade de expandase, que está predominante localizada no citossol (ao contrário de estar localizada principalmente em, ou com os peroxissomos ou microcorpos) da célula hospedeira.
BR9910532-2A 1998-05-19 1999-05-19 Produção melhorada in vivo de cefalosporina BR9910532A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201655 1998-05-19
PCT/EP1999/003455 WO1999060102A2 (en) 1998-05-19 1999-05-19 Improved in vivo production of cephalosporins

Publications (1)

Publication Number Publication Date
BR9910532A true BR9910532A (pt) 2001-10-16

Family

ID=8233737

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910532-2A BR9910532A (pt) 1998-05-19 1999-05-19 Produção melhorada in vivo de cefalosporina

Country Status (16)

Country Link
US (2) US6995003B1 (pt)
EP (2) EP1078069B1 (pt)
JP (1) JP2003527069A (pt)
KR (1) KR100648480B1 (pt)
CN (2) CN100390285C (pt)
AT (1) ATE386123T1 (pt)
AU (1) AU4144999A (pt)
BR (1) BR9910532A (pt)
DE (1) DE69938129D1 (pt)
ES (1) ES2302379T3 (pt)
ID (1) ID27054A (pt)
MX (1) MXPA00011223A (pt)
PL (1) PL344863A1 (pt)
RU (1) RU2230790C2 (pt)
WO (1) WO1999060102A2 (pt)
ZA (1) ZA200006308B (pt)

