AU718361B2 - Camptothecin derivatives and the use thereof as antitumor agents - Google Patents

Camptothecin derivatives and the use thereof as antitumor agents Download PDF

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Publication number
AU718361B2
AU718361B2 AU18753/97A AU1875397A AU718361B2 AU 718361 B2 AU718361 B2 AU 718361B2 AU 18753/97 A AU18753/97 A AU 18753/97A AU 1875397 A AU1875397 A AU 1875397A AU 718361 B2 AU718361 B2 AU 718361B2
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AU
Australia
Prior art keywords
compound
formula
hydrogen
alkyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU18753/97A
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English (en)
Other versions
AU1875397A (en
Inventor
Lucio Merlini
Sergio Penco
Franco Zunino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11373368&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU718361(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Publication of AU1875397A publication Critical patent/AU1875397A/en
Application granted granted Critical
Publication of AU718361B2 publication Critical patent/AU718361B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
AU18753/97A 1996-02-23 1997-02-19 Camptothecin derivatives and the use thereof as antitumor agents Ceased AU718361B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT96MI000338A IT1282673B1 (it) 1996-02-23 1996-02-23 Derivati della camptotecina e loro uso come agenti antitumorali
ITMI96A000338 1996-02-23
PCT/EP1997/000786 WO1997031003A1 (en) 1996-02-23 1997-02-19 Camptothecin derivatives and the use thereof as antitumor agents

Publications (2)

Publication Number Publication Date
AU1875397A AU1875397A (en) 1997-09-10
AU718361B2 true AU718361B2 (en) 2000-04-13

Family

ID=11373368

Family Applications (1)

Application Number Title Priority Date Filing Date
AU18753/97A Ceased AU718361B2 (en) 1996-02-23 1997-02-19 Camptothecin derivatives and the use thereof as antitumor agents

Country Status (22)

Country Link
US (2) US6130227A (enExample)
EP (1) EP0885230B1 (enExample)
JP (1) JP4171527B2 (enExample)
KR (1) KR100497906B1 (enExample)
CN (1) CN1107677C (enExample)
AT (1) ATE221071T1 (enExample)
AU (1) AU718361B2 (enExample)
BR (1) BR9707622B1 (enExample)
CZ (1) CZ289268B6 (enExample)
DE (1) DE69714220T2 (enExample)
DK (1) DK0885230T3 (enExample)
EE (1) EE03529B1 (enExample)
ES (1) ES2180932T3 (enExample)
HU (1) HUP9900987A3 (enExample)
IL (1) IL125856A (enExample)
IT (1) IT1282673B1 (enExample)
NZ (1) NZ331126A (enExample)
PT (1) PT885230E (enExample)
RU (1) RU2165935C2 (enExample)
SK (1) SK283217B6 (enExample)
UA (1) UA49005C2 (enExample)
WO (1) WO1997031003A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69900689T2 (de) * 1998-06-26 2002-08-29 Quanam Medical Corp., Santa Clara Topoisomerase inhibitoren zur restenose-prevention
US7105492B2 (en) 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
EP1044977B1 (en) * 1999-03-09 2002-05-02 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Camptothecin derivatives having antitumor activity
AR025587A1 (es) 1999-09-13 2002-12-04 Hoffmann La Roche Formulaciones en dispersion que contienen inhibidores de lipasa
AU2002258787A1 (en) * 2001-04-11 2002-10-28 Emerald Biostructures, Inc. Screening methods for identifying ligands
RU2319482C2 (ru) * 2001-11-23 2008-03-20 Чугаи Сейяку Кабусики Кайся Способ идентификации противоопухолевых целевых ферментов
PL372318A1 (en) * 2002-03-01 2005-07-11 Pharmacia Italia S.P.A. Crystalline polymorphic form of irinotecan hydrochloride
TW200306314A (en) * 2002-04-16 2003-11-16 Tanabe Seiyaku Co Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
AR046579A1 (es) * 2003-11-12 2005-12-14 Smithkline Beecham Corp Compuesto cristalino de topotecan, composicion farmaceutica que lo comprende, procedimiento para prepararlo y su uso para preparar dicha composicion farmaceutica
PL1962850T3 (pl) * 2005-12-21 2012-07-31 Sigma Tau Ind Farmaceuti Leczenie lekoopornych nowotworów
WO2007095389A2 (en) * 2006-02-17 2007-08-23 Novacea, Inc. Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
CN101033230B (zh) 2006-03-10 2010-12-08 中国科学院上海药物研究所 一类喜树碱衍生物及其应用
ITMI20061474A1 (it) * 2006-07-26 2008-01-27 Indena Spa Derivati della camptotecina ad attivita antitumorale
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物
CN104774209B (zh) * 2014-01-15 2018-06-19 上海海和药物研究开发有限公司 一种9-烯丙基喜树碱衍生物的合成方法
WO2023030364A1 (zh) * 2021-09-01 2023-03-09 上海弼领生物技术有限公司 一种喜树碱类化合物、其制备方法和用途
CN120554369A (zh) * 2024-05-24 2025-08-29 深圳微芯生物科技股份有限公司 喜树碱类似物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
US5459269A (en) * 1992-06-18 1995-10-17 North Carolina State University 14-halo-camptothecins
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
IL127800A (en) * 1996-08-19 2005-11-20 Bionumerik Pharmaceuticals Inc Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
SK283217B6 (sk) 2003-03-04
CN1211987A (zh) 1999-03-24
CZ265298A3 (cs) 1999-01-13
RU2165935C2 (ru) 2001-04-27
SK112798A3 (en) 1999-01-11
US6306868B1 (en) 2001-10-23
ITMI960338A1 (it) 1997-08-23
ITMI960338A0 (enExample) 1996-02-23
EP0885230A1 (en) 1998-12-23
NZ331126A (en) 2000-02-28
AU1875397A (en) 1997-09-10
US6130227A (en) 2000-10-10
HUP9900987A2 (hu) 1999-08-30
WO1997031003A1 (en) 1997-08-28
KR19990087110A (ko) 1999-12-15
BR9707622B1 (pt) 2010-08-10
ATE221071T1 (de) 2002-08-15
IL125856A0 (en) 1999-04-11
EE03529B1 (et) 2001-10-15
IL125856A (en) 2001-08-26
UA49005C2 (uk) 2002-09-16
DK0885230T3 (da) 2002-11-18
EP0885230B1 (en) 2002-07-24
EE9800259A (et) 1999-02-15
ES2180932T3 (es) 2003-02-16
DE69714220T2 (de) 2002-11-14
HUP9900987A3 (en) 2000-01-28
DE69714220D1 (de) 2002-08-29
CZ289268B6 (cs) 2001-12-12
IT1282673B1 (it) 1998-03-31
KR100497906B1 (ko) 2006-03-09
CN1107677C (zh) 2003-05-07
JP4171527B2 (ja) 2008-10-22
BR9707622A (pt) 1999-07-27
JP2000505448A (ja) 2000-05-09
PT885230E (pt) 2002-12-31

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