DE69714220T2 - Campotecinderivate und ihre verwendung als antitumormittel - Google Patents

Campotecinderivate und ihre verwendung als antitumormittel

Info

Publication number
DE69714220T2
DE69714220T2 DE69714220T DE69714220T DE69714220T2 DE 69714220 T2 DE69714220 T2 DE 69714220T2 DE 69714220 T DE69714220 T DE 69714220T DE 69714220 T DE69714220 T DE 69714220T DE 69714220 T2 DE69714220 T2 DE 69714220T2
Authority
DE
Germany
Prior art keywords
formula
compound
hydrogen
alkyl
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69714220T
Other languages
German (de)
English (en)
Other versions
DE69714220D1 (de
Inventor
Lucio Merlini
Sergio Penco
Franco Zunino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
Original Assignee
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11373368&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69714220(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" filed Critical Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
Application granted granted Critical
Publication of DE69714220D1 publication Critical patent/DE69714220D1/de
Publication of DE69714220T2 publication Critical patent/DE69714220T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
DE69714220T 1996-02-23 1997-02-19 Campotecinderivate und ihre verwendung als antitumormittel Expired - Lifetime DE69714220T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI000338A IT1282673B1 (it) 1996-02-23 1996-02-23 Derivati della camptotecina e loro uso come agenti antitumorali
PCT/EP1997/000786 WO1997031003A1 (en) 1996-02-23 1997-02-19 Camptothecin derivatives and the use thereof as antitumor agents

Publications (2)

Publication Number Publication Date
DE69714220D1 DE69714220D1 (de) 2002-08-29
DE69714220T2 true DE69714220T2 (de) 2002-11-14

Family

ID=11373368

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69714220T Expired - Lifetime DE69714220T2 (de) 1996-02-23 1997-02-19 Campotecinderivate und ihre verwendung als antitumormittel

Country Status (22)

Country Link
US (2) US6130227A (enExample)
EP (1) EP0885230B1 (enExample)
JP (1) JP4171527B2 (enExample)
KR (1) KR100497906B1 (enExample)
CN (1) CN1107677C (enExample)
AT (1) ATE221071T1 (enExample)
AU (1) AU718361B2 (enExample)
BR (1) BR9707622B1 (enExample)
CZ (1) CZ289268B6 (enExample)
DE (1) DE69714220T2 (enExample)
DK (1) DK0885230T3 (enExample)
EE (1) EE03529B1 (enExample)
ES (1) ES2180932T3 (enExample)
HU (1) HUP9900987A3 (enExample)
IL (1) IL125856A (enExample)
IT (1) IT1282673B1 (enExample)
NZ (1) NZ331126A (enExample)
PT (1) PT885230E (enExample)
RU (1) RU2165935C2 (enExample)
SK (1) SK283217B6 (enExample)
UA (1) UA49005C2 (enExample)
WO (1) WO1997031003A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002519335A (ja) * 1998-06-26 2002-07-02 クアナム メディカル コーポレイション 再狭窄の予防のためのトポイソメラーゼインヒビター
DK1044977T3 (da) * 1999-03-09 2002-07-08 Sigma Tau Ind Farmaceuti Camptothecinderivater med antitumoraktivitet
US7105492B2 (en) 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
AR025587A1 (es) 1999-09-13 2002-12-04 Hoffmann La Roche Formulaciones en dispersion que contienen inhibidores de lipasa
US6950757B2 (en) * 2001-04-11 2005-09-27 Emerald Biostructures, Inc. Screening methods for identifying ligands
RU2319482C2 (ru) * 2001-11-23 2008-03-20 Чугаи Сейяку Кабусики Кайся Способ идентификации противоопухолевых целевых ферментов
NZ534999A (en) * 2002-03-01 2007-03-30 Pharmacia Italia Spa Crystalline polymorphic form c of irinotecan hydrochloride
TW200306314A (en) * 2002-04-16 2003-11-16 Tanabe Seiyaku Co Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
AR046579A1 (es) * 2003-11-12 2005-12-14 Smithkline Beecham Corp Compuesto cristalino de topotecan, composicion farmaceutica que lo comprende, procedimiento para prepararlo y su uso para preparar dicha composicion farmaceutica
SI1962850T1 (sl) * 2005-12-21 2012-06-29 Sigma Tau Ind Farmaceuti Zdravljenje tumorjev, odpornih proti zdravilom
WO2007095389A2 (en) * 2006-02-17 2007-08-23 Novacea, Inc. Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
CN101033230B (zh) * 2006-03-10 2010-12-08 中国科学院上海药物研究所 一类喜树碱衍生物及其应用
ITMI20061474A1 (it) * 2006-07-26 2008-01-27 Indena Spa Derivati della camptotecina ad attivita antitumorale
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物
CN104774209B (zh) * 2014-01-15 2018-06-19 上海海和药物研究开发有限公司 一种9-烯丙基喜树碱衍生物的合成方法
CN117940432B (zh) * 2021-09-01 2025-12-23 上海弼领生物技术有限公司 一种喜树碱类化合物、其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
US5459269A (en) * 1992-06-18 1995-10-17 North Carolina State University 14-halo-camptothecins
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
DE69728152T2 (de) * 1996-08-19 2004-08-05 Bionumerik Pharmaceuticals, Inc., San Antonio Hoch-lipophile campothecin-derivate