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EP2388331A1 (en) 2010-05-21 2011-11-23 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Constitutive promoter
US9353376B2 (en) 2010-10-13 2016-05-31 Dsm Ip Assets, B.V. Pentose and glucose fermenting yeast cell
EP2699589A2 (en) 2011-04-22 2014-02-26 DSM IP Assets B.V. Yeast cell capable of converting sugars including arabinose and xylose
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AR087423A1 (es) 2011-08-04 2014-03-19 Dsm Ip Assets Bv Celula capaz de fermentar azucares pentosas
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WO2014060377A1 (en) 2012-10-16 2014-04-24 Dsm Ip Assets B.V. Cells with improved pentose conversion
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CN108064135A (zh) 2013-07-15 2018-05-22 帝斯曼知识产权资产管理有限公司 二萜的生产
DK3027632T3 (da) 2013-07-31 2019-06-17 Dsm Ip Assets Bv Indvinding af steviolglycosider fra et fermenteringsmedium
WO2016131818A1 (en) 2015-02-16 2016-08-25 Dsm Ip Assets B.V. Process for producing itaconic acid under anaerobic conditions
US10604743B2 (en) 2015-03-16 2020-03-31 Dsm Ip Assets B.V. UDP-glycosyltransferases
CA2979957A1 (en) 2015-03-23 2016-09-29 Dsm Ip Assets B.V. Udp-glycosyltransferases from solanum lycopersicum
CA2980090A1 (en) 2015-04-03 2016-10-06 Dsm Ip Assets B.V. Steviol glycosides
WO2016172282A1 (en) 2015-04-21 2016-10-27 Dsm Ip Assets B.V. Microbial production of terpenoids
PL3298133T3 (pl) 2015-05-22 2020-03-31 Dsm Ip Assets B.V. Komórki drożdży zużywające octan
EP3320104B1 (en) 2015-07-10 2021-11-10 DSM IP Assets B.V. Method for preparing a steviol glycoside composition
CA2993744A1 (en) 2015-08-13 2017-02-16 Dsm Ip Assets B.V. Steviol glycoside transport
WO2017050652A1 (en) 2015-09-25 2017-03-30 Dsm Ip Assets B.V. Asparaginase
CA2999638A1 (en) 2015-10-05 2017-04-13 Dsm Ip Assets B.V. Kaurenoic acid hydroxylases
US11136600B2 (en) 2015-10-06 2021-10-05 Dsm Ip Assets B.V. Eukaryotic cell with increased production of fermentation product
CN116064263A (zh) 2015-12-30 2023-05-05 帝斯曼知识产权资产管理有限公司 三酰基甘油的部分酶水解
EP3397759A2 (en) 2015-12-30 2018-11-07 DSM IP Assets B.V. Partial enzymatic hydrolysis of triacylglycerols
WO2017167847A1 (en) 2016-03-31 2017-10-05 Dsm Ip Assets B.V. Production of milk with low lactose content
EP3435771A1 (en) 2016-03-31 2019-02-06 DSM IP Assets B.V. Enzyme composition and preparation of a dairy product with improved properties
EP3435772A1 (en) 2016-03-31 2019-02-06 DSM IP Assets B.V. Enzyme composition and preparation of a dairy product with improved properties
US10689670B2 (en) 2016-06-14 2020-06-23 Dsm Ip Assets B.V. Recombinant yeast cell
US10787649B2 (en) 2016-07-13 2020-09-29 Dsm Ip Assets B.V. Malate dehyrogenases
WO2018029274A1 (en) 2016-08-09 2018-02-15 Dsm Ip Assets B.V. Crystallization of steviol glycosides
BR112019002417B1 (pt) 2016-08-09 2023-05-02 Dsm Ip Assets B.V. Cristalização de glicosídeos de esteviol
CN110036114B (zh) 2016-08-26 2023-09-29 勒萨弗尔公司 提高的衣康酸生产
WO2018073107A1 (en) 2016-10-19 2018-04-26 Dsm Ip Assets B.V. Eukaryotic cell comprising xylose isomerase
WO2018078014A1 (en) 2016-10-27 2018-05-03 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthases
JP2020500520A (ja) 2016-12-08 2020-01-16 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． カウレン酸ヒドロキシラーゼ
WO2018114938A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114912A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
EP3559222A1 (en) 2016-12-21 2019-10-30 DSM IP Assets B.V. Lipolytic enzyme variants
CA3046153A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114995A1 (en) 2016-12-22 2018-06-28 Dsm Ip Assets B.V. Fermentation process for producing steviol glycosides
US11667886B2 (en) 2017-06-13 2023-06-06 Dsm Ip Assets B.V. Recombinant yeast cell
US11639497B2 (en) 2017-06-27 2023-05-02 Dsm Ip Assets B.V. UDP-glycosyltransferases
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EP3533878A1 (en) 2018-02-28 2019-09-04 Dutch DNA Biotech B.V. Process for producing citramalic acid employing aspergillus
BR112020025589A2 (pt) 2018-06-19 2021-03-23 Dsm Ip Assets B.V. variantes de enzima lipolítica
AU2021367159A1 (en) 2020-10-22 2023-05-04 Cargill, Incorporated Microorganisms for diterpene production
CA3225417A1 (en) 2021-06-24 2022-12-29 Fonterra Co-Operative Group Limited Recombinant proteins
WO2023285279A1 (en) 2021-07-12 2023-01-19 Dsm Ip Assets B.V. Recombinant yeast cell
WO2023285297A1 (en) 2021-07-12 2023-01-19 Dsm Ip Assets B.V. Recombinant yeast cell
EP4370690A1 (en) 2021-07-12 2024-05-22 Danisco Us Inc Recombinant yeast cell
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Also Published As

Publication number Publication date
RU2230790C2 (ru) 2004-06-20
ID27054A (id) 2001-02-22
AU4144999A (en) 1999-12-06
US20060127972A1 (en) 2006-06-15
CN100390285C (zh) 2008-05-28
WO1999060102A2 (en) 1999-11-25
JP2003527069A (ja) 2003-09-16
EP1078069A2 (en) 2001-02-28
ZA200006308B (en) 2001-05-23
WO1999060102A3 (en) 2000-02-03
MXPA00011223A (es) 2002-04-17
CN1301303A (zh) 2001-06-27
DE69938129D1 (de) 2008-03-27
US6995003B1 (en) 2006-02-07
CN101353660A (zh) 2009-01-28
PL344863A1 (en) 2001-11-19
EP1078069B1 (en) 2008-02-13
ES2302379T3 (es) 2008-07-01
KR20010025039A (ko) 2001-03-26
ATE386123T1 (de) 2008-03-15
EP1953230A1 (en) 2008-08-06
KR100648480B1 (ko) 2006-11-24

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