DE69814667T2 - Camptothecin-derivate - Google Patents

Camptothecin-derivate Download PDF

Info

Publication number
DE69814667T2
DE69814667T2 DE69814667T DE69814667T DE69814667T2 DE 69814667 T2 DE69814667 T2 DE 69814667T2 DE 69814667 T DE69814667 T DE 69814667T DE 69814667 T DE69814667 T DE 69814667T DE 69814667 T2 DE69814667 T2 DE 69814667T2
Authority
DE
Germany
Prior art keywords
group
och
dimethylamino
ethylamide
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69814667T
Other languages
German (de)
English (en)
Other versions
DE69814667D1 (en
Inventor
Takanori Minato-ku OGAWA
Takashi Minato-ku YAEGASHI
Seigo Minato-ku SAWADA
Tomio Minato-ku FURUTA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Publication of DE69814667D1 publication Critical patent/DE69814667D1/de
Application granted granted Critical
Publication of DE69814667T2 publication Critical patent/DE69814667T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DE69814667T 1997-11-06 1998-11-06 Camptothecin-derivate Expired - Lifetime DE69814667T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP31918297 1997-11-06
JP31918297A JP4094710B2 (ja) 1997-11-06 1997-11-06 新規なカンプトテシン誘導体
PCT/JP1998/005000 WO1999024430A1 (en) 1997-11-06 1998-11-06 Novel camptothecin derivatives

Publications (2)

Publication Number Publication Date
DE69814667D1 DE69814667D1 (en) 2003-06-18
DE69814667T2 true DE69814667T2 (de) 2004-04-08

Family

ID=18107341

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69814667T Expired - Lifetime DE69814667T2 (de) 1997-11-06 1998-11-06 Camptothecin-derivate

Country Status (15)

Country Link
US (1) US6310210B1 (enExample)
EP (1) EP1029863B1 (enExample)
JP (1) JP4094710B2 (enExample)
KR (1) KR100563210B1 (enExample)
CN (1) CN1114605C (enExample)
AT (1) ATE240330T1 (enExample)
AU (1) AU738823B2 (enExample)
BR (1) BR9813972A (enExample)
CA (1) CA2309196C (enExample)
DE (1) DE69814667T2 (enExample)
DK (1) DK1029863T3 (enExample)
EA (1) EA002211B1 (enExample)
ES (1) ES2193574T3 (enExample)
PT (1) PT1029863E (enExample)
WO (1) WO1999024430A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR027687A1 (es) 2000-03-22 2003-04-09 Yakult Honsha Kk Procedimiento para preparar camptotecina
HUP0401912A3 (en) 2001-09-25 2007-02-28 Reddys Lab Ltd Dr Pharmaceutically acceptable salts of 20(s)-camptothecins, process for their preparation and pharmaceutical compositions containing them
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
US6608076B1 (en) 2002-05-16 2003-08-19 Enzon, Inc. Camptothecin derivatives and polymeric conjugates thereof
AU2003288467A1 (en) * 2002-12-13 2004-07-09 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
DE602005024923D1 (de) * 2004-02-13 2011-01-05 Yakult Honsha Kk Wässrige lösung mit einem camptothecin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS5839684A (ja) 1981-09-04 1983-03-08 Yakult Honsha Co Ltd １０−置換カンプテシン誘導体の製造法
JPS58134095A (ja) 1982-02-05 1983-08-10 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5951287A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5951289A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規な９−置換−カンプトテシン誘導体
US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5049668A (en) 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US5122606A (en) 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
JP2540357B2 (ja) 1987-06-24 1996-10-02 第一製薬株式会社 六環性化合物
US4939255A (en) 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
JP2538792B2 (ja) 1987-06-25 1996-10-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
CA1332413C (en) * 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPH0615547B2 (ja) 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
WO1991004260A2 (en) 1989-09-15 1991-04-04 Research Triangle Institute 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
US5162532A (en) 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
JPH0873461A (ja) * 1994-09-06 1996-03-19 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体、その製造法および抗腫瘍剤

