ZA200006308B - Improved in vivo production of cephalosporins. - Google Patents

Improved in vivo production of cephalosporins. Download PDF

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Publication number
ZA200006308B
ZA200006308B ZA200006308A ZA200006308A ZA200006308B ZA 200006308 B ZA200006308 B ZA 200006308B ZA 200006308 A ZA200006308 A ZA 200006308A ZA 200006308 A ZA200006308 A ZA 200006308A ZA 200006308 B ZA200006308 B ZA 200006308B
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ZA
South Africa
Prior art keywords
expandase
dna fragment
host cell
host
apa
Prior art date
Application number
ZA200006308A
Other languages
English (en)
Inventor
Maarten Nieboer
Roelof Ary Lans Bovenberg
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Publication of ZA200006308B publication Critical patent/ZA200006308B/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200006308A 1998-05-19 2000-11-03 Improved in vivo production of cephalosporins. ZA200006308B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98201655 1998-05-19

Publications (1)

Publication Number Publication Date
ZA200006308B true ZA200006308B (en) 2001-05-23

Family

ID=8233737

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200006308A ZA200006308B (en) 1998-05-19 2000-11-03 Improved in vivo production of cephalosporins.

Country Status (16)

Country Link
US (2) US6995003B1 (pt)
EP (2) EP1953230A1 (pt)
JP (1) JP2003527069A (pt)
KR (1) KR100648480B1 (pt)
CN (2) CN101353660A (pt)
AT (1) ATE386123T1 (pt)
AU (1) AU4144999A (pt)
BR (1) BR9910532A (pt)
DE (1) DE69938129D1 (pt)
ES (1) ES2302379T3 (pt)
ID (1) ID27054A (pt)
MX (1) MXPA00011223A (pt)
PL (1) PL344863A1 (pt)
RU (1) RU2230790C2 (pt)
WO (1) WO1999060102A2 (pt)
ZA (1) ZA200006308B (pt)

