CA2309196C - Novel camptothecin derivatives - Google Patents

Novel camptothecin derivatives Download PDF

Info

Publication number
CA2309196C
CA2309196C CA002309196A CA2309196A CA2309196C CA 2309196 C CA2309196 C CA 2309196C CA 002309196 A CA002309196 A CA 002309196A CA 2309196 A CA2309196 A CA 2309196A CA 2309196 C CA2309196 C CA 2309196C
Authority
CA
Canada
Prior art keywords
compound
ch2ch3
group
och2
dimethylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002309196A
Other languages
English (en)
French (fr)
Other versions
CA2309196A1 (en
Inventor
Takanori Ogawa
Takashi Yaegashi
Seigo Sawada
Tomio Furuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Publication of CA2309196A1 publication Critical patent/CA2309196A1/en
Application granted granted Critical
Publication of CA2309196C publication Critical patent/CA2309196C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CA002309196A 1997-11-06 1998-11-06 Novel camptothecin derivatives Expired - Fee Related CA2309196C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP31918297A JP4094710B2 (ja) 1997-11-06 1997-11-06 新規なカンプトテシン誘導体
JP9/319182 1997-11-06
PCT/JP1998/005000 WO1999024430A1 (en) 1997-11-06 1998-11-06 Novel camptothecin derivatives

Publications (2)

Publication Number Publication Date
CA2309196A1 CA2309196A1 (en) 1999-05-20
CA2309196C true CA2309196C (en) 2007-09-11

Family

ID=18107341

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002309196A Expired - Fee Related CA2309196C (en) 1997-11-06 1998-11-06 Novel camptothecin derivatives

Country Status (15)

Country Link
US (1) US6310210B1 (enExample)
EP (1) EP1029863B1 (enExample)
JP (1) JP4094710B2 (enExample)
KR (1) KR100563210B1 (enExample)
CN (1) CN1114605C (enExample)
AT (1) ATE240330T1 (enExample)
AU (1) AU738823B2 (enExample)
BR (1) BR9813972A (enExample)
CA (1) CA2309196C (enExample)
DE (1) DE69814667T2 (enExample)
DK (1) DK1029863T3 (enExample)
EA (1) EA002211B1 (enExample)
ES (1) ES2193574T3 (enExample)
PT (1) PT1029863E (enExample)
WO (1) WO1999024430A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR027687A1 (es) 2000-03-22 2003-04-09 Yakult Honsha Kk Procedimiento para preparar camptotecina
HUP0401912A3 (en) 2001-09-25 2007-02-28 Reddys Lab Ltd Dr Pharmaceutically acceptable salts of 20(s)-camptothecins, process for their preparation and pharmaceutical compositions containing them
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
US6608076B1 (en) 2002-05-16 2003-08-19 Enzon, Inc. Camptothecin derivatives and polymeric conjugates thereof
AU2003288467A1 (en) * 2002-12-13 2004-07-09 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
DE602005024923D1 (de) * 2004-02-13 2011-01-05 Yakult Honsha Kk Wässrige lösung mit einem camptothecin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS5839684A (ja) 1981-09-04 1983-03-08 Yakult Honsha Co Ltd １０−置換カンプテシン誘導体の製造法
JPS58134095A (ja) 1982-02-05 1983-08-10 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5951287A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5951289A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規な９−置換−カンプトテシン誘導体
US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5049668A (en) 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US5122606A (en) 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
JP2540357B2 (ja) 1987-06-24 1996-10-02 第一製薬株式会社 六環性化合物
US4939255A (en) 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
JP2538792B2 (ja) 1987-06-25 1996-10-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
CA1332413C (en) * 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPH0615547B2 (ja) 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
WO1991004260A2 (en) 1989-09-15 1991-04-04 Research Triangle Institute 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
US5162532A (en) 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
JPH0873461A (ja) * 1994-09-06 1996-03-19 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体、その製造法および抗腫瘍剤

Also Published As

Publication number Publication date
AU9761998A (en) 1999-05-31
DE69814667D1 (en) 2003-06-18
EP1029863A4 (en) 2001-05-02
BR9813972A (pt) 2000-09-26
KR20010031595A (ko) 2001-04-16
EP1029863B1 (en) 2003-05-14
CN1278261A (zh) 2000-12-27
ES2193574T3 (es) 2003-11-01
PT1029863E (pt) 2003-09-30
DK1029863T3 (da) 2003-08-11
US6310210B1 (en) 2001-10-30
AU738823B2 (en) 2001-09-27
JPH11140085A (ja) 1999-05-25
EA002211B1 (ru) 2002-02-28
EP1029863A1 (en) 2000-08-23
ATE240330T1 (de) 2003-05-15
KR100563210B1 (ko) 2006-03-22
EA200000491A1 (ru) 2000-10-30
CN1114605C (zh) 2003-07-16
WO1999024430A1 (en) 1999-05-20
DE69814667T2 (de) 2004-04-08
CA2309196A1 (en) 1999-05-20
JP4094710B2 (ja) 2008-06-04

Similar Documents

Publication Publication Date Title
EP0705833B1 (en) Dc-89 derivative
CA2309196C (en) Novel camptothecin derivatives
KR0163267B1 (ko) 캄토테신 유도체 및 약제학적으로 허용되는 그의 염, 제조 방법 및 이를 함유하는 항암제
US6228855B1 (en) Aromatic esters of camptothecins and methods to treat cancers
Rivalle et al. Antitumor amino-substituted pyrido [3', 4': 4, 5] pyrrolo [2, 3-g] isoquinolines and pyrido [4, 3-b] carbazole derivatives: synthesis and evaluation of compounds resulting from new side chain and heterocycle modifications
EP0580812A1 (en) Anti-tumor and anti-psoriatic agents
EP0226508A1 (fr) Dérivés de l'indolo(3,2-c)quinoléine, leur procédé de préparation et leur activité antitumorale
EP0975637B1 (en) Amidino-camptothecin derivatives
EP0028936B1 (en) 4-carbamoylimidazol-5-ol derivatives, their production and pharmaceutical compositions containing them
RU2147303C1 (ru) Промежуточные продукты и способ получения солей нафтиридонкарбоновой кислоты
US5939428A (en) Alkyl N- 3-(acridin-9-yl)amino-5-hydroxymethyl! phenylcarbamates
CA2271940C (en) Novel phenanthridinium derivatives
HUT71240A (en) Process for the preparation of 9-amino camptothecin
Croisy-Delcey et al. Aza analogs of lucanthone: synthesis and antitumor and bactericidal properties
HUP0202485A2 (hu) Új benzo[b]pirano[3,2-h]akridin-7-on-származékok, eljárás azok előállítására és a vegyületeket tartalmazó gyógyszerkészítmények
US5061791A (en) 4-bromo-4'-demethylepipodophyllotoxin derivatives
JPWO1998023614A1 (ja) 新規なフェナンスリジニウム誘導体
US5733890A (en) Adenylate analogs as potent anti-herpes virus agents
US4992551A (en) DC-52 derivatives
AU646163C (en) Anti-tumor and anti-psoriatic agents
HU188606B (en) Process for producing derivatives of esters of 2-beta-chloro-methyl-2-alpha-carboxylic acids
KR100267595B1 (ko) 신규한 이소퀴놀린계 항암 활성 화합물
JPH0276883A (ja) 置換ベンゾキサジノリファマイシン誘導体

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20141106