Also Published As

Publication number Publication date
HUP9900987A2 (hu) 1999-08-30
ES2180932T3 (es) 2003-02-16
EP0885230B1 (en) 2002-07-24
US6130227A (en) 2000-10-10
BR9707622A (pt) 1999-07-27
IL125856A0 (en) 1999-04-11
SK283217B6 (sk) 2003-03-04
EE03529B1 (et) 2001-10-15
HUP9900987A3 (en) 2000-01-28
CZ289268B6 (cs) 2001-12-12
KR19990087110A (ko) 1999-12-15
SK112798A3 (en) 1999-01-11
UA49005C2 (uk) 2002-09-16
EP0885230A1 (en) 1998-12-23
JP4171527B2 (ja) 2008-10-22
IL125856A (en) 2001-08-26
EE9800259A (et) 1999-02-15
AU1875397A (en) 1997-09-10
DE69714220D1 (de) 2002-08-29
NZ331126A (en) 2000-02-28
AU718361B2 (en) 2000-04-13
ITMI960338A1 (it) 1997-08-23
RU2165935C2 (ru) 2001-04-27
IT1282673B1 (it) 1998-03-31
KR100497906B1 (ko) 2006-03-09
PT885230E (pt) 2002-12-31
US6306868B1 (en) 2001-10-23
CN1107677C (zh) 2003-05-07
CN1211987A (zh) 1999-03-24
JP2000505448A (ja) 2000-05-09
WO1997031003A1 (en) 1997-08-28
ITMI960338A0 (enExample) 1996-02-23
BR9707622B1 (pt) 2010-08-10
ATE221071T1 (de) 2002-08-15
DK0885230T3 (da) 2002-11-18
CZ265298A3 (cs) 1999-01-13

Similar Documents

Publication Publication Date Title
DE3855575T2 (de) Wasserlösliche Camptothecin-Analoge
DE10230917A1 (de) Fredericamycin-Derivate
DE19744027A1 (de) Substituierte Pyrazolo[3,4-b]pyridine, ihre Herstellung und Verwendung in Arzneimitteln
EP1104421A1 (de) 3-(4-amino-5-ethylpyrimidin-2-yl)-1-(2-fluorbenzyl)-1h-pyrazolo[ 3,4-b]pyridin
EP1226143B1 (de) Imidazopyridinderivate als phosphodiesterase vii-hemmer
EP0885230B1 (en) Camptothecin derivatives and the use thereof as antitumor agents
DE2923368C2 (enExample)
DE3877386T2 (de) Antikrebsverbindungen.
DE2044172C3 (de) Pyrrolderivate, ein Verfahren zu ihrer Herstellung und Arzneimittel
DE2945701A1 (de) S-triazinone und s-triazinthione, verfahren zu deren herstellung und diese verbindungen enthaltende therapeutische zubereitungen
DE2724478C2 (de) 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE68905363T2 (de) Heterotetracyclische laktamderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
CH675125A5 (enExample)
DE2042504A1 (de) Neue Derivate von Furan, Thiophen und Thiazol
DE2457309A1 (de) 2-phenylhydrazinothiazolin- beziehungsweise 2-phenylhydrazinothiazininderivate sowie ihre verwendung und verfahren zur herstellung derselben
CH616935A5 (en) Process for the preparation of chromone derivatives
EP0196330B1 (de) Verwendung von pyrrothinderivaten
DE1620434A1 (de) Verfahren zur Herstellung neuer heterocyclischer Verbindungen
DE2029510C3 (de) Dibenzofuranderivate und deren pharmazeutisch verträgliche Säureadditionssalze sowie Verfahren zu deren Herstellung und Arzneimittel mit einem Gehalt dieser Verbindungen
DE2410201A1 (de) 6-substituierte 3-carbaethoxyhydrazinopyridazine beziehungsweise ihre salze sowie ihre verwendung und verfahren zur herstellung derselben
DE2656678C2 (de) 4-Amino-trans-decahydrochinolin-Derivate und Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE2140601A1 (de) Derivate von Thiazolino Pyrin idinon und Verfahren zu deren Herstellung
DE69805709T2 (de) Bis Pyrido[4,3-B]Carbazolverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE1470084A1 (de) Verfahren zur Herstellung von substituierten Piperidin-derivaten
DE3843481A1 (de) Substituierte 3-azabicyclo/3.1.1/heptane, ihre herstellung und ihre verwendung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition