BR9813972A - Derivados de camptotecina - Google Patents

Derivados de camptotecina

Info

Publication number
BR9813972A
BR9813972A BR9813972-0A BR9813972A BR9813972A BR 9813972 A BR9813972 A BR 9813972A BR 9813972 A BR9813972 A BR 9813972A BR 9813972 A BR9813972 A BR 9813972A
Authority
BR
Brazil
Prior art keywords
camptothecin derivatives
salts
carbon atoms
lower alkylamino
alkoxyl
Prior art date
Application number
BR9813972-0A
Other languages
English (en)
Inventor
Takanori Ogwa
Takashi Yaegashi
Seigo Sawada
Tomio Furuta
Original Assignee
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk
Publication of BR9813972A publication Critical patent/BR9813972A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE CAMPTOTECINA"<D>. A presente invenção refere-se a novos derivados de camptotecina mostrados pela fórmula abaixo, que são solúveis em água e excelentes em uma atividade antitumor, e aos sais destes. Na fórmula, R¹ representa um átomo de hidrogênio ou um grupo alquila com 1 a 6 átomos de carbono, R² representa identicamente ou diferentemente 0 a 4 grupos alquila com 1 a 6 átomos de carbono, um átomo de halogênio, um grupo alcoxila ou hidroxila, R³ representa um grupo alquilamino inferior, alquilamino di-inferior, arilamino, ciclicamino ou alcoxila inferior, e os sais destes.
BR9813972-0A 1997-11-06 1998-11-06 Derivados de camptotecina BR9813972A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31918297A JP4094710B2 (ja) 1997-11-06 1997-11-06 新規なカンプトテシン誘導体
PCT/JP1998/005000 WO1999024430A1 (fr) 1997-11-06 1998-11-06 Nouveaux derives de la camptothecine

Publications (1)

Publication Number Publication Date
BR9813972A true BR9813972A (pt) 2000-09-26

Family

ID=18107341

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813972-0A BR9813972A (pt) 1997-11-06 1998-11-06 Derivados de camptotecina

Country Status (15)

Country Link
US (1) US6310210B1 (pt)
EP (1) EP1029863B1 (pt)
JP (1) JP4094710B2 (pt)
KR (1) KR100563210B1 (pt)
CN (1) CN1114605C (pt)
AT (1) ATE240330T1 (pt)
AU (1) AU738823B2 (pt)
BR (1) BR9813972A (pt)
CA (1) CA2309196C (pt)
DE (1) DE69814667T2 (pt)
DK (1) DK1029863T3 (pt)
EA (1) EA002211B1 (pt)
ES (1) ES2193574T3 (pt)
PT (1) PT1029863E (pt)
WO (1) WO1999024430A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR027687A1 (es) 2000-03-22 2003-04-09 Yakult Honsha Kk Procedimiento para preparar camptotecina
KR20040039404A (ko) 2001-09-25 2004-05-10 닥터 레디스 레보러터리즈 리미티드 20(에스)-캄포테신의 약제학적으로 수용가능한 염
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
US6608076B1 (en) 2002-05-16 2003-08-19 Enzon, Inc. Camptothecin derivatives and polymeric conjugates thereof
CA2508831C (en) * 2002-12-13 2012-05-01 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
JP4451850B2 (ja) * 2004-02-13 2010-04-14 株式会社ヤクルト本社 カンプトテシン類含有水溶液製剤

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58134095A (ja) 1982-02-05 1983-08-10 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5839684A (ja) 1981-09-04 1983-03-08 Yakult Honsha Co Ltd １０−置換カンプテシン誘導体の製造法
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS5951287A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5951289A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規な９−置換−カンプトテシン誘導体
US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5049668A (en) 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US5122606A (en) 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
US4939255A (en) 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
JP2540357B2 (ja) 1987-06-24 1996-10-02 第一製薬株式会社 六環性化合物
JP2538792B2 (ja) 1987-06-25 1996-10-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
CA1332413C (en) 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPH0615547B2 (ja) 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
WO1991004260A2 (en) 1989-09-15 1991-04-04 Research Triangle Institute 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
US5162532A (en) 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
JPH0873461A (ja) 1994-09-06 1996-03-19 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体、その製造法および抗腫瘍剤

Also Published As

Publication number Publication date
CN1114605C (zh) 2003-07-16
EA200000491A1 (ru) 2000-10-30
ES2193574T3 (es) 2003-11-01
KR100563210B1 (ko) 2006-03-22
CA2309196C (en) 2007-09-11
EP1029863A1 (en) 2000-08-23
EA002211B1 (ru) 2002-02-28
EP1029863A4 (en) 2001-05-02
PT1029863E (pt) 2003-09-30
AU738823B2 (en) 2001-09-27
DE69814667T2 (de) 2004-04-08
AU9761998A (en) 1999-05-31
KR20010031595A (ko) 2001-04-16
JP4094710B2 (ja) 2008-06-04
EP1029863B1 (en) 2003-05-14
DE69814667D1 (en) 2003-06-18
US6310210B1 (en) 2001-10-30
CA2309196A1 (en) 1999-05-20
ATE240330T1 (de) 2003-05-15
JPH11140085A (ja) 1999-05-25
DK1029863T3 (da) 2003-08-11
WO1999024430A1 (fr) 1999-05-20
CN1278261A (zh) 2000-12-27

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO COM BASE NOS ARTIGOS 8O, 13, 24 E 25 DA LPI 9279/96

B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time