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US20140141473A1 (en) 2011-04-22 2014-05-22 Dsm Ip Assets B.V. Yeast cell capable of converting sugars including arabinose and xlose
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US20160060660A1 (en) 2013-04-05 2016-03-03 Université Du Luxembourg Biotechnological production of itaconic acid
US9885066B2 (en) 2013-05-02 2018-02-06 Dutch Dna Biotech B.V. Organic acid pathway
MX367033B (es) 2013-05-31 2019-08-02 Dsm Ip Assets Bv Microorganismos para la produccion de diterpeno.
AU2014292150B2 (en) 2013-07-15 2019-04-04 Dsm Ip Assets B.V. Diterpene production
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WO2016151046A1 (en) 2015-03-23 2016-09-29 Dsm Ip Assets B.V. Udp-glycosyltransferases from solanum lycopersicum
US11344051B2 (en) 2015-04-03 2022-05-31 Dsm Ip Assets B.V. Steviol glycosides
CN107532135A (zh) 2015-04-21 2018-01-02 帝斯曼知识产权资产管理有限公司 萜类化合物的微生物生产
BR112017023262A2 (pt) 2015-05-22 2018-07-17 Dsm Ip Assets Bv célula de levedura de consumo de acetato
MY192153A (en) 2015-07-10 2022-08-02 Dsm Ip Assets Bv Steviol glycoside composition
WO2017025649A1 (en) 2015-08-13 2017-02-16 Dsm Ip Assets B.V. Steviol glycoside transport
WO2017050652A1 (en) 2015-09-25 2017-03-30 Dsm Ip Assets B.V. Asparaginase
CN108138152B (zh) 2015-10-05 2023-01-06 帝斯曼知识产权资产管理有限公司 贝壳杉烯酸羟化酶
MY186400A (en) 2015-10-06 2021-07-22 Dsm Ip Assets Bv Eukaryotic cell with increased production of fermentation product
JP2019500041A (ja) 2015-12-30 2019-01-10 ディーエスエム アイピー アセッツ ビー.ブイ.Dsm Ip Assets B.V. トリアシルグリセロールの部分的酵素加水分解
CA3009871A1 (en) 2015-12-30 2017-07-06 Dsm Ip Assets B.V. Partial enzymatic hydrolysis of triacylglycerols
EP3435770A1 (en) 2016-03-31 2019-02-06 DSM IP Assets B.V. Production of milk with low lactose content
EP3435771A1 (en) 2016-03-31 2019-02-06 DSM IP Assets B.V. Enzyme composition and preparation of a dairy product with improved properties
WO2017167849A1 (en) 2016-03-31 2017-10-05 Dsm Ip Assets B.V. Enzyme composition and preparation of a dairy product with improved properties
BR112018074490A2 (pt) 2016-06-14 2019-03-19 Dsm Ip Assets B.V. célula de levedura recombinante
CN109689864B (zh) 2016-07-13 2023-04-04 帝斯曼知识产权资产管理有限公司 苹果酸脱氢酶
BR112019002432A2 (pt) 2016-08-09 2019-06-04 Dsm Ip Assets Bv cristalização de glicosídeos de esteviol
CA3032656A1 (en) 2016-08-09 2018-02-15 Dsm Ip Assets B.V. Crystallization of steviol glycosides
US11066681B2 (en) 2016-08-26 2021-07-20 Lesaffre Et Compagnie Production of itaconic acid
WO2018073107A1 (en) 2016-10-19 2018-04-26 Dsm Ip Assets B.V. Eukaryotic cell comprising xylose isomerase
EP3532611B1 (en) 2016-10-27 2021-12-01 DSM IP Assets B.V. Geranylgeranyl pyrophosphate synthases
BR112019011525A2 (pt) 2016-12-08 2020-01-28 Dsm Ip Assets Bv ácido caurenoico hidroxilases
CA3046153A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
US10918113B2 (en) 2016-12-21 2021-02-16 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114938A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
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CN111032854A (zh) 2017-06-13 2020-04-17 帝斯曼知识产权资产管理有限公司 重组酵母细胞
WO2019002264A1 (en) 2017-06-27 2019-01-03 Dsm Ip Assets B.V. UDP-glycosyltransferase
BR112020004921A2 (pt) 2017-09-26 2020-09-15 Dsm Ip Assets B.V. cepa consumidora de ácido acético
EP3533878A1 (en) 2018-02-28 2019-09-04 Dutch DNA Biotech B.V. Process for producing citramalic acid employing aspergillus
EP3809852A1 (en) 2018-06-19 2021-04-28 DSM IP Assets B.V. Lipolytic enzyme variants
EP4232568A1 (en) 2020-10-22 2023-08-30 DSM IP Assets B.V. Microorganisms for diterpene production
EP4359426A2 (en) 2021-06-24 2024-05-01 Fonterra Co-Operative Group Limited Recombinant beta-lactoglobulin
WO2023285280A1 (en) 2021-07-12 2023-01-19 Dsm Ip Assets B.V. Recombinant yeast cell
WO2023285279A1 (en) 2021-07-12 2023-01-19 Dsm Ip Assets B.V. Recombinant yeast cell
MX2024000515A (es) 2021-07-12 2024-03-11 Danisco Us Inc Celula de levadura recombinante.
MX2024000511A (es) 2021-07-12 2024-03-11 Danisco Us Inc Celula de levadura recombinante.
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Also Published As

Publication number Publication date
JP2003527069A (ja) 2003-09-16
BR9910532A (pt) 2001-10-16
PL344863A1 (en) 2001-11-19
ID27054A (id) 2001-02-22
AU4144999A (en) 1999-12-06
CN101353660A (zh) 2009-01-28
KR20010025039A (ko) 2001-03-26
EP1953230A1 (en) 2008-08-06
WO1999060102A2 (en) 1999-11-25
WO1999060102A3 (en) 2000-02-03
US6995003B1 (en) 2006-02-07
ATE386123T1 (de) 2008-03-15
RU2230790C2 (ru) 2004-06-20
KR100648480B1 (ko) 2006-11-24
CN1301303A (zh) 2001-06-27
CN100390285C (zh) 2008-05-28
EP1078069B1 (en) 2008-02-13
US20060127972A1 (en) 2006-06-15
ES2302379T3 (es) 2008-07-01
MXPA00011223A (es) 2002-04-17
DE69938129D1 (de) 2008-03-27
EP1078069A2 (en) 2001-02-28

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