CN1114605C - 新型喜树碱衍生物 - Google Patents

新型喜树碱衍生物 Download PDF

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Publication number
CN1114605C
CN1114605C CN98810870A CN98810870A CN1114605C CN 1114605 C CN1114605 C CN 1114605C CN 98810870 A CN98810870 A CN 98810870A CN 98810870 A CN98810870 A CN 98810870A CN 1114605 C CN1114605 C CN 1114605C
Authority
CN
China
Prior art keywords
compound
och
dimethylamino
ethyl
ethylamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN98810870A
Other languages
English (en)
Chinese (zh)
Other versions
CN1278261A (zh
Inventor
小川贵德
八重樫隆
泽田诚吾
古田富雄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Publication of CN1278261A publication Critical patent/CN1278261A/zh
Application granted granted Critical
Publication of CN1114605C publication Critical patent/CN1114605C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CN98810870A 1997-11-06 1998-11-06 新型喜树碱衍生物 Expired - Fee Related CN1114605C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31918297A JP4094710B2 (ja) 1997-11-06 1997-11-06 新規なカンプトテシン誘導体
JP319182/1997 1997-11-06

Publications (2)

Publication Number Publication Date
CN1278261A CN1278261A (zh) 2000-12-27
CN1114605C true CN1114605C (zh) 2003-07-16

Family

ID=18107341

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98810870A Expired - Fee Related CN1114605C (zh) 1997-11-06 1998-11-06 新型喜树碱衍生物

Country Status (15)

Country Link
US (1) US6310210B1 (enExample)
EP (1) EP1029863B1 (enExample)
JP (1) JP4094710B2 (enExample)
KR (1) KR100563210B1 (enExample)
CN (1) CN1114605C (enExample)
AT (1) ATE240330T1 (enExample)
AU (1) AU738823B2 (enExample)
BR (1) BR9813972A (enExample)
CA (1) CA2309196C (enExample)
DE (1) DE69814667T2 (enExample)
DK (1) DK1029863T3 (enExample)
EA (1) EA002211B1 (enExample)
ES (1) ES2193574T3 (enExample)
PT (1) PT1029863E (enExample)
WO (1) WO1999024430A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR027687A1 (es) 2000-03-22 2003-04-09 Yakult Honsha Kk Procedimiento para preparar camptotecina
HUP0401912A3 (en) 2001-09-25 2007-02-28 Reddys Lab Ltd Dr Pharmaceutically acceptable salts of 20(s)-camptothecins, process for their preparation and pharmaceutical compositions containing them
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
US6608076B1 (en) 2002-05-16 2003-08-19 Enzon, Inc. Camptothecin derivatives and polymeric conjugates thereof
AU2003288467A1 (en) * 2002-12-13 2004-07-09 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
DE602005024923D1 (de) * 2004-02-13 2011-01-05 Yakult Honsha Kk Wässrige lösung mit einem camptothecin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS5839684A (ja) 1981-09-04 1983-03-08 Yakult Honsha Co Ltd １０−置換カンプテシン誘導体の製造法
JPS58134095A (ja) 1982-02-05 1983-08-10 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5951287A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5951289A (ja) 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規な９−置換−カンプトテシン誘導体
US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5049668A (en) 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US5122606A (en) 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
JP2540357B2 (ja) 1987-06-24 1996-10-02 第一製薬株式会社 六環性化合物
US4939255A (en) 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
JP2538792B2 (ja) 1987-06-25 1996-10-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
CA1332413C (en) * 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPH0615547B2 (ja) 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
WO1991004260A2 (en) 1989-09-15 1991-04-04 Research Triangle Institute 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
US5162532A (en) 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
JPH0873461A (ja) * 1994-09-06 1996-03-19 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体、その製造法および抗腫瘍剤

Also Published As

Publication number Publication date
AU9761998A (en) 1999-05-31
DE69814667D1 (en) 2003-06-18
EP1029863A4 (en) 2001-05-02
BR9813972A (pt) 2000-09-26
KR20010031595A (ko) 2001-04-16
EP1029863B1 (en) 2003-05-14
CN1278261A (zh) 2000-12-27
ES2193574T3 (es) 2003-11-01
PT1029863E (pt) 2003-09-30
DK1029863T3 (da) 2003-08-11
US6310210B1 (en) 2001-10-30
AU738823B2 (en) 2001-09-27
JPH11140085A (ja) 1999-05-25
EA002211B1 (ru) 2002-02-28
EP1029863A1 (en) 2000-08-23
ATE240330T1 (de) 2003-05-15
CA2309196C (en) 2007-09-11
KR100563210B1 (ko) 2006-03-22
EA200000491A1 (ru) 2000-10-30
WO1999024430A1 (en) 1999-05-20
DE69814667T2 (de) 2004-04-08
CA2309196A1 (en) 1999-05-20
JP4094710B2 (ja) 2008-06-04

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20030716

Termination date: 20131106