Also Published As

Publication number Publication date
AU9761998A (en) 1999-05-31
DE69814667D1 (en) 2003-06-18
EP1029863A4 (en) 2001-05-02
BR9813972A (pt) 2000-09-26
KR20010031595A (ko) 2001-04-16
EP1029863B1 (en) 2003-05-14
CN1278261A (zh) 2000-12-27
ES2193574T3 (es) 2003-11-01
PT1029863E (pt) 2003-09-30
DK1029863T3 (da) 2003-08-11
US6310210B1 (en) 2001-10-30
AU738823B2 (en) 2001-09-27
JPH11140085A (ja) 1999-05-25
EA002211B1 (ru) 2002-02-28
EP1029863A1 (en) 2000-08-23
ATE240330T1 (de) 2003-05-15
CA2309196C (en) 2007-09-11
KR100563210B1 (ko) 2006-03-22
EA200000491A1 (ru) 2000-10-30
CN1114605C (zh) 2003-07-16
WO1999024430A1 (en) 1999-05-20
CA2309196A1 (en) 1999-05-20
JP4094710B2 (ja) 2008-06-04

Similar Documents

Publication Publication Date Title
DE69533277T2 (de) Dc-89 derivat
EP0726899B1 (de) Neue pyrazincarboxamidderivate, ihre herstellung und ihre verwendung in arzneimitteln
DE69818041T2 (de) Cyanoguanidine als zellproliferation inhibitoren
DD282686A5 (de) Verfahren zur herstellung eines benzothiazolderivates
DE69332945T2 (de) Indol-derivat, verfahren zu dessen herstellung und dessen medizinische anwendung
DE69431856T2 (de) 9-Amino und 9-Nitrocamptothecinderivate, Verfahren zu ihrer Herstellung unf ihre Verwendung als Antitumormittel
DE69814667T2 (de) Camptothecin-derivate
DE69312567T2 (de) 2-Formylpyridin-Thiosemicarbazonderivate, ihre Herstellung und ihre Verwendung als Antitumor Mittel
CH634308A5 (de) Verfahren zur herstellung neuer pyrimidonderivate.
Rivalle et al. Antitumor amino-substituted pyrido [3', 4': 4, 5] pyrrolo [2, 3-g] isoquinolines and pyrido [4, 3-b] carbazole derivatives: synthesis and evaluation of compounds resulting from new side chain and heterocycle modifications
KR100549631B1 (ko) 시아노구아니딘, 이의 제조방법 및 이를 함유하는 약제학적 제제
DE68912818T2 (de) Antitumormittel.
DE69201141T2 (de) NMDA-Antagonisten.
KR20010013158A (ko) 세포 증식 억제제로서의 시아노구아니딘
DE2749988A1 (de) N-substituierte imidazolcarboxamide, verfahren zu deren herstellung und dieselben enthaltendes mittel
DE68918257T2 (de) 4,5,6,7-Tetrahydrobenzimidazol-Derivate und ihre Herstellung.
EP0662960A1 (de) Neue asymmetrisch substituierte bis-naphthalimide
DE69521266T2 (de) Verfahren zur herstellung von 9-amino camptothecin
EP0802195A2 (de) Substituierte 2,3-Benzodiazepinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate sowie ihre Verwendung
DE69828780T2 (de) Amidinocamptpthecin-derivate
EP0000538A1 (de) 6,7-Dihydro-5H,13H-chinazolino(3,2-a)(1,4)benzodiazepin-5,13-dione, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
JP2005523324A (ja) カンプトテシン誘導体の調製に有用な化合物
Temple Jr et al. New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1, 2-dihydro-3-phenylpyrido [3, 4-b] pyrazin-7-yl) carbamates
DE69719071T2 (de) Phenanthridiniumderivate
US5939428A (en) Alkyl N- 3-(acridin-9-yl)amino-5-hydroxymethyl! phenylcarbamates

Legal Events

Date Code Title Description
8364 No opposition during term of opposition